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| 1 | The clinical impact of bacterial biofilms显示文摘Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis. | Niels Hoiby Oana Ciofu Helle Krogh Johansen Zhi-jun Song Claus Moser Peter Ostrup Jenser Soren Molin Michael Givskov Tim Tolker-Nieisen Thomas Bjamsholt | 2011 | International Journal of Oral Science2011，3，2： | 48 |
| 2 | 减少急性冠状动脉综合征和卒中患者求医的延误——美国心脏协会心血管护理委员会和卒中委员会的科学声明显示文摘在寻求急性冠状动脉综合征和卒中症状的治疗方面,患者延误是限制提供这些疾病的确定性治疗的主要因素。尽管数十年来的研究和公众教育活动一直旨在缩短患者延误时间,但大多数患者仍然不能及时求医。在本科学声明中,我们总结了以下证据:(1)证明早期治疗的益处;(2)描述患者延误问题的程度;(3)确定与患者延误及时求医有关的因素;(4)揭示当前减少患者延误措施的不足。最后,提出临床实践和今后研究的建议。 | Debra K. Moser Laura P. Kimble Mark J. Alberts Angelo Alonzo Janet B. Croft Kathleen Dracup Kelly R. Evenson Alan S. Go Mary M. Hand Rashmi U. Kothari George A. Mensah Dexter L. Morris Arthur M. Pancioli Barbara Riegel Julie Johnson Zerwic 李宏建 曲东锋 | 2006 | 国际脑血管病杂志2006，14，10： | 39 |
| 3 | Strategies for combating bacterial biofilm infections显示文摘Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress,which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active,sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents. | Hong Wu Claus Moser Heng-Zhuang Wang Niels Hφiby Zhi-Jun Song | 2015 | International Journal of Oral Science2015，7，1： | 27 |
| 4 | 杏基因性状遗传规律分析显示文摘分析了26个杏杂交组合F_1 1235个体亲子代基因性状的遗传规律,结果表明,F_1开花期和果实成熟期比亲本平均推迟1~2周,Rossolella是晚花型亲本,Sundrop和S Castrese可作为早熟亲本;早花性与早熟性(r=0.44)和亲子代果实成熟期(r=0.55)均呈正相关;亲子代丰产性的遗传力极低,且在F_1广泛分离;子代的平均树势弱于亲本,从Hatif Colomer,Prete和Buttianese后代中可获得矮化、半矮化个体;F_1平均果个小于亲本,而Ivonne Liverani,Prete和Sundrop可作为大果亲本;果形呈数量性状遗传,F_1中,圆形和椭圆形个体明显占优势,桔红色相对于红色和黄色呈隐性,黄肉个体占绝对优势,从红肉果亲本中可分离出白肉果后代,但机率极低;F_1果实风味呈退化趋势,人工杂交子代果实风味的育种值高于自由授粉后代;子代果肉硬度的平均值低于亲本平均值,自由授粉后代果肉硬度的分离度明显高于人工杂交;离核属显性性状,由F基因控制,与粘核(半粘核)个体成3:1比例。 | 田建保 籍小琴 Nicotra A Moser L | 1993 | 山西农业科学1993，21，4： | 16 |
| 5 | Residual or recurrent cerebellar low-grade glioma in children after tumor resection: is re-treatment needed? A single center experience from 1983 to 2003显示文摘 | Benesch M Eder HG Sovinz P Raith J Lackner H Moser A Urban C | 2006 | 中国神经肿瘤杂志2006，4，3： | 15 |
| 6 | Role of microparticles in endothelial dysfunction and arterial hypertension显示文摘Microparticles are small cell vesicles that can be released by almost all eukaryotic cells during cellular stress and cell activation. Within the last 1-2 decades it has been shown that microparticles are useful blood surrogate markers for different pathological conditions, such as vascular inflammation, coagulation and tumour diseases. Several studies have investigated the abundance of microparticles of different cellular origins in multiple cardiovascular diseases. It thereby has been shown that microparticles released by platelets, leukocytes and endothelial cells can be found in conditions of endothelial dysfunction, acute and chronic vascular inflammation and hypercoagulation. In addition to their function as surrogate markers, several studies indicate that circulating microparticles can fuse with distinct target cells, such as endothelial cells or leukocyte, and thereby deliver cellular components of their parental cells to the target cells. Hence, microparticles are a novel entity of circulating, paracrine, biological vectors which can influence the phenotype, the function and presumably even the transcriptome of their target cells.This review article aims to give a brief overview about the microparticle biology with a focus on endothelial activation and arterial hypertension. More detailed information about the role of microparticles in pathophysiology and disease can be found in already published work. | Thomas Helbing Christoph Olivier Christoph Bode Martin Moser Philipp Diehl | 2014 | World Journal of Cardiology2014，6，11： | 14 |
