|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | P13K and Akt as molecular targets for cancer therapy: current clinical outcomes显示文摘 | Ipsita PAL, Mahitosh MANDAq | 2012 | Acta Pharmacologica Sinica2012，33，12： | 28 |
| 2 | Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats显示文摘Aim:To investigate the effect of arsenic on spermatogenesis.Methods:Mature(4 months old)Wistar rats were intraperitoneally administered sodium arsenite at doses of 4,5 or 6mg·kg^-1·day^-1 for 26 days.Different varieties of germ cells at stage Ⅶ seminiferous epithelium cycle,namely,type A spermatogonia(ASg),preleptotene spermatocytes(pLSc),midpachytene spermatocytes(mPSc) and step 7 spermatids(7Sd) were quantitatively evaluated, along with radioimmunoassay of plasma follicle-stimulating hormone(FSH),lutuneizing hormone(LH),testosterone and assessment of the epididymal sperm count.Results:In the 5 and 6 mg/kg groups,there were significant dosedependent decreases in the accessory sex organ weights,epididymal sperm count and plasma concentrations of LH,FSH and testosterone with massive degeneration of all the germ cells at stage Ⅶ,The changes were insignificant in the 4 mg/kg group.Conclusion:Arsenite has a suppressive influence on spermatogenesis and gonadotrophin and testosterone release in rats. | Mahitosh Sarkar Gargi Ray Chaudhuri Aloke Chattopadhyay Narendra Mohan Biswas | 2003 | Asian Journal of Andrology2003，5，1： | 24 |
| 3 | nsights into molecular therapy of glioma: current .-hallenges and next generation blueprint显示文摘Glioma 说明人的大脑肿瘤的多数。与占优势的治疗政体,病人有差的幸存率。尽管有在主流的 glioma 治疗的当前的开发,为 glioma 的痊愈看起来从活动范围。glioma 和获得的电阻的渗透性的性质 substancially 限制治疗学的选择。glioma 和 proteogenomic 描述的复杂 pathobiology 的更好的说明可能最后为更复杂、有效的联合政体的设计打开新奇大街。这能被个别地定制进步 neuroimaging 技术完成,终止有 激活prodrug 基因的 DNA 合成, silencing gliomagenesis 基因(基因治疗),指向的 miRNA oncogenic 活动( miRNA-mRNA 相互作用),有干细胞治疗的联合 Hedgehog-Gli/Akt 禁止者,作为抗原采用肿瘤 lysates 由细胞毒素的 T 淋巴细胞(树枝状的房间种痘)为肿瘤特定的癌症干细胞的有效弄空采购原料,妄想的反的采纳转移因此,现在的评论捕获与分子的机制象外科,放射和化疗的限制一样在 glial tumorigenesis 包含了联系的最近的趋势。在这篇文章,我们极其也讨论下一代为 glioma 的成功的治疗的分子的治疗学的策略和他们的机制。 | Y RAJESH Ipsita PAL Payel BANIK Sandipan CHAKRABORTY Sachin A BORKAR Goutam DEY Ahona MUKHERJEE Mahitosh MANDAL | 2017 | Acta Pharmacologica Sinica2017，38，5： | 16 |
| 4 | Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells显示文摘AIM:To investigate the events associated with the apoptotic effect of p-Coumaric acid,one of the phenolic components of honey,in human colorectal carcinoma(HCT-15)cells.METHODS:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltertazolium-bromide assay was performed to determine the antiproliferative effect of p-Coumaric acid against colon cancer cells.Colony forming assay was conducted to quantify the colony inhibition in HCT15 and HT 29 colon cancer cells after p-Coumaric acid treatment.Propidium Iodide staining of the HCT15 cells using flow cytometry was done to study the changes in the cell cycle of treated cells.Identification of apoptosis was done using scanning electron microscope and photomicrograph evaluation of HCT 15cells after exposing to p-Coumaric acid.Levels of reactive oxygen species(ROS)of HCT 15 cells exposed to p-Coumaric acid was evaluated using 2’,7’-dichlorfluorescein-diacetate.Mitochondrial membrane potential of HCT-15 was assessed using rhodamine-123 with the help of flow cytometry.Lipid layer breaks associated with p-Coumaric acid treatment was quantified using the dye merocyanine 540.Apoptosis was confirmed and quantified using flow cytometric analysis of HCT15 cells subjected to p-Coumaric acid treatment after staining with YO-PRO-1.RESULTS:Antiproliferative test showed p-Coumaric acid has an inhibitory effect on HCT 15 and HT 29 cells with an IC50(concentration for 50%inhibition)value of 1400 and 1600μmol/L respectively.Colony forming assay revealed the time-dependent inhibition of HCT 15 and HT 29 cells subjected to p-Coumaric acid treatment.Propidium iodide staining of treated HCT 15cells showed increasing accumulation of apoptotic cells(37.45±1.98 vs 1.07±1.01)at sub-G1phase of the cell cycle after p-Coumaric acid treatment.HCT-15 cells observed with photomicrograph and scanning electron microscope showed the signs of apoptosis like blebbing and shrinkage after p-Coumaric acid exposure.Evaluation of the lipid layer showed increasing lipid layer breaks was associated with the growth inhibition of p-Coumaric acid.A fall in mitochondrial membrane potential and increasing ROS generation was observed in the p-Coumaric acid treated cells.Further apoptosis evaluated by YO-PRO-1 staining also showed the timedependent increase of apoptotic cells after treatment.CONCLUSION:These results depicted that p-Coumaric acid inhibited the growth of colon cancer cells by inducing apoptosis through ROS-mitochondrial pathway. | Saravana Kumar Jaganathan Eko Supriyanto Mahitosh Mandal | 2013 | World Journal of Gastroenterology2013，19，43： | 12 |
