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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Can inhibin-B predict the outcome of microsurgical epididymal sperm aspiration in patients with suspected primary obstructive azoospermia?显示文摘瞄准:评估 inhibin-B 是否能预言 microsurgicalepidymal 精子渴望(方山) 的结果在有怀疑的主要妨碍的精子缺乏(OA ) 的病人的过程并且如果 inhibin-B 能在这些病人的诊断病情的检查代替阴囊的活体检视。方法:Inhibin-B 层次和阴囊的活体检视分数与有怀疑的主要 OA 的 MESAin 43 病人的结果有关。当 epididymalsperm 能在过程期间被识别时,方山被认为成功。结果:精子从 43 个病人(65%) 在在 28 的 epididymalaspirate 是在场的。Inhibin-B 价值不是有成功或失败的方山的显著地不同的住院病人。然而,修改 Johnsen 分数在有失败的方山的病人是显著地更低的(P = 0.003 ) 。失灵的睾丸网阻塞 orepididymal 与怀疑的主要 OA 在 15% 病人被发现,尽管有正常 inhibin-B 层次和正常阴囊的组织学,由失败的方山思考了。结论: Inhibin-B 不能用怀疑的主要 OA 在病人的病情的检查作为一个诊断工具代替阴囊的活体检视。阴囊的活体检视在识别可能有正常 inhibin-B 价值的有精子发生的拘捕的病人是有用的。 | Marij Smit Gert R. Dohle Mark F. Wildhagen Rob F. A. Weber | 2007 | Asian Journal of Andrology2007，9，3： | 12 |
| 3 | On the Origin of SERKs: Bioinformatics Analysis ol the Somatic Embryogenesis Receptor Kinases显示文摘 | Marije aan den Toorn Catherine Albrecht Sacco de Vdes | 2015 | Molecular Plant2015，8，5： | 10 |
| 4 | Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry显示文摘Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients. | Martijn S.van Mourik Nathalie van der Velde Giulio Mannarino Marie-Pierre Thibodeau Jean-Bernard Masson Gennaro Santoro Jan Baan Sofie Jansen Jana Kurucova Martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage M Marije Vis | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 5 | The Importance of General Self-Efficacy for the Quality of Life of Adolescents with Chronic Conditions显示文摘 | Jane M. Cramm Mathilde M. H. Strating Marij E. Roebroeck Anna P. Nieboer | 2013 | Social Indicators Research2013，，1： | 3 |
| 6 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 7 | High cardiovascular risk in severely obese young children and adolescents显示文摘 | Nathalie M A van Emmerik Carry M Renders Marije van de Veer Stef van Buuren Olga H van der Baan-Slootweg Joana E Kist-van Holthe Remy A HiraSing | 2012 | Archives of Disease in Childhood2012，，9： | 2 |
| 8 | A Randomized Controlled Trial in Second-Generation Zotarolimus-Eluting Resolute Stents Versus Everolimus-Eluting Xience V Stents in Real-World Patients显示文摘 | Clemens von Birgelen Mounir W.Z. Basalus Kenneth Tandjung K. Gert van Houwelingen Martin G. Stoel J.(Hans) W. Louwerenburg Gerard C.M. Linssen Salah A.M. Sa?d Miep A.W.J. Kleijne Hanim Sen Marije M. L?wik Job van der Palen Patrick M.J. Verhorst Frits H.A. | 2012 | Journal of the American College of Cardiology2012，，15： | 1 |
| 9 | Relation Between the Assessment of Microvascular Injury by Cardiovascular Magnetic Resonance and Coronary Doppler Flow Velocity Measurements in Patients With Acute Anterior Wall Myocardial Infarction显示文摘 | Alexander Hirsch Robin Nijveldt Joost D.E. Haeck Aernout M. Beek Karel T. Koch José P.S. Henriques Rene J. van der Schaaf Marije M. Vis Jan Baan Robbert J. de Winter Jan G.P. Tijssen Albert C. van Rossum Jan J. Piek | 2008 | Journal of the American College of Cardiology2008，，23： | 1 |
| 10 | Novel therapeutic targets in rheumatoid arthritis 显示文摘 | Marije IK Wim BV | 2015 | Trends Pharrnacol Sci2015，36，4： | 1 |
| 11 | Anti-carbamylated protein antibodies in rheumatoid arthritis patients of Asian descent显示文摘 | Marije K Verheul Kazuko | 2015 | Rheumatology2015，54，10： | 1 |
| 12 | Association of Coexisting Dia- betes and Depression With Mortality After Myocardial Infarction显示文摘 | Mariska B Francois P Marij Z | 2012 | Diabetes2012，35，3： | 1 |
| 13 | Decreased expression of voltageand Ca2+-activated K+ channels in coronary smooth muscle during aging显示文摘 | MARIJIC J LI Q SONG M | 2001 | Cite Res2001，88，2： | 1 |
| 14 | Nonablative 1550-nm fractional laser therapy versus triple topical therapy for the treatment of melasma:A randomized controlled pilot study 显示文摘 | Marije W Bas S Johan F | | 1 Am Acad Dermatol0，64，3： | 1 |
| 15 | Decreased expression of coltage and Ca2+-activated K+ channels in coronary smooth muscle during aging显示文摘 | Li Q Song M | 2001 | Circ Res2001，88，2： | 1 |
| 16 | Aging,ion channel expression,and vascular function显示文摘 | Marijic J Nishimaru K | 2002 | Vascul Pharmacol2002，38，1： | 1 |
| 17 | Serum IL-6, IL-8, IL-10 and beta2-microglobulin in association with International Prognostic Index in diffuse large B cell lymphoma显示文摘 | Duletic-Nacinovic A Stifler S Marijic B | 2008 | Tumori2008，94，4： | 1 |
| 18 | Decreased expression of voltage-and Ca^2+- activated K^+ in coronary smooth muscle during aging显示文摘 | Marijic J Li Q Song M | 2001 | Circ Res2001，88，2： | 1 |
| 19 | Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis,their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage显示文摘 | Mikael B Marije K Verheul | 2015 | Arthritis Res Ther2015，17，2： | 1 |
| 20 | Lumbar and abdomi- nal muscle activity during walking in subjects with chronic low back pain:Support of the 'guarding' hypothesis? 显示文摘 | MARIJE VAN DER HULST MIRIAM M VOLLENBROEK- HUTTEN JOHAN S RIETMAN | 2010 | J Elec- tromyograph Kinesiol2010，20，： | 1 |
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