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| 1 | Relationship between Fusobacterium nucleatum,inflammatory mediators and microRNAs in colorectal carcinogenesis显示文摘AIM To examine the effect of Fusobacterium nucleatum(F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs(miRNAs).METHODS Levels of F. nucleatum DNA, cytokine gene mRNA(TLR2, TLR4, NFKB1, TNF, IL1 B, IL6 and IL8), and potentially interacting miRNAs(miR-21-3p, miR-22-3p, mi R-28-5p, miR-34a-5p, miR-135b-5p) were measured by quantitative polymerase chain reaction(qPCR) TaqMan? assays in DNA and/or RNA extracted from the disease and adjacent normal fresh tissues of 27 colorectal adenoma(CRA) and 43 colorectal cancer(CRC) patients. KRAS mutations were detected by direct sequencing and microsatellite instability(MSI) status by multiplex PCR. Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction network.RESULTS Overabundance of F. nucleatum in neoplastic tissue compared to matched normal tissue was detected in CRA(51.8%) and more markedly in CRC(72.1%). We observed significantly greater expression of TLR4, IL1 B, IL8, and miR-135 b in CRA lesions and TLR2, IL1 B, IL6, IL8, mi R-34 a and miR-135 b in CRC tumours compared to their respective normal tissues. Only two transcripts for miR-22 and miR-28 were exclusively downregulated in CRC tumour samples. The mRNA expression of IL1 B, IL6, IL8 and miR-22 was positively correlated with F. nucleatum quantification in CRC tumours. The mRNA expression of miR-135 b and TNF was inversely correlated. The miRNA:mRNA interaction network suggested that the upregulation of miR-34 a in CRC proceeds via a TLR2/TLR4-dependent response to F. nucleatum. Finally, KRAS mutations were more frequently observed in CRC samples infected with F. nucleatum and were associated with greater expression of miR-21 in CRA, while IL8 was upregulated in MSI-high CRC.CONCLUSION Our findings indicate that F. nucleatum is a risk factor for CRC by increasing the expression of inflammatory mediators through a possible mi RNA-mediated activation of TLR2/TLR4. | Marcela Alcantara Proenca Joice Matos Biselli Maysa Succi Fábio Eduardo Severino Gustavo Noriz Berardinelli Alaor Caetano Rui Manuel Reis David J Hughes Ana Elizabete Silva | 2018 | World Journal of Gastroenterology2018，24，47： | 15 |
| 2 | Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal)显示文摘 | José Manuel Neves Carla Matos Carla Moutinho Glória Queiroz Lígia Rebelo Gomes | 2009 | Journal of Ethnopharmacology2009，，2： | 1 |
| 3 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 4 | Acinar Cell Carcinoma of the Pancreas in the United States: Prognostic Factors and Comparison to Ductal Adenocarcinoma显示文摘 | C. Max Schmidt Jesus Manuel Matos David J. Bentrem Mark S. Talamonti Keith D. Lillemoe Karl Y. Bilimoria | 2008 | Journal of Gastrointestinal Surgery2008，，12： | 1 |
| 5 | Gas Mass-flow Meters: Measurement and Uncertainties显示文摘 | Manuel Arlindo Arnador de Matos Nuno Jos6 Femandes Rodrigues | 2013 | Flow Measurement and Instrumentation2013，33，： | 1 |
| 6 | Optimization of pumped storage capacity in an isolated power system with large renewable penetration 显示文摘 | PAUL D BROWN J A PECAS LOPES MANUEL A MATOS | 2008 | IEEE TRANSACTIONS ON POWER SYS- TEMS2008，34，2： | 1 |
