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| 1 | Gastrointestinal imaging-practical magnetic resonance imaging approach显示文摘Over the past two decades, advances in cross-sectionalimaging such as computed tomography and magneticresonance imaging(MRI) have dramatically changed theconcept of gastrointestinal imaging. MR is playing anincreasing role in the evaluation of gastrointestinal disorders. MRI combines the advantages of excellent soft-tissue contrast, noninvasiveness, functional informationand lack of ionizing radiation. Furthermore, recent developments of MRI have led to improved spatial and temporal resolution as well as decreased motion artifacts. Inthis article we describe the technical aspects of gastroin-testinal MRI and present a practical approach for a well-known spectrum of gastrointestinal disease processes. | Baodong Liu Miguel Ramalho Mamdoh AlObaidy Kiran K Busireddy Ersan Altun Janaka Kalubowila Richard C Semelka | 2014 | World Journal of Radiology2014，6，8： | 11 |
| 2 | Magnetic resonance imaging of pancreatitis: An update显示文摘Magnetic resonance(MR)imaging plays an important role in the diagnosis and staging of acute and chronic pancreatitis and may represent the best imaging technique in the setting of pancreatitis due to its unmatched soft tissue contrast resolution as well as nonionizing nature and higher safety profile of intravascular contrast media,making it particularly valuable in radiosensitive populations such as pregnant patients,and patients with recurrent pancreatitis requiring multiple follow-up examinations.Additional advantages include the ability to detect early forms of chronic pancreatitis and to better differentiate adenocarcinoma from focal chronic pancreatitis.This review addresses new trends in clinical pancreatic MR imaging emphasizing its role in imaging all types of acute and chronic pancreatitis,pancreatitis complications and other important differential diagnoses that mimic pancreatitis. | Sriluxayini Manikkavasakar Mamdoh AlObaidy Kiran K Busireddy Miguel Ramalho Viragi Nilmini Madhavi Alagiyawanna Richard C Semelka | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 3 | Focal liver lesions:Practical magnetic resonance imaging approach显示文摘With the widespread of cross-sectional imaging, a growth of incidentally detected focal liver lesions(FLL) has been observed. A reliable detection and characterization of FLL is critical for optimal patient management. Maximizing accuracy of imaging in the context of FLL is paramount in avoiding unnecessary biopsies, which may result in post-procedural complications. A tremendous development of new imaging techniques has taken place during these last years. Nowadays, Magnetic resonance imaging(MRI) plays a key role in management of liver lesions, using a radiation-free technique and a safe contrast agent profile. MRI plays a key role in the non-invasive correct characterization of FLL. MRI is capable of providing comprehensive and highly accurate diagnostic information, with the additional advantage of lack of harmful ionizing radiation. These properties make MRI the mainstay for the noninvasive evaluation of focal liver lesions. In this paper we review the state-of-the-art MRI liver protocol, briefly discussing different sequence types, the unique characteristics of imaging non-cooperative patients and discuss the role of hepatocyte-specific contrast agents. A review of the imaging features of the most common benign and malignant FLL is presented, supplemented by a schematic representation of a simplistic practical approach on MRI. | António P Matos Fernanda Velloni Miguel Ramalho Mamdoh AlObaidy Aruna Rajapaksha Richard C Semelka | 2015 | World Journal of Hepatology2015，7，16： | 6 |
| 4 | Magnetic resonance imaging of the cirrhotic liver: An update显示文摘Noninvasive imaging has become the standard for hepatocellular carcinoma(HCC) diagnosis in cirrhotic livers. In this review paper, we go over the basics of MR imaging in cirrhotic livers and describe the imaging appearance of a spectrum of hepatic nodules marking the progression from regenerative nodules to low- and high-grade dysplastic nodules, and ultimately to HCCs. We detail and illustrate the typical imaging appearancesof different types of HCC including focal, multifocal, massive, diffuse/infiltrative, and intra-hepatic metastases; with emphasis on the diagnostic value of MR in imaging these lesions. We also shed some light on liver imaging reporting and data system, and the role of different magnetic resonance imaging(MRI) contrast agents and future MRI techniques including the use of advanced MR pulse sequences and utilization of hepatocyte-specific MRI contrast agents, and how they might contribute to improving the diagnostic performance of MRI in early stage HCC diagnosis. | Agnes Watanabe Miguel Ramalho Mamdoh Al Obaidy Hye Jin Kim Fernanda G Velloni Richard C Semelka | 2015 | World Journal of Hepatology2015，7，3： | 5 |
| 5 | Pancreatitis-imaging approach显示文摘Pancreatitis is defined as the inflammation of the pancreas and considered the most common pancreatic disease in children and adults. Imaging plays a significant role in the diagnosis, severity assessment, recognition of complications and guiding therapeutic interventions. In the setting of pancreatitis, wider availability and good image quality make multi-detector contrastenhanced computed tomography(MD-CECT) the most used imaging technique. However, magnetic resonance imaging(MRI) offers diagnostic capabilities similar to those of CT, with additional intrinsic advantages including lack of ionizing radiation and exquisite soft tissue characterization. This article reviews the proposed definitions of revised Atlanta classification for acute pancreatitis, illustrates a wide range of morphologic pancreatic parenchymal and associated peripancreatic changes for different types of acute pancreatitis. It also describes the spectrum of early and late chronic pancreatitis imaging findings and illustrates some of the less common types of chronic pancreatitis, with special emphasis on the role of CT and MRI. | Kiran K Busireddy Mamdoh AlObaidy Miguel Ramalho Janaka Kalubowila Liu Baodong Ilaria Santagostino Richard C Semelka | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 4 |
| 6 | In silico Proteome-wide Amino aCid and Elemental Composition (PACE) Analysis of Expression Proteomics Data Provides A Fingerprint of Dominant Metabolic Processes显示文摘Proteome-wide Amino aCid and Elemental composition(PACE) analysis is a novel and informative way of interrogating the proteome.The PACE approach consists of in silico decomposition of proteins detected and quantifed in a proteomics experiment into 20 amino acids and fve elements(C,H,N,O and S),with protein abundances converted to relative abundances of amino acids and elements.The method is robust and very sensitive;it provides statistically reliable differentiation between very similar proteomes.In addition,PACE provides novel insights into proteome-wide metabolic processes,occurring,e.g.,during cell starvation.For instance,both Escherichia coli and Synechocystis down-regulate sulfur-rich proteins upon sulfur deprivation,but E.coli preferentially down-regulates cysteine-rich proteins while Synechocystis mainly downregulates methionine-rich proteins.Due to its relative simplicity,flexibility,generality and wide applicability,PACE analysis has the potential of becoming a standard analytical tool in proteomics. | David M. Good Anwer Mamdoh Harshavardhan Budamgunta Roman A. Zubarev | 2013 | Genomics, Proteomics & Bioinformatics2013，11，4： | 2 |
| 7 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 8 | Removal of rhodamine B (a basic dye) and thoron (an acidic dye) from dilute aqueous solutions and wastewater simulants by ion flotation显示文摘 | Kamal Shakir Ahmed Faouzy Elkafrawy Hussein Fouad Ghoneimy Shokry Gad Elrab Beheir Mamdoh Refaat | 2009 | Water Research2009，，5： | 1 |
| 9 | Removal of cervical mucus prior to embryo transfer improves pregnancy rates in women undergoing assisted reproduction显示文摘 | Mamdoh A Eskandar Ahmed M Abou-Setta Mohamed El-Amin Mona A Almushait Adekunle A Sobande | 2007 | Reproductive BioMedicine Online2007，，3： | 1 |
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