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| 1 | Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia:a molecular docking study exploring possible neuroprotection显示文摘The main pathophysiology of cerebral ischemia is the structural alteration in the neurovascular unit, coinciding with neurovascular matrix degradation. Resveratrol has been reported to be one of the most potent chemopreventive agents that can inhibit cellular processes associated with ischemic stroke. Matrix metalloproteinases(MMPs) has been considered as a potential drug target for the treatment of cerebral ischemia. To explore this, we tried to investigate the interaction of resveratrol with MMPs through molecular docking studies. At 30 minutes before and 2 hours after cerebral ischemia/reperfusion induced by occlusion of the middle cerebral artery, 40 mg/kg resveratrol was intraperitoneally administered. After resveratrol administration, neurological function and brain edema were significantly alleviated, cerebral infarct volume was significantly reduced, and nitrite and malondialdehyde levels in the cortical and striatal regions were significantly decreased. The molecular docking study of resveratrol and MMPs revealed that resveratrol occupied the active site of MMP-2 and MMP-9. The binding energy of the complexes was –37.848672 k J/mol and –36.6345 k J/mol for MMP-2 and MMP-9, respectively. In case of MMP-2, Leu 164, Ala 165 and Thr 227 were engaged in H-Bonding with resveratrol and in case of MMP-9, H-bonding was found with Glu 402, Ala 417 and Arg 424 residues. These findings collectively reveal that resveratrol exhibits neuroprotective effects on cerebral ischemia through inhibiting MMP-2 and MMP-9 activity. | Anand Kumar Pandey Pallab Bhattacharya Swet Chand Shukla Sudip Paul Ranjana Patnaik | 2015 | Neural Regeneration Research2015，10，4： | 12 |
| 2 | 当量比对斜爆轰波诱导区特性影响的数值模拟研究显示文摘为探索斜爆轰波诱导区特性变化的内在机制,利用带H2/O2详细化学反应模型的二维欧拉方程进行数值模拟,研究了当量比对诱导区特性的影响。结果表明,随着当量比增大,诱导区长度呈U型曲线变化,在此过程中温度起到了关键作用。通过研究诱导区末端的压力分布发现,诱导区末端的压缩波强度是影响诱导区过渡形式的决定性因素。当量比在0.6~2.5时,压缩波强度较强,过渡形式为突变型,超出该范围,压缩波强度较弱,过渡形式为平滑型。此外,结合定容燃烧(CVC)理论分析了不同来流压力下的诱导区长度随当量比的变化情况,得出诱导区内的化学动力学效应影响了诱导区长度,使其沿理论所预测的U型曲线变化;气动力学效应影响了诱导区长度的变化幅度和速率,避免其过度增大或减小。 | 陈楠 Seyed Amin Esfehani Sudip Bhattrai 刘禹 唐豪 | 2018 | 推进技术2018，39，12： | 8 |
| 3 | 当量比和间隙尺寸对爆震波传播过程的影响显示文摘为探索微型脉冲爆震发动机推进系统的可行性,进行了微空间内爆震极限特性的研究.通过对预混氢气/氧气爆震火焰在平板狭缝中的传播过程进行测量,分析了爆震波压力、速度随当量比和间隙尺寸的变化趋势,发现在极限范围外,来自稳流段的爆震波都能在间隙内通过压力和速度的自我调整后达到稳定状态,调整过程所需的距离随间隙尺寸减小而增长.根据爆震波速度衰减的定义,给出了激波和火焰锋面速度沿间隙通道方向的变化特点,观察到了微尺寸下爆震波的4种传播模式:稳定爆震波、准稳定爆震波、低速爆震波和非爆震波. | 张超 唐豪 李明 Sudip Bhattrai | 2012 | 航空动力学报2012，27，9： | 7 |
| 4 | Comparative performance analysis of combinedcycle pulse detonation turbofan engines (PDTEs)显示文摘Combined-cycle pulse detonation engines are promising contenders for hypersonic propulsion systems.In the present study,design and propulsive performance analysis of combined-cycle pulse detonation turbofan engines(PDTEs)is presented.Analysis is done with respect to Mach number at two consecutive modes of operation:(1)Combined-cycle PDTE using a pulse detonation afterburner mode(PDA-mode)and(2)combined-cycle PDTE in pulse detonation ramjet engine mode(PDRE-mode).The performance of combined-cycle PDTEs is compared with baseline afterbuming turbofan and ramjet engines.The comparison of afterburning modes is done for Mach numbers from 0 to 3 at 15.24 km altitude conditions,while that of pulse detonation ramjet engine(PDRE)is done for Mach 1.5 to Mach 6 at 18.3 km altitude conditions.The analysis shows that the propulsive performance of a tubine engine can be greatly improved by replacing the conventional afterbumer with a pulse detonation afterburner(PDA).The PDRE also outperforms its ramjet counterpart at all flight conditions considered herein.The gains obtained are outstanding for both the combined-cycle PDTE modes compared to baseline turbofan and ramjet engines. | Sudip Bhattrai Hao Tangn | 2013 | Propulsion and Power Research2013，2，3： | 7 |
