|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preoperative diagnosis of malignant pulmonary nodules in lung cancer screening with a radiomics nomogram显示文摘Background:Lung cancer is the most commonly diagnosed cancer worldwide.Its survival rate can be significantly improved by early screening.Biomarkers based on radiomics features have been found to provide important physiological information on tumors and considered as having the potential to be used in the early screening of lung cancer.In this study,we aim to establish a radiomics model and develop a tool to improve the discrimination between benign and malignant pulmonary nodules.Methods:A retrospective study was conducted on 875 patients with benign or malignant pulmonary nodules who underwent computed tomography(CT)examinations between June 2013 and June 2018.We assigned 612 patients to a training cohort and 263 patients to a validation cohort.Radiomics features were extracted from the CT images of each patient.Least absolute shrinkage and selection operator(LASSO)was used for radiomics feature selection and radiomics score calculation.Multivariate logistic regression analysis was used to develop a classification model and radiomics nomogram.Radiomics score and clinical variables were used to distinguish benign and malignant pulmonary nodules in logistic model.The performance of the radiomics nomogram was evaluated by the area under the curve(AUC),calibration curve and Hosmer-Lemeshow test in both the training and validation cohorts.Results:A radiomics score was built and consisted of 20 features selected by LASSO from 1288 radiomics features in the training cohort.The multivariate logistic model and radiomics nomogram were constructed using the radiomics score and patients’age.Good discrimination of benign and malignant pulmonary nodules was obtained from the training cohort(AUC,0.836;95%confidence interval[CI]:0.793-0.879)and validation cohort(AUC,0.809;95%CI:0.745-0.872).The Hosmer-Lemeshow test also showed good performance for the logistic regression model in the training cohort(P=0.765)and validation cohort(P=0.064).Good alignment with the calibration curve indicated the good performance of the nomogram.Conclusions:The established radiomics nomogram is a noninvasive preoperative prediction tool for malignant pulmonary nodule diagnosis.Validation revealed that this nomogram exhibited excellent discrimination and calibration capacities,suggesting its clinical utility in the early screening of lung cancer. | Ailing Liu Zhiheng Wang Yachao Yang Jingtao Wang Xiaoyu Dai Lijie Wang Yuan Lu Fuzhong Xue | 2020 | Cancer Communications2020，40，1： | 22 |
| 2 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 3 | Studies on Lung Cancer Angiogenesis-Application of Interventional Therapy (A Report of 56 Cases)显示文摘OBJECTIVE To investigate the significance of angiogenesis of lung cancer, in order to provide a scientific basis for interventional therapy. METHODS Double-phase enhancementscanning spiral CT and DSA were performed in 56 pathologically confi rmed lung cancer cases, in order to evaluate angiogenesis of the tumors. The patients included 36 males and 20 females, with ages ranging from 33 to 76 years (average of 53). Assessments and indexes for SCT and DSA examinations were as follows: a) Peak value (PV) of the cancerous focus was the difference between the maximum CT value after enhancement and the CT value of a plain scan; b) The abnormally distorted and expanded new vessels of the cancerous focus which could be macroscopically discriminated; c) DSA staining of the focus of cancer was sparse, grid-like and dense. Chemotherapy and embolotherapy via the bronchial artery (interventional therapy) were conducted. Radiotherapy was added for some of the solid tumors with a diameter exceeding 4 cm. RESULTS a) There were 25 cases with a central-type lesion, among which 4 were small cell lung cancers (SCLC) and 21 non-small cell lung cancers (NSCLC). The cases with a peripheral location accounted for 31 of the total, with a maximum diameter of 1.5 to 13.5 cm and a median of 4.2 cm, including 5 small cell lung cancers and 26 NSCLC