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| 1 | Micro RNA-124 slows down the progression of Huntington's disease by promoting neurogenesis in the striatum显示文摘Micro RNA-124 contributes to neurogenesis through regulating its targets,but its expression both in the brain of Huntington's disease mouse models and patients is decreased.However,the effects of micro RNA-124 on the progression of Huntington's disease have not been reported.Results from this study showed that micro RNA-124 increased the latency to fall for each R6/2 Huntington's disease transgenic mouse in the rotarod test.5-Bromo-2'-deoxyuridine(Brd U) staining of the striatum shows an increase in neurogenesis.In addition,brain-derived neurotrophic factor and peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein levels in the striatum were increased and SRY-related HMG box transcription factor 9 protein level was decreased.These findings suggest that micro RNA-124 slows down the progression of Huntington's disease possibly through its important role in neuronal differentiation and survival. | Tian Liu Wooseok Im Inhee Mook-Jung Manho Kim | 2015 | Neural Regeneration Research2015，10，5： | 8 |
| 2 | Scalp electroacupuncture at the Baihui acupoint (DU 20) improves functional recovery in rats with cerebral ischemia Association with increased expression of vascular endothelial growth factors显示文摘In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint (DU 20). Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor. | Min-Wook Kim You Chul Chung Hee Chan Jung Moon-Seo Park Young-Min Han Yong-An Chung Lee-So Maeng Sang-In Park Jiyeon Lim Seung Chan Kim Woo-Seok Im Jin Young Chung Minky Kim Manho Kim | 2011 | Neural Regeneration Research2011，6，36： | 4 |
| 3 | Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1(G93A)mice and SOD1(G17S and G86S)ALS patients显示文摘Background:MicroRNAs(miRNAs)are endogenous non-coding RNAS that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases.Overexpressed miRNAs play an important role in amyotrophic lateral sclerosis(ALS);however,the pathogenic mechanisms of deregulated miRNAS are still unclear.Methods:We aimed to assess the dysfunction of RNAS or miRNAs in fALS(SOD1 mutations).We compared the RNA-seq of subcellular fractions in NSC-34 WT(hSOD1)and MT(hSOD1(G93A))cells to find altered RNAs or miRNAs.We identified that Hif1a and Mef2c were upregulated,and Mctp1 and Rarb were downregulated in the cytoplasm of NSC-34 MT cells.Results:SOD1 mutations decreased the level of miR-18b-5p.Induced Hif1a which is the target for miR-18b increased Mef2c expression as a transcription factor.Mef2c upregulated miR-206 as a transcription factor.Inhibition of Mctp1 and Rarb,which are targets of miR-206,induced intracellular Ca^2+ levels and reduced cell differentiation,respectively.The miR-18b-5p pathway was also observed in G93A Tg mice,fALS(G86S)patient,and iPSC-derived motor neurons from fALS(G17S)patient.Conclusions:Our data indicate that SOD1 mutation decreases miR-18b-5p,which sequentially regulates Hif1a,Mef2c,miR-206,Mctp1 and Rarb in fALS-linked SOD1 mutation.These results provide new insights into the downregulation of miR-18b-5p-dependent pathogenic mechanisms of ALS. | Ki Yoon Kim Yu Ri Kim Kyung Won Choi Mijung Lee Somyung Lee Wooseok Im Je-Young Shin Jin Young Kim Yoon Ho Hong Manho Kim Jong-ll Kim Jung-Joon Sung | 2020 | Translational Neurodegeneration2020，9，3： | 2 |
