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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 3 | The omaha system and quality measurement in academic nurse-managed centers:ten steps for implementation显示文摘 | Canham D Mao CL Marian Y | 2008 | J Nurs Educ2008，47，3： | 1 |
| 4 | Disrupted in schizophrenia 1regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-cateninsignaling显示文摘 | Mao Y Ge X Frank CL | 2009 | Cell2009，136，6： | 1 |
| 5 | Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3-beta/beta-catenin signaling显示文摘 | Mao Y Ge X Frank CL | 2009 | Cell2009，136，： | 1 |
| 6 | Update on pressure ul- cer management and deep tissue injury 显示文摘 | Mao CL Rivet AJ Sidora T | 2010 | Ann Pharmacother2010，44，2： | 1 |
| 7 | Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory 显示文摘 | Lin HC Mao SC Su CL | 2010 | Int J Neuropsychopharmacol2010，13，3： | 1 |
| 8 | The role of prefrontal cortex CB1 receptors in the modulation of fear memory显示文摘 | Lin HC Mao SC Su CL | 2009 | Cereb Cortex2009，19，1： | 1 |
| 9 | Rapid detection of human immunodeficiency virus type 1 subtype E infection by PCR显示文摘 | Mao YC Wei KW Ming CL | 2002 | Journal of Clinical Microbiology2002，40，10： | 1 |
| 10 | The development and identification of constructing tissue engineered bone by seeding osteoblasts from differentiated rat marrow stromal stem cells onto three-dimensional porous nanohydroxylapatite bone matrix in vitro显示文摘 | Man X Chu CL Mao Z | 2005 | Tissue Cell2005，37，5： | 1 |
| 11 | Cocoa Flavonols and procyanidins promote Transforming Growth Factor -β Homeostasis in peripheral Blood Mononuclear Cells 显示文摘 | Mao TK Van de Water J Keen CL | 2003 | Exp Biol Meal (Maywood)2003，228，1： | 1 |
| 12 | The development and identification of constructing tissue engineered bone by seeding osteoblasts from differentiated rat marrow stromal stem cells onto three-dimensional porous nano-hydroxylapatite bone matrix in vitro显示文摘 | Mao X Chu CL Mao Z | 2005 | Tissue Cell2005，37，5： | 1 |
| 13 | Effect of cocoa flavanols and their related oligomers on the secretion of interleukin -5 in peripheral blood mononuclear cells 显示文摘 | Mao TK Van WJ Keen CL | 2002 | J Med Food2002，5，1： | 1 |
| 14 | Update on pressure ulcer management and deep tissue injury显示文摘 | Mao CL Rivet AJ Sidora T | 2010 | Ann Pharmacother2010，44，2： | 1 |
| 15 | Role of Oxygen consumption in hypoxiaprotection by translation factor depletion显示文摘 | Scott B Sun CL Mao X | 2013 | J Exp Biol2013，216，12： | 1 |
| 16 | Transfection of primary chondrocytes using chitosan-pEGFP nanoparticles 显示文摘 | Zhao X Yu SB Wu FL Mao ZB Yu CL | 2006 | J Control Release2006，112，： | 1 |
| 17 | Update on pressure ulcer management and deep tissue injury'显示文摘 | Mao CL Rivet AJ Sidora T etal | 2010 | Ann Phannacothe2010，44，2： | 1 |
| 18 | Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling 显示文摘 | Mao Y Ge X Frank CL | 2013 | Ce112013，1366，： | 1 |
| 19 | Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta- catenin sigualing显示文摘 | Mao Y Ge X Frank CL | 2009 | Ce112009，136，6： | 1 |
| 20 | Characteristics of suicide at-tempters and nonattempters with schizophrenia in a rural com-munity显示文摘 | Ran MS Xiang MZ Mao WJ Hou ZJ Tang MN Chen EY Chan CL Yip PS Conwell Y | 2005 | Suicide Life Threat Behav2005，35，： | 1 |
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