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| 1 | Alternatives for large-scale production of cultured beef: A review显示文摘Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today's 2-dimensional(2D) standard technique that was used to make the first cultured hamburger. Options for efficient large-scale production of stem cells are to culture cells on microcarriers, either in suspension or in a packed bed bioreactor, or to culture aggregated cells in suspension. We discuss the pros and cons of these systems as well as the possibilities to use the systems for tissue culture. Either of the production systems needs to be optimized to achieve an efficient production of cultured beef. It is anticipated that the optimization of large-scale cell culture as performed for other stem cells can be translated into successful protocols for bovine satellite cells resulting in resource and cost efficient cultured beef. | Matilda S M Moritz Sanne E L Verbruggen Mark J Post | 2015 | Journal of Integrative Agriculture2015，14，2： | 7 |
| 2 | Proton pump inhibitor-induced hypomagnesemia: A new challenge显示文摘Proton pump inhibitors(PPIs)are commonly used in clinical practice for the prevention and treatment of peptic ulcer,gastritis,esophagitis and gastroesophageal reflux.Hypomagnesemia has recently been recognized as a side effect of PPIs.Low magnesium levels may cause symptoms from several systems,some of which being potentially serious,such as tetany,seizures and arrhythmias.It seems that PPIs affect the gastrointestinal absorption of magnesium.Clinicians should be vigilant in order to timely consider and prevent or reverse hypomagnesemia in patients who take PPIs,especially if they are prone to this electrolyte disorder. | Matilda Florentin Moses S Elisaf | 2012 | World Journal of Nephrology2012，1，6： | 5 |
| 3 | Socio-cultural determinants of timely and delayed treatment of Buruli ulcer: implications for disease control显示文摘Introduction:Public health programmes recommend timely medical treatment for Buruli ulcer(BU)infection to prevent pre-ulcer conditions from progressing to ulcers,to minimise surgery,disabilities and the socio-economic impact of BU.Clarifying the role of socio-cultural determinants of timely medical treatment may assist in guiding public health programmes to improve treatment outcomes.This study clarified the role of socio-cultural determinants and health system factors affecting timely medical treatment for BU in an endemic area in Ghana.Methods:A semi-structured explanatory model interview based on the explanatory model interview catalogue(EMIC)was administered to 178 BU-affected persons.Based on research evidence,respondents were classified as timely treatment(use of medical treatment 3 months from awareness of disease)and delayed treatment(medical treatment 3 months after onset of disease and failure to use medical treatment).The outcome variable,timely treatment was analysed with cultural epidemiological variables for categories of distress,perceived causes of BU,outside-help and reasons for medical treatment in logistic regression models.The median time for the onset of symptoms to treatment was computed in days.Qualitative phenomenological analysis of respondents’narratives clarified the meaning,context and dynamic features of the relationship of explanatory variables with timely medical treatment.Results:The median time for initiating treatment was 25 days for pre-ulcers,and 204 days for ulcers.Income loss and use of herbalists showed significantly negative associations with timely treatment.Respondents’use of herbalists was often motivated by the desire for quick recovery in order to continue with work and because herbalists were relatives and easily accessible.However,drinking unclean water was significantly associated with timely treatment and access to health services encouraged timely treatment(OR 8.5,p=0.012).Findings show that health system factors of access are responsible for non-compliance to treatment regimes.Conclusions:Findings highlight the importance of an integrated approach to BU control and management considering the social and economic features that influence delayed treatment and factors that encourage timely medical treatment.This approach should consider periodic screening for early case-detection,collaboration with private practitioners and traditional healers,use of mobile services to improve access,adherence and treatment outcomes. | Mercy M Ackumey Margaret Gyapong Matilda Pappoe Cynthia Kwakye Maclean Mitchell G Weiss | 2012 | Infectious Diseases of Poverty2012，1，1： | 3 |
| 4 | Role of dipeptidyl peptidase 4 inhibitors in the new era of antidiabetic treatment显示文摘The last few years important changes have occurred in the field of diabetes treatment.The priority in the therapy of patients with diabetes is not glycemic control per se rather an overall management of risk factors,while individualization of glycemic target is suggested.Furthermore,regulatory authorities now require evidence of cardiovascular(CV)safety in order to approve new antidiabetic agents.The most novel drug classes,i.e.,sodium-glucose transporter 2 inhibitors(SGLT2-i)and some glucagon-like peptide-1 receptor agonists(GLP-1 RA),have been demonstrated to reduce major adverse CV events and,thus,have a prominent position in the therapeutic algorithm of hyperglycemia.In this context,the role of previously used hypoglycemic agents,including dipeptidyl peptidase 4(DPP-4)inhibitors,has been modified.DPP-4 inhibitors have a favorable safety profile,do not cause hypoglycemia or weight gain and do not require dose uptitration.Furthermore,they can be administered in patients with chronic kidney disease after dose modification and elderly patients with diabetes.Still,though,they have been undermined to a third line therapeutic choice as they have not been shown to reduce CV events as is the case with SGLT2-i and GLP-1 RA.Overall,DPP-4 inhibitors appear to have a place in the management of patients with diabetes as a safe class of oral glucose lowering agents with great experience in their use. | Matilda Florentin Michael S Kostapanos Athanasia K Papazafiropoulou | 2022 | World Journal of Diabetes2022，13，2： | 3 |