| 5 | Regulation of cyclooxygenase-2 pathway by HER2 receptor显示文摘 | Ratna V Mahitosh M Liana A | 1999 | Oncogene1999，18，2： | 1 |
| 6 | Stimulation of indoleacetic acid production in a Rhizobium isolate of Vigna mungo by root nodule phenolic acids显示文摘 | Santi M Mahitosh M Amit D | 2009 | Archives of Microbiology2009，191，： | 1 |
| 7 | Bcl-2 modulates telomerase activity显示文摘 | Mahitosh M Rakesh K | 1997 | J Biol Chem1997，272，14： | 1 |
| 8 | Gallic acid induced apoptotic events in HCT-15 colon cancer cells显示文摘AIM: To investigate the inhibitory action of diet-derived phenolic compound gallic acid(GA) against HCT-15 colon cancer cells.METHODS: The antiproliferative effect of GA against colon cancer cells was determined by performing thiazolyl blue tetrazolium bromide(MTT) assay. The colony forming ability of GA treated colon cancer cells was evaluated using the colony forming assay. The cell cycle changes induced by GA in HCT-15 cells were analyzed by propidium iodide staining. Levels of reactive oxygen species(ROS) and mitochondrial membrane potential of HCT-15 exposed to GA was assessed using 2',7'-dichlorfluorescein-diacetate and rhodamine-123 respectively, with the help of flow cytometry. Morphological changes caused by GA treatment in the colon cancer cells were identified by scanning electron microscope and photomicrograph examination. Apoptosis was confirmed using flow cytometric analysis of GA treated HCT-15 cells after staining with Yo-Pro-1.RESULTS: MTT assay results illustrated that GA has an inhibitory effect on HCT-15 cells with IC50 value of 740 μmol/L. A time-dependent inhibition of colony formation was evident with GA treatment. Cell cycle arrest was evident from the accumulation of GA treated HCT-15 cells at sub-G1 phase(0.98 ± 1.03 vs 58.01 ± 2.05)with increasing exposure time. Flow cytometric analysis of GA treated HCT-15 cells depicted early events associated with apoptosis like lipid layer breakage and fall in mitochondrial membrane potential apart from an increase in the generation of ROS which were in a time dependent manner. SEM and photomicrograph images of the GA-treated cells displayed membrane blebbing and cell shrinking characteristics of apoptosis. Further apoptosis confirmation by Yo-Pro-1 staining also showed the time-dependent increase of apoptotic cells after treatment.CONCLUSION: These results show that GA induced ROS dependent apoptosis and inhibited the growth of colon cancer cells. | Aruna Priyadharshni Subramanian Saravana Kumar Jaganathan Mahitosh Mandal Eko Supriyanto Ida Idayu Muhamad | 2016 | World Journal of Gastroenterology2016，22，15： | 1 |
| 9 | Regulation of cyclooxygenase-2 pathway by HER-2 receptor显示文摘 | Ratna V Mahitosh M Liana A | 1999 | Oncogene1999，18，2： | 1 |
| 10 | Bcl-2deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells 显示文摘 | Mahitosh J Wu Xi Rakesh K | 1997 | Carcinogenesis1997，18，： | 1 |
| 11 | Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes显示文摘 | Rupesh Dash Mahitosh Mandal Sudip K. Ghosh S. C. Kundu | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 12 | Nuclear targeting of Bax during apoptosis in human eolocecal caucer cells显示文摘 | Mahitosh M Liana A John M | 1998 | Oncogene1998，17，： | 1 |
| 13 | Effect of Honey and Eugenol on Ehrlich Ascites and Solid Carcinoma显示文摘 | Saravana Kumar Jaganathan Dilip Mondhe Z. A. Wani Harish C. Pal Mahitosh Mandal Soldano Ferrone | 2010 | Journal of Biomedicine and Biotechnology2010，，： | 1 |
| 14 | Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis显示文摘 | Saravana Kumar Jaganathan Mahitosh Mandal | 2010 | Investigational New Drugs2010，，5： | 1 |
| 15 | Bcl-2 modulates telornerase activity显示文摘 | Mahitosh M Rakesh K | 1997 | BiolChem1997，272，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员