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| 1 | 花粉记录的青藏高原中部中全新世以来植被与环境显示文摘青藏高原中部的草甸/草原混合生态群落,对气候变化非常敏感.孢粉记录显示草原发育时期,莎草减少,区域气候是相对干旱的,在时间上对应季风相对弱的时期.依据唐古拉山垭口湖、阿洪错和错那3个淡水湖泊钻孔孢粉分析,定量重建的温度和降水指标,探讨该地区8200 cal a BP以来的植被与气候变化.8200~6500 cal a BP,尤其是8200~7200 cal a BP,植被以草甸/草原混合生态群落为主,显示强季风控制着青藏高原中部;6000~4900,4400~3900以及2800~2400 cal a BP时期区域植被以草原植被为主,应是3次百年尺度的干旱事件;4900~4400 cal a BP期间植被类型由草原向草甸转变;6500~5400和3000~1600 cal a BP出现两次大的变干事件;数值摸拟估计,高原中部接近于现今的环境,最早可能出现在6500cal a BP,自3000cal a BP以后高原中部季风性降水和湿度逐渐减少至现今水平,可能在700~300cal a BP出现一次小冰期变冷事件. | 唐领余 沈才明 李春海 彭金兰 刘惠 Kam-Biu Liu Carrie Morrill Jonathan T.Overpeck Jonathan E.Cole 杨保 | 2009 | 中国科学(D辑)2009，39，5： | 28 |
| 2 | History of the infantile hepatic hemangioma:From imaging to generating a differential diagnosis显示文摘We aim to provide an up-to-date summary of infantile hepatic hemangioma(IHH) and its misnomers and to dialectically present the differential diagnosis of these rare entities of the liver.Eligible peer-reviewed articles on hepatic infantile hemangiomas,published between 2000 and 2015,were reviewed for this study.IHH is the most common hepatic vascular tumor in children.Once a liver mass is identified in an infant,the differential diagnosis ranges from vascular malformations to benign and malignant tumors including mesenchymal hamartoma,hepatoblastoma,metastatic neuroblastoma,so careful physical examination,imaging studies,and,if indicated,tumor markers and biopsy,are of pivotal importance to ascertain the correct diagnosis.Despite the benign nature of IHHs,some of these lesions may demand medical and/or surgical intervention,especially for multiple and diffuse IHH.Complications can include hepatomegaly,hypothyroidism and cardiac failure.Therefore,a close follow-up is required until complete involution of the lesions.We propose an algorithm to guide the physicians towards the proper management of hepatic lesions. | Maria Gnarra Gerald Behr Alison Kitajewski June K Wu Sudha A Anupindi Carrie J Shawber Nick Zavras Dimitrios Schizas Chris Salakos Konstantinos P Economopoulos | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 27 |
| 3 | 美国人文护理实践与人文精神培养对我国人文护理发展的启示显示文摘分析美国人文护理实践和护士各阶段人文精神的培养特点,提出我国护士人文精神无缝培养思路,以增强护理人员的服务意识,升华服务境界,提升服务品质。 | 刘立美 Carrie Dierdorff | 2017 | 护理研究(上旬版)2017，31，1： | 23 |
| 4 | Pollen-inferred vegetation and environmental changes in the central Tibetan Plateau since 8200 yr BP显示文摘The ecotone between alpine steppe and meadow in the central Tibetan Plateau is sensitive to climate changes. Here we used the pollen records from three lakes in this region to reconstruct the evolution of local vegetation and climate since 8200 cal. yr BP. The history of temperature and precipitation was reconstructed quantitatively with multi-bioclimatic indexes and a transfer function from pollen