cases. b) The reinforced PVs of the cancerous foci were as follows: The PV ranged from 45 to 70 Hu in 34 cases, 25 to 45 Hu in 19, and 10 to 25 Hu in 3. Sparse DSA staining occurred in 3 cases, there was uneven grid-like staining in 22 and dense staining in 31; c) The interventional therapy via the bronchial artery was con-ducted twice in 5 cases with the SCLC, and three times in 4 SCLC cases. For 3 of the latter cases, a dose of 5,000 to 7,000 cGy radiation therapy was added during the interventional treatment. Complete remissions (CR) were seen in 88.9% of the cases (8/9) and partial remission (PR) in 11.1% (1/9). Interventional therapy was conducted twice in 8 cases with NSCLC and three times in 30 with NSCLC and four times in 9 cases. Among the total cases, 13 received radiotherapy during interventional therapy, with a radiation dose of 5,000-7,000 cGy; The CR rate was 78.7% (37/47), PR was 14.9% (7/47) and the rate of non-remission was 6.4% (3/47). CONCLUSION Using imaging technology, analysis of angiogenesis of lung cancers was employed to accurately detect and quantify angiogenesis. This analysis was combined for interventional therapy, using embolizing agents and large doses of the anti-tumor drugs and angiogenesis inhibitors. The agents were selectively delivered into the tumor vessels to eliminate the primary tumor, in order to depress distant metastases and thus enhance the curative effect of the therapy. | Qiang Zhang Jun Guo Hailong Qian Baoqi Shi Jigang Zhang Chunjing Li Ailing Yang Zhuang Tian Baotou No. 7 Hospital Department of Radiol-ogy, Baotou Cancer Hospital, Baotou 014030, Inner Mongolia Autonomous Region, China. | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 5 |
| 4 | Photoluminescence and defect evolution of nano-ZnO thin films at low temperature annealing显示文摘Nano-ZnO thin films composed of nanoparticles with sizes of 10-16 nm on silicon substrates at low temperature were prepared by sol-gel method.By placing the nano-ZnO thin films at room temperature or annealing at 100°C in air for 10 h intermittently,within a total 70 h annealing time,the evolution of PL spectra of the nano-ZnO thin films were studied in detail.As the annealing time increases,the PL peaks shift from violet to blue and green bands.The PL peaks at violet and blue bands decrease with the annealing time,but the PL peaks at green band are opposite.The PL spectra are related to the defects in the nano-ZnO thin films.The PL peaks positioned at 430 nm are mainly related to defects of zinc interstatials(Zni),oxygen vacancies and(Vo);the ones at 420 nm to oxygen interstitials(Oi),Zinc vacancies(Vzn),Zni ;and the ones at 468 nm to Vzn,Zni,and charged oxygen interstatials(Vo+).The green luminescence is related to Oi,Vo and Zni.The evolutions of PL spectra and the defects are also related to the concentrations of Zn in the thin films,the thicknesses of the films and the annealing time.For the films with 0.5 M and 1.0 M Zn concentrations,after 20 h and 30 h annealing in air at 100°C,respectively,either placing them in air at room temperature or continuing anneal in air at 100°C,the PL spectra are stable.Under the low temperature annealing,Zni decreases with the annealing time,and Oi increases.Sufficient Oi favors to keep the nano-ZnO thin films stable.This result is important to nano-ZnO thin films as electron transport layers in inverted or tandem organic solar cells. | YANG AiLing YANG Yun ZHANG ZhenZhen BAO XiChang YANG RenQiang LI ShunPin SUN Liang | 2013 | Science China(Technological Sciences)2013，56，1： | 5 |
| 5 | Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘 | Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng | 2013 | Cell Research2013，23，7： | 5 |
