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| 1 | Current concepts and future strategies in the antimicrobial therapy of emerging Gram-positive spontaneous bacterial peritonitis显示文摘Spontaneous bacterial peritonitis(SBP) is the most common infection in end-stage liver disease patients.SBP is defined as an ascitic fluid infection with a polymorphonuclear leucocyte count ≥ 250/mm^3 without an evident intra-abdominal surgically treatable source.Several mechanisms contribute to SBP occurrence,including translocation of gut bacteria and their products,reduced intestinal motility provoking bacterial overgrowth,alteration of the gut's barrier function and local immune responses.Historically,Gram-negative enteric bacteria have been the main causative agents of SBP,thereby guiding the empirical therapeutic choice.However,over the last decade,a worryingly increasing prevalence of Gram-positive and multi-drug resistant(MDR) SBP has been seen.Recently,the microbiological spectrum of SBP seems to have changed in Europe due to a high prevalence of Gram-positive bacteria(48%-62%).The overall proportion of MDR bacteria is up to 22%-73% of cases.Consequently,empirical therapy based on thirdgeneration cephalosporins or amoxicillin/clavulanic acid,can no longer be considered the standard of care,as these drugs are associated with poor outcomes.Theaim of this review is to describe,with an epidemiological focus,the evidence behind this rise in Gram-positive and MDR SBP from 2000 to present,and illustrate potential targeted therapeutic strategies.An appropriate treatment protocol should include daptomycin plus ceftaroline and meropenem,with prompt stepdown to a narrower spectrum when cultures and sensitivity data are available in order to reduce both cost and potential antibiotic resistance development. | Marco Fiore Alberto Enrico Maraolo Ivan Gentile Guglielmo Borgia Sebastiano Leone Pasquale Sansone Maria Beatrice Passavanti Caterina Aurilio Maria Caterina Pace | 2017 | World Journal of Hepatology2017，9，30： | 13 |
| 2 | Nosocomial spontaneous bacterial peritonitis antibiotic treatment in the era of multi-drug resistance pathogens: A systematic review显示文摘AIM To systematically review literature upon aetiology of nosocomial spontaneous bacterial peritonitis(N-SBP) given the rising importance of multidrug-resistant(MDR) bacteria.METHODS A literature search was performed on MEDLINE and Google Scholar databases from 2000 to 15 th of November 2016, using the following search strategy: 'spontaneous' AND 'peritonitis'.RESULTS The initial search through electronic databases retrieved 2556 records. After removing duplicates, 1958 records remained. One thousand seven hundred and thirty-five of them were excluded on the basis of the screening of titles and abstract, and the ensuing number of remaining articles was 223. Of these records, after careful evaluation, only 9 were included in the qualitative analysis. The overall proportion of MDR bacteria turned out to be from 22% to 73% of cases across the studies.CONCLUSION N-SBP is caused, in a remarkable proportion, by MDR pathogens. This should prompt a careful re-assessment of guidelines addressing the treatment of this clinical entity. | Marco Fiore Alberto Enrico Maraolo Ivan Gentile Guglielmo Borgia Sebastiano Leone Pasquale Sansone Maria Beatrice Passavanti Caterina Aurilio Maria Caterina Pace | 2017 | World Journal of Gastroenterology2017，23，25： | 9 |
| 3 | Holographic optics in planar optical systems for next generation small form factor mixed reality headsets显示文摘Helmet Mounted Displays(HMDs),such as in Virtual Reality(VR),Augmented Reality(AR),Mixed reality(MR),and Smart Glasses have the potential to revolutionize the way we live our private and professional lives,as in communicating,working,teaching and learning,shopping and getting entertained.Such HMD devices have to satisfy draconian requirements in weight,size,form factor,power,compute,wireless communication and of course display,imaging and sensing performances.We review in this paper the various optical technologies and architectures that have been developed in the past 10 years to provide adequate solutions for the drastic requirements of consumer HMDs,a market that has yet to become mature in the next years,unlike the existing enterprise and defense markets that have already adopted VR and AR headsets as practical tools to improve greatly effectiveness and productivity.We focus specifically our attention on the optical combiner element,a crucial element in Optical See-Through(OST)HMDs that combines the see-through scene with a world locked digital image.As for the technological platform,we chose optical waveguide combiners,although there is also a considerable effort today dedicated to free-space combiners.Flat and thin optics as in micro-optics,holographics,diffractives,metasurfaces and other nanostructured optical elements are key building blocks to achieve the target form factor. | Bernard C.Kress Maria Pace | 2022 | Light(Advanced Manufacturing)2022，3，4： | 3 |
