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| 1 | Gut microbiota imbalance and colorectal cancer显示文摘The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-organisms and the digestive tract highly contribute to maintain the gut homeostasis. However, alterations to the microbiome caused by environmental changes(e.g., infection, diet and/or lifestyle) can disturb this symbiotic relationship and promote disease, such as inflammatory bowel diseases and cancer. Colorectal cancer is a complex association of tumoral cells, non-neoplastic cells and a large amount of micro-organisms, and the involvement of the microbiota in colorectal carcinogenesis is becoming increasingly clear. Indeed, many changes in the bacterial composition of the gut microbiota have been reported in colorectal cancer, suggesting a major role of dysbiosis in colorectal carcinogenesis. Some bacterial species have been identified and suspected to play a role in colorectal carcinogenesis, such as Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis, Enterococcus faecalis, Clostridium septicum, Fusobacterium spp. and Escherichia coli. The potential pro-carcinogenic effects of these bacteria are now better understood. In this review, we discuss the possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial derived metabolism, oxidative stress and anti-oxidative defenses modulation. We lastly describe how bacterial microbiota modifications could represent novel prognosis markers and/or targets for innovative therapeutic strategies. | Johan Gagnière Jennifer Raisch Julie Veziant Nicolas Barnich Richard Bonnet Emmanuel Buc Marie-Agnès Bringer Denis Pezet Mathilde Bonnet | 2016 | World Journal of Gastroenterology2016，22，2： | 76 |
| 2 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 3 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 4 | Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor a and carnitine palmitoyl acyl-CoA transferase 1A显示文摘AIM: To elucidate the role of the peroxisome proliferator-activated receptor α (PPARα) and its target gene carnitine palmitoyl acyl-CoA transferase 1A (CPT1A)in the pathogenesis of hepatitis C virus (HCV) infection.METHODS: Liver samples were collected from the patients with chronic HCV infection and controls. HepG2cells were transfected with vector pEF352neo carrying.Two independent clones (clone N3 and N4) stably expressing HCV core protein were analyzed. Total RNA was extracted from cells and liver tissues. PPARα and CPT1A mRNAs were quantified by real-time polymerase chain reaction (PCR) using SYBR Green Master. Total extracted proteins were separated by polyacrylamide gel electrophoresis, and electroblotted. Membranes were incubated with the anti-PPARα antibody, then with a swine anti-rabbit IgG conjugated to horseradish peroxidase for PPARα. Protein bands were revealed by an enhanced chemiluminescence reaction for PPARα. For immunohistochemical staining of PPARα, sections were incubated with the primary goat polyclonal antibody directed against PPARα at room temperature.RESULTS: Real-time PCR indicated that the PPARα level and expression level of CPT1A gene in hepatitis C patients lowered significantly as compared with the controls (1.8±2.8 vs 13±3.4, P = 0.0002; 1.1±1.5 vs 7.4+1, ,P = 0.004). Western blot results showed that the level of PPARα protein in the livers of hepatitis C patients was lower