|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 2 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 3 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 4 | Vision-based hand-gesture applications显示文摘 | Juan Pablo Wachs Mathias K?lsch Helman Stern Yael Edan | 2011 | Communications of the ACM2011，，2： | 2 |
| 5 | miR-21 and its target gene CCL20 are both highly overexpressed in themicroenvironment of colorectal tumors: Significance of their regulation显示文摘 | Benjamin Vicinus Claudia Rubie Nathalie Stegmaier Vilma Frick Kathrin K?lsch Anne Kauffels Pirus Ghadjar Mathias Wagner Matthias Glanemann | 2013 | Oncology Reports2013，，3： | 2 |
| 6 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 7 | Comparative evaluation of the effect of storage temperature fluctuation on modified atmosphere packages of selected fruit and vegetables 显示文摘 | Kablan T Mathias K O Gilles D | 2007 | Postharvest Biology and Technology2007，46，3： | 1 |
| 8 | Deepwater canyons:An escape route for methane sealed by methane hydrate显示文摘 | Davies R J Thatcher K E Mathias S A | 2011 | Earth and Planetary Science Letters2011，，： | 1 |
| 9 | Adiponectin gene expresion is inhibited by B-adrenergic stimulation via pro- tein Kinase A in 3T3-L1 adipocyte显示文摘 | Mathias F Johannes K Susanne N | 2001 | FEBS Letters2001，507，： | 1 |
| 10 | Clinical results of cerebral protection with a filter device during stent implantation of the carotid artery显示文摘 | Jaeger H Mathias K Drescher R | | 0，，： | 1 |
| 11 | Deep intrauterine insemination in sows: first field trial in a USA commercial farm with a newly developed device显示文摘 | Day B N Mathias K Didion B A | 2003 | Theriogenology2003，，59： | 1 |
| 12 | Diagnostic and therapeutic strategies in locally recurrent rectal cancer显示文摘 | Mathias K Hasse FM Theophil B | 2009 | Radiologe2009，32，2： | 1 |
| 13 | Current evidence for transurethral laser therapy of non-muscle invasive bladder cancer 显示文摘 | Mario W K Thorsten B Mathias W | 2011 | World J Urol2011，29，4： | 1 |
| 14 | Time reversed lamb waves显示文摘 | Ing Mathias Fink | 1998 | IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL1998，45，4： | 1 |
| 15 | Clinical results of cerebral protection with a filter device during stent implantation of the carotid artery显示文摘 | Jaeger H Mathias K Drescher R | 2001 | Cardiovasc Intervent Radiol2001，24，： | 1 |
| 16 | Erectile and urinary dysfunction may be the presenting features in patients with multiple system atrophy:a retroive study显示文摘 | Kirchhof K Apostolidis AN Mathias CJ | 2003 | Int J Impot Res2003，15，14： | 1 |
| 17 | Spinous process strength 显示文摘 | Shepherd DE Leahy JC Mathias K J | 2000 | Spine2000，3，： | 1 |
| 18 | Who do you trust? Beyond encryption,secure e-business显示文摘 | Mathias K | 2001 | Decision Support Systems2001，31，3： | 1 |
| 19 | Development and manufacture of an adaptive light- weight mirror for space application显示文摘 | Johannes K D Robert Honkel Mathias V A | 2003 | Smart Materi- als and Structures2003，12，： | 1 |
| 20 | Erectile and urinary dysfunction may be the presenting features in patients with multiple system atrophy: a retrospective study显示文摘 | Kirchhof K Apostolidis AN Mathias CJ | 2003 | Int J Impot Res2003，15，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员