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| 1 | Alternatives for large-scale production of cultured beef: A review显示文摘Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today's 2-dimensional(2D) standard technique that was used to make the first cultured hamburger. Options for efficient large-scale production of stem cells are to culture cells on microcarriers, either in suspension or in a packed bed bioreactor, or to culture aggregated cells in suspension. We discuss the pros and cons of these systems as well as the possibilities to use the systems for tissue culture. Either of the production systems needs to be optimized to achieve an efficient production of cultured beef. It is anticipated that the optimization of large-scale cell culture as performed for other stem cells can be translated into successful protocols for bovine satellite cells resulting in resource and cost efficient cultured beef. | Matilda S M Moritz Sanne E L Verbruggen Mark J Post | 2015 | Journal of Integrative Agriculture2015，14，2： | 7 |
| 2 | Socio-cultural determinants of timely and delayed treatment of Buruli ulcer: implications for disease control显示文摘Introduction:Public health programmes recommend timely medical treatment for Buruli ulcer(BU)infection to prevent pre-ulcer conditions from progressing to ulcers,to minimise surgery,disabilities and the socio-economic impact of BU.Clarifying the role of socio-cultural determinants of timely medical treatment may assist in guiding public health programmes to improve treatment outcomes.This study clarified the role of socio-cultural determinants and health system factors affecting timely medical treatment for BU in an endemic area in Ghana.Methods:A semi-structured explanatory model interview based on the explanatory model interview catalogue(EMIC)was administered to 178 BU-affected persons.Based on research evidence,respondents were classified as timely treatment(use of medical treatment 3 months from awareness of disease)and delayed treatment(medical treatment 3 months after onset of disease and failure to use medical treatment).The outcome variable,timely treatment was analysed with cultural epidemiological variables for categories of distress,perceived causes of BU,outside-help and reasons for medical treatment in logistic regression models.The median time for the onset of symptoms to treatment was computed in days.Qualitative phenomenological analysis of respondents’narratives clarified the meaning,context and dynamic features of the relationship of explanatory variables with timely medical treatment.Results:The median time for initiating treatment was 25 days for pre-ulcers,and 204 days for ulcers.Income loss and use of herbalists showed significantly negative associations with timely treatment.Respondents’use of herbalists was often motivated by the desire for quick recovery in order to continue with work and because herbalists were relatives and easily accessible.However,drinking unclean water was significantly associated with timely treatment and access to health services encouraged timely treatment(OR 8.5,p=0.012).Findings show that health system factors of access are responsible for non-compliance to treatment regimes.Conclusions:Findings highlight the importance of an integrated approach to BU control and management considering the social and economic features that influence delayed treatment and factors that encourage timely medical treatment.This approach should consider periodic screening for early case-detection,collaboration with private practitioners and traditional healers,use of mobile services to improve access,adherence and treatment outcomes. | Mercy M Ackumey Margaret Gyapong Matilda Pappoe Cynthia Kwakye Maclean Mitchell G Weiss | 2012 | Infectious Diseases of Poverty2012，1，1： | 3 |
| 3 | Is the intermediate syndrome in organophosphate poisoning the result of insufficient oxime therapy显示文摘 | Benson BJ David T Matilda M | 1992 | Toxicol Clin Toxicol1992，30，： | 1 |
| 4 | Effect of 2-deoxy-D-glucose on herpes simplex virus replication显示文摘 | RICHARD J C SHELDOM M S MATILDA B M | 1973 | Virology1973，52，： | 1 |
| 5 | Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity显示文摘 | K.-H. William Lau David J. Baylink Xiao-Dong Zhou Denise Rodriguez Lynda F. Bonewald Zihui Li Davide Ruffoni Ralph Müller Chandrasekhar Kesavan Matilda H.-C. Sheng | 2013 | AJP: Endocrinology and Metabolism2013，，2： | 1 |
| 6 | Is the intermediate syndrome in organophosphate poisoning the result of insufficient oxime therapy显示文摘 | Benson BJ David T Matilda M | 1992 | Toxicol Clin Toxicol1992，30，2： | 1 |
| 7 | Unidentified seroroups of entropathogenic Escherichia coli (EPEC)associated with diarrhea in infants in Londrina, Parana, Brazil 显示文摘 | Matilda C V Kobayashi R K T Dias A M G | 2000 | J Med Microbiol2000，49，4： | 1 |
| 8 | Is the intermediate svndrome in organgophosphate poisoning the result of insufficient oxime therapy显示文摘 | Benson BJ David T Matilda M | 2012 | Toxicol Clin Toxicol2012，50，3： | 1 |
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