| 5 | Viral degradasome hijacks mitochondria to suppress innate immunity显示文摘在主人和病原体的能力的天生的免疫之间的平衡影响致病和毒力强烈躲避它。二 nonstructural (NS ) 蛋白质, NS1 和 NS2,呼吸 syncytial,病毒(RSV ) 极其为 RSV 被要求毒力。一起,他们强烈压制类型我干扰素(IFN ) 调停了由降级或禁止多重细胞的因素的主人房间的天生的免疫为 IFN 正式就职或反应要求了小径包括 RIG-I, IRF3, IRF7, TBK1 和 STAT2。这里,我们为 NS 蛋白质装配的大、异构的 degradative 建筑群的存在提供证据,我们把它称为 “ NS-degradasome”(NSD ) 。NSD 是粗略地,在尺寸的 ~ 300-750 kD,和它的 degradative 活动被净化的线粒体的增加在 vitro 提高。在房间, NS 蛋白质的多数和到在 RSV 感染之上的线粒体的 NSD translocated 的底层内。基因并且药理学证据证明天生的豁免的最佳的抑制要求 mitochondrial MAVS 和 mitochondrial 活动性。一起,我们建议在的一个新奇范例线粒体,知道为主人的天生的有免疫力的激活重要,为天生的免疫的病毒的抑制也是重要的。 | Ramansu Goswami Tanmay Majumdar Jayeeta Dhar Saurabh Chattopadhya3~ Sudip K Bandyopadhyay Valentina Verbovetskaya Ganes C Sen Sailen Barik | 2013 | Cell Research2013，23，8： | 6 |
| 6 | Z-Box Binding Transcription Factors (ZBFs): A Ne~ Class of Transcription Factors in Arabidopsis Seedlinq Development显示文摘 | Sreeramaiah N. Gangappa Anjil Kumar Srivastava Jay R Maurya Hathi Ram Sudip Chattopadhyay | 2013 | Molecular Plant2013，6，6： | 5 |
| 7 | Effect of pouring temperature on cooling slope casting of semi-solid Al-Si-Mg alloy显示文摘Present trend of semi-solid processing is directed towards rheocasting route which allows manufacturing of near-net-shape cast components directly from the prepared semi-solid slurry. Generation of globular equi-axed grains during solidification of rheocast components, compared to the columnar dendritic structure of conventional casting routes, facilitates the manufacturing of components with improved mechanical properties and structural integrity. In the present investigation, a cooling slope has been designed and indigenously fabricated to produce semi solid slurry of Al-Si-Mg (A356) alloy and successively cast in a metallic mould. The scope of the present work discusses about development of a numerical model to simulate the liquid metal flow through cooling slope using Eulerian two-phase flow approach and to investigate the effect of pouring temperature on cooling slope semi-solid slurry generation process. The two phases considered in the present model are liquid metal and air. Solid fraction evolution of the solidifying melt is tracked at different locations of the cooling slope, following Schiel s equation. The continuity equation, momentum equation and energy equation are solved considering thin wall boundary condition approach. During solidification of the liquid metal, a modified temperature recovery scheme has been employed taking care of the latent heat release and change of fraction of liquid. The results obtained from simulations are compared with experimental findings and good agreement has been found. | Prosenjit Das Sudip K. Samanta Himadri Chattopadhyay Pradip Dutta | 2012 | Acta Metallurgica Sinica(English Letters)2012，25，5： | 4 |
| 8 | 温度扰动对ODW结构影响的数值模拟显示文摘利用二维非稳态无黏可压欧拉方程模拟得到了能够稳定自持的斜爆震波(ODW)结构,在某时刻从进口边界施加一温度的瞬间变化(分别为下降100 K、上升100 K),从而得到一次温度扰动。模拟结果表明,ODW结构能够顺利过渡,但扰动传播过后,ODW的内部不稳定性被进一步被释放,胞格结构更加清晰;结合定量和定性分析发现,扰动主要以激波、膨胀波和弱压缩波3种形式在燃烧室内传播;对比2种扰动下的结果得出,3种波在爆震区内传播过程中的位置分布相同,但在爆燃区内却完全相反,造成这种结果的主要原因是2种扰动引发的弱压缩波的强度不同,从而对ODW结构调整所起到的作用也存在很大区别;在温降扰动下,3种波沿壁面向下游传播,其中激波会呈现出弓形激波、马赫反射、规则反射和近乎垂直于壁面的正激波4种形态,而在温升扰动下,3种波沿ODW面向下游传播,传播形态也较为稳定。 | 陈楠 Sudip BHATTRAI 唐豪 | 2018 | 北京航空航天大学学报2018，44，7： | 4 |