records. Results show that the steppe/meadow dominated during the period of 8200―6500 cal. yr BP, especially 8200―7200 cal. yr BP, indicating the central Tibetan Plateau was controlled by strong monsoon. The steppe dominated during the periods of 6000―4900, 4400―3900, and 2800―2400 cal. yr BP. The steppe decreased gradually and the meadow expanded during the period of 4900―4400 cal. yr BP. Three century-scale drought events occurred during 5800―4900, 4400―3900 and 2800 cal. yr BP, respectively. The first time when the regional climate shifted to the present level was at 6500 cal. yr BP in the central Plateau. Since 3000 cal. yr BP, the temperature and precipitation have decreased gradually to the present level. However, the cold climate between 700―300 cal. yr BP likely corresponds to the Little Ice Age. | LIU Kam-Biu Carrie MORRILL Jonathan T. OVERPECK Julia E. COLE | 2009 | Science China Earth Sciences2009，52，8： | 13 |
| 5 | 骨形态发生蛋白-2对软骨寡聚基质蛋白在软骨细胞内表达的影响显示文摘目的 :定量研究骨形态发生蛋白 (BMP 2 )对软骨寡聚基质蛋白 (COMP)基因在人软骨细胞及ATDC5 5细胞内表达的影响。方法 :原代培养成人及胚胎的关节软骨细胞 ,经BMP 2刺激后 ,利用real timeRT PCR定量分析COMP基因的表达情况 ;采用静息期不表达COMP基因的鼠源性成软骨细胞株ATDC5 5作为研究对象 ,给以BMP 2刺激 ,通过RT PCR检测COMP表达的变化 ;将COMP基因的全长启动子克隆到报告基因Luciferase的上游并转染入ATDC5 5细胞 ,分别给以 5 0 0 μg·L-1的BMP 2和 /或 10 μg·L-1的Noggin刺激 ,测定其对Luciferase活性的影响。结果 :BMP 2使成人软骨细胞内的COMP基因表达提高近 3倍 ,而对胚胎软骨细胞的作用较弱 ,提高了1.5倍 ;COMP基因在胚胎软骨细胞内的基础表达量约是在成人软骨细胞内的 2倍 ;经BMP 2刺激后ATDC5 5细胞株明显表达COMP基因 ,并且BMP 2的这种效应能够被其拮抗剂Noggin所抑制 ;BMP 2明显促进了Luciferase的活性 ,约提高了 5倍 ,且Noggin特异性的抑制了BMP 2的这种作用。 结论 :BMP 2能够明显促进COMP基因在人关节软骨细胞及鼠源性成软骨细胞株ATDC5 5内的表达。 | 田华 Carrie FANG Paul E.DICESARE | 2003 | 北京大学学报(医学版)2003，35，3： | 9 |
| 6 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 7 | 小反刍兽疫病毒(PPRV)N蛋白的表达与ELISA检测方法的建立显示文摘通过对下载的16株小反刍兽疫病毒(PPRV)N基因片段进行序列分析,合成了PPRV N基因。用NP1和NP2引物扩增。纯化的PPRV N基因在T4DNA连接酶的作用下,和PET32-a载体进行连接反应构建重组质粒pET-a-PPRV-N。经诱导表达和纯化后,得到了大量的PPRV N蛋白。用PPRV N蛋白制备免疫血清,经国际标准血清标化后作为参考阳性血清,同时以PPRV N蛋白为抗原建立间接ELISA(I-ELISA)方法。对山东省的467份羊血清检测,使用S/P(样品值/阳性值)平均值加3倍标准差的方法,计算出其临界点为0.28。应用间接ELISA和针对H蛋白的单抗为基础的C-ELISA检测来自于疫区的69份血清,结果两者的符合率为79.7%。 | 张喜悦 王志亮 刘春菊 李林 包静月 何昭阳 Mandy C Carrie B Anderson J | 2008 | 中国兽医学报2008，28，2： | 8 |
| 8 | Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis. | Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，35： | 6 |
| 9 | 胜任力结果与表现评估模型在护理教育领域的应用与发展显示文摘随着综合医学模式的出现及医疗环境日趋复杂,护士不仅要在不同环境下承担多种角色,还必须具备综合的护理专业体系,这样才能胜任护理工作。具备扎实的基础知识和技能是成为护士最基本的要求,而个人特质、价值观、态度等隐性因素是决定能否胜任护理工作更为重要的元素。 | 孔祥萍 李春燕 Carrie B Lenburg 张艳 李小红 刘小娟 | 2011 | 中华护理教育2011，8，10： | 6 |