| 7 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 8 | Agreement between IOLMaster 500 and Pentacam HR for keratometry assessment in type 2 diabetic and nondiabetic patients显示文摘AIM:To evaluate inter-device agreement of anterior keratometry obtained by the IOLMaster 500 and Pentacam HR in type 2 diabetic and non-diabetic patients.METHODS:Corneal measurements were sequentially performed in 60 diabetes mellitus(DM)and 48 age and sex-matched controls undergoing cataract surgery.Variables recorded included flat and steep keratometry,mean keratometry(Km),astigmatism magnitude,axis location,JO and J45 components.Bland-Altman plots and intraclass correlation coefficients were used for examination of agreement.Subgroup analyses were performed for astigmatism magnitude,diabetes duration,hemoglobin A1c(HbA1c)levels and diabetic retinopathy(DR)stage.RESULTS:Agreement for Km and astigmatism magnitude were considered good and moderate,with 95%limits of agreement(LoA)of-1.09 to 1.23 diopters(D)and-0.83 to 0.86 D in DM group,respectively;and-0.59 to 0.72 D and-0.98 to 0.75 D in non-DM group,respectively.In contrast,the 95%LoA for corneal axis exceeded the clinically relevant margins in both groups.In the total sample,only 41 eyes(38%)had a smaller than 5-degree difference.Diabetes duration,HbA1c levels and DR stage were not found to significantly affect agreement.Logistic regression showed that higher corneal power(P=0.021)and astigmatism magnitude(P=0.011)were associated with a decreased risk of having a difference in axis location greater than 10-degrees.CONCLUSION:In both groups,IOLMaster and Pentacam agree well for corneal power and moderately for astigmatism.However,axis location disagreement is frequent in eyes with flatter corneas and small amounts of astigmatism. | Joao N Beato Joao Esteves-LeANDro David Reis Rita Matos Manuel Falcao Vítor Rosas Angela Carneiro FernANDo Falcao-Reis | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 1 |
| 9 | Economic andtechnical management of an aggregation agent for electricvehicles: a literature survey 显示文摘 | Bessa Ricardo J Matos Manuel A | 2012 | European Transactions onElectrical Power2012，22，3： | 1 |
| 10 | How earthworm density affects microbial biomas and activity in pig manure显示文摘 | Manuel Aira Fernando Monroy Jorge Domínguez Salustiano Mato | 2002 | European Journal of Soil Biology2002，，1： | 1 |
| 11 | Optimization of Pumped Storage Capacity in an Iso- lated Power System with Large Renewable Penetra- tion显示文摘 | Brown Paul D Pecas Lopes J A Matos Manuel A | 2008 | IEEE Transactions on Power Systems2008，23，2： | 1 |
| 12 | Loss allocation in distribution networks with embedded generation显示文摘 | Paulo Moises Costa Manuel A Matos | 2004 | IEEE Trans on Power Systems2004，19，1： | 1 |
| 13 | Simulated Annealing for the Unit Commitment Problem显示文摘 | Ana Viana Jorge Pinho De Sousa Manuel Matos | 2001 | IEEE Porto Power Tech Conference 10th-13th September Porto Portugal2001，2001，： | 1 |
| 14 | Optimiza- tion of pumped storage capacity in an isolated power system with large renewable penetration显示文摘 | PAUL D Brown PECAS Lopes J A MANUEL A Matos | 2008 | IEEE Transactions on Power Sys- tems2008，23，2： | 1 |
| 15 | A Selection Process as a Game显示文摘The aim of this paper is to exemplify how to solve the problem of selecting a candidate up to his/her acceptance trough game theory.The originality this paper proposes is how this problem will be approached:It will be treated as a single game which is made up of two parts,going as far as to state that the payoffs in the first part of the game will be the mediators of the second part of the game. | Manuel Alberto M.Ferreira Maria Cristina Peixoto de Matos | 2018 | Management Studies2018，6，6： | 0 |
| 16 | Control of Indoor Swimming Pools with Potential for Demand Response显示文摘 | Eliseu Manuel Artilheiro Ribeiro | 2014 | Journal of Energy and Power Engineering2014，8，1： | 0 |
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