| 6 | Tuning the intermolecular interaction of A_(2)-A_(1)-D-A_(1)-A_(2) type non-fullerene acceptors by substituent engineering for organic solar cells with ultrahigh V_(OC) of ~1.2 V显示文摘For non-fullerene acceptors(NFAs)with linear A_(2)-A_(1)-D-A_(1)-A_(2) backbone,there are three kinds of possible intermolecular interaction,A_(1)-A_(1),A_(1)-A_(2) and A_(2)-A_(2) stacking.Hence,it is a huge challenge to control this interaction and investigate the effect of intermolecular stacking model on the photovoltaic performance.Here,we adopt a feasible strategy,by utilizing different substituent groups on terminal A2 unit of dicyanomethylene rhodanine(RCN),to modulate this stacking model.According to theoretical calculation results,the molecule BTA3 with ethyl substituent packs via heterogeneous interaction between A_(2) and A_(1) unit in neighboring molecules.Surprisingly,the benzyl group can effectively transform the aggregation of BTA5 into homogeneous packing of A_(2)-A_(2) model,which might be driven by the strong interaction between benzyl and A1(benzotriazole)unit.However,different with benzyl,phenyl end group impedes the intermolecular interaction of BTA4 due to the large steric hindrance.When using a BTA-based D-π-A polymer J52-F as donor according to“Same-A-Strategy”,BTA3-5 could achieve ultrahigh open-circuit voltage(VOC)of 1.17–1.21 V.Finally,BTA5 with benzyl groups realized an improved power conversion efficiency(PCE)of 11.27%,obviously higher than that of BTA3(PCE=9.04%)and BTA4(PCE=5.61%).It is also worth noting that the same trend can be found when using other four classic p-type polymers of P3HT,PTB7,PTB7-Th and PBDB-T.This work not only investigates the intermolecular interaction of A_(2)-A_(1)-D-A_(1)-A_(2) type NFAs for the first time,but also provides a straightforward and universal method to change the interaction model and improve the photovoltaic performance. | Xiaochen Wang Ailing Tang Jing Yang Mengzhen Du Jianfeng Li Gongqiang Li Qiang Guo Erjun Zhou | 2020 | Science China Chemistry2020，63，11： | 5 |
| 7 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 8 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 9 | Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome显示文摘The fungus Trichophyton schoenleinii(T.schoenleinii)is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa.Hu-man innate immune system plays an important role in combating with various pathogens including fungi.The inflammasome is one of the most critical arms of host innate immunity,which is a protein complex controlling maturation of IL-1β.To clarify whether T.schoenleinii is able to activate the infl ammasome,we analyzed human monocytic cell line THP-1 for IL-1βproduction upon infec-tion with T.schoenleinii strain isolated from Tinea favosa patients,and rapid IL-1βsecretion from THP-1 cells was observed.Moreover,applying competitive inhibitors and gene specifi c silencing with shRNA,we found that T.sch-oenleinii induced IL-1βsecretion,ASC pyroptosome for-mation as well as caspase-1 activation were all dependent on NLRP3.Cathepsin B activity,ROS production and K+effl ux were required for the infl ammasome activation by T.schoenleinii.Our data thus reveal that the NLRP3 infl am-masome plays an important role in host defense against T.schoenleinii,and suggest that manipulating NLRP3 signaling can be a novel approach for control of diseases caused by T.schoenleinii infection. | Hua Li Shuxian Wu Liming Mao Guowei Lei Liping Zhang Ailing Lu Liguo An Guiwen Yang Paride Abliz Guangxun Meng | 2013 | Protein & Cell2013，4，7： | 3 |
| 10 | Stepwise synthesis of cuprous oxide nanoparticles with adjustable structures and growth model显示文摘By stepwise adding of reducer N2H4·H2O,cuprous oxide(Cu2O)nanoparticles(NPs)with adjustable structures were synthesized.The features of Cu2O NPs were characterized by XRD,TEM and UV-Vis absorption spectra.When the reducer was added into the reactant system at one time,the sizes of the Cu2O NPs are in the range of 120–140 nm.Most Cu2O NPs are solid spheres.As the reducer was divided into two equal parts and stepwisely added,almost all the NPs are hollow spheres with good size(150–170 nm)distribution and dispersity.But when the reducer was divided into three or four equal parts and stepwisely added,the NPs are hollow spheres,core-shell structures or solid spheres,and the sizes distribution of the products is deteriorated.The effect of sodium hydrate(NaOH)was also probed.Addition of NaOH speeded up the nucleation and growth processes of Cu2O NPs.With the alkalinity increase,the shells of the hollow