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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | The Auxin-Regulated Protein ZmAuxRPI Coordinates the Balance between Root Growth and Stalk Rot Disease Resistance in Maize显示文摘To optimize fitness, plants must efficiently allocate their resources between growth and defense. Although phytohormone crosstalk has emerged as a major player in balancing growth and defense, the genetic basis by which plants man age this balance remai ns elusive. We previously ide ntified a quantitative disease . resistance locus, qRfg2, in maize (Zea mays) that protects against the fungal disease Gibberella stalk rot. Here, through map-based cloning, we demonstrate that the causal gene at qRfg2 is ZmAuxRPI, which encodes a plastid stroma-localized auxin-regulated protein. ZmAuxRPI responded quickly to pathogen challenge with a rapid yet transient reduction in expression that led to arrested root growth but enhanced resista nee to Gibberella stalk rot and Fusarium ear rot. ZmAuxRPI was show n to promote the biosynthesis of indole-3-acetic acid (IAA), while suppressing the formation of benzoxazinoid defense compounds. ZmAuxRPI presumably acts as a resource regulator modulating indole-3-glycerol phosphate and/or indole flux at the branch point between the IAA and benzoxazinoid biosynthetic pathways. The concerted interplay between IAA and benzoxazinoids can regulate the growth-defense balance in a timely and efficient manner to optimize plant fitness. | Jianrong Ye Tao Zhong Dongfeng Zhang Chuanyu Ma Lina Wang Lishan Yao Qianqian Zhang Mang Zhu Mingliang Xu | 2019 | Molecular Plant2019，12，3： | 19 |
| 3 | The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral ischemia显示文摘The Rho/Rho-kinase signaling pathway plays an important role in cerebral ischemia/reperfusion injury. However, very few studies have examined in detail the changes in the Rho/Rho-kinase signaling pathway in chronic cerebral ischemia. In this study, rat models of chronic cerebral ischemia were established by permanent bilateral common carotid artery occlusion and intragastrically administered 9 mg/kg fasudil, a powerful ROCK inhibitor, for 9 weeks. Morris water maze results showed that cognitive impairment progressively worsened as the cerebral ischemia proceeded. Immunohistochemistry, semi-quantitative RT-PCR and western blot analysis showed that the expression levels of Rho-kinase, its substrate myosin-binding subunit, and its related protein alpha smooth muscle actin, significantly increased after chronic cerebral ischemia. TUNEL staining showed that chronic cerebral ischemia could lead to an increase in neuronal apoptosis, as well as the expression level of caspase-3 in the frontal cortex of rats subjected to chronic cerebral ischemia. Fasudil treatment alleviated the cognitive impairment in rats with chronic cerebral ischemia, and decreased the expression level of Rho-kinase, myosin-binding subunit and alpha smooth muscle actin. Furthermore, fasudil could regulate cerebral injury by reducing cell apoptosis and decreasing caspase-3 expression in the frontal cortex. These findings demonstrate that fasudil can protect against cognitive impairment induced by chronic cerebral ischemia via the Rho/Rho-kinase signaling pathway and anti-apoptosis mechanism. | Ya-yun Yan Xiao-ming Wang Yan Jiang Han Chen Jin-ting He Jing Mang Yan-kun Shao Zhong-xin Xu | 2015 | Neural Regeneration Research2015，10，9： | 11 |
| 4 | MINTEQ modeling for evaluating the leaching behavior of heavy metals in MSWI fly ash显示文摘At present,all kinds of municipal solid waste incineration (MSWI) fly ash stabilization technology has been reported and successfully applied in many countries.However,leaching procedures are very different that the technologies lack uniform standard,and it is even impossible to predict the long-term stabilization.Geochemical model can explain the environmental stabilization based on chemical phase and thermodynamic crystal structure,and it is also able to guide the development of environment-friendly stabilization technology and choosing of chemical agents.Both experiment analysis and geochemical modeling were used to study the correlation between leaching behavior of MSWI fly ash and variation of pH.Dissolution/precipitation mechanism was applied in the simulation.The result indicated that the pH-dependent leaching behavior predicted by Visual MINTEQ is well in agreement with the result of pH-dependent test.pH value of leachate can significantly change the leaching behavior of MSWI fly ash.The leaching behavior of heavy metals for Pb and Cd is controlled by dissolution/precipitation mechanism,whereas for Zn and Ni,it is effected by surface adsorption reaction over a special extent of pH value. | Mang Yan Jiang Jianguo Chen Maozhe | 2008 | Journal of Environmental Sciences2008，20，11： | 10 |
