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| 1 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 2 | 一年制心理危机干预热线咨询员培训过程显示文摘介绍北京回龙观医院一年制心理危机干预热线咨询员培训过程与特色。北京回龙观医院北京心理危机干预热线咨询员培训时间为一年制,分3个阶段完成:2个月的理论与技能培训阶段、4个月的上线实践阶段及6个月独立接线试用阶段。提出建议要培训合格的危机干预热线咨询员需编制系统、严谨的培训教材;制订完善的培训计划;配备资深的教师队伍;建立严格的督导机制;制订科学有效的热线质量评估标准;并注重咨询员的专业成长与心理维护以防止心理枯竭。 | 王翠玲 赵秀芹 Marlys Bueber | 2010 | 中国健康心理学杂志2010，18，1： | 10 |
| 3 | Molecular and Physiological Analysis of Growth-Limiting Drought Stress in Brachypodium distachyon Leaves显示文摘干旱容忍的草 Brachypodium distachyon 是为适度的草和谷物庄稼的新兴的模型种。为了为干旱探索这种的实用性,学习,一在 vivo 可再现干旱试金被开发。弄干的自发的土壤在叶尺寸导致了 45% 减小,并且这主要由于在细胞扩大的减少,而细胞分割由干旱仍然保持大部分未受影响。调查观察的叶生长减小的分子的基础,第三片 Brachypodium 叶在三个地区被把,也就是增长,扩大,和成熟地区,并且使分析遭到了到 transcriptome,基于一个整个染色体的并列数组。这条途径允许我们加亮不同的发展的叶地区的侧面不同地回答到干旱的那 transcriptome。涉及干旱忍耐的几基因和功能的过程被识别。transcriptome 数据在增长地区建议增加的精力可获得性,与甾醇合成的一条起来规定一起,那可以影响膜流动性。这个信息可以被用来改进适度的谷物的忍耐到干旱,它无疑是今天并且在不久的将来的农业面对的主要环境挑战之一。 | Wim Verelst Edoardo Bertolini Stefanie De Bodt Klaas Vandepoele Marlies Demeulenaere Mario Enrico pè Dirk Inzé | 2013 | Molecular Plant2013，6，2： | 6 |
| 4 | Biomarkers in precision therapy in colorectal cancer显示文摘Colorectal cancer(CRC)is the most commonly diagnosed cancer in Europe.Because CRC is also a major cause of cancerrelated deaths worldwide,a lot of research has been focused on the discovery and development of biomarkers to improve the diagnostic process and to predict treatment outcomes.Up till now only a few biomarkers are recommended by expert panels.Current TNM criteria,however,cause substantial under-and overtreatment of CRC patients.Consequently,there is a growing need for new and efficient biomarkers to ensure optimal treatment allocation.An ideal biomarker should be easily translated into clinical practice,to identify patients who can be spared from treatment or benefit from therapy,ultimately resulting in precision medicine in the future.In this review we aim to provide an overview of a number of frequently studied biomarkers in CRC and,at the same time,we will emphasize the challenges and controversies that withhold the clinical introduction of these biomarkers.We will discuss both prognostic and predictive markers of chemotherapy,aspirin therapy as well as overall therapy toxicity.Currently,only mutant KRAS,mutant BRAF,MSI and the Oncotype DXColon Cancer Assay are used in clinical practice.Other biomarker studies showed insufficient evidence to be introduced into clinical practice.Divergent patient selection criteria,absence of validation studies and a large number of single biomarker studies are possibly responsible.We therefore recommend that future studies focus on combining key markers,rather than analysing single markers,standardizing study protocols,and validate the results in independent study cohorts,followed by prospective clinical trials. | Marlies S.Reimers Eliane C.M.Zeestraten Peter J.K.Kuppen Gerrit Jan Liefers Cornelis J.H.van de Velde | 2013 | Gastroenterology Report2013，1，3： | 3 |
| 5 | Current treatment of dysfunctional uterine bleeding显示文摘 | Marlies Y Ben WJ Hans AM | 2004 | Maturitas2004，14，3： | 1 |
| 6 | Loss of caveolae,vascular dysfunction,and pulmonary defects in caveolin-1 gene-disrupted mice显示文摘 | Marek Drab Paul Verkade Marlies Elger Michael Kasper Matthias Lohn Birgit Lauterbach | 2001 | Science2001，294，： | 1 |
| 7 | Students ap proaches to learnmg and assessment preferences in a portfolio-based learning environment 显示文摘 | Marlies Baeten Filip Dochy & Katrien Struyven | 2008 | Journal Instructional Science2008，，36： | 1 |
| 8 | A pain monitoring program for nurses: effects on nurses' pain knowledge and at ti tude显示文摘 | Marlie E J Rianne M S Frits S A M | 2000 | Journal of Pain and Symptom Management2000，19，： | 1 |
| 9 | Expression and subcellular localization of Spred proteins in mouse and human tissues显示文摘 | Catherine M. Engelhardt Karin Bundschu Marlies Messerschmitt Thomas Renné Ulrich Walter Matthias Reinhard Kai Schuh | 2004 | Histochemistry and Cell Biology2004，，6： | 1 |
| 10 | Adding valproate Io lamotrigine: A study of their pharmaeokinetie interaeton显示文摘 | Andre MK Marli SF | 2000 | Neurology2000，55，： | 1 |
| 11 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 12 | Genetic characterization of polypeptide deformylase a distinctive enzyme of eubacterial translation显示文摘 | Mazel D Pochet S Marlière P | 1994 | EMBO J1994，13，4： | 1 |
| 13 | The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y in- dependent pathogenic role during acute lung infection 显示文摘 | Marlies G Shouguang J Pieter B | 2012 | PLoS One2012，7，41： | 1 |
| 14 | Using student-centred learning environments to stimulate deep approaches to leafing:Factors encouraging or discouraging their effeciveness显示文摘 | MARLIES BAETEN EVA KYNDT KATRIEN STRUYVEN etc | 2010 | Edueational Research Review2010，，5： | 1 |
| 15 | Macromolecular coupling agents for flame retardant materials显示文摘 | Sonia Marli Bohrz Nachtigall Maximiliano Miotto Elisangeta Edila Schneider | 2006 | European Polymer Journal2006，42，： | 1 |
| 16 | Estradiol and Progesterone Strongly Inhibit the Innate Immune Response of Mononuclear Cells in Newborns显示文摘 | Eric Giannoni Laurence Guignard Marlies Knaup Reymond | 2011 | Infect Immun2011，79，7： | 1 |
| 17 | Genetic correlates of musical pitch recognition in humans显示文摘 | Dennis D Ani M Marlies D L | 2001 | Science2001，，291： | 1 |
| 18 | Haemodynamic consequences of mild therapeutic hypothermia after cardiac arrest显示文摘 | Remco Bergman Annemarije Braber Marlies A Adriaanse Roel van Vugt David HT Tjan Arthur RH van Zanten | 2010 | European Journal of Anaesthesiology2010，，4： | 1 |
| 19 | Lipase-catalyzed degradation of poly (e-caprolactone) 显示文摘 | LAURA P FRANCO P MARLI Z | 2004 | Enzyme and Microbial Technology2004，35，4： | 1 |
| 20 | Aberrant splicing in MLH1 and MSH2 due to exonic and intronic variants显示文摘 | Constanze Pagenstecher Maria Wehner Waltraut Friedl Nils Rahner Stefan Aretz Nicolaus Friedrichs Marlies Sengteller Wolfram Henn Reinhard Buettner Peter Propping Elisabeth Mangold | 2006 | Human Genetics2006，，1： | 1 |
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