| 10 | Inactivation of Mitochondrial Complex Ⅰ Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function显示文摘At12Cys-1 (At5g64400 ) 和 At12Cys-2 (At5g09570 ) 是二密切相关的 isogenes 编码小、成双的半胱氨酸蛋白质,典型地在线粒体定位了。At12Cys-2 抄本与破坏 mitochondrial 蛋白质,而是 At12Cys 的增加在许多异种被导致蛋白质仅仅与减少的 mitochondrial 在异种被检测复杂我丰富。在缺乏 mitochondrial 建筑群的异种的 At12Cys 蛋白质感应我被位于线粒体,叶绿体,和 cytosol 的 At12Cys 蛋白质伴随。生物化学的分析揭示了那甚至单个的基因删除,即, At12cys-1 或 At12cys-2,在 mitochondrial 和叶绿体功能上有效果。然而,仅仅加倍异种,即, At12cys-1 : At12cys-2,影响许多蛋白质和 mRNA 抄本编码翻译延伸因素以及 rRNA 丰富。蓝本国的页证明 At12Cys 与 mitochondrial supercomplex 共同移居我 + III。同样, At12cys-1 和 At12cys-2 基因的删除,然而并非单个基因删除,导致提高的忍耐到干旱和轻应力和增加的抗氧化剂能力。正式就职和在在建筑群的减小之上的 At12Cys 的多重本地化我丰富提供机制明确地表明 mitochondrial 机能障碍到 cytosol 然后在以外到在房间的另外的细胞器。 | Yan Wang Wenhui Lyu Oliver Berkowitz Jordan D. Radomiljac Simon R. Law Monika W. Murcha Chris Carrie Pedro F. Teixeira Beata Kmiec Owen Duncan Olivier Van Aken Reena Narsai Elzbieta Glaser Shaobai Huang Ute Roessner A. Harvey Millar James Whelan | 2016 | Molecular Plant2016，9，5： | 5 |
| 11 | Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common chronic liver disease in the United States and represents an increasingly important etiology of hepatocellular carcinoma(HCC) with annual cumulative incidence rates ranging from 2% to 12% in cohorts of NAFLD cirrhosis. While the risk of progression of NAFLD to HCC remains higher among patients with fibrosis or cirrhosis, an increasing amount of literature describes NAFLD-HCC as a disease that can occur in the absence of cirrhosis. Efforts to characterize the pathogenesis of NAFLD-HCC have suggested mechanisms that strongly associate with states of hyperinsulinemia and chronic inflammation, cellular mechanisms including adaptive immune responses and hepatic progenitor cell populations, and genetic polymorphisms including mutations of PNPLA3. Current literature describes NAFLD-HCC mostly as a disease of late presentation with lower rates of receipt of curative therapy and worse prognosis. However, a growing body of evidence has reported comparable and potentially more favorable disease-free and overall survival rates among patients with NAFLD-HCC after receipt of curative treatment. This review summarizes current evidence of epidemiology, pathophysiology, disease presentation, demand and receipt of curative therapy, post-treatment outcomes, and overall survival of NAFLD-associated HCC. | Carrie R Wong Mindie H Nguyen Joseph K Lim | 2016 | World Journal of Gastroenterology2016，22，37： | 5 |
| 12 | 有机磷杀虫剂对M2受体磷酸化的影响显示文摘目的研究有机磷类杀虫剂对G蛋白结合受体激酶2介导的毒蕈碱乙酰胆碱m2受体磷酸化的影响和可能存在的其他作用途径。方法将纯化的毒蕈碱乙酰胆碱m2受体,G蛋白结合受体激酶-2,[γ-p32]ATP与对氧磷(PO)、氧毒死蜱(CPO)共同保温,聚丙烯酰胺凝胶电泳分离蛋白,放射性自显影检测m2受体磷酸化结果。结果氧毒死蜱完全抑制m2受体的磷酸化,其半数抑制浓度为(IC50)70μmol/L;毒死蜱也抑制m2受体的磷酸化,而对氧磷与对硫磷不抑制m2受体的磷酸化。结论不同的有机磷杀虫剂对m2受体的磷酸化有完全不同的作用;毒死蜱阻断m2受体的磷酸化,提示有机磷杀虫剂的毒性作用存在其他途径。 | 邹黎明 Carry Pope | 2005 | 中国公共卫生2005，21，11： | 4 |