| 4 | Intensive care treatment of ovarian hyper - stimulation syndrome (OHSS) 显示文摘 | Pasquale Sansone Caterina Aurilio Maria Pace | 2011 | Reproductive Science2011，1221，： | 1 |
| 5 | Is flexible bronchoscopy necessary to confirm the position of double-lumen tubes before thoracic surgery? ☆显示文摘 | Mario de Bellis Rosanna Accardo Massimo Di Maio Carmine Lamanna Giovanni Battista Rossi Maria Caterina Pace Vincenzo Romano Gaetano Rocco | 2011 | European Journal of Cardio-Thoracic Surgery2011，，4： | 1 |
| 6 | Outcomes assessment of hepatitis C virus-positive psoriatic patients treated using pegylated interferon in combination with ribavirin compared to new Direct-Acting Antiviral agents显示文摘AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α plus ribavirin(P/R) therapy.METHODS This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus(HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017. The patients were divided into two groups: patients that underwent therapy with DAAs and patients that underwent HCV treatment with P/R. Patients were assessed by a dermatologist for psoriasis symptoms, collecting Psoriasis Area Severity Index(PASI) scores and the Dermatology Quality of Life Index(DLQI). PASI and DLQI scores were evaluated 24 wk after the end of HCV treatment and were assumed as an outcome of the progression of psoriasis. Switching to a different b DMARD was considered as an inadequate response to biological therapy. The dropout of HCV therapy and sustained virological response(SVR) were considered as outcomes of HCV therapy.RESULTS Fifty-nine psoriatic patients in biological therapy underwent antiviral therapy for CHC. Of this, 27 patients were treated with DAAs and 32 with P/R. After 24 wk post treatment, the DLQI and the PASI scores were significantly lower(P < 0.001 and P < 0.005, respectively) in the DAAs group compared with P/R group. None of the patients in the DAAs group(0/27) compared to 8 patients of the P/R group(8/32) needed a shift in biological treatment.CONCLUSION DAAs seem to be more effective and safe than P/R in HCV-positive psoriatic patients on biological treatment. Fewer dermatological adverse events may be due to interferon-free therapy. | Giovanni Damiani Chiara Franchi Paolo Pigatto Andrea Altomare Alessia Pacifico Stephen Petrou Sebastiano Leone Maria Caterina Pace Marco Fiore | 2018 | World Journal of Hepatology2018，10，2： | 1 |
| 7 | Spontaneous bacterial peritonitis due to carbapenemase-producing Enterobacteriaceae:Etiology and antibiotic treatment显示文摘Carbapenem antibiotics were first introduced in the 1980s and have long been considered the most active agents for the treatment of multidrug-resistant gramnegative bacteria.Over the last decade,carbapenem-resistant Enterobacteriaceae(CRE)have emerged as organisms causing spontaneous bacterial peritonitis.Infections caused by CRE have shown a higher mortality rate than those caused by bacteria sensitive to carbapenem antibiotics.Current antibiotic guidelines for the treatment of spontaneous bacterial peritonitis are insufficient,and rapid deescalation of empiric antibiotic treatment is not widely recognized.This review summarizes the molecular characteristics,epidemiology and possible treatment of spontaneous bacterial peritonitis caused by CRE. | Marco Fiore Sveva Di Franco Aniello Alfieri Maria Beatrice Passavanti Maria Caterina Pace Stephen Petrou Francesca Martora Sebastiano Leone | 2020 | World Journal of Hepatology2020，12，12： | 1 |
| 8 | A prospective evaluation of iron deficiency anemia in the GI endoscopy setting: role of standard endoscopy, videocapsule endoscopy, and CT-enteroclysis显示文摘 | Angelo Milano Chrysanthi Balatsinou Antonella Filippone Maria Pia Caldarella Francesco Laterza Domenico Lapenna Sante Donato Pierdomenico Fabio Pace Franco Cuccurullo Matteo Neri | 2011 | Gastrointestinal Endoscopy2011，，5： | 1 |
| 9 | Intensive care treatment of ovarian hyperstimulation syndrome (OHSS)显示文摘 | PASQUALE SANSONE CATERINA AURILIO MARIA CATERINA PACE | 2011 | Reproductive Science2011，1221，： | 1 |
| 10 | MicroRNA as new tools for prostate cancer risk assessment and therapeutic intervention:results from clinical data set and patients'samples显示文摘 | Cannistraci A Di Pace AL De Maria R | 2014 | Biomed Res Int2014，2014，14： | 1 |
| 11 | Reduced apoptosis of CD8+ T-Lymphocytes in the airways of smokers with mild/moderate COPD显示文摘 | Liboria Siena Mark Gjomarkaj John Elliot Elisabetta Pace Andreina Bruno Simonetta Baraldo Marina Saetta Maria Rosaria Bonsignore Alan James | 2011 | Respiratory Medicine2011，，10： | 1 |
| 12 | Medicinal cannabis products for the treatment of acute pain显示文摘For thousands of years,medicinal cannabis has been used for pain treatment,but its use for pain management is still controversial.Meta-analysis of the literature has shown contrasting results on the addition of cannabinoids to opioids compared with placebo/other active agents to reduce pain.Clinical studies are mainly focused on medicinal cannabis use in chronic pain management,for which the analgesic effect has been proven in many studies.This review focuses on the potential use of medical cannabis for acute pain management in preclinical studies,studies on healthy subjects and the few pioneering studies in the clinical setting. | Marco Fiore Aniello Alfieri Sveva Di Franco Stephen Petrou Giovanni Damiani Maria Caterina Pace | 2023 | World Journal of Clinical Cases2023，11，12： | 0 |
