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| 1 | Chromosome-level Genomes Reveal the Genetic Basis of Descending Dysploidy and Sex Determination in Morus Plants显示文摘Multiple plant lineages have independently evolved sex chromosomes and variable karyotypes to maintain their sessile lifestyles through constant biological innovation.Morus notabilis,a dioecious mulberry species,has the fewest chromosomes among Morus spp.,but the genetic basis of sex determination and karyotype evolution in this species has not been identified.In this study,three high-quality genome assemblies were generated for Morus spp.[including dioecious M.notabilis(male and female)and Morus yunnanensis(female)]with genome sizes of 301–329 Mb and were grouped into six pseudochromosomes.Using a combination of genomic approaches,we found that the putative ancestral karyotype of Morus species was close to 14 protochromosomes,and that several chromosome fusion events resulted in descending dysploidy(2n=2x=12).We also characterized a~6.2-Mb sex-determining region on chromosome 3.Four potential male-specific genes,a partially duplicated DNA helicase gene(named MSDH)and three Ty3_Gypsy long terminal repeat retrotransposons(named MSTG1/2/3),were identified in the Y-linked area and considered to be strong candidate genes for sex determination or differentiation.Population genomic analysis showed that Guangdong accessions in China were genetically similar to Japanese accessions of mulberry.In addition,genomic areas containing selective sweeps that distinguish domesticated mulberry from wild populations in terms of flowering and disease resistance were identified.Our study provides an important genetic resource for sex identification research and molecular breeding in mulberry. | Zhongqiang Xia Xuelei Dai Wei Fan Changying Liu Meirong Zhang Peipei Bian Yuping Zhou Liang Li Baozhong Zhu Shuman Liu Zhengang Li Xiling Wang Maode Yu Zhonghuai Xiang Yu Jiang Aichun Zhao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 2 | A smart card based efficient and secured multi-server authentication scheme显示文摘 | Wang Bin Ma Maode | 2013 | Wireless Personal Communication2013，68，2： | 1 |
| 3 | Expression of p75 NTR and TrkA and its relationship with apoptosis in the surrounding brain tissues of hematoma in patients with intracerebral hemorrhage 显示文摘 | Bao Gang Han Yuliang Wang Maode | 2011 | The Journal of International Medical Research2011，39，： | 1 |
| 4 | miR-4530 inhibits the malignant biological behaviors of human glioma cells by directly targeting RTEL1显示文摘Human glioma is the most com m on prim ary brain tumor and is associated with high morbidity and mortality.Aberrant expressions of microRNAs(miRNAs)are involved in gliom a progression.In the present study,we aimed to elucidate the roles of miR-4530 in the pathogenesis of gliomas.miR-4530 expression was examined in human gliom a clinical tissues and cell lines including U251 and T98G.The target gene of miR-4530,RTEL1,was predicted with online tools and validated by luciferase reporter assay.Lentivirus infection,transfection of plasmids,and miRNA m im ics were used to m anipulate gene expression.Cell proliferation was determined using the CCK-8 method,and m igration and invasion assays were determ ined w ith transwell experim ents.Colony form ation was measured by crystal violet staining,while apoptosis was determined by Annexin V/PI staining.The anti-tumor effects of miR-4530 were evaluated in nude mice xenografted using U251 cells.Our results showed that miR-4530 was significantly down-regulated in human gliom a tissues and cell iines.miR-4530 over-expression inhibited the malignant behaviors of U251 and T98G cells,including reduced proliferation,dim inished colony form ation,migration and invasion,and increased apoptosis.Further mechanistic investigations revealed that RTEL1 is a direct functional target of miR-4530 in gliom as,and its over-expression rem arkably reverses the effects of miR-4530 m im ics on inhibiting these m alignant behaviors.In addition,miR-4530 over-expression inhibited the growth of xenografted U251 gliom a in nude mice.Therefore,miR-4530 acts as atum or-suppressor gene and inhibits the m alignant biological behaviors of human glioma cells,which is associated w ith directly targeting RTEL1.The miR-4530/RTEL1 axis is a potential therapeutic target for gliomas. | Tuo Wang Yan Zhang Bo Cui Maode Wang Ya Li Ke Gao | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 1 |