| 9 | Piroxicam-mediated modulatory action of 5-hydroxytryptamine serves as a “brake” on neuronal excitability in ischemic stroke显示文摘Our previous studies indicated an increase in extracellular γ-aminobutyric acid(GABA) in rodent's ischemic brain after Piroxicam administration, leading to alleviation of glutamate mediated excitotoxicity through activation of type A GABA receptor(GABAA). This study was to investigate if GABAA activation by Piroxicam affects extracellular 5-hydroxytryptamine or not. High performance liquid chromatography revealed that there was a significant decrease in extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum in Piroxicam pre-treated rat brains. This suggests a probable role of Piroxicam in reducing extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum possibly due to the GABAA activation by Piroxicam. | Pallab Bhattacharya Anand Kumar Pandey Sudip Paul Ranjana Patnaik | 2015 | Neural Regeneration Research2015，10，9： | 4 |
| 10 | Effect of pioglitazone on nerve conduction velocity of the median nerve in the carpal tunnel in type 2 diabetes patients显示文摘AIM To evaluate the impact of pioglitazone pharmacotherapy in median nerve electrophysiology in the carpal tunnel among type 2 diabetes patients.METHODS The study was executed in patients with type 2 diabetes, treated with oral drugs, categorized under pioglitazone or non-pioglitazone group(14 in each group), and who received electrophysiological evaluation by nerve conduction velocity at baseline and 3 mo.RESULTS At 3 mo, pioglitazone-category had inferior amplitude in sensory median nerve [8.5 interquartile range(IQR) = 6.5 to 11.5) vs non-pioglitazone 14.5(IQR 10.5 to 18.75)](P = 0.002). Non-pioglitazone category displayed amelioration in amplitude in the sensory median nerve [baseline 13(IQR = 9 to 16.25) vs 3 mo 8.5(IQR = 6.5 to 11.5)](P = 0.01) and amplitude in motor median nerve [baseline 9(IQR = 4.75 to 11) vs 3 mo 6.75(IQR = 4.75 to 10.25)](P = 0.049); and deterioration of terminal latency of in motor ulnar nerve [baseline 2.07(IQR = 1.92 to 2.25) vs 3 mo 2.16(IQR = 1.97 to 2.325)](P = 0.043). There was amelioration of terminal latency in sensory ulnar nerve [baseline 2.45(IQR = 2.315 to 2.88) vs 3 mo 2.37(IQR = 2.275 to 2.445) for pioglitazone group(P = 0.038).CONCLUSION Treatment with pioglitazone accentuates probability of compressive neuropathy. In spite of comparable glycemic control over 3 mo, patients treated with pioglitazone showed superior electrophysiological parameters for the ulnar nerve. Pioglitazone has favourable outcome in nerve electrophysiology which was repealed when the nerve was subjected to compressive neuropathy. | Sudip Chatterjee Debmalya Sanyal Sourav Das Choudhury Mili Bandyopadhyay Suraj Chakraborty Arabinda Mukherjee | 2016 | World Journal of Diabetes2016，7，19： | 3 |
| 11 | Molecular dynamics study on growth of carbon dioxide and methane hydrate from a seed crystal显示文摘In the current work,molecular dynamics simulation is employed to understand the intrinsic growth of carbon dioxide and methane hydrate starting from a seed crystal of methane and carbon dioxide respectively.This comparison was carried out because it has relevance to the recovery of methane gas from natural gas hydrate reservoirs by simultaneously sequestering a greenhouse gas like CO2.The seed crystal of carbon dioxide and methane hydrate was allowed to grow from a super-saturated mixture of carbon dioxide or methane molecules in water respectively.Two different concentrations(1:6 and 1:8.5)of CO2/CH4 molecules per water molecule were chosen based on gas–water composition in hydrate phase.The molecular level growth as a function of time was investigated by all atomistic molecular dynamics simulation under suitable temperature and pressure range which was well above the hydrate stability zone to ensure significantly faster growth kinetics.The concentration of CO2 molecules in water played a significant role in growth kinetics,and it was observed that maximizing the CO2 concentration in the aqueous phase may not result in faster growth of CO2 hydrate.On the contrary,methane hydrate growth was independent of methane molecule concentration in the aqueous phase.We have validated our results by performing experimental work on carbon dioxide hydrate where it was seen that under conditions appropriate for liquid CO2,the growth for carbon dioxide hydrate was very slow in the beginning. | Prajakta Nakate Bappa Ghosh Subhadip Das Sudip Roy Rajnish Kumar | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 2 |