spheres become compact and the thicknesses of the shells increase,but the size distribution of the NPs is deteriorated.The absorption spectra of the Cu2O NPs are tunable.With the shell thicknesses increase,the absorption peaks have red shifts.An inside-outside growth model of Cu2O NPs was proposed to explain the results.The Cu2O single crystalline grains grow not only in the reactant solution,but also inside of the hollow nanospheres.The new Cu2O nanocrystallines can not only aggregate onto the shells of the nano hollow spheres,but also inside and outside of the hollow spheres,which leads to increasing the shell thicknesses of the hollow spheres,forming core-shell structures or small solid spheres of Cu2O NPs,respectively. | YANG AiLing WANG YuJin LI ShunPin BAO XiChang YANG RenQiang | 2014 | Science China(Technological Sciences)2014，57，11： | 3 |
| 11 | Bioactive glass sol as a dual function additive for chitosan-alginate hybrid scaffold显示文摘Bioactive glass-chitosan-alginate hybrid scaffolds(BG-C-A scaffolds) were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-linker to improve the structural stability and mechanical properties. The microstructure,physicochemical and mechanical properties, in vitro bioactivity and cellular biocompatibility of the scaffolds were investigated. The results indicated that BG component was successfully incorporated into the BG-C-A scaffolds through a facile BG sol-immersing method and the original interconnected microstructure could be well preserved. The obtained BG-C-A scaffolds showed improved mechanical properties and structural stability as compared to C-A scaffolds. At the same time, they presented excellent in vitro bioactivity and cellular compatibility. All these results demonstrated that these BG-C-A scaffolds have promising potential for tissue engineering. | Huihui Ren Yang Cui Ailing Li Dong Qiu | 2018 | Chinese Chemical Letters2018，29，3： | 2 |
| 12 | Tectonic Implications and Petrogenesis of the Various Types of Magmatic Rocks from the Zedang Area in Southern Tibet显示文摘In this study,we report systematically field observations,geochronology,whole-rock geochemistry and Sr-Nd-Hf isotopic dataset on the various types of magmatic rocks collected from the Zedang area.Chemically,the diabase and gabbro have a low-K calc-alkaline affinity,whereas the basalt and plagiogranite have medium to high-K calc-alkaline characteristics.In addition,the basalts are highly enriched in light rare earth elements(LREE)and large ion lithophile elements(LILE),but strongly depleted in high strength field elements(HFSE),indicating that their magma source probably was derived from a subduction-or arc-related setting.In contrast,both the gabbro and diabase mainly demonstrate an N-MORB-like affinity consistent with normal mid-oceanic ridge basalt(N-MORB)origin.The zircon U-Pb dating results suggest that the basalts were crystallized earlier at ca.158–161 Ma(Oxfordian stage),but the gabbro was crystallized at ca.131 Ma(Hauterivian stage of Early Cretaceous).The zircon U-Pb dating results correspond with the field observations that the veins of gabbro intruded basalt.Furthermore,the plagiogranite has a weighted mean age of ca.160 Ma(MSWD=2.1)consistent with the basalt within the uncertainty.The basalt and the plagiogranite have significantly positiveεHf(t)values(+5.8 to+15.6 and+8.6 to+16.1,respectively),suggesting that they were originated from partial melting of a depleted source.However,basalt and plagiogranite are characterized by the wide variations ofεHf(t)values indicating minor amounts of exotic crustal material input during the later magma evolution.Additionally,the basalt shows duplex geochemical features of island-arc and mid-oceanic ridge basalt,corresponding to the supra-subduction zone-(SSZ)type affinity.To sum up,two distinct magmatic events identified in this study probably suggest an intra-oceanic arc system existing in the Zedang area during the Late Jurassic,but the intra-oceanic arc subduction extinguished in the Early Cretaceous as suggested by the N-MORB-like gabbro and diabase.Integrated with regional background and different rock types,as well as geochemical features,we conclude that intra-oceanic arc subduction setting developed during the Late Jurassic in the Zedang area,southern Tibet. | Yuanku Mengc Fahui Xiong Jingsui Yang Zhao Liu Kieran AIles Paul TRobinson Xiangzhen Xu | 2019 | Journal of Earth Science2019，30，6： | 2 |