| 5 | Network life time maximization with cross - layer design in wireless sensor networks 显示文摘 | WANG Hui YANG Yuhang MA Maode | 2008 | IEEE Transactions on Wireless Com- munications2008，7，10： | 1 |
| 6 | The expression of matrix metalloproteinase-2 and-9 in human gliomas of different pathological grades显示文摘 | Maode Wang Tuo Wang Shuoxun Liu Daizo Yoshida Akira Teramoto | 2003 | Brain Tumor Pathology2003，，2： | 1 |
| 7 | Micropapillary Component in Colorectal Carcinoma is Associated With Lymph Node Metastasis in T1 and T2 Stages and Decreased Survival Time in TNM Stages I and II显示文摘 | Fangying Xu Jinping Xu Zhongming Lou Meijuan Di Fenjuan Wang Hu Hu Maode Lai | 2009 | The American Journal of Surgical Pathology2009，，9： | 1 |
| 8 | The expression of matrix metalloproteinase-2 and-9 in human gliomas of different pathological grades显示文摘 | Maode Wang Tuo Wang Shuoxun Liu Daizo Yoshida Akira Teramoto | 2003 | Brain Tumor Pathology2003，，2： | 1 |
| 9 | Combustion syn- thesis of CuO-ZnO-ZrOz catalysts for the hydrogenation of carbon dioxide to methanol 显示文摘 | GuoXM MaoDS WangS etal | 2009 | Catal Commun2009，10，13： | 1 |
| 10 | OpenNAU:An open-source platform for normalizing,analyzing,and visualizing cancer untargeted metabolomics data显示文摘Objective:As an important part of metabolomics analysis,untargeted metabolomics has become a powerful tool in the study of tumor mechanisms and the discovery of metabolic markers with high-throughput spectrometric data which also poses great challenges to data analysis,from the extraction of raw data to the identification of differential metabolites.To date,a large number of analytical tools and processes have been developed and constructed to serve untargeted metabolomics research.The different selection of analytical tools and parameter settings lead to varied results of untargeted metabolomics data.Our goal is to establish an easily operated platform and obtain a repeatable analysis result.Methods:We used the R language basic environment to construct the preprocessing system of the original data and the LAMP(Linux+Apache+MySQL+PHP)architecture to build a cloud mass spectrum data analysis system.Results:An open-source analysis software for untargeted metabolomics data(openNAU)was constructed.It includes the extraction of raw mass data and quality control for the identification of differential metabolic ion peaks.A reference metabolomics database based on public databases was also constructed.Conclusions:A complete analysis system platform for untargeted metabolomics was established.This platform provides a complete template interface for the addition and updating of the analysis process,so we can finish complex analyses of untargeted metabolomics with simple human-computer interactions.The source code can be downloaded from http://gffzz188fe103f8f1460as055u9v5wxcop6xnw.ffgz.tsg.suse.edu.cn/zjuRong/openNAU. | Qingrong Sun Qingqing Xu Majie Wang Yongcheng Wang Dandan Zhang Maode Lai | 2023 | Chinese Journal of Cancer Research2023，35，5： | 1 |
| 11 | Efficient localization for mobile sensor networks based on constraint rules optimized Monte Carlo method显示文摘 | Ze Wang Yunlong Wang Maode Ma Jigang Wu | 2013 | Computer Networks2013，57，14： | 1 |
| 12 | Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells显示文摘 | Yu Ma Bingjian Lu Wenjing Ruan Hongqiang Wang Jie Lin Hu Hu Hong Deng Qiong Huang Maode Lai | 2008 | Experimental and Molecular Pathology2008，，2： | 1 |
| 13 | Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study 显示文摘 | Maode Wang Daizo Yoshida Shouxun Liu | 2005 | Neuro-Oncol2005，72，： | 1 |
