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您的检索式：作者名="David M. Good"
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| 1 | In silico Proteome-wide Amino aCid and Elemental Composition (PACE) Analysis of Expression Proteomics Data Provides A Fingerprint of Dominant Metabolic Processes显示文摘Proteome-wide Amino aCid and Elemental composition(PACE) analysis is a novel and informative way of interrogating the proteome.The PACE approach consists of in silico decomposition of proteins detected and quantifed in a proteomics experiment into 20 amino acids and fve elements(C,H,N,O and S),with protein abundances converted to relative abundances of amino acids and elements.The method is robust and very sensitive;it provides statistically reliable differentiation between very similar proteomes.In addition,PACE provides novel insights into proteome-wide metabolic processes,occurring,e.g.,during cell starvation.For instance,both Escherichia coli and Synechocystis down-regulate sulfur-rich proteins upon sulfur deprivation,but E.coli preferentially down-regulates cysteine-rich proteins while Synechocystis mainly downregulates methionine-rich proteins.Due to its relative simplicity,flexibility,generality and wide applicability,PACE analysis has the potential of becoming a standard analytical tool in proteomics. | David M. Good Anwer Mamdoh Harshavardhan Budamgunta Roman A. Zubarev | 2013 | Genomics, Proteomics & Bioinformatics2013，11，4： | 2 |
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