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| 1 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 2 | 小型无人直升机纵向和横向动力学的鲁棒反推控制(英文)显示文摘研究了阵风情况下悬停飞行模式中的无人直升机的纵向与横向位置的稳定性问题.由于通用的线性模型成功地描述了大多数小型直升机的行为,其被用来设计控制器.基于控制Lyapunov方法,一种递归(反推)设计流程被用来设计纵向和横向动力学的鲁棒控制器.为了比较,我们基于线性二次调节器(LQR)准则设计了另一种控制器.仿真结果表明,所提出的反馈控制器能有效地减弱阵风的影响,在阵风下能够实现纵向和横向位置的快速、准确跟踪. | Tushar K Roy Matt Garratt Hemanshu R Pota Hamid Teimoori | 2012 | 中国科学技术大学学报2012，42，7： | 2 |
| 3 | Polypyrrole composites for shielding applications 显示文摘 | Ozlem Yayuz Mannoj K Ram Matt Aldissi | 2005 | Synthetic Metals2005，151，3： | 1 |
| 4 | Fusion of the tissue factor extracellular domain to a tumor stroma specific single-chain fragment variable antibody results in an antigen-specific coagulation-promoting molecule显示文摘 | Rippmann JF Pfizenmaier K Mattes R | 2000 | Biochemistrv2000，349，3： | 1 |
| 5 | Outside Influence: TLRs direct hematopoietic cell fates显示文摘 | T Matt Holl Gamett K | 2006 | Immtmity2006，24，： | 1 |
| 6 | NO in exhaled air is correlated with markers of eosinophilic airway inflammation in corticosteroid-dependent childhood asthma 显示文摘 | Mattes J Storm van's Gravesande K | 1999 | Eur Respir J1999，13，： | 1 |
| 7 | Fusion of the tissue factor extracellular domain to a tumor stroma specific single -chain fragment variable antibody results in an antigen - specific coagulation - promoting molecule 显示文摘 | Rippmarm JF Pfizenmaier K Mattes R | 2000 | Biochem J2000，349，3： | 1 |
| 8 | Hydroxy fatty acids as indicators for ageing and the influence of oxygen in the brewhouse on the flavour stability of beer显示文摘 | Wackerbauer K Meyna S Matte S | 2003 | Monatsschrift Fur Brauwissenschaft2003，56，910： | 1 |
| 9 | New potent antihyperglycemie agents in db/db mice:synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl) pyrazoles and pyrazolones 显示文摘 | Kees K L Steiner K E Mattes J F | 1996 | J Med Chem1996，，39： | 1 |
| 10 | Successful RNA extraction from various human postmortem tissues显示文摘 | Heinrich M Matt K Lutz-Bonengel S | 2007 | Int J Leg Med2007，121，2： | 1 |
| 11 | Die kristallstruktur yon BeB3 显示文摘 | Mattes R Tebbe K F Neidhard | 1975 | Z Anorg Allg Chem1975，413，1： | 1 |
| 12 | Lessons on longevity from budding yeast显示文摘 | Matt K | | 0，，7288： | 1 |
| 13 | Advancing post-anoxic denitrification for biological nutrient removal 显示文摘 | MATT W E R C BRINKMAN C K | 2011 | Water Res2011，45，12： | 1 |
| 14 | Real-time PCR detection of five different'endogenous control gene'transcripts in forensic autopsy material显示文摘 | Heinrich M Lutz-Bonengel S Matt K | 2007 | Forensic Sci Int Genet2007，1，2： | 1 |
| 15 | Summer heat and mortality in New York city: How hot is too hot 显示文摘 | Metzger K B Ito K Matte T | 2010 | Environmental Health Perspectives2010，118，1： | 1 |
| 16 | Application of in-line near infrared spectroscopy and multivariate batch modeling for process monitoring in fluid bed granulation 显示文摘 | Kona R K Qu H B Mattes R | 2013 | Int J Pharm2013，452，12： | 1 |
| 17 | Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis 显示文摘 | Dev K K Mullershausen F Mattes H | 2008 | Pharmacol Ther2008，117，1： | 1 |
| 18 | MoS2 and WS2 analogues of graphene显示文摘 | Matte H Gomathi A Manna A K | | 0，，24： | 1 |
| 19 | Muscular coordination of the lower extremities of oarsmen during ergometer rowing 显示文摘 | JANSHEN L MATTES K TIDOW G | 2009 | Journal of Applied Biomechanics2009，25，2： | 1 |
| 20 | Should patients with challenging anatomy be offered endovascular aneurysm repair?显示文摘 | Roy K Greenberg Daniel Clair Sunita Srivastava Guru Bhandari Adrian Turc Jennifer Hampton Matt Popa Richard Green Kenneth Ouriel | 2003 | Journal of Vascular Surgery2003，，： | 1 |
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