| 5 | Neuroprotective effects of Activin A on endoplasmic reticulum stress-mediated apoptotic and autophagic PC12 cell death显示文摘Activin A, a member of the transforming growth factor-beta superfamily, plays a neuroprotective role in multiple neurological diseases. Endoplasmic reticulum(ER) stress-mediated apoptotic and autophagic cell death is implicated in a wide range of diseases, including cerebral ischemia and neurodegenerative diseases. Thapsigargin was used to induce PC12 cell death, and Activin A was used for intervention. Our results showed that Activin A significantly inhibited morphological changes in thapsigargin-induced apoptotic cells, and the expression of apoptosis-associated proteins [cleaved-caspase-12, C/EBP homologous protein(CHOP) and cleaved-caspase-3] and biomarkers of autophagy(Beclin-1 and light chain 3), and downregulated the expression of thapsigargin-induced ER stress-associated proteins [inositol requiring enzyme-1(IRE1), tumor necrosis factor receptor-associated factor 2(TRAF2), apoptosis signal-regulating kinase 1(ASK1), c-Jun N-terminal kinase(JNK) and p38]. The inhibition of thapsigargin-induced cell death was concentration-dependent. These findings suggest that administration of Activin A protects PC12 cells against ER stress-mediated apoptotic and autophagic cell death by inhibiting the activation of the IRE1-TRAF2-ASK1-JNK/p38 cascade. | Long-xing Xue Hong-yu Liu Yang Cui Yue Dong Jiao-qi Wang Qiu-ye Ji Jin-ting He Min Yao Ying-ying Wang Yan-kun Shao Jing Mang Zhong-xin Xu | 2017 | Neural Regeneration Research2017，12，5： | 7 |
| 6 | A User-Centric Data Secure Creation Scheme in Cloud Computing显示文摘Due to the use of the cloud computing technology,the ownership is separated from the administration of the data in cloud and the shared data might be migrated between different clouds,which would bring new challenges to data secure creation,especially for the data privacy protection.We propose a User-centric data secure creation scheme(UCDSC) for the security requirements of resource owners in cloud.In this scheme,a data owner first divides the users into different domains.The data owner encrypts data and defines different secure managing policies for the data according to domains.To encrypt the data in UCDSC,we present an algorithm based on Access control conditions proxy re-encryption(ACC-PRE),which is proved to be master secret secure and Chosen-ciphertext attack(CCA) secure in random oracle model.We give the application protocols and make the comparisons between some existing approaches and UCDSC. | SU Mang LI Fenghua SHI Guozhen GENG Kui XIONG Jinbo | 2016 | Chinese Journal of Electronics2016，25，4： | 7 |
| 7 | Realization of quantum discrete Fourier transform with NMR显示文摘The pulse sequences of the logic operations used in quantum discrete Fourier transform are designed for the experiment of nuclear magnetic resonance(NMR), and 2-qubit discrete Fourier transforms are implemented experimentally with NMR. The experimental errors are examined and methods for reducing the errors are proposed. | FANG Ximing ZHU Xiwen FENG Mang MAO Xi’an DU Fei | 2000 | Chinese Science Bulletin2000，45，12： | 7 |
| 8 | Exact Solution of Quantum Dynamics of a Cantilever Coupling to a Single Trapped Ultracold Ion显示文摘precooled 伸臂的量行为能被静电的联盟者联合到一个套住的极端冷离子,到扎根的震动的状态的下面的伸臂的快冷却在是可能的高效地高度探查。在有与仅仅很少震动的量联合到 cantiiever 的 anultracold 离子的一个简单模型以内,我们由一种压榨状态的扩大技术解决联合系统的动力学,并且能原则上当 rotating-waveapproximation 不在时获得联合系统的时间进化的准确溶液。在旋转波浪近似下面比作处理,我们在场对伸臂的量行为的更精确的描述。 | LIU Tao FENG Mang WANG Ke-Lin | 2007 | Communications in Theoretical Physics2007，47，3： | 6 |
