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| 1 | Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells显示文摘AIM:To investigate the events associated with the apoptotic effect of p-Coumaric acid,one of the phenolic components of honey,in human colorectal carcinoma(HCT-15)cells.METHODS:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltertazolium-bromide assay was performed to determine the antiproliferative effect of p-Coumaric acid against colon cancer cells.Colony forming assay was conducted to quantify the colony inhibition in HCT15 and HT 29 colon cancer cells after p-Coumaric acid treatment.Propidium Iodide staining of the HCT15 cells using flow cytometry was done to study the changes in the cell cycle of treated cells.Identification of apoptosis was done using scanning electron microscope and photomicrograph evaluation of HCT 15cells after exposing to p-Coumaric acid.Levels of reactive oxygen species(ROS)of HCT 15 cells exposed to p-Coumaric acid was evaluated using 2’,7’-dichlorfluorescein-diacetate.Mitochondrial membrane potential of HCT-15 was assessed using rhodamine-123 with the help of flow cytometry.Lipid layer breaks associated with p-Coumaric acid treatment was quantified using the dye merocyanine 540.Apoptosis was confirmed and quantified using flow cytometric analysis of HCT15 cells subjected to p-Coumaric acid treatment after staining with YO-PRO-1.RESULTS:Antiproliferative test showed p-Coumaric acid has an inhibitory effect on HCT 15 and HT 29 cells with an IC50(concentration for 50%inhibition)value of 1400 and 1600μmol/L respectively.Colony forming assay revealed the time-dependent inhibition of HCT 15 and HT 29 cells subjected to p-Coumaric acid treatment.Propidium iodide staining of treated HCT 15cells showed increasing accumulation of apoptotic cells(37.45±1.98 vs 1.07±1.01)at sub-G1phase of the cell cycle after p-Coumaric acid treatment.HCT-15 cells observed with photomicrograph and scanning electron microscope showed the signs of apoptosis like blebbing and shrinkage after p-Coumaric acid exposure.Evaluation of the lipid layer showed increasing lipid layer breaks was associated with the growth inhibition of p-Coumaric acid.A fall in mitochondrial membrane potential and increasing ROS generation was observed in the p-Coumaric acid treated cells.Further apoptosis evaluated by YO-PRO-1 staining also showed the timedependent increase of apoptotic cells after treatment.CONCLUSION:These results depicted that p-Coumaric acid inhibited the growth of colon cancer cells by inducing apoptosis through ROS-mitochondrial pathway. | Saravana Kumar Jaganathan Eko Supriyanto Mahitosh Mandal | 2013 | World Journal of Gastroenterology2013，19，43： | 12 |
| 2 | Role of pomegranate and citrus fruit juices in colon cancer prevention显示文摘Colorectal cancer is the second leading cause of cancer-related deaths in the United States.Recent studies prove that though chemotherapeutic agents are being used for the treatment of colon cancer,they become non-effective when the cancer progresses to an invasive stage.Since consumption of certain dietary agents has been linked with various cancers,fruit juices have been investigated for their consistently protective effect against colon cancer.The unique biochemical composition of fruit juices is responsible for their anticancer properties.In this review,the chemo-preventive effect of fruit juices such as pomegranate and citrus juices against colon cancer are discussed.For this purpose,the bioavailability,in vitro and in vivo effects of these fruit juices on colorectal cancer are highlighted.Moreover,there is a scarcity of studies involving human trials to estimate the preventive nature of these juices against colon cancer.This review will support the need for more preclinical tests with these crude juices and their constituents in different colorectal cancer cell lines and also some epidemiological studies in order to have a better understanding and promote pomegranate and citrus juices as crusaders against colon cancer. | Saravana Kumar Jaganathan Muthu Vignesh Vellayappan Gayathri Narasimhan Eko Supriyanto | 2014 | World Journal of Gastroenterology2014，20，16： | 6 |
| 3 | Chemopreventive effect of apple and berry fruits against colon cancer显示文摘Colon cancer arises due to the conversion of precancerous polyps(benign)found in the inner lining of the colon.Prevention is better than cure,and this is very true with respect to colon cancer.Various epidemiologic studies have linked colorectal cancer with food intake.Apple and berry juices are widely consumed among various ethnicities because of their nutritious values.In this review article,chemopreventive effects of these fruit juices against colon cancer are discussed.Studies dealing with bioavailability,in vitro and in vivo effects of apple and berry juices are emphasized in this article.A thorough literature survey indicated that various phenolic phytochemicals present in these fruit juices have the innate potential to inhibit colon cancer cell lines.This review proposes the need for more preclinical evidence for the effects of fruit juices against different colon cancer cells,and also strives to facilitate clinical studies using these juices in humans in large trials.The conclusion of the review is that these apple and berry juices will be possible candidates in the campaign against colon cancer. | Saravana Kumar Jaganathan Muthu Vignesh Vellayappan Gayathri Narasimhan Eko Supriyanto Dyah Ekashanti Octorina Dewi Aqilah Leela T Narayanan Arunpandian Balaji Aruna Priyadarshini Subramanian Mustafa Yusof | 2014 | World Journal of Gastroenterology2014，20，45： | 3 |
