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| 1 | Utility of linked color imaging for endoscopic diagnosis of early gastric cancer显示文摘BACKGROUND Linked color imaging(LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal color.AIM To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological findings.METHODS Endoscopic images were obtained for 39 patients(43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging(WLI) and LCI. Color values in Commission Internationale de l'Eclairage(CIE)1976 L*a*b* color space were used to calculate the color difference(ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection,blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images(WLI and LCI) and pathological analyses.RESULTS LCI was superior for lesion recognition(P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI(29.4 vs 18.6, P <0.0001). Blood vessel density was significantly higher in cancer lesions(5.96% vs4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%.CONCLUSION LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis. | Toshihisa Fujiyoshi Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Tsunaki Sawada Keiko Maeda Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Masato Nakaguro Masahiro Nakatochi Yoshiki Hirooka | 2019 | World Journal of Gastroenterology2019，25，10： | 12 |
| 2 | Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?显示文摘AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection reservoir.Intra-arterial cisplatin or subcutaneous interferon was administered in combination with the 5-FU.The patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two groups.RESULTS:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to TACE.Other tools for treatment,i.e.,molecular-targeting agents may be considered for these cases. | Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo Shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke Kubota Shin Maeda Atsushi Nakajima Satoru Saito | 2012 | World Journal of Gastroenterology2012，18，16： | 9 |
| 3 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 4 | BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts显示文摘Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation.Osteocytes or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,respectively.Bone morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of osteoclastogenesis.However,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains unclear.In the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in osteoblasts.In vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult mice.Although global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult phase.Atoh8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow cells.Atoh8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ratio.Moreover,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression ratio.These results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption. | Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi | 2020 | Bone Research2020，8，3： | 6 |
| 5 | Modified docetaxel, cisplatin and capecitabine for stage Ⅳ gastric cancer in Japanese patients: A feasibility study显示文摘AIM To evaluate the feasibility of chemotherapy including fluoropyrimidine, platinum and taxane with modified dosages for unresectable gastric cancer in Japanese patients.METHODS We performed a feasibility study of a modified docetaxel, cisplatin and capecitabine (DCX) regimen for stage Ⅳ gastric cancer. In particular, 30 or 40 mg/m^2 of docetaxel on day 1, 60 mg/m^2 of cisplatin on day 1, and 2000 mg/m^2 of capecitabine for 2 wk were administered every three weeks.RESULTS Three patients were treated with modified DCX(m DCX) with 30 mg/m^2 docetaxel, and five patients were treated with this regimen with 40 mg/m^2 docetaxel. Grade 3 or 4 neutropenia was observed in six of the eight patients; no patients exhibited febrile neutropenia. Partial response was achieved in four of the eight patients. Three patients underwent gastrectomy, which achieved R0 resection without residual tumors in dissected lymph nodes. In one of these three patients, resected specimens revealed pathological complete response in the primary lesion and in lymph nodes.CONCLUSION m DCX was well tolerated by Japanese patients with stage Ⅳ gastric cancer. This regimen might be useful for allowing gastric cancer patients with distant lymph node metastasis to undergo conversion surgery. | Osamu Maeda Ayumu Matsuoka Ryoji Miyahara Kohei Funasaka Yoshiki Hirooka Masahide Fukaya Masato Nagino Yasuhiro Kodera Hidemi Goto Yuichi Ando | 2017 | World Journal of Gastroenterology2017，23，6： | 4 |
| 6 | Cell culture in esophageal squamous cell carcinoma and the associa- tion with molecular markers 显示文摘 | Yutaka Shimada Masato Maeda Go Watanabe | 2003 | Clinical Cancer Research2003，，9： | 1 |
