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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | Clinical outcome of closed isolated subtalar dislocations显示文摘 | de Palma L Santucci A Marinelli M | 2008 | Arch Orthop Trauma Surg2008，128，6： | 1 |
| 3 | Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 显示文摘 | Cosconati S Marinelli L La Motta C | 2009 | J Med Chem2009，52，18： | 1 |
| 4 | On the nature of mycobacteriophage diversity and host preference显示文摘 | Jacobs-seca D Marinelli L J Bowman C | 2012 | Virology2012，434，2： | 1 |
| 5 | Organic thin filmtransistors as plastic chiral sensors 显示文摘 | TORSI L FARrNOLA G MARINELLI F | 2008 | Sensors IEEE2008，，： | 1 |
| 6 | T2 relaxation times correlated with stage of lumbar intervertebral disk degeneration and patient age 显示文摘 | Marinelli N L Haughton V M Anderson P A | 2010 | AJNR Am J Neuroradiol2010，31，7： | 1 |
| 7 | Toll-like receptors 2,-3 and-4 prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1βrelease显示文摘 | Facci L Barbierato M Marinelli C | 2014 | Sci Rep2014，4，： | 1 |
| 8 | Changes in GE2270 antibiotic production in planobisporarosea through modulation of methylation metabolism显示文摘 | Gastaldo L Marinelli F | 2003 | Microbiology2003，149，： | 1 |
| 9 | Mini-review of studies on the effect of smoking and drinking habits on semen parameters显示文摘 | Marinelli D Gaspari L Pedotti P | 2004 | Int J Hyg Environ Health2004，207，3： | 1 |
| 10 | Chemose-lective hydrogenation of unsaturated carbanyl-compounds over group-8 and group-9 titania-supported metal catalyst 显示文摘 | Raa C G English M Marinelli T B L W | 1993 | Stud Surf Sci Catal1993，78，： | 1 |
| 11 | Ubiquitin ligases MuRF-1 and MAFbx in human skeletal muscle atrophy显示文摘 | de-Palma L Marinelli M Pavan M | 2008 | Joint Bone Spine2008，75，1： | 1 |
| 12 | Toll-like receptors2, -3and -4prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1β release显示文摘 | Facci L Barbierato M Marinelli C | 2014 | Sci Rep2014，4，： | 1 |
| 13 | Reaction of O2(a1△g) with O- and O2-显示文摘 | Upschulte B L Marinelli W J,Green B D | 1994 | J PhysChem,1994，98，： | 1 |
| 14 | The pastaphase within density dependent hadronic models显示文摘 | Avancini S S Brito L Marinelli J R | 2009 | Physical Review C2009，79，03： | 1 |
| 15 | Composite pulse excitation schemes for MQMAS NMR of half-integer quadrupolar spins显示文摘 | Marinelli L Medek A Frydman L | 1998 | J Magn Resort1998，132，1： | 1 |
| 16 | An heteroduplex mobility analysis assay based on capillary electrophoresis for thestudy of HCV quasispecies显示文摘 | Rossi L Leveri M Marinelli D etal | 2003 | J Virol Methods2003，110，1： | 1 |
| 17 | Mini-review of studies on the effect of smoking and drinking habits on semen parameters显示文摘 | Marinelli D Gaspari L Pedotti P et a l | 2004 | Int J Hyg Environ Health2004，207，3： | 1 |
| 18 | T2 re- laxation times correlated with stage of lumbar intervertebral disk degeneration and patient age显示文摘 | MARINELLI N L HAUGHTON V M ANDERSON P A | 2010 | AJNR Am J Neuroradiol2010，31，7： | 1 |
| 19 | The external rotation method for reduction of acute anterior shoulder dislocations显示文摘 | Marinelli M de Palma L | 2009 | 1 Orthop Traumatol2009，10，1： | 1 |
| 20 | T2 re- laxation times of intervertebral disc tissue correlated with water content and proteoglycan content 显示文摘 | MARINELLI N L HAUGHTON V M MUNOZ A | 2009 | Spine ( Phila Pa 1976 )2009，34，5： | 1 |
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