| 7 | Psychosocial issues in evidence-based guidelines on inflammatory bowel diseases: A review显示文摘AIM:To study statements and recommendations on psychosocial issues as presented in international evidence-based guidelines on the management of inflammatory bowel diseases(IBD).METHODS:MEDLINE,guidelines International Network,National Guideline Clearing House and National Institute for Health and Care Excellence were searched from January 2006 to June 30,2013 for evidencebased guidelines on the management of IBD.RESULTS:The search yielded 364 hits.Thirteen guidelines were included in the review,of which three wereprepared in Asia,eight in Europe and two in the United States.Eleven guidelines made statements and recommendations on psychosocial issues.The guidelines were concordant in that mental health disorders and stress do not contribute to the aetiology of IBD,but that they can influence its course.It was recommended that IBD-patients should be screened for psychological distress.If indicated,psychotherapy and/or psychopharmacological therapy should be recommended.IBDcentres should collaborate with mental health care specialists.Tobacco smoking patients with Crohn’s disease should be advised to quit.CONCLUSION:Patients and mental health specialists should be able to participate in future guideline groups to contribute to establishing recommendations on psychosocial issues in IBD.Future guidelines should acknowledge the presence of psychosocial problems in IBD-patients and encourage screening for psychological distress. | Winfried Huser Gabriele Moser Petra Klose Antonina Mikocka-Walus | 2014 | World Journal of Gastroenterology2014，20，13： | 14 |
| 8 | Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies显示文摘The elastic and vibrational properties of a material,bulk or planar waveguide,are studied by Brillouin and Raman spectroscopy to follow the process of nanocrystals growth in glass-ceramics. The nanoparticles cause the appearance,in the low fre-quency Raman spectrum,of characteristic peaks,whose position depends on the size of the crystals. At the same time,sharp crystal peaks,due to optical phonons,appear in the Raman spectra,allowing the determination of the nucleated phase,and a frequency shift of the Brillouin peaks is observed. | M. Mattarelli S.Caponi A. Chiappini M. Montagna E. Moser F. Rossi C.Tosello C. Armellini A. Chiasera M. Ferrari Y. Jestin G. Nunzi Conti S. Pelli G.C. Righini | 2007 | Optoelectronics Letters2007，3，3： | 11 |
| 9 | Multimode optical fiber transmission with a deep learning network显示文摘Multimode fibers(MMFs)are an example of a highly scattering medium,which scramble the coherent light propagating within them to produce seemingly random patterns.Thus,for applications such as imaging and image projection through an MMF,careful measurements of the relationship between the inputs and outputs of the fiber are required.We show,as a proof of concept,that a deep neural network can learn the input-output relationship in a 0.75 m long MMF.Specifically,we demonstrate that a deep convolutional neural network(CNN)can learn the nonlinear relationships between the amplitude of the speckle pattern(phase information lost)obtained at the output of the fiber and the phase or the amplitude at the input of the fiber.Effectively,the network performs a nonlinear inversion task.We obtained image fidelities(correlations)as high as~98%for reconstruction and~94%for image projection in the MMF compared with the image recovered using the full knowledge of the system transmission characterized with the complex measured matrix.We further show that the network can be trained for transfer learning,i.e.,it can transmit images through the MMF,which belongs to another class not used for training/testing. | Babak Rahmani Damien Loterie Georgia Konstantinou Demetri Psaltis Christophe Moser | 2018 | Light(Science & Applications)2018，7，1： | 9 |