than that in controls (2.3±0.3 vs 3.6±0.2,P = 0.009). The immunohistochemical staining results in chronic hepatitis C patients indicated a decrease in PPARα staining in hepatocytes compared with those in the control livers. The in vitro studies found that in the N3 and N4 colon stably expressing HCV core protein, the PPARα mRNA levels were significantly lower than that in the controls.CONCLUSION: The impaired intrahepatic PPARα expression is associated with the pathogenic mechanism in hepatic injury during chronic HCV infection. HCV infection reduced the expression of PPARα and CPT1A at the level of not only mRNAs but also proteins. PPARα plays an important role in the pathogenesis of chronic HCV infection, but the impaired function of this nuclear receptor in HCV infection needs further studies. | Yang Cheng Sébastien Dharancy Mathilde Malapel Pierre Desreumaux | 2005 | World Journal of Gastroenterology2005，11，48： | 11 |
| 5 | Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging显示文摘AIM: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical imaging.METHODS: We choose to evaluate the tumor metabolic activity using a fluorodeoxyglucose analogue as 2-deoxyglucosone fluorescent probes and to correlate it with tumoral volume(mm^3). Inflammation measuring myeloperoxidase(MPO) activity and reactive oxygen species production was monitored by a bioluminescent(BLI) inflammation probe and related to histological examination and MPO levels by enzyme-linked immunosorbent assay(ELISA) on tumor specimens. The detection and quantitation of these two signals were validated on a xenograft model of human colon adenocarcinoma epithelial cells(HCT116) in nude mice infected with a pks-positive E. coli. The inflammatory BLI signal was validated intra-digestively in the colitisCEABAC10 DSS models, which mimicked Crohn's disease. RESULTS: Using a 2-deoxyglucosone fluorescent probe, we observed a high and specific HCT116 tumor uptake in correlation with tumoral volume(P = 0.0036). Using the inflammation probe targeting MPO, we detected a rapid systemic elimination and a significant increase of the BLI signal in the pks-positive E. coli-infected HCT116 xenograft group(P < 0.005). ELISA confirmed that MPO levels were significantly higher(1556 ± 313.6 vs 234.6 ± 121.6 ng/m L P = 0.001) in xenografts infected with the pathogenic E. coli strain. Moreover, histological examination of tumor samples confirmed massive infiltration of pks-positive E. coli-infected HCT116 tumors by inflammatory cells compared to the uninfected group. These data showed that infection with the pathogenic E. coli strain enhanced inflammation and ROS production in tumors before tumor growth. Moreover, we demonstrated that the intra-digestive monitoring of inflammation is feasible in a reference colitis murine model(CEABAC10/DSS).CONCLUSION: Using BLI and fluorescence optical imaging, we provided tools to better understand hostpathogen interactions at the early stage of disease, such as inflammatory bowel disease and colorectal cancer. | Julie Veziant Johan Gagnière Elodie Jouberton Virginie Bonnin Pierre Sauvanet Denis Pezet Nicolas Barnich Elisabeth Miot-Noirault Mathilde Bonnet | 2016 | World Journal of Clinical Oncology2016，7，3： | 10 |