| 4 | Development of a mi- crochannel evaporator model for a CO2 air-conditioning system 显示文摘 | Kim ManHoe Bullard W Clark | 2001 | Energy2001，26，10： | 1 |
| 5 | Watching a protein as it functionswith 150ps time-resolved X-ray crystallography显示文摘 | FRIEDRICH SCHOTTE MANHO LIM TIMOTHY A JACKSON | 2003 | Science2003，300，6： | 1 |
| 6 | The role of interleukin (IL)‐17 in anxiety and depression of patients with rheumatoid arthritis显示文摘 | YangLIU Roger Chun‐ManHO AnselmMAK | 2012 | International Journal of Rheumatic Diseases2012，，： | 1 |
| 7 | Aging and neurodegeneration molecular mechanisms of neuronal loss in Huntington's disease显示文摘 | Lee Soon-Tae Kim Manho | 2006 | Mech Ageing Dev2006，127，： | 1 |
| 8 | Neuronal Properties, In Vivo Effects, and Pathology of a Huntington’s Disease Patient‐Derived Induced Pluripotent Stem Cells显示文摘 | Iksoo Jeon Nayeon Lee Jia‐Yi Li In‐Hyun Park Kyoung Sun Park Jisook Moon Sung Han Shim Chunggab Choi Da‐Jeong Chang Jihye Kwon Seung‐Hun Oh Dong Ah Shin Hyun Sook Kim Jeong Tae Do Dong Ryul Lee Manho Kim Kyung‐Sun Kang George Q. Daley Patrik Brundin Jihwa | 2012 | STEM CELLS2012，，9： | 1 |
| 9 | Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia显示文摘 | Soon-Tae Lee Kon Chu Keun-Hwa Jung Song-Yi Ko Eun-Hee Kim Dong In Sinn Yong Seok Lee Eng H. Lo Manho Kim Jae Kyu Roh | 2005 | Brain Research2005，，1： | 1 |
| 10 | Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus显示文摘 | Keun-Hwa Jung Kon Chu Soon-Tae Lee Juhyun Kim Dong-In Sinn Jeong-Min Kim Dong-Kyu Park Jung-Ju Lee Seung U. Kim Manho Kim Sang Kun Lee Jae-Kyu Roh | 2006 | Neurobiology of Disease2006，，2： | 1 |
| 11 | Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia显示文摘 | Kon Chu Manho Kim Kyung-II Park | 2004 | Brain Research2004，1016，： | 1 |
| 12 | Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions显示文摘 | Jihwan Song Soon-Tae Lee Wonsuk Kang Jung-Eun Park Kon Chu Song-ee Lee Taesun Hwang Hyungmin Chung Manho Kim | 2007 | Neuroscience Letters2007，，1： | 1 |
| 13 | Hyperglycemia Exacerbates Brain Edema and Perihematomal Cell Death After Intracerebral Hemorrhage显示文摘 | Eun-Chol Song Kon Chu Sang-Wuk Jeong Keun-Hwa Jung Seong-Hoon Kim Manho Kim Byung-Woo Yoon | 2003 | Stroke: Journal of the American Heart Association2003，，9： | 1 |
| 14 | Airside thermal hydraulic performance of muhilouvered fin aluminum heat exchanger 显示文摘 | Manhoe K Bullard C | 2002 | International Journal of Refrigeration2002，25，： | 1 |
| 15 | Low pH increases the yield of exosome isolation显示文摘 | Jae-Jun Ban Mijung Lee Wooseok Im Manho Kim | 2015 | Biochemical and Biophysical Research Communicatio2015，，： | 1 |
| 16 | Intracranial Involvement by Metastatic Advanced Gastric Carcinoma显示文摘 | Manho Kim | 1999 | Journal of Neuro - Oncology1999，，1： | 1 |
| 17 | Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia显示文摘 | Kon Chu Manho Kim Kyung-I1 Park | 2004 | Brain Research2004，1016，2004： | 1 |
| 18 | miR‐206 regulates brain‐derived neurotrophic factor in Alzheimer disease model显示文摘 | Soon‐Tae Lee Kon Chu Keun‐Hwa Jung Jin Hee Kim Ji‐Young Huh Hyejin Yoon Dong‐Kyu Park Ji‐Yeon Lim Jeong‐Min Kim Daejong Jeon Hoon Ryu Sang Kun Lee Manho Kim Jae‐Kyu Roh | 2012 | Ann Neurol2012，，2： | 1 |
| 19 | Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with trasient forebrain ischemia 显示文摘 | Kon Chu Manho Kim Sang-Wuk Jeong | 2003 | Neurosci Lett2003，343，： | 1 |
| 20 | Intracranial Involvement by Metastatic Advanced Gastric Carcinoma显示文摘 | Manho Kim | 1999 | Journal of Neuro - Oncology1999，，1： | 1 |
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