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| 1 | Mitochondrial uncoupling protein 2 and pancreatic cancer:A new potential target therapy显示文摘Overall 5-years survival of pancreatic cancer patients is nearly 5%,making this cancer type one of the most lethal neoplasia.Furthermore,the incidence rate of pancreatic cancer has a growing trend that determines a constant increase in the number of deceases caused by this pathology.The poor prognosis of pancreatic cancer is mainly caused by delayed diagnosis,early metastasis of tumor,and resistance to almost all tested cytotoxic drugs.In this respect,the identification of novel potential targets for new and efficient therapies should be strongly encouraged in order to improve the clinical management of pancreatic cancer.Some studies have shown that the mitochondrial uncoupling protein 2(UCP2) is over-expressed in pancreatic cancer as compared to adjacent normal tissues.In addition,recent discoveries established a key role of UCP2 in protecting cancer cells from an excessive production of mitochondrial superoxide ions and in the promotion of cancer cell metabolic reprogramming,including aerobic glycolysis stimulation,promotion of cancer progression.These observations together with the demonstration that UCP2 repression can synergize with standard chemotherapy to inhibit pancreatic cancer cell growth provide the molecular rationale to consider UCP2 as a potential therapeutic target for pancreatic cancer.In this editorial,recent advances describing the relationship between cancer development and mitochondrial UCP2 activity are critically provided. | Massimo Donadelli Ilaria Dando Elisa Dalla Pozza Marta Palmieri | 2015 | World Journal of Gastroenterology2015，21，11： | 9 |
| 2 | Adolescent male genitalia dissatisfaction:a surgical perspective显示文摘Genital dissatisfaction is well known in female and adults.Less is known about male adolescents and their genital satisfaction.The aim of this study was to investigate and report the role of surgery in male adolescents to improve the evaluation of their genitalia.We considered all patients treated for external genital pathology in the period of adolescence.Inclusion and exclusion criteria were created.Patients underwent an evaluation test before and after surgery.During the study period,137 patients were treated,and at the end of the study,98 cases were considered for analysis.The most frequent pathologies were webbed penis and penile curvature.A postoperative score improvement was noted and patients with concealed penis and webbed penis showed a better postoperative outcome.Overweight was considered an important factor associated with a worse preoperative score.Evaluation of the external genitalia is important in adolescents,and it is an understudied problem.Overweight may be associated with a worse evaluation of one’s genital and should be clinically considered to avoid related social problems in adulthood.Therefore,cosmetic genital surgery should be considered even in male adolescents. | Nicola Zampieri Ilaria Dando Francesco Saverio Camoglio | 2022 | Asian Journal of Andrology2022，24，2： | 2 |
| 3 | UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells显示文摘 | Ilaria Dando Claudia Fiorini Elisa Dalla Pozza Chiara Padroni Chiara Costanzo Marta Palmieri Massimo Donadelli | 2013 | BBA - Molecular Cell Research2013，，3： | 2 |
| 4 | Cloning and expression of mouse legumain, a lysosmal endopeptidase 显示文摘 | Chen JM Dando PM Stevens RA | 1988 | Biochem J1988，335，1： | 1 |
| 5 | Adefovir dipivoxil : a review of itsuse in chronic hepatitis B显示文摘 | Dando T Plosker G | 2003 | Drugs2003，63，20： | 1 |
| 6 | Maternal administration of erythromycin fails to eradicate intrauterine ureaplasma infection in an ovine model显示文摘 | Dando S J Nitsos I Newnham JP | 2010 | Biol Reprod2010，83，4： | 1 |
| 7 | Quetiapine:a review of its use in acute mania and depression associated with bipolar disorder显示文摘 | Dando TM Keating GM | 2005 | Drugs2005，65，17： | 1 |
| 8 | Role of Deformation Twinning and Dislocation Slip in the Fatigue Failure Mechanism of AZ31 Mg Alloys显示文摘 | J Koike N Fujiyama DAndo et at | 2010 | Scripta Materialia2010，63，： | 1 |
| 9 | Challenge of Biotechnology显示文摘 | DANDO M R PEARSON G S | 2001 | Def Sci J2001，51，4： | 1 |
| 10 | Using hypergames to model difficult social issues: An approach to the case of soccer hooliganism显示文摘 | Bennett P G Dando M R Sharp R C | 1980 | The Journal of the Operational Research Society1980，31，7： | 1 |
| 11 | Conversion of diaspore to corundum: A new alumina transformation sequence 显示文摘 | CARIM A H ROHRER G S DANDO N R | 1997 | J Am Ceram Soc1997，80，10： | 1 |
| 12 | The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases(LDH1 and LDH2)from Toxoplasma gondii:comoarsons with pLDH from Plasmodium falciparum显示文摘 | DANDO C SCHROEDER ER HUNSAKER LA | 2001 | Mol Biochem Parasitol2001，118，： | 1 |
| 13 | Complex strategic analysis: A hypergame study of the fall France 显示文摘 | Bennett P G Dando M R | 1979 | Journal of the Operational Research Society1979，30，1： | 1 |
| 14 | UCP2, a mitochondrial protein regulated at multiple levels显示文摘 | Massimo Donadelli Ilaria Dando Claudia Fiorini Marta Palmieri | 2014 | Cellular and Molecular Life Sciences2014，，7： | 1 |
| 15 | Legumain forms from plantsand animals differ in their specificity显示文摘 | ROTARI V I DANDO P M BARRETT A J | 2001 | Biol Chem2001，382，： | 1 |
| 16 | Environmental effects of submarine seeping natural gas显示文摘 | Dando P R Hovland M | 1992 | Continental Shelf Research1992，12，10： | 1 |
| 17 | Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine显示文摘 | Elisa Dalla Pozza Claudia Fiorini Ilaria Dando Marta Menegazzi Anna Sgarbossa Chiara Costanzo Marta Palmieri Massimo Donadelli | 2012 | BBA - Molecular Cell Research2012，，10： | 1 |
| 18 | Cloning, isolation, and characterization of mammalian legumain, an asparaginylendopeptidase 显示文摘 | Chen J M Dando P M Rawlings N D | 1997 | Biological Chemistry1997，272，12： | 1 |
| 19 | The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases(LDH1 and LDH2) from toxoplasma gondii:comparisons with pLDH from plasmodium falciparum显示文摘 | Dando C Schroeder ER Hunsaker La | 2001 | Mol Biochem Parasit2001，118，： | 1 |
| 20 | The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with falciparum显示文摘 | Dando C Schroeder E R Hunsaker L A | 2001 | Mol Biochem pLDH from Plasmodium Parasitol2001，118，1： | 1 |
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