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| 1 | Mitochondrial uncoupling protein 2 and pancreatic cancer:A new potential target therapy显示文摘Overall 5-years survival of pancreatic cancer patients is nearly 5%,making this cancer type one of the most lethal neoplasia.Furthermore,the incidence rate of pancreatic cancer has a growing trend that determines a constant increase in the number of deceases caused by this pathology.The poor prognosis of pancreatic cancer is mainly caused by delayed diagnosis,early metastasis of tumor,and resistance to almost all tested cytotoxic drugs.In this respect,the identification of novel potential targets for new and efficient therapies should be strongly encouraged in order to improve the clinical management of pancreatic cancer.Some studies have shown that the mitochondrial uncoupling protein 2(UCP2) is over-expressed in pancreatic cancer as compared to adjacent normal tissues.In addition,recent discoveries established a key role of UCP2 in protecting cancer cells from an excessive production of mitochondrial superoxide ions and in the promotion of cancer cell metabolic reprogramming,including aerobic glycolysis stimulation,promotion of cancer progression.These observations together with the demonstration that UCP2 repression can synergize with standard chemotherapy to inhibit pancreatic cancer cell growth provide the molecular rationale to consider UCP2 as a potential therapeutic target for pancreatic cancer.In this editorial,recent advances describing the relationship between cancer development and mitochondrial UCP2 activity are critically provided. | Massimo Donadelli Ilaria Dando Elisa Dalla Pozza Marta Palmieri | 2015 | World Journal of Gastroenterology2015，21，11： | 9 |
| 2 | UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells显示文摘 | Ilaria Dando Claudia Fiorini Elisa Dalla Pozza Chiara Padroni Chiara Costanzo Marta Palmieri Massimo Donadelli | 2013 | BBA - Molecular Cell Research2013，，3： | 2 |
| 3 | UCP2, a mitochondrial protein regulated at multiple levels显示文摘 | Massimo Donadelli Ilaria Dando Claudia Fiorini Marta Palmieri | 2014 | Cellular and Molecular Life Sciences2014，，7： | 1 |
| 4 | Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine显示文摘 | Elisa Dalla Pozza Claudia Fiorini Ilaria Dando Marta Menegazzi Anna Sgarbossa Chiara Costanzo Marta Palmieri Massimo Donadelli | 2012 | BBA - Molecular Cell Research2012，，10： | 1 |
| 5 | To metabolomics and beyond:a technological portfolio to investigate cancer metabolism显示文摘Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support tumour initiation, progression,metastasis and resistance to therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosyntheticand redox status to sustain the increased energetic demand of the cells. Over the last decades, the cancer metabolism field hasseen an explosion of new biochemical technologies giving more tools than ever before to navigate this complexity. Within a cell ora tissue, the metabolites constitute the direct signature of the molecular phenotype and thus their profiling has concrete clinicalapplications in oncology. Metabolomics and fluxomics, are key technological approaches that mainly revolutionized the fieldenabling researchers to have both a qualitative and mechanistic model of the biochemical activities in cancer. Furthermore, theupgrade from bulk to single-cell analysis technologies provided unprecedented opportunity to investigate cancer biology at cellularresolution allowing an in depth quantitative analysis of complex and heterogenous diseases. More recently, the advent offunctional genomic screening allowed the identification of molecular pathways, cellular processes, biomarkers and noveltherapeutic targets that in concert with other technologies allow patient stratification and identification of new treatmentregimens. This review is intended to be a guide for researchers to cancer metabolism, highlighting current and emergingtechnologies, emphasizing advantages, disadvantages and applications with the potential of leading the development ofinnovative anti-cancer therapies. | Federica Danzi Raffaella Pacchiana Andrea Mafficini Maria TScupoli Aldo Scarpa Massimo Donadelli Alessandra Fiore | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 6 | Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin -A 显示文摘 | Daniela Cecconi Aldo Scarpa Massimo Donadelli | 2003 | Electrophoresis2003，24，： | 1 |
| 7 | Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation显示文摘 | Paolo Piacentini Massimo Donadelli Chiara Costanzo Patrick S. Moore Marta Palmieri Aldo Scarpa | 2006 | Virchows Archiv2006，，6： | 1 |
| 8 | Expression of the Antiapoptotic Protein BAG3 Is a Feature of Pancreatic Adenocarcinoma and Its Overexpression Is Associated With Poorer Survival显示文摘 | Alessandra Rosati Samantha Bersani Francesca Tavano Elisa Dalla Pozza Margot De Marco Marta Palmieri Vincenzo De Laurenzi Renato Franco Giosuè Scognamiglio Raffaele Palaia Andrea Fontana Pierluigi di Sebastiano Massimo Donadelli Ilaria Dando Jan Paul Mede | 2012 | The American Journal of Pathology2012，，5： | 1 |
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