| 13 | Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions显示文摘Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective therapies.The majority of patients with colon cancer are diagnosed at an early stage(stages I to III),which provides an opportunity for cure.The current treatment paradigm of early stage colon cancer consists of surgery followed by adjuvant chemotherapy in a select group of patients,which is directed at the eradication of minimal residual disease to achieve a cure.Surgery alone is curative for the vast majority of colon cancer patients.Currently,surgery and adjuvant chemotherapy can achieve long term survival in about two-thirds of colon cancer patients with nodal involvement.Adjuvant chemotherapy is recommended for all patients with stage III colon cancer,while the benefit in stage II patients is not unequivocally established despite several large clinical trials.Contemporary research in early stage colon cancer is focused on minimally invasive surgical techniques,strategies to limit treatment-related toxicities,precise patient selection for adjuvant therapy,utilization of molecular and clinicopathologic information to personalize therapy and exploration of new therapies exploiting the evolving knowledge of tumor biology.In this review,we will discuss the current standard treatment,evolving treatment paradigms,and the emerging biomarkers,that will likely help improve patient selection and personalization of therapy leading to superior outcomes. | Sakti Chakrabarti Carrie Y Peterson Deepika Sriram Amit Mahipal | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 4 |
| 14 | Defining the Mitochondrial Stress Response in Arabidopsis thaliana显示文摘获得的全球概述线粒体对应力作出回应,我们试图定义工厂 mitochondrial 压力反应(MSR ) 。由联合通常认为地与压力相关的条件的 16 个 microarray 实验编码 mitochondrial 蛋白质的一套 1196 Arabidopsis thaliana 基因, 45 原子编码基因被定义为广泛地压力应答。用绿色荧光灯蛋白质(GFP ) 熔化试金,很多这些指向蛋白质的 mitochondrial 被测试,在是的总数 26 蛋白质证实 mitochondrially 指向了。几这些蛋白质被观察双指向了到线粒体和质体,包括小热吃惊蛋白质 sHSP23.5 和 sHSP23.6。除了线粒体的明确的压力部件,例如其他的 oxidases,菸碱腺嘌 dinucleotide (NAD (P) H ) 脱氢酶,和热震惊蛋白质,许多另外的蛋白质,许多与未知功能,被识别。mitochondrial 搬运人蛋白质家庭在压力应答的基因是过去代表的,建议那个压力越过 mitochondrial 为代谢物运输导致改变的需要内部膜。尽管这些蛋白质编码许多的基因包含普通行动 cis 规章的元素,很多个不同规章的过程或信号多半触发了 MSR,是明显的。因此,这些基因提供新模型系统学习 mitochondrial 后退规定,除了广泛地使用的其他的 oxidase 模型。另外,当在对应力应答的蛋白质的变化没在一个抄本与变化相关很好,铺平,它建议 post-transcriptional 机制也在定义 MSR 起一个重要作用。 | Olivier Van Aken Botao Zhang Chris Carrie Vindya Uggalla Ellen Paynter Estelle Giraud James Whelan | 2009 | Molecular Plant2009，2，6： | 4 |
| 15 | 胜任力表现测验体系中文版的信度和效度研究显示文摘目的检测胜任力表现测验体系(Competency Performance Examination,CPE)中文版的信度和效度,为胜任力本位教育的效果评价提供可靠的评价工具。方法通过专家效度法评价CPE中文版的表面效度和内容效度。使用CPE中文版对20名护理本科实习生胜任力表现进行评价,检测CPE中文版的内部一致性及评定者间信度。结果 CPE中文版各个条目的 CVI在0.6~1.0,全部条目的平均CVI为0.965。7项核心胜任力的KR-20值在0.730~0.921,整个测验体系的KR-20值为0.855。7项核心胜任力判定的一致Kappa系数在0.685~0.823(P均〈0.05)。结论 CPE中文版具有良好的信度和效度,可作为评价胜任力本位教育临床教学效果的评价工具。 | 李春燕 孔祥萍 Carrie B Lenburg 张艳 李小红 刘小娟 | 2011 | 中华护理教育2011，8，9： | 4 |