| 6 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 7 | GSTM1,GSTT1,GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population:Different pattern of squamous cell carcinoma and adenocarcinoma显示文摘AIM: To evaluate the association between CYPIA1 and GSTs genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma (SCC) and esophageal adenocarcinorna (ADC) in a high risk area of northwest of France.METHODS: A case-control study was conducted to investigate the genetic polymorphisms of these enzymes (CYPIAI*2C and GSTP1 exon 7 Val alleles, GSTM1 *2/*2 and GSl-l-l*2/*2 null genotypes). A total of 79 esophagealcancer cases and 130 controls were recruited. RESULTS: GSTM2*2/*2 and CYP1A1*1A/*2C genotype frequencies were higher among squamous cell cardnomas at a level close to statistical significance (OR = 1.83, 95% CI0.88-3.83, P= 0.11; OR = 3.03, 95% CI 0.93-9.90, P= 0.07,respectively). For GSTP1 polymorphism, no difference wasfound between controls and cases, whatever their histological status. Lower frequency of GST/-1 deletion was observed in ADC group compared to controls with a statistically significant difference (OR=13.31, 95% CI 1.66-106.92, P<0.01).CONCLUSION: In SCC, our results are consistent with the strong association of this kind of turnout with tobacco exposure. In ADC, our results suggest 3 distinct hypotheses:(1) activation of exogenous procarcinogens, such as small halogenated compounds by GSTTI', (2) contribution of GSTT1 to the inflammatory response of esophageal mucosa, which is known to be a strong risk factor for ADC,possibly through leukotriene synthesis; (3) higher sensitivity to the inflammatory process associated with intracellular depletion of glutathione. | Ahmed Abbas Karine Delvinquière Mathilde Lechevrel Pierre Lebailly Pascal Gauduchon Guy Launoy Fran ois Sichel | 2004 | World Journal of Gastroenterology2004，10，23： | 7 |
| 8 | 基因组分析揭示番茄育种的历史显示文摘番茄(Solanum lycopersicum)适应性广,产量高,营养丰富,风味独特,栽培方式多样,是世界范围内广泛种植的第一大蔬菜作物。2012年全球产量达到1.62亿吨(联合国粮农组织(FAO)统计),产值超过550亿美元。番茄也是植物遗传、发育和生理研究的重要模式系统。番茄起源于南美洲的安第斯山脉,随着人类迁移和驯化逐渐传到中美洲和墨西哥一代,16世纪传到欧洲,在随后的几百年中番茄被传播到世界各地,在这一过程中受到不同的人工选择,产生了丰富的变异类型。番茄果实大小的变化是驯化的一个重要特征,今天人们食用的大果栽培番茄是由野生醋栗番茄(Solanum pimpinellifolium)驯化而来,野生番茄果实非常小,只有1~2g 重,经过人工的长期驯化,现代栽培番茄的果重是其祖先的100多倍。然而,番茄果实变大的人工驯化过程一直未有全面的研究,人类选择如何改变番茄基因组仍是知之甚少。 | 林涛 祝光涛 张俊红 许向阳 余庆辉 郑铮 张忠华 伦尧尧 李帅 王孝宣 黄泽军 李君明 张春芝 王涛涛 张余洋 王傲雪 张艳聪 林魁 李传友 熊国胜 薛勇彪 Andrea Mazzucato Mathilde Causse Zhangjun Fei James J.Giovannoni Roger T.Chetelat Dani Zamir Thomas Stadler 李景富 叶志彪 杜永臣 黄三文 | 2014 | 遗传2014，36，12： | 7 |
| 9 | 基于随机森林算法的多作物同步识别显示文摘作物类型遥感识别是农业遥感的重要组成部分,为获取作物种植面积、长势信息并进行产量估算提供了手段。目前,对玉米、水稻和小麦等大宗农作物进行单一识别或两类间分类识别的技术研究较多,对研究区多种农作物同步分类识别的研究较少。本研究基于随机森林分类器利用Landsat 8数据开展宁夏农作物分类,对八种主要农作物春小麦、玉米、水稻、苜蓿、蔬菜、葡萄、枸杞和瓜类进行同步分类试验。结果表明:随机森林方法可以满足研究区内多类作物同步监测的需求,精度可达80%以上。单时相分类精度可达到81.8%,后分类处理精度可达到82.8%,时间序列分类精度可达到85.1%,时间序列分类和后分类处理可以有效提高分类精度。随机森林分类精度随着树数量的增加而增大,当树的数量足够多时,模型趋于稳定,特征变量对精度的影响被控制在一定范围内,当特征变量设置为总特征变量的平方根或对数时,精度达到最佳。因此,基于对分类实验时效性的考虑,将参数分别设置为Ntree=100,Mtry=总特征变量的平方根或对数。 | 许淇 李启亮 Mathilde De Vroey 张吴平 范锦龙 | 2019 | 山东农业科学2019，51，3： | 6 |