| 13 | Antimicrobial approach of abdominal post-surgical infections显示文摘Abdominal surgical site infections(SSIs)are infections that occur after abdominal surgery.They can be superficial,involving the skin tissue only,or more profound,involving deeper skin tissues including organs and implanted materials.Currently,SSIs are large global health problem with an incidence that varies significantly depending on the United Nations’Human Development Index.The purpose of this review is to provide a practical update on the latest available literature on SSIs,focusing on causative pathogens and treatment with an overview of the ongoing studies of new therapeutic strategies. | Marco Fiore Antonio Corrente Sveva Di Franco Aniello Alfieri Maria Caterina Pace Francesca Martora Stephen Petrou Claudio Mauriello Sebastiano Leone | 2023 | World Journal of Gastrointestinal Surgery2023，15，12： | 0 |
| 14 | Burden of severe infections due to carbapenem-resistant pathogens in intensive care unit显示文摘Intensive care units(ICU)for various reasons,including the increasing age of admitted patients,comorbidities,and increasingly complex surgical procedures(e.g.,transplants),have become'the epicenter'of nosocomial infections,these are characterized by the presence of multidrug-resistant organisms(MDROs)as the cause of infection.Therefore,the perfect match of fragile patients and MDROs,as the cause of infection,makes ICU mortality very high.Furthermore,carbapenems were considered for years as last-resort antibiotics for the treatment of infections caused by MDROs;unfortunately,nowadays carbapenem resistance,mainly among Gram-negative pathogens,is a matter of the highest concern for worldwide public health.This comprehensive review aims to outline the problem from the intensivist's perspective,focusing on the new definition and epidemiology of the most common carbapenem-resistant MDROs(Acinetobacter baumannii,Pseudomonas aeruginosa and Enterobacterales)to emphasize the importance of the problem that must be permeating clinicians dealing with these diseases. | Maria Caterina Pace Antonio Corrente Maria Beatrice Passavanti Pasquale Sansone Stephen Petrou Sebastiano Leone Marco Fiore | 2023 | World Journal of Clinical Cases2023，11，13： | 0 |
| 15 | Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),is responsible for the first pandemic of the 21st century.As found in adults,signs and symptoms related to the disease mainly involve the respiratory tract in the paediatric population.However,a considerable number of children present with gastrointestinal symptoms such as vomiting,abdominal pain,and diarrhea.The purpose of this review is an accurate description,from pathogenesis to clinical presentation,diagnosis and treatment,of COVID-19 effects on the gastrointestinal system at a paediatric age.SARS-CoV-2 can be identified in stool specimens of affected children by real-time polymerase chain reaction techniques.Positivity can last for several weeks after the end of the symptomatic phase.Gastrointestinal signs and symptoms are generally self-limited,can correlate with blood tests and imaging alterations,and may require supportive treatment such as hydration.However,they can precede severe disease manifestations such as the COVID-19-related multisystem inflammatory syndrome.Children belonging to risk categories such as those affected by celiac disease,inflammatory bowel disease,and hepatic disease seem to not have a more severe course than the others,even if they are undergoing immunosuppressant treatment.Medical follow-ups of patients with chronic diseases need to be revised during the pandemic period in order to postpone unnecessary tests,mainly endoscopic ones. | Carmelina Calitri Ilaria Fumi Maria Giovanna Ignaccolo Elena Banino Stefania Benetti Maria MaddalenaLupica Francesca Fantone Mariella Pace Franco Garofalo | 2021 | World Journal of Gastroenterology2021，27，23： | 0 |
| 16 | Current status of COVID-19 treatment:An opinion review显示文摘The pandemic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has garnered the attention of scientists worldwide in the search for an effective treatment while also focusing on vaccine development.Several drugs have been used for the management of coronavirus disease 2019(COVID-19),which has affected many hospitals and health centers worldwide.Statistically significant results are lacking on the effectiveness of the experimented drugs in reducing COVID-19 morbidity or mortality,as there are very few published randomized clinical trials.Despite this,the literature offers some material for study and reflection.This opinion review attempts to address three burning questions on COVID-19 treatment options.(1)What kind of studies are currently published or ongoing in the treatment of patients with COVID-19?(2)What drugs are currently described in the literature as options of treatment for patients affected by the infection?And(3)Are there specific clinical manifestations related to COVID-19 that can be treated with a customized and targeted therapy?By answering these questions,we wish to create a summary of current COVID-19 treatments and the anti-COVID-19 treatments proposed in the recent clinical trials developed in the last 3 mo,and to describe examples of clinical manifestations of the SARS-CoV-2 infection with a cause-related treatment. | Sveva Di Franco Aniello Alfieri Stephen Petrou Giovanni Damiani Maria Beatrice Passavanti Maria Caterina Pace Sebastiano Leone Marco Fiore | 2020 | World Journal of Virology2020，9，3： | 0 |