| 13 | Wide Band Gap Non-Fullerene Small Molecular Acceptors Containing Spirobifluorene and Benzotriazole with Three Different End-Capped Groups for P3HT-Based Organic Solar Cells显示文摘 | Xiaoyu Wen Bo Xiao Ailing Tang Junyi Hu Chunhe Yang Erjun Zhou | 2018 | Chinese Journal of Chemistry2018，36，5： | 2 |
| 14 | Management Algorithm for Prevention of Mother-to-child Transmission of Hepatitis B Virus(2022)显示文摘The World Health Organization(WHO)has set the goal of eliminating hepatitis as a threat to public health by 2030.Blocking mother-to-child transmission(MTCT)of hepatitis B virus(HBV)is not only the key to eliminating viral hepatitis,but also a hot issue in the field of hepatitis B prevention and treatment.To standardize the clinical management of preventing MTCT of HBV and achieve zero HBV infection among infants,the Chinese Foundation for Hepatitis Prevention and Control organized experts to compile a management algorithm for prevention of MTCT of HBV based on the latest research progress and guidelines,including 10 steps of pregnancy management and postpartum follow-up,among which screening,antiviral treatment,and infant immunization are its core components. | Zhihua Liu Zhongdan Chen Fuqiang Cui Yang Ding Yunfei Gao Guorong Han Jidong Jia Jie Li Zengde Li Yingxia Liu Qing Mao Ailing Wang Wei Wang Lai Wei Jianhong Xia Qing Xie Xizhong Yang Xueru Yin Hua Zhang Liaoyun Zhang Wenhong Zhang Hui Zhuang Xiaoguang Dou Jinlin Hou | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 2 |
| 15 | 增温和放牧对高寒草甸凋落物分解及其养分释放的影响不依赖于凋落物品质显示文摘在放牧生态系统中,增温、放牧和调落物品质共同决定着凋落物分解和养分释放。然而,在以往的研究中这些因子的效应通常被单独地研究。在本研究中,我们在青藏高原高寒草甸开展了一个昼夜非对称增温和中度放牧两因子的调落物分解试验。从每个处理中收集了调落物样品,这些调落物一部分放在它们的来源处理小区,另一部分放在其他处理小区以此来探究增温、放牧以及调落物品质对调落物分解和养分释放的影响。研究结果表明,增温而不是放牧显著增加了调落物质量的损失、单位面积全碳、全氮以及全磷含量的损失,这主要是因为增温增加了落物生物量和分解速率。然而,尽管同时增温放牧处理也加快了调落物分解速率,但由于降低了调落物生物量,所以增温放牧处理并没有显著影响单位面积的凋落物碳和养分释放量。相比木质素含量和碳氮比而言,季节性土壤平均温度能够更好地预测调落物分解速率。增温和放牧对调落物分解存在交互作用,但它们和调落物品质对调落物的影响均不存在交互作用。单位面积的总氮释放的温度敏感性要高于总磷。因此,我们的结果表明,增温对调落物分解以及养分释放的影响要显著大于调落物品质变化对其分解的影响。在高寒草甸,氮释放的增加可能会间接导致土壤磷有效性的缺乏。 | Bowen Li Wangwang Lv Jianping Sun Lirong Zhang Lili Jiang Yang Zhou Peipei Liu Huan Hong Qi Wang Wang A Suren Zhang Lu Xia Zongsong Wang Tsechoe Dorji Ailing Su Caiyun Luo Zhenhua Zhang Shiping Wang | 2022 | Journal of Plant Ecology2022，15，5： | 1 |
| 16 | Synthesis of Ag@Cu_2O core-shell metal-semiconductor nanoparticles and conversion to Ag@Cu core-shell bimetallic nanoparticles显示文摘Ag@Cu2O core-shell metal-semiconductor nanoparticles(NPs) were prepared by using solution phase strategy. It was found that Ag@Cu2O core-shell NPs were easily converted to Ag@Cu bimetallic core-shell NPs with the help of surfactant PVP and excessive reducer ascorbic acid in air at room temperature, which is a unique phenomenon. Varying volumes of Ag colloidal solutions were added into the reaction mixtures containing fixed initial concentrations of Cu2+ and PVP, Ag@Cu2O and Ag@Cu core-shell NPs with fixed core size but varying outer shell thicknesses could be obtained. The composites, structures, morphologies and extinction properties of Ag@Cu2O and Ag@Cu core-shell NPs were systematically characterized by XRD, TEM and extinction spectra. Both of these NPs show wide tunable optical properties. The extinction peaks could be shifted from 421 nm to 700 nm. FTIR results reveal that Cu+ ions on the surface of Cu2 O nanocrystalline coordinate with N and O atoms in PVP and further are reduced to metallic Cu by excessive ascorbic acid and then form a nucleation site on the surface of Cu2 O nanocrystalline. PVP binds onto a different site to proceed with the reduction until all the Cu sources in Cu2 O NPs are completely assumed. And the shell of Cu2 O is converted to Cu shell. The synthesis approach in this paper is simple and also a promising reference for synthesizing other core-shell NPs. Ag@Cu2O NPs can be easily converted to Ag@Cu NPs in air at room temperature, which is promising to be used in electronic devices. | YANG AiLing LI ShunPin WANG YuJin WANG LeLe BAO XiChang YANG RenQiang | 2015 | Science China(Technological Sciences)2015，58，5： | 1 |