| 14 | A meta-analysis of tight versus conventional glycemia control in critically ill brain-injured adults显示文摘Objective: To evaluate the benefits and risks of tight glycemia control (TGC) versus conventional glucose control (CGC) in critically ill brain-injured adults. Methods: We performed meta-analysis by systematically searching PubMed, EMBASE, OVID, ScienceDirect, Web of Science, CNKI, Wanfang Data, and CQVIP databases to retrieve RCTs in any languages. We used Review Manager to perform meta-analysis. Odds ratios (ORs) or weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated in analyses. Results: Twenty-six RCTs with a total of 3,759 participants were included in this meta-analysis. In-hospital mortality showed significant dissimilarity between TGC and CGC groups with OR of 0.76 (95%CI 0.58, 0.99). However, in terms of overall mortality and long-term neurological severity outcome, it didn't show differences with ORs of 0.93 (95%CI 0.79, 1.10) and 1.15 (95%CI 0.96, 1.37). There were also discrepancies in infection rate and ICU length of stay with OR of 0.51 (95%CI 0.42, 0.62) and WMD of -2.37 (95%CI -2.99, -1.74). Significances were observed in hypoglycemia events with ORs of 6.24 (95%CI 4.83, 8.07) and 2.73 (95%CI 2.56, 2.91) using two methods. Conclusion: In critically ill brain injury, TGC did not show beneficial effects on reducing overall mortality and long term neurological outcome, but it increased the risk of hypoglycemia. | Qi Lei Wang Maode Liu Xin Wang Tuo Xu Gaofeng Li Qi Li Ruichun | 2012 | Journal of Medical Colleges of PLA(China)2012，27，1： | 1 |
| 15 | A Smart Card Based Efficient and Secured Multi-Server Authentication Scheme显示文摘 | Wang Bin Ma Maode | 2013 | Wireless Personal Communications2013，68，2： | 1 |
| 16 | Green Prevention and Control Technology of Pests in Cotton Fields in Shandong Province显示文摘In order to better serve cotton farmers,green prevention and control technologies of pests are formulated according to the sowing,seedling and adult stages of cotton from the aspects of ecological prevention and control,physical prevention and control,biological control and scientific use of pesticides,thus realizing green prevention and control of pests during the whole growth period of cotton. | Jidi Wang Maode Xing Jun Geng Chao Liu Ping Liu | 2021 | Plant Diseases and Pests2021，12，4： | 0 |
| 17 | Dynamic admission control in hybrid QoS networks with WiFi access显示文摘Providing quality of service (QoS) guarantees for multimedia applications over Hybrid networks by wired and wireless LANs is rapidly becoming an important issue. In order to protect the high priority traffic flows and improve network performance in a heavy-loaded network, a new dynamic admission control algorithm is proposed in this paper. We firstly propose a method to fit the fractional autoregressive integrated moving average (FARIMA) models to four actual wireless traffic traces and a traffic prediction based on the upper probability limit. Our experiments show that the one-step forecasts based on the FARIMA models are better than those based on autoregressive integrated moving average (ARIMA) models. We also propose a prediction-based admission control algorithm in hybrid QoS networks with WiFi access using the FARIMA models. The com- prehensive simulation experiments are performed to verify the effectiveness of the pro- posed admission control algorithm. | SHU Yantai FENG Huifang WANG Hua MA Maode | 2006 | Science in China(Series F)2006，49，4： | 0 |
| 18 | Hypoxia regulates reactive oxygen species levels in SHG-44 glioma cells显示文摘In the present study,cultured human SHG-44 glioma cells were subjected to a hypoxic environment simulated using the CoCl2 method.Flow cytometry showed increased reactive oxygen species production in these cells.Real-time reverse transcription-PCR showed significantly increased hypoxia-inducible factor-1α mRNA expression in cells exposed to the hypoxic condition.The antioxidant N-acetylcysteine significantly inhibited reactive oxygen species production and reduced hypoxia-inducible factor-1α mRNA expression in normoxic and hypoxic groups,especially in the latter group.These findings indicate that hypoxia induces reactive oxygen species production and hypoxia-inducible factor-1α mRNA expression in human SHG-44 glioma cells,and that the antioxidant N-acetylcysteine can inhibit these changes. | Haitao Jiang Jiangtao Xie Gaofeng Xu Yongyong Su Jinzheng Li Mang Zhu Maode Wang | 2013 | Neural Regeneration Research2013，8，6： | 0 |