| 4 | Review of the potential of mesenchymal stem cells for the treatment of infectious diseases显示文摘The therapeutic value of mesenchymal stem cells (MSCs) for the treatment of infectious diseases and the repair of disease-induced tissue damage has been explored extensively. MSCs inhibit inflammation, reduce pathogen load and tissue damage encountered during infectious diseases through the secretion of antimicrobial factors for pathogen clearance and they phagocytose certain bacteria themselves. MSCs dampen tissue damage during infection by downregulating thelevels of pro-inflammatory cytokines, and inhibiting the excessive recruitment ofneutrophils and proliferation of T cells at the site of injury. MSCs aid in theregeneration of damaged tissue by differentiating into the damaged cell types orby releasing paracrine factors that direct tissue regeneration, differentiation, andwound healing. In this review, we discuss in detail the various mechanisms bywhich MSCs help combat pathogens, tissue damage associated with infectiousdiseases, and challenges in utilizing MSCs for therapy. | Amit Sharma Anuja Chakraborty Bithiah Grace Jaganathan | 2021 | World Journal of Stem Cells2021，13，6： | 3 |
| 5 | 龙井茶茶树种质资源低温保存特性研究显示文摘针对茶树种子在国际种质资源库建设标准下(干燥至3%~7%的含水量,-20℃保存)长期保存的可能性,研究了龙井茶种子的脱水敏感性及低温保存特性。结果表明:龙井茶不是顽拗性种子,当含水量在7%~9%时,其生命力最为旺盛;在-20℃环境下保存超过1星期后,其活性显著降低,超过3个月后种子全部失活。通过冷冻干燥技术和扫描电镜,观察了茶种子内部胚轴、胚乳和断面形态,发现当保存温度维持在-20℃时,种子失活的原因很可能是内部遭受了冰晶破坏性的损伤。 | 宋丹萍 JAGANATHAN Ganesh K. 刘威 刘宝林 | 2018 | 上海理工大学学报2018，40，5： | 2 |
| 6 | Hydrogenation of 2,4-dinitrotoluene using Pd/Al2O3 catalyst in a slurry reactor:a molecular level approach to kinetic modeling and nonisothermal effects显示文摘 | RAJASHEKHARAM M V NIKALJEE D D JAGANATHAN R | 1997 | Ind Eng Chem Res1997，36，3： | 1 |
| 7 | On the pressure drop prediction of filter media composed of fibers with bimodal diameter distributions显示文摘 | JAGANATHAN S VAHEDI T H | 2008 | Power Technology2008，181，： | 1 |
| 8 | Hand-assistedlaparoscopic nephrectomy for renal cell cancer with renal veintumor thrombus显示文摘 | Henderson A Murphy D Jaganathan K | 2008 | Urology2008，72，： | 1 |
| 9 | Involvement of non - protein thiols, mito- chondrial dysfunction, reactive oxygen species and p53 in honey -in- duced apoptosis 显示文摘 | Jaganathan SK Mandal M | 2010 | Investigational New Drugs2010，28，5： | 1 |
| 10 | Optimiastion of extracellulara tannase production from Paecilomyces variotii显示文摘 | Raaman N Mahendran B Jaganathan C | 2010 | Word Journal of Microbiology and Biotechnology2010，26，6： | 1 |
| 11 | Development of a single dose tetanus toxoid formulation based on polymeric microspheres:a comparative study of poly (d,l-lactic-co-glycolicacid) versus chitosan microspheres显示文摘 | JAGANATHAN K S RAO Y U SINGH P | 2005 | Int J Pharm2005，294，1： | 1 |
| 12 | A realistic approach for modeling permeability of fibrous media: 3-D imaging coupled with CFD simulation 显示文摘 | Jaganathan S Vahedi Tafreshi H Pourdeyhimi B | 2008 | Chemical Engineering Science2008，63，1： | 1 |
| 13 | Osmotically regulated asymmetric capsular systems for simultaneous sustained delivery of anti-tubercular drugs显示文摘 | Prabakaran D Singh P Jaganathan KS | 2004 | J Control Release2004，95，2： | 1 |
| 14 | Tumor necrosis factorrelated apoptosis-inducing ligand-mediated apoptosis in established and primary glioma cell lines显示文摘 | Jaganathan J Petit J H Lazio B E | 2002 | Neurosurg Focus2002，13，： | 1 |
| 15 | Effects of MSC co-injection on the reconstitution of aplastic anemia patient following hematopoietic stem cell transplantation显示文摘 | Jaganathan BG Tisato V Vulliamy T | | 0，，： | 1 |
| 16 | Effect of upper extremity exercise in people with COPD显示文摘 | Kathiresan G Jeyaraman KS Jaganathan J | 2010 | J Thorac Dis2010，2，4： | 1 |
| 17 | Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and aetivator of transcription 3 and epidermal growth factor receptor or Src显示文摘 | JAGANATHAN S YUE P TURKSON J | 2010 | J Pharmacol Exp Ther2010，333，2： | 1 |
| 18 | Hydrogenation of nitrobenzene to p-aminophenol in a four-phase reactor:reaction kinetics and mass transfer effects显示文摘 | Rode C V Vsidya M J Jaganathan R | 2001 | Chemical Engineering Science2001，56，4： | 1 |
| 19 | A threshold fuzzy entropy based feature selection for medical database classification显示文摘 | Jaganathan P Kuppuchamy R | 2013 | Compu- ters in Biology and Medicine2013，43，12： | 1 |
| 20 | Effect of mangiferin and mahanimbine on glucose utilization in 3T3-L1 cells显示文摘 | KUMAR D B KRISHNAKUMAR K JAGANATHAN S K | 2013 | Pharmacogn Magazine2013，，33： | 1 |
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