| 16 | Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells显示文摘 | Jalees Rehman Dmitry Traktuev Jingling Li Stephanie Merfeld-Clauss Constance J. Temm-Grove Jason E. Bovenkerk Carrie L. Pell Brian H. Johnstone Robert V. Considine Keith L. March | 2004 | Circulation: Journal of the American Heart Association2004，，10： | 4 |
| 17 | TBL教学模式在高校医院管理学课程教学中的应用研究显示文摘探讨高校医院管理学课程教学中应用TBL教学模式的整体效果,从而提高教学效果和效率。 | 朱小颖 王高玲 Carrie Wong | 2021 | 卫生职业教育2021，39，12： | 4 |
| 18 | 猪超剂量饲喂植酸酶——饲料性能改善上的一场革命显示文摘植酸是植物源性饲料中重要的抗营养成分,能促进内源性粘蛋白的分泌,结合矿物质,减少其可用性,降低氨基酸消化率,抑制内源性酶的活性。本文主要讨论如何通过超剂量(使用高剂量的植酸酶以确保几乎所有的植酸都被破坏)使用大肠杆菌植酸酶,以减少植酸相关的抗营养作用。1抗营养效应植酸能与锌、铜、铁和钙等矿物质螯合。 | 傅强 陈琳 Mike Bedford Carrie Walk | 2014 | 国外畜牧学(猪与禽)2014，0，4： | 3 |
| 19 | 肝静脉压力梯度可鉴别肝移植后有丙肝复发高风险的患者显示文摘Liver biopsy is essential in the follow-up of HCV-infected liver transplant recipients.The aim of this study was to prospectively compare percutaneous(PLB)versus transjugular liver biopsy(TLB)in the assessment of liver damage.We also explored the diagnostic value of hepatic venous pressure gradient(HVPG)to identify patients at risk of severe HCV disease recurrence after liver transplantation(LT).One hundred and sixty paired PLB and TLB(with HVPG measurement)were performed 3 or 12 months after LT in 80 patients.Concordance for necroinflammation and fibrosis was fair or good,particularly 1 year after LT(kappa > or = 0.6).At this point,a significant positive association was seen between the median HVPG and the fibrosis stage(2.5 mm Hg for F0;5 mm Hg for F1,6 mm Hg for F2,and 11.5 mm Hg for F3;Kruscal-Wallis < 0.001).Despite this strong association,portal hypertension(HVPG > or = 6 mm Hg)was detected in 1(5%)of 22,4(16%)of 25,and 6(60%)of 10 patients with fibrosis stages 0,1,and 2,respectively.After a median follow-up of 38 months,clinical decompensation occurred in 15(19%)of 80 patients.Although the presence of significant fibrosis(F2-F3)1 year after transplantation was good to predict clinical decompensation(AUC:0.80),an HVPG of 6 mm Hg or greater was extremely accurate at identifying patients at risk of disease progression(AUC:0.96).In conclusion,HVPG determination is a valuable tool for follow-up in patients with HCV recurrence after LT. | Blasco A. Forns X. Carrión J.A. 陈云茹 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，9： | 3 |
| 20 | Understanding the forces acting in self-assembly and the implications for constructing three-dimensional (3D) supercrystals显示文摘进称为 supercrystals 或上层建筑的订的结构的 nanocrystals 的集会由于象相关那样的众多的有用应用成为了枢轴的边疆在宏观的晶体的原子的安排并且调节集体性质遇见各种各样的应用的要求。在这篇文章,在 nanocrystals 的三维的超点阵的准备的最近的进步被构画出,与在有序的汇编以外的驱动力和进化线路上的一个特别重音。首先,带或内部并且外部地管理三维的 supercrystals 的形成的斥力系统地在三维的组织工会关于他们的起源和功能被识别并且讨论。然后,基于象微滴蒸发和一个液体 / 液体接口那样的生长情形自己组装的 nanocrystal 的通常应用的工具的摘要的介绍与特定的盒子被介绍并且详细说明了分析。最后,为这块地的存在挑战和前景简短被加亮。 | Chenyu wang1 Carrie Siu Jun Zhang Jiye Fang | 2015 | Nano Research2015，8，8： | 3 |
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