| 19 | Parent vessel occlusion for traumatic pseudoaneurysm of P3 segment of posterior cerebral artery:A case report and review of literatures显示文摘创伤的 intracranial pseudoaneurysms (TIPA ) 是稀罕的,以后的服的动脉(PCA ) 的 P3 片断的 pseudoaneurysm 极其很少被报导。一个 27 岁的人受不了率直的头损害并且与头 CT 扫描,服的 CT angiograms (CTA ) 和数字减法 angiograms (DSA ) 经历了诊断过程。反常高密度的损害在 quadrigeminal 水塘的左边被检测, pseudoaneurysm 出现在 PCA 的 P3 片断。pseudoaneurysm 成功地与父母动脉吸藏(PAO ) 被对待。做创伤的 intracranial pseudoaneurysms 的准确外科手术前的诊断是很重要的。Endovascular 技术允许一条安全途径到复杂 intracranial 损害,因此 PCA pseudoaneurysms 的 endovascular 管理变得安全、有效。然而, pseudoaneurysm 不能是顺从的这样,在一些条件下面卷放置父母容器的吸藏可以是一个更好的处理。 | Xu Gaofeng Xie Wanfu Li Ruichun Wang Maode | 2011 | Journal of Medical Colleges of PLA(China)2011，26，1： | 0 |
| 20 | Pharmacokinetics of gene recombined angiogenesis inhibitor Kringle 5 in vivo using 131I specific markers and SPECT/CT显示文摘The previous pharmacokinetic methods can be only limited to drug analysis in vitro, which provide less information on the distribution and metabolismof drugs, and limit the interpretation and assessment of pharmacokinetics, the determination of metabolic principles, and evaluation of treatment effect. The objective of the study was to investigate the pharmacokinetic characteristics of gene recombination angiogenesis inhibitor Kringle 5 in vivo. The SPECT/CT and specific^(131)I-Kringle 5 marked by Iodogen method were both applied to explore the pharmacokinetic characteristics of^(131)I-Kringle 5 in vivo, and to investigate the dynamic distributions of^(131)I-Kringle 5 in target organs. Labeling recombinant angiogenesis inhibitor Kringle 5 using131 I with longer half-life and imaging in vivo using SPECT instead of PET,could overcome the limitations of previous methods. When the doses of^(131)I-Kringle 5 were 10.0, 7.5 and5.0 g/kg, respectively, the two-compartment open models can be determined within all the metabolic process in vivo. There were no significant differences in t1/2α, t1/2β, apparent volume of distribution and CL between those three levels. The ratio of AUC(0 1)among three different groups of 10.0, 7.5 and 5.0 g/kg was 2.56:1.44:1.0, which was close to the ratio(2:1.5:1.0). It could be clear that in the range of 5.0–10.0 g/kg, Kringle 5 was characterized by the first-order pharmacokinetics. Approximately 30 min after^(131)I-Kringle 5 was injected,^(131)I-Kringle 5 could be observed to concentrate in the heart, kidneys, liver and other organs by means of planar imaging and tomography. After 1 h of being injected, more radionuclide retained in the bladder, but not in intestinal. It could be concluded that^(131)I-Kringle 5 is mainly excreted through the kidneys. About 2 h after the injection of^(131)I-Kringle 5, the radionuclide in the heart, kidneys,liver and other organs was gradually reduced, while more radionuclide was concentrated in the bladder.The radionuclide was completely metabolized within 24 h, and the distribution of radioactivity in rats was similar to normal levels. In our study, the specific marker^(131)I-Kringle 5 and SPECT/CT were successfully used to explore pharmacokinetic characteristics of Kringle 5 in rats. The study could provide a new evaluation platform of the specific, in vivo and real-time functional imaging and pharmacokinetics for the clinical application of^(131)I-Kringle 5. | Ge Yan Danrong Yang Yan Yu Jianjun Xue Yifan Jia Xuanzi Sun Boyu Wang Zewei Zhao Maode Wang | 2016 | Journal of Pharmaceutical Analysis2016，6，5： | 0 |
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