|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | Pancreatic Cyst Fluid and Serum Mucin Levels Predict Dysplasia in Intraductal Papillary Mucinous Neoplasms of the Pancreas显示文摘 | Maker A V 、 Katabi N Gonen M | 2011 | Ann Surg Oncol2011，18，1： | 1 |
| 3 | Cyst fluid biomarkers for intraductal papillary mutinous neoplasms of the pancreas: A critical review from the international expert meet- ing on pancreatic branch-duct-intraductal papillary mucinous neoplasms显示文摘 | MAKER A V CARRARA S JAMIESON N B | 2015 | Journal of the American College of Surgeons2015，220，2： | 1 |
| 4 | Annular pancreas in the adult : two case reports and review of more than a century of liter'- ature显示文摘 | Maker V Gerzenshtein J Lerner T | 2003 | Am Surg2003，69，5： | 1 |
| 5 | Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB - 2 显示文摘 | ATRIA P POWELL D J MAKER A V | 2006 | Immunother2006，29，2： | 1 |
| 6 | Insulin receptor(IR)and glucose transporter 2(GLUT2) proteins form a complex on the ra t hepatocyte membrane显示文摘 | Eisenberg M L Maker A V Slezak L A | | 0，，1： | 1 |
| 7 | Insulin receptor(IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane显示文摘 | Eisenberg M L Maker A V Slezak L A | 2005 | Cell Physiol Biochem2005，15，14： | 1 |
| 8 | Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4显示文摘 | Atria P Phan G Q Maker A V | 2005 | Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology2005，23，25： | 1 |
| 9 | Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-a显示文摘 | ATTIA P PHAN GQ MAKER A V | 2005 | J Clin Oncol2005，23，25： | 1 |
| 10 | Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte- associated antigen 4 blockade and interleukin 2: A phase I/II study 显示文摘 | Maker A V Phan G Q Attia P | 2005 | Annals of Surgical Oncology2005，12，12： | 1 |
| 11 | Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase IIII study显示文摘 | MAKER A V PHAN GQ ATTIA P | 2005 | Ann Surg Oncol2005，12，12： | 1 |
| 12 | Gastrointestinal injury secondary to extracorporeal shock wave lithotripy:A review of the literature since its inception显示文摘 | Maker V Layke J | 2004 | Journal of the American College of Surgeons2004，198，1： | 1 |
| 13 | Selective elimination of human regulatory Tlymphocytes in vitro with the recombinant immunotoxin LMB-2 显示文摘 | ATTIA P POWELL D J JR MAKER A V | 2006 | J Immunother2006，29，： | 1 |
| 14 | Annular pancreas in the adult: two case reports and review of more than a century of literature显示文摘 | Maker V Gerzenshtein J Lerner T | 2003 | Am Surg2003，69，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员