| 12 | 多西紫杉醇节律化疗联合地塞米松抗小鼠肺癌血管生成的实验研究显示文摘目的探讨多西紫杉醇节律化疗及地塞米松对C57BL/6小鼠Lewis肺癌(LLC)肿瘤生长和血管生成的影响。方法C57BL/6小鼠皮下接种LLC细胞,随机分组后分别给予相应治疗。隔天测量小鼠体重及肿瘤体积。小鼠处死后称瘤重,应用免疫组化检测小鼠肿瘤组织中CD34和HIF-1α蛋白表达。结果对照组皮下瘤重明显大于节律组、地塞米松组和联合组。对照组微血管密度(MVD)明显高于三个实验组(P〈0.05),三个实验组HIF-1α蛋白表达较对照组显著下降(P〈0.05)。结论多西紫杉醇节律化疗和地塞米松可明显抑制LLC的生长及血管生成,其可能的机制之一是通过下调小鼠肿瘤组织中HIF—1α的表达而间接实现抗肿瘤血管生成作用。 | 蔡政 胡秀峰 周芳 韩颖 Soumitra sudip bhuyan 李醒亚 | 2007 | 中原医刊2007，34，8： | 2 |
| 13 | Evaluation of rapid molecular diagnostics for differentiating medicinal Kaempferia species from its adulterants显示文摘Accurate detection of unique herbs is crucial for herbal medicine preparation. Zingiberaceae species, which are important in Ayurvedic medicine of India, are often misidentified in Northeast (NE) Indian herbal markets. Kaempferia galanga (Zingiberaceae) is one of the major components of popular Ayurvedic drugs used for rheumatic diseases (i.e.,“Gandha Thailam” and “Rasnairandadi Kashayam”), contusions, fractures, and sprains. In NE India, herbal healers often misidentify plants from the Marantaceae family (e.g., Calathea bachemiana and Maranta leuconeura) as Kaempferia, which leads to adulteration of the medicinal herb. This misidentification of herbs occurs in NE India because Zingiberaceae plant barcoding information is inadequate. As a consequence, herbal medicine is not only therapeutically less effective but may also cause adverse reactions that range from mild to life-threatening. In this study, we used eight barcoding loci to develop “fingerprints” for four Kaempferia species and two species frequently mistaken for Kaempferia. The PCR and sequencing success of the loci matK, rbcL and trnH-psbA were found to be 100%;the combination of matK, rbcL, and trnH-psbA proved to be the ideal locus for discriminating the Kaempferia species from their adulterants because the combined loci showed greater variability than individual loci. This reliable tool was therefore developed in the current study for accurate identification of Kaempferia plants which can effectively resolve identification issues for herbal healers. | Supriyo Basak Ramesh Aadi Moolam Ajay Parida Sudip Mitra Latha Rangan | 2019 | Plant Diversity2019，41，3： | 2 |
| 14 | Nitration of Jharia basin coals,India:a study of structural modifications by XRD and FTIR techniques显示文摘Four coal samples from Jharia basin,India are treated with nitric acid in glacial acetic acid and aqueous media to find out the chemical,petrographic and spatial structure of the organic mass by X-ray diffraction(XRD)and Fourier Transform Infrared Spectroscopy(FTIR)techniques.X-ray parameters of coal like interlayer spacing(d_(002)),crystallite size(L_(c)),aroamticity(f_(a)),average number of aromatic layers(N_(c)),and coal rank(I_(26)/I_(20))have been determined using profilefitting software.Considerable variation is observed in treated coals in comparison to the demineralized coals.The d_(002)values of treated coals have increased in both the media showing increase in disordering of organic moieties.A linear relationship has been observed between d_(002)values with the volatile matter of the coals.Similarly,the d_(002)values show linear relationship with C_(dmf) contents for demineralized as well as for the treated coals in both the media.The L_(c) and N_(c) values have decreased in treated coals corresponding to demineralized coals.The present study shows that nitration in both the