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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 3 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 4 | Complications of ureteroscopy显示文摘 | D.Brooke Johnson Margaret S Pearle | 2004 | Urologic Clinics of North America2004，，1： | 3 |
| 5 | 成人高血压:NICE指南更新概要显示文摘高血压是全球发病率和死亡率的首位原因。超过25%的英国成年人患有高血压,其中有近30%患者的血压未得到控制。8月,英国国家健康与临床优选研究所(NICE)发表了更新的高血压诊疗指南。指南回顾了自2011年更新指南以来有关启动、监测及降压治疗内容,选择新的随机临床试验证据。更新指南的内容有所增加,纳人了合并2型糖尿病的患者,但对合并慢性肾脏疾病、心血管疾病或妊娠期高血压未给予推荐(译者注:这些部分有专业指南)。 | Rebecca J Boffa Margaret Constanti Christopher N Floyd Anthony S Wierzbicki 杨靓(译) 刘靖(校) | 2020 | 英国医学杂志中文版2020，23，4： | 3 |
| 6 | Rapid detection of Listeria monocytogenes in food using culture enrichment combined with real-time PCR显示文摘 | Justin O’Grady Margaret Ruttledge Sara Sedano-Balbás Terry J. Smith Thomas Barry Majella Maher | 2008 | Food Microbiology2008，，1： | 2 |
| 7 | The formation and early differentiation of sea urchin gonads显示文摘 | Houk Margaret S Hingardner Ralph T | 1980 | Biological Bulletin1980，159，： | 1 |
| 8 | Critique of Present Wetlands Mitigation Policies in the United States based on an Analysis of Past Restoration Projects in San Francisco Bay显示文摘 | Margaret S R | 2000 | Environmental Management2000，9，1： | 1 |
| 9 | Immediate and de- layed cord clamping in infants born between 24 and 32 weeks:a pilot randomized controlled trial显示文摘 | Judith S Margaret M Hensman A | 2003 | J Perinatol2003，23，6： | 1 |
| 10 | TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer显示文摘 | Margaret S Kristinc CY | | 0，，8： | 1 |
| 11 | Target volume definition in conformal radiotherapy for prostate cancer: quality assurance in the MRC RT-01 trial显示文摘 | Beatrice S Margaret B Jane W | 2000 | Radiother Oncol2000，56，1： | 1 |
| 12 | Cell compartmentalization in planctomycetes:novel types of structural organization for the bacterial cell 显示文摘 | Margaret R L Richard I W Marc S | 2001 | Arch Microbiol2001，175，： | 1 |
| 13 | Synthesis and Activity of a C- 8 Keto plertomutilin derivative 显示文摘 | Dane M S Margaret E S Stella H | 2003 | Bioorganic & Medicinal Chemistry Letters2003，，13： | 1 |
| 14 | estima- tiong income effects of a sports of a sport tourism event显示文摘 | Margaret J Daniels William C Norman Mark S Henry | 2004 | An-nals of Tourism Research2004，31，1： | 1 |
| 15 | Surveillance for enteric pathogens in a case - control study of acute diarrhea in Western Kenya显示文摘 | Brett E S Elizabeth A O Margaret C K | 2013 | Transactions of the Royal Society of Trop- ical Medicine and Hygiene2013，107，2： | 1 |
| 16 | Composi- tional controls on early diagenetic pathways in fine-grained sedimentary rocks : Implications for predicting unconventional reservoir attributes of mudstones 显示文摘 | Joe H S Macquaker Kevin G Taylor Margaret Keller | 2014 | AAPG Bulletin2014，98，3： | 1 |
| 17 | Metadiscourse in Persuasive Writing: A Study of Texts Written by American and Finish University Students显示文摘 | Crismore Avon Markkanen Raija Steffensen Margaret S | 1993 | Written Communication1993，，： | 1 |
| 18 | Genetic interaction of an orgin recognition complex subunit and the polycomb group gene MEDEA during seed development显示文摘 | MARGARET A C CHARLES S CLAUDIA K | 2004 | Plant Cell2004，16，： | 1 |
| 19 | Persistence of soil organic matter as an e- cosystem property显示文摘 | Michael W I S Margaret S T Samuel A | 2011 | Nature2011，478，7367： | 1 |
| 20 | Computer assisted fault-tree construction using a knowledge based approach显示文摘 | Margaret S Elliott | 1994 | IEEE Trans-Reliability March1994，43，： | 1 |
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