| 5 | Colonoscopy preparation-induced disorders in renal function and electrolytes显示文摘Colonoscopy and flexible sigmoidoscopy are commonly used mainly for colon cancer screening and detection, but also in several other situations such as inflammatory bowel disease (for diagnosis and follow up) and gastrointestinal hemorrhage. Bowel cleansing preparations mainly include polyethylene glycol and oral sodium phosphate solutions, with the later being most frequently used due to better toleration from patients. Despite their favourable safety profile these agents have been associated with renal function deterioration and electrolyte disorders, some of which were serious or even fatal. The present paper discusses the complications associated with colonoscopy preparation agents. | Matilda Florentin George Liamis Moses S Elisaf | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，2： | 2 |
| 6 | Association of Helicobacter pylori infection with cardiovascular disease—Is it just a myth?显示文摘 | Dimitrios K. Christodoulou Haralampos J. Milionis Panagiota Pappa Konstantinos H. Katsanos Dimitrios Sigounas Matilda Florentin Moses Elisaf Epameinondas V. Tsianos | 2010 | European Journal of Internal Medicine2010，，2： | 2 |
| 7 | Sport burnout inventoryDual career form for student-athletes: Assessing validity and reliability in a Finnish sample of adolescent athletes显示文摘Background:The pressure of pursuing an athletic career simultaneously with education may set adolescent student-athletes at risk for sport and school burnout.Although the 2 life domains of student-athletes are strongly intertwined,so far,there has not been an instrument for investigating sport burnout parallel to school burnout.The aim of the present study was to introduce a sport burnout measure for adolescents in a dual career context and investigate its validity and reliability by using confirmatory factor analysis.Methods:The participants were 391 student-athletes(51%females)who filled in a questionnaire of sport burnout and background variables in the beginning of upper secondary school.Results:A 3-factor model or a second-order-factor model described the data better and gave better reliability indices than a 1-factor model.The 3 dimensions of sport burnout were shown to be separate,but closely related constructs.Evidence for convergent and discriminant validity was obtained by correlating the 3 sport burnout dimensions with depressive symptoms,self-esteem,and sport task values.Conclusion:The results suggest that Sport Burnout InventoryDual Career Form(SpBI-DC)is a valid and reliable instrument for investigating sport burnout among adolescent student-athletes. | Matilda Sorkkila Tatiana V.Ryba Kaisa Aunola Harri Selanne Katariina Salmela-Aro | 2020 | Journal of Sport and Health Science2020，9，4： | 2 |
| 8 | Is the intermediate syndrome in organophosphate poisoning the result of insufficient oxime therapy显示文摘 | Benson BJ David T Matilda M | 1992 | Toxicol Clin Toxicol1992，30，： | 1 |
| 9 | Polysilazane Derived Micro/nano Si3Ng/SiC Composites显示文摘 | Matilda Zemanova Emmanuel Lecomte Pavol Sajgalik | 2002 | Journal of the European Ceramic Society2002，22，8： | 1 |
| 10 | Suzuki–Miyaura coupling under air in water promoted by polymer supported palladium nanoparticles显示文摘 | Maria Michela Dell’Anna Matilda Mali Piero Mastrorilli Antonino Rizzuti Chiara Ponzoni Cristina Leonelli | 2013 | Journal of Molecular Catalysis A Chemical2013，，： | 1 |
| 11 | Levamisol nAo previne lesOes de estomatite aftosa recorrente显示文摘 | Luc louis maurice weckx Cleonice hitomi watashi hirata Matilda aparecida milanez morgado de abreu | 2009 | Rev Assoc Med Bras2009，55，2： | 1 |
| 12 | Chemical composition and microbiological changes during spontaneous and starter culture fermentation of Enam Ne-Setaakye, a West African fermented fish- carbohydrate product显示文摘 | MATILDA A ABIODUM I S | 2002 | European Food Research and Technology2002，215，1： | 1 |
| 13 | Development and statistical evaluation of models in forecasting moth phenology of major lepidopterous peach pest complex for Integrated Pest Management programs显示文摘 | Petros T. Damos Matilda Savopoulou-Soultani | 2010 | Crop Protection2010，，10： | 1 |
| 14 | Effect of 2-deoxy-D-glucose on herpes simplex virus replication显示文摘 | RICHARD J C SHELDOM M S MATILDA B M | 1973 | Virology1973，52，： | 1 |
| 15 | The effect of simvastatin alone versus simvastatin plus ezetimibe on the concentration of small dense low-density lipoprotein cholesterol in subjects with primary hypercholesterolemia显示文摘 | Matilda Florentin Evangelos N. Liberopoulos Elisavet Moutzouri Christos V. Rizos Alexandros D. Tselepis Moses S. Elisaf | 2011 | Current Medical Research & Opinion2011，，： | 1 |
| 16 | Development and statistical evaluation of models in forecasting moth phenology of major lepidopterous peach pest complex for Integrated Pest Management programs 显示文摘 | PETROS T D MATILDA S S | 2010 | Crop Protection2010，29，10： | 1 |
| 17 | Microalbuminuria: A Neglected Cardiovascular Risk Factor in Non-diabetic Individuals?显示文摘 | Eirini Lioudaki Matilda Florentin Emmanuel S. Ganotakis Dimitri P. Mikhailidis | 2013 | Current Pharmaceutical Design2013，，27： | 1 |
| 18 | Fatigue in cancer patients treated with cytotoxic drugs显示文摘 | PER HP JOHAN A MATILDA H | 2006 | J Oncol Pharm Practice2006，12，2： | 1 |
| 19 | Corrigendum to 'A comprehensive characterization of chemically treated Brazilian sponge- gourds ( Luffa cylindrical ) ' 显示文摘 | Valeineide O A Tanobe Thais H D Sydenstricker Matilda Munaro | 2010 | Polymer Testing2010，29，2： | 1 |
| 20 | EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity显示文摘 | Matilda WN Kara LC | 2006 | J Immunol2006，177，： | 1 |
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