| 10 | 听神经病及亚型听突触病:声音编码与突触研究进展显示文摘听神经病及亚型听突触病是目前耳科学领域国际研究的难点和热点。随着听神经病在遗传学、生理学、分子细胞学以及动物模型的深入研究,逐渐明确并定义听突触病是听神经病中的一个亚型,进一步认识到突触在听神经的神经传导和声音编码中的重要作用,对听神经病及亚型听突触病的发病机制有了更加清晰的认识。本文总结国内外听神经病及亚型听突触病的最新研究进展,综述目前与其相关密切的毛细胞声音编码和突触功能研究进展的部分内容,便于更好的理解听神经病及其亚型听突触病,为临床精准的分子分型诊断干预提供理论依据。 | 王秋菊 Tobias Moser | 2019 | 中华耳科学杂志2019，17，1： | 8 |
| 11 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 12 | Robot-Assisted Minimally Invasive Distal Pancreatectomy Is Superior to the Laparoscopic Technique显示文摘 | Mustapha Daouadi Amer H. Zureikat Mazen S. Zenati Haroon Choudry Alan Tsung David L. Bartlett Steven J. Hughes Ken K. Lee A. James Moser Herbert J. Zeh | 2013 | Annals of Surgery2013，，1： | 6 |
| 13 | An ensemble method for gene discovery based on DNA microarray data显示文摘The advent of DNA microarray technology has offered the promise of casting new insights onto deciphering secrets of life by monitoring activities of thousands of genes simulta-neously. Current analyses of microarray data focus on precise classification of biological types, for example, tumor versus normal tissues. A further scientific challenging task is to extract dis-ease-relevant genes from the bewildering amounts of raw data, which is one of the most critical themes in the post-genomic era, but it is generally ignored due to lack of an efficient approach. In this paper, we present a novel ensemble method for gene extraction that can be tailored to fulfill multiple biological tasks including (i) precise classification of biological types; (ii) disease gene mining; and (iii) target-driven gene networking. We also give a numerical application for (i) and (ii) using a public microarrary data set and set aside a separate paper to address (iii). | Kathy L. MOSER Eric J. TOPOL | 2004 | Science China(Life Sciences)2004，47，5： | 5 |
| 14 | 气候变化传播:历史、挑战、进程和发展方向显示文摘20世纪80年代中后期,人为气候变化出现在公共议程中,气候变化传播开始得到广泛关注。本文梳理了有效气候传播的已有认知、假定及尚未厘清的问题,回顾了气候传播的历史,进而讨论了面临的挑战,如不可见的起因、远隔性的影响、缺乏对影响的直观感受、缺少采取减缓行动的动力、怀疑人类活动的全球性影响、气候变化的复杂性和不确定性、要做出改变的迹象不够充分、知觉局限及利己主义等。本文重点关注传播进程中的关键要素,如目的、传播范围、受众、框架、信息、传播者、传播模式和渠道、对结果和传播有效性的评估等。这些要素和一些影响传播进程的语境因素息息相关。最后本文对气候传播研究的发展方向提出了建议。 | Susanne Moser 赖晨希 | 2013 | 东岳论丛2013，34，10： | 5 |
| 15 | Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease显示文摘 | Mark L. Palmeri Michael H. Wang Ned C. Rouze Manal F. Abdelmalek Cynthia D. Guy Barry Moser Anna Mae Diehl Kathryn R. Nightingale | 2011 | Journal of Hepatology2011，，3： | 5 |
| 16 | Operational concepts of HVDC in the context of security assessment in the German transmission grid显示文摘Because of the realization of HVDC connections parallel to the synchronous grid in Germany, operational concepts become more important in the context of system security aspects. In this article commonly known concepts are analyzed regarding their suitability for the German transmission system. Therefore, an approach for the analysis was developed and exemplary results are given using this approach. Under consideration of the overall system, the concepts of reducing losses in combination with minimizing(n-1)-warnings or-indications^1 as well as the sole minimization of(n-1)-warnings and-indications are the most reasonable approaches. However, under grid security aspects best results can be achieved by reducing operational limits and therefore, by the minimization of(n-1)-warnings. | Annika Klettke Marius Sieberichs Albert Moser | 2019 | Global Energy Interconnection2019，2，2： | 5 |
| 17 | 重型汽车用柴油机4气门技术的评价和潜力显示文摘 | Moser,FX 杨杰民 | 1990 | 国外内燃机1990，22，3： | 4 |
| 18 | 罗伦佐的油治疗89例无症状性肾上腺脑白质营养不良患者的随访研究 | Moser H.W. Raymond G.V. 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，12： | 4 |
| 19 | Non-functional Neuroendocrine Carcinoma of the Pancreas: Incidence, Tumor Biology, and Outcomes in 2,158 Patients显示文摘 | Jan Franko Wentao Feng Linwah Yip Elizabeth Genovese A. James Moser | 2010 | Journal of Gastrointestinal Surgery2010，，3： | 4 |
| 20 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
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