| 17 | Commodity Market and Financial Derivative Instruments: Is There a Cointegration?显示文摘Over the past decade, agricultural commodity prices underwent wild swings, Periods of high growth in 2008 were followed by periods of sudden decrease in 2009, The excessive increase in food price volatility is a subject of great interest because it has to do with the survival of mankind, Recent academic studies and policy makers have reached sharply different conclusions about the dynamics of such fluctuations, Also, some of them have indicated the main cause in speculative transactions and in the little regulation of futures markets, This paper intends to verify if there exists a co-implication between wheat futures price and some financial “speculative” variables, The results of cointegration analysis show that there is no evidence that financial derivative instruments determine the fluctuations of wheat futures price. | Maria Leone Alberto Manelli Roberta Pace | 2019 | Journal of Modern Accounting and Auditing2019，15，4： | 0 |
| 18 | First Italian outbreak of VIM-producing Serratia marcescens in an adult polyvalent intensive care unit, August-October 2018: A case report and literature review显示文摘BACKGROUND Carbapenem-resistant Enterobacteriaceae has become a significant public health concern as hospital outbreaks are now being frequently reported and these organisms are becoming difficult to treat with the available antibiotics.CASE SUMMARY An outbreak of VIM-producing Serratia marcescens occurred over a period of 11 wk(August,1 to October,18)in patients admitted to the adult polyvalent intensive care unit of the University of Campania“Luigi Vanvitelli”located in Naples.Four episodes occurred in three patients(two patients infected,and one patient colonized).All the strains revealed the production of VIM.CONCLUSION After three decades of carbapenem antibiotics use,the emergence of carbapenemresistance in Enterobacteriaceae has become a significant concern and a stricter control to preserve its clinical application is mandatory.This is,to our knowledge,the first outbreak of VIM-producing Serratia marcescens in Europe.Surveillance policies must be implemented to avoid future outbreaks. | Maria Rosaria Iovene Vincenzo Pota Massimiliano Galdiero Giusy Corvino Federica Maria Di Lella Debora Stelitano Maria Beatrice Passavanti Maria Caterina Pace Aniello Alfieri Sveva Di Franco Caterina Aurilio Pasquale Sansone Vettakkara Kandy Muhammed Niyas Marco Fiore | 2019 | World Journal of Clinical Cases2019，7，21： | 0 |
| 19 | Climate change and human health: Last call to arms for us显示文摘Climate change,now the foremost global health hazard,poses multifaceted challenges to human health.This editorial elucidates the extensive impact of climate change on health,emphasising the increasing burden of diseases and the exacerbation of health disparities.It highlights the critical role of the healthcare sector,particularly anaesthesia,in both contributing to and mitigating climate change.It is a call to action for the medical community to recognise and respond to the health challenges posed by climate change. | Antonio Corrente Maria Caterina Pace Marco Fiore | 2024 | World Journal of Clinical Cases2024，12，11： | 0 |
| 20 | Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver(NAFL) and non-alcoholic steatohepatitis(NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease(ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern.Hidradenitis suppurativa(HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed.AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients.METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH.RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients(P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index(ADDI) was significantly higher among patients with HS/NASH(5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only(2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups.CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores. | Giovanni Damiani Sebastiano Leone Kristen Fajgenbaum Nicola L Bragazzi Alessia Pacifico Rosalynn RZ Conic Paolo DM Pigatto Carlo Maiorana Pierpaolo Poli Emilio Berti Maria C Pace Piergiorgio Malagoli Vincenzo Bettoli Marco Fiore | 2019 | World Journal of Hepatology2019，11，4： | 0 |
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