media is capable of removing the aliphatic side chains from the coals and aromaticity(f_(a))increases with increase in rank and shows a linear relationship with the vitrinite reflectance.The corresponding I_(26)/I_(20)values are least for treated coals in glacial acetic acid medium followed by raw and then to treated coals in aqueous medium.FTIR studies show that coal arenes of the raw coals are converted into nitro-arenes in structurally modified coals(SMCs)in both the media,the corresponding bands at 1550-1490 and 1355-1315 cm^(-1) respectively.FTIR study confirms that nitration is the predominant phenomenon,though,oxidation and nitration phenomena takes place simultaneously during treatment with nitric acid to form SMCs.In comparison to raw coals,the SMCs show higher aromaticity and may be easily converted to coal derived products like activated carbon and specialty carbon materials. | Prabal Boral Atul K.Varma Sudip Maity | 2021 | International Journal of Coal Science & Technology2021，8，5： | 2 |
| 15 | Timing of metamorphism and deformation in the Swat valley, northern Pakistan:Insight into garnet-monazite HREE partitioning显示文摘New metamorphic petrology and geochronology from the Loe Sar dome in the Swat region of northern Pakistan place refined constraints on the pressure, temperature and timing of metamorphism and deformation in that part of the Himalayan orogen. Thermodynamic modelling and monazite petrochronology indicate that metamorphism in the area followed a prograde evolution from ~525 ± 25 ℃and 6 士 0.5 kbar to ~610 ± 25 ℃ and 9 士 0.5 kbar, between ca. 39 Ma and 28 Ma. Partitioning of heavy rare earth elements between garnet rims and 30-28 Ma monazite are interpreted to indicate coeval crystallization at peak conditions. Microtextural relationships indicate that garnet rim growth post-dated the development of the main foliation in the area. The regional foliation is folded about large-scale N-S trending fold axes and overprinting E-W trending folds to form km-scale domal culminations. The textural relationships observed indicate that final dome development must be younger than the 30-28 Ma monazite that grew with garnet rims post-regional foliation development, but pre-doming-related deformation. This new timing constraint helps resolve discrepancy between previous interpretations,which have alternately suggested that N-S trending regional folds must be either pre-or post-early Oligocene. Finally, when combined with existing hornblende and white mica cooling ages, these new data indicate that the study area was exhumed rapidly following peak metamorphism. | Kyle P.Larson Asghar Ali Sudip Shrestha Mathieu Soret John M.Cottle Rafique Ahmad | 2019 | Geoscience Frontiers2019，10，3： | 2 |
| 16 | Obesity: A Challenge to Esophagogastric Junction Integrity显示文摘 | John E. Pandolfino Hashem B. El–Serag Qing Zhang Nimeesh Shah Sudip K. Ghosh Peter J. Kahrilas | 2006 | Gastroenterology2006，，3： | 2 |
| 17 | 显示文摘 | Norizah Abdul Rahmana Marija Gizdavic~Nikolaidisa Sudip Ray | 2010 | Synthetic Metals2010，160，1718： | 1 |
| 18 | T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity显示文摘 | Huaizhu Wu Sudip Ghosh Xiaoyuan Dai Perrard Lili Feng Gabriela E. Garcia Jerry L. Perrard John F. Sweeney Leif E. Peterson Lawrence Chan C Wayne Smith Christie M. Ballantyne | 2007 | Circulation2007，，8： | 1 |
| 19 | S29 ribosomal protein induces apoptosis in H520 cells and sensitizes them to chemotherapy显示文摘 | Neeru Khanna Sudip Sen Himani Sharma Neeta Singh | 2003 | Biochemical and Biophysical Research Communications2003，，1： | 1 |
| 20 | Algorithmic and theoretical aspects of wireless ad hoc and sensor networks显示文摘 | SUDIP MISRA SUBHAS MISRA ISAAC WOUNGANG | 2008 | Computer Communications2008，31，4： | 1 |
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