| 10 | Combining Metabolomics and Gene Expression Analysis Reveals that Propionyl- and Butyryl- Carnitines Are Involved in Late Stages of Arbuscular Mycorrhizal Symbiosis显示文摘arbuscular mycorrhizal (AM ) 共生是在土壤真菌(Glomeromycota ) 和 theroots 之间的一个普遍 mutualistic 协会大多数植物种类。AM 真菌是要求其开发部分在他们的 planthost 的控制下面的 biotrophs。我们探索了可能性联合 metabolomic 和 transcriptomic 途径发现通常认为的 mycorrhiza-associatedmetabolites 调整 AM 真菌的开发。与 AM 真菌 Rhizophagus irregularis 开拓殖民地于的 Medicago truncatula 根的甲醇摘录被极端高效的液体层析(UHPLC ) 分析并且比较,高分辨率的集体 spectrometry (Q-TOF ) ,和 multivariate 统计辨别。我们检测了只在场的 71 联系 mycorrhiza 的 analytes 或在更充满 mycorrhizal 根的 least10 褶层。为了在这些 analytes 之中识别那些,那能调整 AM 真菌的开发,我们由准备、半准备的 HPLC 的 fractionated mycorrhizal 和 non-mycorrhizal 根摘录和 establishedhow 71 analytes 在部分之中被散布。然后,我们在发芽 sporesof R 上测试了部分的活动。由确定的 irregularis 知道为的 96 基因的表示他们的在 planta 表示模式多样。这些调查揭示在 mycorrhizal roots.The 结果积累的那 propionyl 肉毒碱和 butyryl 肉毒碱建议这二个分子在 planta 调整真菌的基因表示并且为进一步生物的 characterization.Key 词代表有趣的候选人: | Jerome Laparre | 2014 | Molecular Plant2014，7，3： | 3 |
| 11 | The Importance of General Self-Efficacy for the Quality of Life of Adolescents with Chronic Conditions显示文摘 | Jane M. Cramm Mathilde M. H. Strating Marij E. Roebroeck Anna P. Nieboer | 2013 | Social Indicators Research2013，，1： | 3 |
| 12 | 以英国FSA营养素度量体系为基础的个体膳食指数在法国的开发和验证显示文摘背景:以食品正面包装的营养标签、广告规范或粮食税为基础的营养素度量体系对于公共健康是一个很有用的工具。然而,它的能耐远超于对产品描述并能够充分地塑造个体膳食有必要更进一步的调查目的:本研究旨在(1)计算个体层面的分值基于英国FSA食物级别的每个食物消耗的营养素度量体系,(2)依据食物组消耗量、营养摄入量以及社会人口和生活方式的改变评估膳食状况评分的正确性。方法:从Nu1riNet-Sante研究(n=4225)中选定法国人群作为代表性样本。采用24小时膳食回顾记录收集膳食数据。社会人口和生活方式的数据采用自我报告形式记录。所有食物消耗量采用FSA营养素度量法描述,并且来自于每个食物消耗的能量摄入量用于计算个体层面的FSA导出的累积分值。遵循法国营养素推荐规范(PNNS-GS)的分数以膳食质量评分作为比较而计算。在食物消耗、营养指标、生活方式和社会人口的变化与累积分的四分位之间的关联性通过ANOVAs和线性回归模型调查。结果:得到有利分值的受试者消耗大量的水果(差异△=156g/d,P<0.001),蔬菜(△=85g/d,P<0.001),以及鱼和少量的零食(△=-72g/d,P<0.001);同时他们也有大量维生素和矿物质的摄入以及少量的饱和脂肪酸的摄入。得到有利分值的受试者很好的遵循了依据PNNS-GS衡量的营养素推荐标准(△=2.13 points,P<0.001)。女性年长的受试者以及高收入的群体更可能得到较高的分值。结论:研究结果表明FSA营养素度量体系对法国人群中个体膳食的概述更加全面可行。NutriNet-Sante研究已被登录于2013-000929-31欧洲临床试验数据库(EudraCT)。 | Chantal Julia Mathilde Touvier Caroline Mejean Pauline Ducrot Sandrine Peneau Serge Hercberg Emmanuelle Kesse-Guyot 刘轶群 | 2014 | 营养健康新观察2014，0，1： | 2 |
| 13 | Sent2Agri System Based Crop Type Mapping in Yellow River Irrigation Area显示文摘Agricultural monitoring is essential for adequate management of food production and distribution.Crop land and crop type classification,using remote sensing time series,form an important tool to capture the agricultural production information.The recently launched Sentinel-2 satellites provide unprecedented monitoring capacities in terms of spatial resolution,swath width,and revisit frequency.The Sentinel-2 for Agriculture(Sen2-Agri)system has been developed to fully exploit those capacities,by providing four relevant earth observation products for agricultural monitoring.Under the Dragon 4 Program,the crop mapping with various satellite images and a specific focus on the Yellow River irrigated agricultural area in the Ningxia Hui Autonomous Region in China was carried out with the Sentinel-2 for Agriculture system(Sent2Agri).9 types of crops were classified and the crop type map in 2017 was produced based on 35 scenes Sentinel 2A/B images.The overall accuracy computed from the error confusion matrix is 88%,which includes the cropped and uncropped types.After the removal of the uncropped area,the overall accuracy for a cropped decrease to 73%.In order to further improve the crop classification accuracy,the training dataset should be further improved and tuned. | Jinlong FAN Pierre DEFOURNY Qinghan DONG Xiaoyu ZHANG Mathilde De VROEY Nicolas BELLEMANS Qi XU Qiliang LI Lei ZHANG Hao GAO | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 14 | 10 PW peak power femtosecond laser pulses at ELI-NP显示文摘We report on the generation and delivery of 10.2 