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您的检索式：作者名="Adam Matson"
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| 1 | Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice显示文摘Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study, we discovered bivalent hormetic functions of PXR/CAR modulating the richness of the gut microbiome using genetically engineered mice. The absence of PXR or CAR increased microbial richness, and absence of both receptors synergistically increased microbial richness. PXR and CAR deficiency increased the pro-inflammatory bacteria Helicobacteraceae and Helicobacter. Deficiency in both PXR and CAR increased the relative abundance of Lactobacillus, which has bile salt hydrolase activity, corresponding to decreased primary taurine-conjugated bile acids(BAs) in feces, which may lead to higher internal burden of taurine and unconjugated BAs, both of which are linked to inflammation, oxidative stress, and cytotoxicity. The basal effect of PXR/CAR on the gut microbiome was distinct from pharmacological and toxicological activation of these receptors. Common PXR/CAR-targeted bacteria were identified, the majority of which were suppressed by these receptors. h PXR-TG mice had a distinct microbial profile as compared to wild-type mice. This study is the first to unveil the basal functions of PXR and CAR on the gut microbiome. | Mallory Little Moumita Dutta Hao Li Adam Matson Xiaojian Shi Gabby Mascarinas Bruk Molla Kris Weigel Haiwei Gu Sridhar Mani Julia Yue Cui | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 2 | 护士关于早产儿疼痛的护理体验:质性研究系统综述显示文摘目的通过系统文献综述整合与揭示护士在护理早产儿疼痛过程中的体验。方法研究检索了近10年发表的文献,检索数据库包括:PubMed,CINAHL,PsycINFO,Scopus,BIOSIS和ProQuest Dissertation and Theses Database。纳入标准:对重症监护室护理早产儿护士的质性研究。排除标准:非英文文献,文献不包括质性研究数据或质性数据无法从文章中提取,以及文章不包含护士体验的内容。文献质量评价采用英国牛津循证医学中心文献评价项目方案(Critical Appraisal Skills Programme,CASP)。结果经过比较纳入和排除标准,研究者最终筛选出8篇文献,共包括205名护士,分别来自伊朗、加拿大、美国、芬兰、瑞典、瑞士和澳大利亚。共归纳出5个关于早产儿疼痛护理体验的主题:1)护士可以觉察早产儿疼痛;2)早产儿疼痛未缓解导致的不良后果;3)疼痛管理的障碍;4)对现有疼痛管理方式的担忧;5)与家长合作困难。结论这篇质性研究系统综述揭示了护士对早产儿疼痛未缓解会导致新生儿发育障碍的理解。改善工作环境、降低工作负荷,研制适应不同年龄组的疼痛评估和干预方法,为护士提供有效的情感支持和培训,建立与家长的良好合作关系,均为重症监护室护士为早产儿疼痛提供更好护理的迫切需要。 | Tingting Zhao Angela R.Starkweather Adam Matson Shabnam Lainwala Wanli Xu Xiaomei Cong | 2022 | International Journal of Nursing Sciences2022，9，4： | 1 |
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