| 9 | Hierarchical peony-like FeCo-NC with conductive network and highly active sites as efficient electrocatalyst for rechargeable Zn-air battery显示文摘Carbon materials featuring hierarchical pores and atomically dispersed metal sites are promising catalysts for energy storage and conversion applications.Herein,we developed a facile strategy to construct functional carbon materials with a fluffy peony-like structure and dense binary FeCo-Nx active sites(termed as f-FeCo-CNT).By regulating the metal content in precursors,a three-dimensional(3D)interconnected conductive carbon nanotubes network was in-situ formed throughout the atomically dispersed FeCo-NC matrix during pyrolysis.Taking advantage of rich pore hierarchy and co-existence of highly active FeCo-Nx sites and beneficial FeCo alloy nanoparticles,the f-FeCo-CNT material exhibited excellent bifunctional performance towards oxygen reduction reaction/oxygen evolution reactions(ORR/OER)with respect to the atomically dispersed FeCo-NC(SA-f-FeCo-NC)and commercial Pt/C+Ru02 mixture,surpassing the SA-f-FeCo-NC with a 20 mV higher ORR half-wave potential and a 100 mV lower OER overpotential(at 10.0 mA/cm^2).Remarkably,the f-FeCo-CNT-assembled Zn-air battery(ZAB)possessed a maximum specific power of 195.8 mW/cm^2,excellent rate capability,and very good cycling stability at large current density of 20.0 mA/cm^2.This work provides a facile and feasible synthetic strategy of constructing low-cost cathode materials with excellent comprehensive ZAB performance. | Yiyan Wang Anuj Kumar Mang Ma Yin Jia Yu Wang Ying Zhang Guoxin Zhang Xiaoming Sun Zifeng Yan | 2020 | Nano Research2020，13，4： | 5 |
| 10 | Activin A prevents neuron-like PC12 cell apoptosis after oxygen-glucose deprivation显示文摘In this study, PC12 cells were induced to differentiate into neuron-like cells using nerve growth facto and were subjected to oxygen-glucose deprivation. Cells were treated with 0, 10, 20, 30, 50, 100 ng/mL exogenous Activin A. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide assay and Hoechst 33324 staining showed that the survival percentage of PC12 cells significantly decreased and the rate of apoptosis significantly increased after oxygen-glucose deprivation. Exogenous Activin A significantly increased the survival percentage of PC12 cells in a dose-dependent manner. Reverse transcription-PCR results revealed a significant increase in Activin receptor IIA, Smad3 and Smad4 mRNA levels, which are key sites in the Activin A/Smads signaling pathway, in neuron-like cells subjected to oxygen-glucose deprivation, while mRNA expression of the apoptosis-regulation gene caspase-3 decreased. Our experimental findings indicate that exogenous Activin A plays an anti-apoptotic role and protects neurons by means of activating the Activin A/Smads signaling pathway. | Guihua Xu Jinting He Hongliang Guo Chunli Mei Jiaoqi Wang Zhongshu Li Han Chen Jing Mang Hong Yang Zhongxin Xu | 2013 | Neural Regeneration Research2013，8，11： | 5 |
| 11 | MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease显示文摘AIM:To determine the contributions of insulin-like growth factor 1 (IGF-1),cytokines and liver disease severity to bone mineral density in patients pre-transplantation.METHODS:Serum IGF-1,tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) were measured and the Model for End-Stage Liver Disease (MELD) score calculated in 121 adult patients referred to a single centre for liver transplantation.Bone mineral density (BMD) of the lumbar spine and femoral neck were assessed via dual energy X-ray absorptiometry.Demographics,liver disease etiology,medication use and relevant biochemistry were recorded.RESULTS:A total of 117 subjects were included,with low BMD seen in 68.6%,irrespective of disease etiol-ogy.In multivariable analysis,low body mass index (BMI),increased bone turnover and low IGF-1 were independent predictors of low spinal bone density.At the hip,BMI,IGF-1 and vitamin D status were predictive.Despite prevalent elevations of TNFα and IL-6,levels did not correlate with degree of bone loss.The MELD score failed to predict low BMD in this pre-transplant population.CONCLUSION:Osteopenia/osteoporosis is common in advanced liver disease.Low serum IGF-1 is weakly predictive but serum cytokine and MELD score fail to predict the severity of bone disease. | Rebecca Mitchell Jill McDermid Mang M Ma Constance L Chik | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 12 | Changes of hypoxia-inducible factor-1 signaling and the effect of