| 17 | SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling显示文摘Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains unknown.To answer this question,we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome.In our screen,Prosap was identified as a novel regulator of the Hippo pathway that potently affects tissue growth.Interestingly,a mammalian homolog of Prosap,SHANK2,is the most frequently amplified gene on 11 q13,a major tumor amplicon in human cancer.Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.More importantly,across the human cancer genome,SHANK2 is the most frequently amplified gene that is not located within the Myc amplicon.Further studies in multiple human cell lines confirmed that SHANK2 overexpression causes deregulation of Hippo signaling through competitive binding for a LATS1 activator,and as a potential oncogene,SHANK2 promotes cellular transformation and tumor formation in vivo.In cancer cell lines with deregulated Hippo pathway,depletion of SHANK2 restores Hippo signaling and ceases cellular proliferation.Taken together,these results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator,commonly amplified in human cancer and potently promotes cancer.Our study for the first time illustrated oncogenic function of SHANK2,one of the most frequently amplified gene in human cancer.Furthermore,given that in normal adult tissues,SHANK2 s expression is largely restricted to the nervous system,SHANK2 may represent an interesting target for anticancer therapy. | Liang Xu Peixue Li Xue Hao Yi Lu Mingxian Liu Wenqian Song Lin Shan Jiao Yu Hongyu Ding Shishuang Chen Ailing Yang Yi Arial Zeng Lei Zhang Hai Jiang | 2021 | Protein & Cell2021，12，3： | 1 |
| 18 | A Case of Refractory Childhood Glaucoma Secondary to Weill-Marchesani Syndrome:Management with Combined CO_(2) Laser-Assisted Sclerectomy Surgery and Trabeculectomy显示文摘A 2-year-old girl was diagnosed as Weill-Marchesani syndrome with typical systemic features of short stature,short and stubby hands and feet,language disorders and mental retardation.He developed bilateral angle closure glaucoma,ectopia lentis and suffered visual loss from the ocular features of Weill-Marchesani syndrome.The child was successfully treated by combined CO_(2) laser-assisted sclerectomy surgery and trabeculectomy. | Yang Zhang Ailing Bian Anyi Liang Fei Mo Gangwei Cheng | 2022 | Chinese Medical Sciences Journal2022，37，2： | 1 |
| 19 | Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment显示文摘For coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),15–30%of patients are likely to develop COVID-19-related acute respiratory distress syndrome(ARDS).There are still few effective and well-understood therapies available.Novel variants and short-lasting immunity are posing challenges to vaccine efficacy,so finding antiviral and antiinflammatory treatments remains crucial.Here,tripterin(TP),a traditional Chinese medicine,was encapsulated into liposome(TP lipo)to investigate its antiviral and antiinflammatory effects in severe COVID-19.By using two severe COVID-19 models in human ACE2-transgenic(hACE2)mice,an analysis of TP lipo’s effects on pulmonary immune responses was conducted.Pulmonary pathological alterations and viral burden were reduced by TP lipo treatment.TP lipo inhibits SARS-CoV-2 replication and hyperinflammation in infected cells and mice,two crucial events in severe COVID-19 pathophysiology,it is a promising drug candidate to treat SARS-CoV-2-induced ARDS. | Haiying Que Weiqi Hong Tianxia Lan Hao Zeng Li Chen Dandan Wan Zhenfei Bi Wenyan Ren Min Luo Jingyun Yang Cai He Ailing Zhong Xiawei Wei | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 1 |
| 20 | Lead poisoning in China: a nightmare from industrialisation显示文摘 | Ailing Ji Feng Wang Wenjing Luo Ruihua Yang Jingyuan Chen Tongjian Cai | 2011 | The Lancet2011，，9776： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员