PW peak power laser pulses,using the High Power Laser System at the Extreme Laser Infrastructure–Nuclear Physics facility.In this work we demonstrate for the first time,to the best of our knowledge,the compression and propagation of full energy,full aperture,laser pulses that reach a power level of more than 10 PW. | Christophe Radier Olivier Chalus Mathilde Charbonneau Shanjuhan Thambirajah Guillaume Deschamps Stephane David Julien Barbe Eric Etter Guillaume Matras Sandrine Ricaud Vincent Leroux Caroline Richard François Lureau Andrei Baleanu Romeo Banici Andrei Gradinariu Constantin Caldararu Cristian Capiteanu Andrei Naziru Bogdan Diaconescu Vicentiu Iancu Razvan Dabu Daniel Ursescu Ioan Dancus Calin Alexandru Ur Kazuo ATanaka Nicolae Victor Zamfir | 2022 | High Power Laser Science and Engineering2022，10，3： | 2 |
| 15 | Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats显示文摘 | Michèle Crumeyrolle-Arias Mathilde Jaglin Aurélia Bruneau Sylvie Vancassel Ana Cardona Valérie Daugé Laurent Naudon Sylvie Rabot | 2014 | Psychoneuroendocrinology2014，，： | 2 |
| 16 | 解密世界的方程式显示文摘这是一个神奇的公式!施之于各个领域,它能提供答案,带来发现,提示真相。更神奇的是,神经学家认为它可以为我们开启认知人类思维方式的大门! | Mathilde Fondez Roman lkonicoff Boris Bellanger Florenza Gracci Lassagne Herve Poirier Emilie Rauscher 王佳(编译) | 2013 | 新发现2013，，2： | 2 |
| 17 | Natural variability of in vitro adherence to fibHnogen and fibronretin does not correlate with in vivo infectivity of Staphylococcus aureus显示文摘 | Mathilde Y Entenza JM Jacques B | 2010 | Infect & Immu- nity2010，78，4： | 1 |
| 18 | Post-transcriptional gene silencing in plants显示文摘 | Christophe Béclin Mathilde Fagard | 2001 | Journal of Cell Science2001，144，： | 1 |
| 19 | Medical-grade silicone induces release of proinflammatory cytokines in peripheral blood mononuclear cells without activating T cells显示文摘 | FRANCESC M M MATHILDE H RENUKA K P | 2009 | Inc J Biomed Mater Res:B2009，90，2： | 1 |
| 20 | A machine vision tool for facilitating the optimization of large-area perovskite photovoltaics显示文摘We report a fast,reliable and non-destructive method for quantifying the homogeneity of perovskite thin films over large areas using machine vision.We adapt existing machine vision algorithms to spatially quantify multiple perovskite film properties(substrate coverage,film thickness,defect density)with pixel resolution from pictures of 25 cm2 samples.Our machine vision tool—called PerovskiteVision—can be combined with an optical model to predict photovoltaic cell and module current density from the perovskite film thickness.We use the measured film properties and predicted device current density to identify a posteriori the process conditions that simultaneously maximize the device performance and the manufacturing throughput for large-area perovskite deposition using gas-knife assisted slot-die coating.PerovskiteVision thus facilitates the transfer of a new deposition process to large-scale photovoltaic module manufacturing.This work shows how machine vision can accelerate slow characterization steps essential for the multi-objective optimization of thin film deposition processes. | Nina Taherimakhsousi Mathilde Fievez Benjamin P.MacLeod Edward P.Booker Emmanuelle Fayard Muriel Matheron Matthieu Manceau Stéphane Cros Solenn Berson Curtis P.Berlinguette | 2021 | npj Computational Materials2021，，1： | 1 |
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