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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Molecular mechanisms involved in the angiotensin-(1-7)/Mas signaling pathway in cardiomyocytes显示文摘 | Marco F Dias-Peixoto Robson AS | 2008 | Hypertension2008，52，3： | 1 |
| 3 | Effects of genetic deletion of angiotensin-( 1-7 ) receptor Mas on cardiac function during ischemia/repeffusion in the isolated perfused mouse heart 显示文摘 | Carlos H Castro A Robson AS | 2006 | Life Sciences2006，80，9： | 1 |
| 4 | Molecular mecha- nisms involved in the angiotens in- (1-7)/Mas signaling pathway in eardiomyocytes显示文摘 | MARCO F DIAS-PEIXOTO ROBSON AS | 2008 | Hypertension2008，52，3： | 1 |
| 5 | Angiotensin-(1-7) through receptor mas mediates endothelial nitric oxide synthase activation via aktdependent pathways显示文摘 | Walkyria OS Robson AS Raphael FS | 2007 | Hypertension2007，49，6： | 1 |
| 6 | Tolerance of Bacteriuria After Urinary Diversion Is Linked to Antimicrobial Peptide Activity显示文摘 | Claire L. Townes Ased Ali Wendy Robson Robert Pickard Judith Hall | 2011 | Urology2011，，2： | 1 |
| 7 | Genetic engineering of harvest index in tobacco through overexpressionof a phytochrome gene 显示文摘 | ROBSON PR MCCORMAC AC IRVINE AS 1996 | 1996 | Nat Biotechnol1996，14，8： | 1 |
| 8 | Angiotensin-(1–7) and the renin–angiotensin system显示文摘 | Robson AS Santos Anderson J Ferreira | 2007 | Current Opinion in Nephrology and Hypertension2007，，： | 1 |
| 9 | Molecular mechanisms involved in the angiotensin-(1-7)/Mas signaling pathway in cardiomyocytes 显示文摘 | Marco F Dias-Peixoto Robson AS | 2008 | Hypertension2008，52，3： | 1 |
| 10 | Effects of genetic deletion of an- giotensin-(1-7) receptor Mas on cardiac function during ischemi- a/reperfusion in the isolated perfused mouse heart 显示文摘 | Carlos H Castro A Robson AS | 2006 | Life Sci- ences2006，80，9： | 1 |
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