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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | CONSORT 2010声明:针对随机先导性和可行性试验的扩展显示文摘随机对照试验报告规范声明(consolidated standards of reporting trials,CONSORT)是一个旨在提高随机对照试验(randomized controlled trial,RCT)报告透明度和质量的指南。本扩展版针对将来确定性RCT之前所进行的随机先导性和可行性试验制定统一报告规范。该清单适用于任何随机研究,其中包括确定性RCT及此前的、在小规模研究样本下进行的任何先导性试验,而其设计(如聚类、析因、交叉)或作者用来描述该研究的术语(如先导性(试验)、可行性(试验)、试验、研究)并不会对此造成影响。不过,需要注意的是,本报告规范扩展范围不直接适用于主要试验设计中内置的先导性试验、非随机的先导性和可行性试验,或者Ⅱ期临床试验。不过这些研究都与随机先导性和可行性试验有一定相似性,因此许多原则也同样适用。本扩展版的研发是因为越来越多的研究被描述为可行性试验或先导性试验,但这些研究的报告和实施存在缺陷。我们遵循了所推荐的良好实践来研发CONSORT先导性和可行性试验扩展版,其中包括进行德尔菲调查、召开共识会议和研究团队会议及试行此条目清单等。由于先导性试验和可行性随机试验的目的和目标不同于其他随机试验,因此,尽管在这些试验报告中的许多内容,与评估效果和效力的RCT中的报告内容相似,但在报告内容类型、报告条目解释方面,其与标准CONSORT存在一些关键差异。本文保留了部分标准CONSORT声明的条目,但仔细阅读就会发现,其中大多数条目已经被修改或删除,并且添加了一些新的条目。其中,新增条目包括:如何识别受试者并获得同意;如果适用,用于判断是否或如何进行将来确定性RCT的预先制定的标准;如果相关,其他重要的非预期结果;先导性试验的结果对将来确定性RCT的影响,还包括任何拟定的修正及伦理批准或研究审查委员会的批准,并要求附有获准批号。本扩展版包括26个条目清单、摘要的单独清单、研究的流程图模板及对所做条目更改的解释和相关范例。我们相信,使用CONSORT先导性和可行性试验扩展版,将提高先导性试验的报告质量。 | 蒋寅(翻译) 刘岩(翻译) 商洪才(翻译) 张弛(回译) 段玉婷(审校) 卞兆祥(审校) Eldridge SM Chan CL Campbell MJ | 2021 | 中国循证医学杂志2021，21，3： | 11 |
| 3 | High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation显示文摘The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later. | Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 3 |
| 4 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 5 | Comparative analysis of NS3 sequences of temporally separated dengue virus strains isohted from southeast Asia显示文摘 | Chow VTK Seah CL Chan YC | 1994 | Intervirology1994，37，： | 1 |
| 6 | A randomized,controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma显示文摘 | Lo CM Liu CL Chan SC | | 0，，06： | 1 |
| 7 | Safety of duct-to-duct biliary reconstruction in right-lobe live-donor liver transplantation without biliary drainage显示文摘 | Liu CL Lo CM Chan SC | 2004 | Transplantation2004，77，5： | 1 |
| 8 | Emotional control in Chinese female cancer survivors显示文摘 | Ho RT Chan CL Ho SM | 2004 | Psychooncology2004，13，11： | 1 |
| 9 | Electricity use characteristics of purpose-bulh office buildings in subtropical climates 显示文摘 | Lain C Joseph Chan YC Ricky Tsang CL | 2004 | Energy Conversion and Management2004，45，6： | 1 |
| 10 | Fascin expression predicts survival after potentially curative resection of node-positive colon cancer显示文摘 | Chan C Jankova L Fung CL | | 0，，： | 1 |
| 11 | Measuring quality of life of Chinese cancer patients, a validation of the Chinese ver- sion of the functional assessment of cancer therapy-general (FACT-G)scale显示文摘 | YU CL FIELDING R CHAN CL | 2000 | Cancer2000，88，7： | 1 |
| 12 | Etiology and cytokine expression in patients requiring mechanical ventilation due to severe community-acquired pneumonia 显示文摘 | Wu CL Chan MC Chang GC | 2006 | Formos Med Assoc2006，105，1： | 1 |
| 13 | Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatogra- phy-mass spectrometry显示文摘 | Lu GH Chan K Chan CL | 2004 | J Chromatogram A2004，1046，： | 1 |
| 14 | Differential expression of the suppressor PML and Ki-67 identifies three subtypes of human nasopharyngeal carcinoma显示文摘 | Chan JY Meng CL To KF | 2002 | Eur J Cancer2002，38，12： | 1 |
| 15 | Chikungunya virus diagnosis in the developing world: a pressing need显示文摘 | Sam IC Chua CL Chan YF | 2011 | Expert Rev Anti Infect Ther2011，9，12： | 1 |
| 16 | What factors influence surviv- al in patients with unresected synchronous liver metastases after re- section of colorectal cancer? 显示文摘 | Chafai N Chan CL Bokey EL | 2005 | Colorectal Dis2005，7，2： | 1 |
| 17 | A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepa- tocellular carcinoma显示文摘 | Lo CM Liu CL Chan SC | 2007 | Ann Surg2007，245，6： | 1 |
| 18 | Irradiation-induced expression of O6-methylguanine-DNA methyltransferase in mammalian cells显示文摘 | Chan CL Wu Z Eastman A | 1992 | Cancer Res1992，52，7： | 1 |
| 19 | Measuring quality of life of Chinese cancer patients: A validation of the Chinese version of the Functional Assessment of Cancer Therapy-General ( FACT- G) scale 显示文摘 | Yu CL Fielding R Chan CL | 2000 | Cancer2000，88，7： | 1 |
| 20 | Posttraumatic growth in Chinese cancer survivors 显示文摘 | Ho SM Chan CL Ho RT | 2004 | Psycho - Oncology2004，13，6： | 1 |
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