| 7 | Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor-? Signaling显示文摘 | Shintani Yasushi Maeda Masato Chaika Nina Johnson Keith R Wheelock Margaret J | 2008 | American Journal of Respiratory Cell and Molecular Biology2008，，1： | 1 |
| 8 | Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure显示文摘 | Takashi Tsutsui Takayoshi Tsutamoto Atsuyuki Wada Keiko Maeda Naoko Mabuchi Masaru Hayashi Masato Ohnishi Masahiko Kinoshita | 2002 | Journal of the American College of Cardiology2002，，6： | 1 |
| 9 | Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma显示文摘 | Masayoshi Inoue Mitsunori Ohta Keiji Iuchi Akihide Matsumura Kan Ideguchi Tsutomu Yasumitsu Katsuhiro Nakagawa Kenjiro Fukuhara Hajime Maeda Shin-ichi Takeda Masato Minami Yuko Ohno Hikaru Matsuda | 2004 | The Annals of Thoracic Surgery2004，，1： | 1 |
| 10 | A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations显示文摘 | Minako Imamura Shiro Maeda Toshimasa Yamauchi Kazuo Hara Kazuki Yasuda Takashi Morizono Atsushi Takahashi Momoko Horikoshi Masahiro Nakamura Hayato Fujita Tatsuhiko Tsunoda Michiaki Kubo Hirotaka Watada Hiroshi Maegawa Miki Okada-Iwabu Masato Iwabu Nobuhi | 2012 | Human Molecular Genetics2012，，13： | 1 |
| 11 | Measuiement of Applied Force and Deflection in the Javelin Throw显示文摘 | Masato Maeda Eiji Shamoto Toshimichi Moriwaki | 1999 | Journal of Applied Biomechanics1999，15，4： | 1 |
| 12 | Attenuation of Compensation of Endogenous Cardiac Natriuretic Peptide System in Chronic Heart Failure: Prognostic Role of Plasma Brain Natriuretic Peptide Concentration in Patients With Chronic Symptomatic Left Ventricular Dysfunction显示文摘 | Takayoshi Tsutamoto Atsuyuki Wada Keiko Maeda Tomoko Hisanaga Yukiharu Maeda Daisuke Fukai Masato Ohnishi Yoshihisa Sugimoto Masahiko Kinoshita | 1997 | Circulation1997，，2： | 1 |
| 13 | Low-dose non-enhanced CT versus full-dose contrast-enhanced CT in integrated PET/CT scans for diagnosing ovarian cancer recurrence显示文摘 | Kazuhiro Kitajima Yoshiko Ueno Kayo Suzuki Masato Kita Yasuhiko Ebina Hideto Yamada Michio Senda Tetsuo Maeda Kazuro Sugimura | 2012 | European Journal of Radiology2012，，： | 1 |
| 14 | Effective segmental chemoembolization of advanced hepatocellular carcinoma with tumor thrombus in the portal vein显示文摘 | Tetsuya Katsumori M.D. Masato Fujita Takeshi Takahashi Osamu Satoh Shigeki Ichijima Toshiyuki Nakamura Hiroyuki Morishita Kohji Ohno Yasuhiko Nakano Tomoho Maeda | 1995 | CardioVascular and Interventional Radiology1995，，4： | 1 |
| 15 | Surgical Intervention for Malignant Fibrous Histiocytoma of the Lung: Report of a Case显示文摘 | Jun Maeda Mitsunori Ohta Masayoshi Inoue Meinoshin Okumura Masato Minami Hiroyuki Shiono Hikaru Matsuda | 2007 | Surgery Today2007，，4： | 1 |
| 16 | Color representation method using RGB color binary-weighted computer-generated holograms显示文摘We propose a method for color electroholography using a simple red–green–blue(RGB) gradation representation method without controlling the respective brightness of the reference RGB-colored lights. The proposed method uses RGB multiple bit planes comprising RGB binary-weighted computer-generated holograms with various light transmittances. The object points of a given three-dimensional(3D) object are assigned to RGB multiple bit planes according to their RGB gradation levels. The RGB multiple bit planes are sequentially displayed in a time-division-multiplexed manner. Consequently, the proposed method yields a color gradation representation of a reconstructed 3D object. | Masato Fujiwara Naoki Takada Hiromitsu Araki Shohei Ikawa Yuki Maeda Hiroaki Niwase Minoru Oikawa Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi Ito | 2018 | Chinese Optics Letters2018，16，8： | 1 |
| 17 | Association of CC chemokine receptor 7 with lymphnode metastasis of esophageal squamous cell carcinoma显示文摘 | Ding YZ Yutaka Shimada Masato Maeda | 2003 | Clin Cancer Res2003，9，9： | 1 |
| 18 | Expression Levels of Adiponectin Receptors are Decreased in Human Endometrial Adenocarcinoma Tissues显示文摘 | Naoko Yamauchi Yutaka Takazawa Daichi Maeda Takashi Hibiya Mariko Tanaka Masato Iwabu Miki Okada-Iwabu Toshimasa Yamauchi Takashi Kadowaki Masashi Fukayama | 2012 | International Journal of Gynecological Pathology2012，，： | 1 |
| 19 | FDG-PET/CT for diagnosis of primary ovarian cancer显示文摘 | Kazuhiro Kitajima Kayo Suzuki Michio Senda Masato Kita Yuji Nakamoto Yumiko Onishi Tetsuo Maeda Takeshi Yoshikawa Yoshiharu Ohno Kazuro Sugimura | 2011 | Nuclear Medicine Communications2011，，： | 1 |
| 20 | Effective segmental chemoembolization of advanced hepatocellular carcinoma with tumor thrombus in the portal vein显示文摘 | Tetsuya Katsumori M.D. Masato Fujita Takeshi Takahashi Osamu Satoh Shigeki Ichijima Toshiyuki Nakamura Hiroyuki Morishita Kohji Ohno Yasuhiko Nakano Tomoho Maeda | 1995 | CardioVascular and Interventional Radiology1995，，4： | 1 |
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