cilostazol in chronic cerebral ischemia显示文摘Hypoxia-inducible factor-1 and its specific target gene heme oxygenase-1, are involved in acute cerebral ischemia. However, very few studies have examined in detail the changes in the hypoxia-inducible factor-1/heme oxygenase-1 signaling pathway in chronic cerebral ischemia. In this study, a rat model of chronic cerebral ischemia was established by permanent bilateral common carotid artery occlusion, and these rats were treated with intragastric cilostazol (30 mg/kg) for 9 weeks. Morris water maze results showed that cognitive impairment gradually worsened as the cerebral ischemia proceeded. Immunohistochemistry, semi-quantitative PCR and western blot analysis showed that hypoxia-inducible factor-1α and heme oxygenase-1 expression levels increased after chronic cerebral ischemia, with hypoxia-inducible factor-1α expression peaking at 3 weeks and heme oxygenase-1 expression peaking at 6 weeks. These results suggest that the elevated levels of hypoxia-inducible factor-1α may upregulate heme oxygenase-1 expression following chronic cerebral ischemia and that the hypoxia-inducible factor-1/heme oxygenase-1 signaling pathway is involved in the development of cognitive impairment induced by chronic cerebral ischemia. Cilostazol treatment alleviated the cognitive impairment in rats with chronic cerebral ischemia, decreased hypoxia-inducible factor-1α and heme oxygenase-1 expression levels, and reduced apoptosis in the frontal cortex. These findings demonstrate that cilostazol can protect against cognitive impairment induced by chronic cerebral ischemic injury through an anti-apoptotic mechanism. | Han Chen Aixuan Wei Jinting He Ming Yu Jing Mang Zhongxin Xu | 2013 | Neural Regeneration Research2013，8，19： | 5 |
| 13 | Relationship of gelatinases-tight junction proteins and blood-brain barrier permeability in the early stage of cerebral ischemia and reperfusion显示文摘Gelatinases matrix metalloproteinase-2 and matrix metalloproteinase-9 have been shown to mediate claudin-5 and occludin degradation, and play an important regulatory role in blood-brain barrier permeability. This study established a rat model of 1.5-hour middle cerebral artery occlusion with reperfusion. Protein expression levels of claudin-5 and occludin gradually decreased in the early stage of reperfusion, which corresponded to the increase of the gelatinolytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9. In addition, rats that received treatment with matrix metalloproteinase inhibitor N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpenthanoyl]-L- tryptophan methylamide (GM6001) showed a significant reduction in Evans blue leakage and an inhibition of claudin-5 and occludin protein degradation in striatal tissue. These data indicate that matrix metalloproteinase-2 and matrix metalloproteinase-9-mediated claudin-5 and occludin degradation is an important reason for blood-brain barrier leakage in the early stage of reperfusion. The leakage of the blood-brain barrier was present due to gelatinases-mediated degradation of claudin-5 and occludin proteins. We hypothesized that the timely closure of the structural component of the blood-brain barrier (tight junction proteins) is of importance. | Haolin Xin Wenzhao Liang Jing Mang Lina Lin Na Guo Feng Zhang Zhongxin Xu | 2012 | Neural Regeneration Research2012，7，31： | 4 |
| 14 | 废弃沥青混凝土骨料应用于水泥混凝土路面的可行性研究显示文摘研究使用回收沥青混凝土路面(RAP),使用其中的回收骨料取代混凝土中的部分或全部常规骨料,并应用于路面混凝土上的可行性。在此项目中,我们使用总骨料用量0、20%、40%、70%、100%的回收骨料来取代常规骨料,完成了19个不同配合比的再生混凝土,并进行了力学和热学性能评估。研究表明,随着回收骨料用量的增加,混凝土的抗压强度,劈裂抗拉强度,抗折强度和弹性模量都有一定程度的降低,而热膨胀系数会随着再生骨料的增加而增加。最后,我们通过使用路面系统有限元分析软件FEACONS IV进行分析得出,在佛罗里达典型的温度和荷载条件下,再生混凝土路面系统的性能与常规混凝土路面相仿。 | 陈玉 苏育民 刘艳军 MANG Tia | 2015 | 混凝土2015，，4： | 4 |
| 15 | Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer显示文摘 | Philippe Rougier Hanno Riess Robert Manges Petr Karasek Yves Humblet Carlo Barone Armando Santoro Sylvie Assadourian Laurence Hatteville Philip A. Philip | 2013 | European Journal of Cancer2013，，12： | 4 |
| 16 | Chemoselective Bromodecarboxylation ofα-Carboxy-α-cinnamoyl Ketene Cyclic Dithioacetals显示文摘 | WANG Mang XU Xian-xiu LIU Qun YANG Xiao-xia | 2005 | Chemical Research in Chinese Universities2005，21，5： | 4 |
