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| 1 | Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease. | Jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel Marcos | 2018 | World Journal of Gastroenterology2018，24，36： | 19 |
| 2 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 3 | Robotic transanal total mesorectal excision:Is the future now?显示文摘Total mesorectal excision(TME)is the standard surgical treatment for the curative radical resection of rectal cancers.Minimally invasive TME has been gaining ground favored by the continuous technological advancements.New procedures,such as transanal TME(TaTME),have been introduced to overcome some technical limitations,especially in low rectal tumors,obese patients,and/or narrow pelvis.The earliest TaTME reports showed promising results when compared with the conventional laparoscopic TME.However,recent publications raised concerns regarding the high rates of anastomotic leaks or local recurrences observed in national series.Robotic TaTME(R-TaTME)has been proposed as a novel technique incorporating the potential benefits of a perineal dissection together with precise control of the distal margins,and also offers all those advantages provided by the robotic technology in terms of improved precision and dexterity.Encouraging short-term results have been reported for R-TaTME,but further studies are needed to assess the real role of the new technique in the long-term oncological or functional outcomes.The present review aims to provide a general overview of R-TaTME by analyzing the body of the available literature,with a special focus on the potential benefits,harms,and future perspectives for this novel approach. | Juan Carlos Sebastián-Tomás Aleix Martínez-Pérez Elías Martínez-López Nicola de'Angelis Marcos Gómez Ruiz Eduardo García-Granero | 2021 | World Journal of Gastrointestinal Surgery2021，13，8： | 2 |
| 4 | Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: Which anatomic structures are affected and can they be spared by IMRT?显示文摘 | Avraham Eisbruch Marco Schwartz Coen Rasch Karen Vineberg Eugene Damen Corina J. Van As Robin Marsh Frank A. Pameijer Alfons J.M. Balm | 2004 | International Journal of Radiation Oncology Biology Physics2004，，5： | 1 |
| 5 | Contrast-enhanced multi-detector computed tomography viability imaging after myocardia infarction: characterization of myocyte death,microvascular ohstrution, and chronic scar显示文摘 | Albert C Marco AS Carterina S | 2006 | Circulation2006，113，3： | 1 |
| 6 | Ultralong and Mesoporous ZnO and γ-Al_2O_3 Oriented Nanowires Obtained by Template-assisted Hydrothermal Approach显示文摘Highly mesoporous Zn O and g-Al2O3nanowires(NWs) are both synthesized by a hydrothermal method using commercially available porous anodic aluminium oxide(AAO) as template. AAO membrane acts as template for Zn O NWs and both as template and precursor for g-Al2O3 NWs. The formation of intermediate phases of porous Zn6Al2(OH)16CO3and boehmite(g-Al OOH) were observed, both occurring during the hydrothermal synthesis of porous Zn O and g-Al2O3 NWs, respectively, and disappearing after annealing at 600 C. This novel template-assisted hydrothermal process leads to the formation of porous Zn O and g-Al2O3NWs(specific surface area of 192 m2 g 1and 263 m2 g 1, respectively), showing pore sizes around 4 nm in diameter. The influence of the reaction parameters on the nanostructure morphology was also investigated. A Zn O seed layer, deposited on the AAO channels prior to the hydrothermal synthesis, leads to more compact Zn O nanowires(99 m2 g-1) protecting the AAO host from the chemical attack of the precursor solution. | Carminna Ottone Vivian Farías Rivera Marco Fontana Katarzyna Bejtka Barbara Onida Valentina Cauda | 2014 | Journal of Materials Science & Technology2014，30，12： | 1 |
| 7 | Prognostic significance of exercise induced systemic hypertension in health subjects显示文摘 | Thomas GA Marco AS Cordelro MD | 1999 | Am J Cardiol1999，83，： | 1 |
| 8 | Molecular mechanisms involved in the angiotensin-(1-7)/Mas signaling pathway in cardiomyocytes显示文摘 | Marco F Dias-Peixoto Robson AS | 2008 | Hypertension2008，52，3： | 1 |
| 9 | Prognostic significance of exercise-induced systemic hypertension in healthy subjects显示文摘 | Thomas GA Marco AS Cordeiro MD | 1999 | Am J Cardiol1999，83，： | 1 |
| 10 | Molecular mecha- nisms involved in the angiotens in- (1-7)/Mas signaling pathway in eardiomyocytes显示文摘 | MARCO F DIAS-PEIXOTO ROBSON AS | 2008 | Hypertension2008，52，3： | 1 |
| 11 | lyst for Industrialization显示文摘 | Marco Da Rin and Thomas Hellmann Banks as a Cata | 2002 | Journal of Financial Intermediation2002，，11： | 1 |
| 12 | Antegrade selective cerebral perfusion during operations on the thoracic aorta: Factors influencing survival and neurologic outcome in 413 patients显示文摘 | Marc AS Wim JM | 2002 | J Thorac Cardiovasc Surg2002，124，4： | 1 |
| 13 | Antegrade selective cerebral perfusion during operations on the thoracic aorta:Factors influencing survival and neurologic outcome in 413 patients显示文摘 | Marc AS Win JM | 2002 | J Thorac Cardiovasc Surg2002，124，4： | 1 |
| 14 | Angioarchitectural factors present in brain arteriovenous malformations associated with hemorrhagic presentation显示文摘 | Marco AS Phillip J Porter KG | 2002 | Stroke2002，33，： | 1 |
| 15 | Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: Which anatomic structures are affected and can they be spared by IMRT?显示文摘 | Avraham Eisbruch Marco Schwartz Coen Rasch Karen Vineberg Eugene Damen Corina J. Van As Robin Marsh Frank A. Pameijer Alfons J.M. Balm | 2004 | International Journal of Radiation Oncology, Biology, Physics2004，，： | 1 |
| 16 | Large and deep brain arteriovenous malformations are associated with risk of future hemorrhage显示文摘 | Marco AS Phillip J Porter KG | 2002 | Stroke2002，33，： | 1 |
| 17 | Server consolida?tion with migration control for virtualized data centers显示文摘 | TIAGO C F MARCO AS N RODRIGO N C | 2011 | Future Gen?eration Comp Syst2011，27，8： | 1 |
| 18 | Infrared spectroscopy: A potential tool in huanglongbing and citrus variegated chlorosis diagnosis显示文摘 | Marcelo Camponez do Brasil Cardinali Paulino Ribeiro Villas Boas Débora Marcondes Bastos Pereira Milori Ednaldo José Ferreira Marina Fran?a e Silva Marcos Antonio Machado Barbara Sayuri Bellete Maria Fatima das Gra?as Fernandes da Silva | 2012 | Talanta2012，，： | 1 |
| 19 | The β-GalactosidaseActivity in Kluyveromyces marxianus CBS6556 Decreases byHigh Concentrations of Galactose显示文摘 | Danyelly BG Diogo AS Marcos AM | 2002 | Current Microbiology2002，44，5： | 1 |
| 20 | Antegrade selective cerebral pcrfusion during operations on the thoracic aorta:Factors influencing survival and neurologic outcome in 413 patienls显示文摘 | Marco DE Marc AS Win JM | 2002 | J Thorac Cardiovasc Surg2002，124，4： | 1 |
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