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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | Microwave-assisted dissolution and delignification of wood in 1-ethyl-3-methylimidazolium acetate显示文摘 | WANG H MAXIM M L GURAU G | 2013 | Bioresource Technology2013，136，： | 1 |
| 3 | Categorization and nomenclature of vitreous silicate wools 显示文摘 | Moore M A Boymel P M Maxim L D | 2002 | Regul Toxicol Pharm2002，35，1： | 1 |
| 4 | Risk analysis for mortality from respiratory tumors in a cohort of refractory ceramic fiber workers 显示文摘 | WALKER A M MAXIM L D UTELL M | 2002 | Regul Toxicol Pharmacol2002，35，1： | 1 |
| 5 | Categorization and nomenclature of vitreous silicate wools 显示文摘 | Martin A Moore Paul M Boymel Daniel Maxim L | 2002 | Reg Toxicol Pharmacol2002，35，： | 1 |
| 6 | Hazard assessment and risk analysis of two new synthetic vitreous fibers显示文摘 | Daniel Maxim L Richard W Mast Utell M J | 1999 | Reg Toxicol Pharmacol1999，30，： | 1 |
| 7 | An analysis of risks for biodiversity under the DPSIR framework显示文摘 | Maxim L Spangenberg J H OrConnor M | 2009 | Eco- logical Economics2009，69，1： | 1 |
| 8 | ABF+ +: fast and robust angle based flattening 显示文摘 | SHEFFER A BRUNO L MAXIM M | 2005 | ACM Transactions on Graphics2005，24，2： | 1 |
| 9 | Discovery of symbiotic Nitrogen-fixing Cyanobacteria in Corals显示文摘 | Michael P L Charles H M Maxim Y G | 2004 | Science2004，305，： | 1 |
| 10 | Fiber glass and rock/slag wool exposure of professional and do-it-yourself installers显示文摘 | L Daniel Maxim Walter Eastes John G Hadley Charles M Carter Janis W Reynolds Ron Niebo | 2003 | Regulatory Toxicology and Pharmacology2003，，1： | 1 |
| 11 | Use of Polyoxometalate Catalysts in ionic liquids to enhance the dissolution and delignification of woody biomass 显示文摘 | Sun N Jiang X Y Maxim M L | 2011 | Chem Sus Chem2011，4，1： | 1 |
| 12 | Risk analysis for mortality from respiratory tumors in a cohort of refractory ceramic fiber workers显示文摘 | Walker A M Maxim L D Utell M | 2002 | Regul Toxicol Pharmacol2002，35，1： | 1 |
| 13 | Morphology of ion-sputtered surfaces显示文摘 | MAXIM A M RODOLFO C ALBERT L B | 2002 | Nuclear Instruments and Method in Physics Research B2002，197，： | 1 |
| 14 | Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry显示文摘Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well.However,outcomes after EVT in these late window patients without perfusion imaging are largely unknown.We assessed their characteristics and outcomes in routine clinical practice.Methods The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017.CT perfusion was no standard imaging modality.We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous thrombolysis.Outcomes included 3-month mRS score,functional independence(defined as mRS 0-2),and death.Results Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke onset.CT perfusion was not performed in 87/106(80.2%)late window patients.Late window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics.randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window. | Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H Jansen Maxim J H L Mulder Robin Lemmens Robert-Jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 15 | An analysis of Risks for Biodiversity Under the DPSIR Framework显示文摘 | Maxim L Spangenberg JH O'Connor M | 2009 | Ecological Economics2009，29，1： | 1 |
| 16 | Microwave-assisted dissolu-tion and delignification of wood in 1-ethyl-3-methylimidazolium ace- tate显示文摘 | Wang H Maxim M L Gurau G | 2013 | Bioresource Technology2013，136，： | 1 |
| 17 | An analysis of risks for biodiversity under the DPSIR framework显示文摘 | MAXIM L SPANGERNBERG J H O' CONNOR M | 2009 | Ecological and Economic2009，69，： | 1 |
| 18 | Microwave-assisted dissolution and delignification of wood in 1-ethyl-3-methylimidazolium acetate 显示文摘 | WANG Hui MAXIM M L GURAU G | 2013 | Bioresource Technology2013，136，： | 1 |
| 19 | Use of polyoxometalate catalysts in ionic liquids to enhance the dissolution and delignification of woody biomass显示文摘 | Sun N Liang X Y Maxim M L | 2011 | ChemSusChem2011，4，1： | 1 |
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