|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitochondrial uncoupling protein 2 and pancreatic cancer:A new potential target therapy显示文摘Overall 5-years survival of pancreatic cancer patients is nearly 5%,making this cancer type one of the most lethal neoplasia.Furthermore,the incidence rate of pancreatic cancer has a growing trend that determines a constant increase in the number of deceases caused by this pathology.The poor prognosis of pancreatic cancer is mainly caused by delayed diagnosis,early metastasis of tumor,and resistance to almost all tested cytotoxic drugs.In this respect,the identification of novel potential targets for new and efficient therapies should be strongly encouraged in order to improve the clinical management of pancreatic cancer.Some studies have shown that the mitochondrial uncoupling protein 2(UCP2) is over-expressed in pancreatic cancer as compared to adjacent normal tissues.In addition,recent discoveries established a key role of UCP2 in protecting cancer cells from an excessive production of mitochondrial superoxide ions and in the promotion of cancer cell metabolic reprogramming,including aerobic glycolysis stimulation,promotion of cancer progression.These observations together with the demonstration that UCP2 repression can synergize with standard chemotherapy to inhibit pancreatic cancer cell growth provide the molecular rationale to consider UCP2 as a potential therapeutic target for pancreatic cancer.In this editorial,recent advances describing the relationship between cancer development and mitochondrial UCP2 activity are critically provided. | Massimo Donadelli Ilaria Dando Elisa Dalla Pozza Marta Palmieri | 2015 | World Journal of Gastroenterology2015，21，11： | 9 |
| 2 | UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells显示文摘 | Ilaria Dando Claudia Fiorini Elisa Dalla Pozza Chiara Padroni Chiara Costanzo Marta Palmieri Massimo Donadelli | 2013 | BBA - Molecular Cell Research2013，，3： | 2 |
| 3 | Protein overload stimulates RANTES prodution by proximal tubular cells depending on NF-kappa B activation 显示文摘 | Zoja C Donadelli R Colleoni S | 1998 | Kidney Int1998，53，6： | 1 |
| 4 | The renoprotec- tive properties ofangiotensin converting enzyme in- hibitors in a chronic model of membranous nephropa- thy are solely due to the inhibition of angiotensin Ⅱ: evidence based on comparative studies veith a recep- tor antagonist显示文摘 | Zoja C Donadelli R Corna D | 1997 | Am J Kid Dis1997，29，2： | 1 |
| 5 | Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappa B-and p38 mitogen-activated protein kinase-dependent pathways显示文摘 | Donadelli R Zanchi C Morigi M | 2003 | J Am Soc Nephrol2003，14，10： | 1 |
| 6 | Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions 显示文摘 | Noris M Morigi M Donadelli R | 1995 | Circ Res1995，76，4： | 1 |
| 7 | Nitric oxide synthesi: ! by cultured endothelial cells is modulated by flow conditions显示文摘 | Noris M Morigi M Donadelli R | 1995 | Circ Res1995，76，： | 1 |
| 8 | UCP2, a mitochondrial protein regulated at multiple levels显示文摘 | Massimo Donadelli Ilaria Dando Claudia Fiorini Marta Palmieri | 2014 | Cellular and Molecular Life Sciences2014，，7： | 1 |
| 9 | Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells 显示文摘 | Donadelli M Costanzo C Faggioli L | 2003 | Mol Carcinog2003，38，2： | 1 |
| 10 | Proteunoverlaodstimulates RANTES production by proximal tubular cells depending on NFκB activation显示文摘 | ZojaC Donadelli R Colleoni S etal | 1998 | Kidney Int1998，53，6： | 1 |
| 11 | Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions显示文摘 | Noris M Morigi M Donadelli R | | 0，，： | 1 |
| 12 | Renal expression of monocyte chemoattractant protein - 1 in lupus autoimnmne mice 显示文摘 | Zoja C Liu XH Donadelli R | 1997 | J Am Soc Nephro1997，8，5： | 1 |
| 13 | Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A 显示文摘 | Ceeconi D Donadelli M Rinalducci S | 2007 | Proteomics2007，7，10： | 1 |
| 14 | Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine显示文摘 | Elisa Dalla Pozza Claudia Fiorini Ilaria Dando Marta Menegazzi Anna Sgarbossa Chiara Costanzo Marta Palmieri Massimo Donadelli | 2012 | BBA - Molecular Cell Research2012，，10： | 1 |
| 15 | Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine显示文摘 | Cecconi D Astner H Donadelli M | 2003 | Electrophoresis2003，24，24： | 1 |
| 16 | Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation显示文摘 | Piacentini P Donadelli M Costanzo C Moore PS Palmieri M Scarpa A | 2006 | Virchows Arch2006，448，6： | 1 |
| 17 | Nitric oxide synthesis by cultured endothelial cells is modulated by flow condition显示文摘 | Noris M Morigi M Donadelli R | 1995 | Circ Res1995，76，： | 1 |
| 18 | Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic canc-er cell proliferation显示文摘 | Piacentini P Donadelli M Costanzo C | | 0，，06： | 1 |
| 19 | Protein overload induced NF kappaB activation in proximal tubular cells requires HeOe through a PKC-dependenl pathway 显示文摘 | Morigi M Macconi D Zoja C Donadelli R Buelli S Zanchi C | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 20 | Growth delay of human pancreatic cancer cells by methylase inhibitor 5-Aza- 2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway 显示文摘 | Missiaglia E Donadelli M Palmieri M | 2005 | Oncogene2005，24，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员