| 17 | Pelvic lipomatosis with cystitis glandularis managed with cyclooxygenase-2 inhibitor:A case report显示文摘BACKGROUND Pelvic lipomatosis(PL)is a rare benign condition with characteristic overgrowth of histologically benign fat and invasion and compression of pelvic organs,often leading to non-specific lower urinary tract symptoms(LUTS).Approximately 40%of patients with PL have cystitis glandularis(CG).The cause of PL combined with CG is poorly understood,and there is currently no effective treatment.Refractory CG with upper urinary tract obstruction even requires partial or radical bladder resection.CASE SUMMARY In this case,a patient suffering from PL with CG was treated by transurethral resection of bladder tumour(TUR-BT)and oral administration of celecoxib,a selective cyclooxygenase-2(COX-2)inhibitor.The LUTS were alleviated,and the cystoscopy results improved significantly.Immunohistochemistry showed upregulated COX-2 expression in the epithelium of TUR-BT samples,suggesting that COX-2 may participate in the pathophysiological process of PL combined with CG.CONCLUSION We report for the first time that celecoxib may be an effective treatment strategy for PL combined with refractory CG. | Li-Cai Mo Song-Zhe Piao Hai-Hong Zheng Tao Hong Qin Feng Mang Ke | 2021 | World Journal of Clinical Cases2021，9，17： | 4 |
| 18 | Integrated watershed management:evolution,development and emerging trends显示文摘Watershed management is an ever-evolving practice involving the management of land,water,biota,and other resources in a defined area for ecological,social,and economic purposes.In this paper,we explore the following questions:How has watershed management evolved? What new tools are available and how can they be integrated into sustainable watershed management? To address these questions,we discuss the process of developing integrated watershed management strategies for sustainable management through the incorporation of adaptive management techniques and traditional ecological knowledge.We address the numerous benefits from integration across disciplines and jurisdictional boundaries,as well as the incorporation of technological advancements,such as remote sensing,GIS,big data,and multi-level social-ecological systems analysis,into watershed management strategies.We use three case studies from China,Europe,and Canada to review the success and failure of integrated watershed management in addressing different ecological,social,and economic dilemmas in geographically diverse locations.Although progress has been made in watershed management strategies,there are still numerous issues impeding successful management outcomes;many of which can be remedied through holistic management approaches,incorporation of cutting-edge science and technology,and cross-jurisdictional coordination.We conclude by highlighting that future watershed management will need to account for climate change impacts by employing technological advancements and holistic,cross-disciplinary approaches to ensure watersheds continue to serve their ecological,social,and economic functions.We present three case studies in this paper as a valuable resource for scientists,resource managers,government agencies,and other stakeholders aiming to improve integrated watershed management strategies and more efficiently and successfully achieve ecological and socio-economic management objectives. | Guangyu Wang Shari Mang Haisheng Cai Shirong Liu Zhiqiang Zhang Liguo Wang John L.Innes | 2016 | Journal of Forestry Research2016，27，5： | 4 |
| 19 | A More Efficient Synthetic Route to Perylene-porphyrin Arrays显示文摘We present an efficient synthetic route towards two kinds of perylene-porphyrin arrays. Starting from 5, 10, 15, 20-meso-tetraphenylporphyrin, two novel 9a and 9b were designed and synthesized with 40.3% and 35.1% yield, respectively. | Xin Guo YANG, Jing Zhi SUN, Mang WANG*, Hong Zheng CHEN Department of Polymer Science & Engineering, State Key Laboratory for Silicon Materials, Zhejiang University, Hangzhou 310027 | 2003 | Chinese Chemical Letters2003，14，11： | 3 |
| 20 | 沥青路面骨料再生混凝土的力学性能研究显示文摘研究了使用回收沥青混凝土路面(RAP)中的再生骨料取代混凝土中的部分或全部天然骨料,并应用于路面混凝土中的可行性。用0、20%、40%、70%和100%的再生骨料取代天然骨料,进行了不同配合比的再生混凝土性能试验。研究表明,随着再生骨料用量的增加,混凝土的工作性能下降,破坏形态发生了变化,混凝土的抗压强度、劈裂抗拉强度和抗折强度都有不同程度的降低。使用20%和40%再生骨料制备的再生混凝土可以满足现有的路面强度要求。 | 陈玉 刘艳军 苏育民 MANG Tia | 2014 | 新型建筑材料2014，41，12： | 3 |
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