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310篇 您的检索式:作者名="Zeh"
    题名 作者 年代 出处 被引量
1Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang 2017Cell Research2017,27,7:22
2Robot-Assisted Minimally Invasive Distal Pancreatectomy Is Superior to the Laparoscopic Technique显示文摘Mustapha Daouadi Amer H. Zureikat Mazen S. Zenati Haroon Choudry Alan Tsung David L. Bartlett Steven J. Hughes Ken K. Lee A. James Moser Herbert J. Zeh 2013Annals of Surgery2013,,1:6
3HMGB1 in health and disease显示文摘Rui Kang Ruochan Chen Qiuhong Zhang Wen Hou Sha Wu Lizhi Cao Jin Huang Yan Yu Xue-gong Fan Zhengwen Yan Xiaofang Sun Haichao Wang Qingde Wang Allan Tsung Timothy R. Billiar Herbert J. Zeh Michael T. Lotze Daolin Tang 2014Molecular Aspects of Medicine2014,,:2
4Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center显示文摘Niraj J. Gusani MD Sung W. Cho MD Christos Colovos MD PhD Songwon Seo MS Jan Franko MD PhD Scott D. Richard MD Robert P. Edwards MD Charles K. Brown MD PhD Matthew P. Holtzman MD Herbert J. Zeh MD David L. Bartlett MD 2008Annals of Surgical Oncology2008,,3:2
5Outcomes with FOLFIRINOX for borderline resectable and locally unresectable pancreatic cancer显示文摘Brian A. Boone Jennifer Steve Alyssa M. Krasinskas Amer H. Zureikat Barry C. Lembersky Michael K. Gibson Ronald G. Stoller Herbert J. Zeh Nathan Bahary 2013J Surg Oncol2013,,4:2
6The redox protein HMGB1 regu- lates cell death and survival in cancer treatment 显示文摘Tang D Loze MT Zeh HJ 2010Autophagy2010,6,8:1
7Influence of surgical approach on postoperative femoral bone remodelling after cementless total hip arthroplasty显示文摘Zeh A Pankow F R(o)llinhoff M Delank S 0,,5:1
8The Beclin 1 network regulates autophagy and apoptosis显示文摘Kang R Zeh HJ Lotze MT 2011Cell Death Differ2011,18,:1
9Identification of T-cell epitope: rapid isolation of class Ⅰ -presented peptides from viable cells by mild acid elution 显示文摘STORKUS W J ZEH H J SALTER R D 1993Immunother1993,14,2:1
10The Beclinl network regulates autophagy and apoptosis 显示文摘Kang R Zeh HJ Lotze MT 2011Cell Death Differ2011,18,4:1
11The Beclin 1 network regulates autophagy and apoptosis显示文摘Kang R Zeh H J Lotze M T Tang D 2011Cell Death Differ2011,18,4:1
12A column experiment for study of colloidal radionuclides migragion in gorleben aquifer systems 显示文摘J I Kim B Delakowityb P Zeh 1995Radiochim Acta1995,6667,:1
13Outcomes after robot-assisted for periampullary lesions 显示文摘Zeh HI Zureikat AH Secrest A 2012Ann Surg Oncol2012,19,3:1
14Repositioning for treating pressure ulcers 显示文摘Moore Zeh Cowman S 2009Cochrane Database of Systematic Reviews2009,2,:1
15Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center显示文摘Niraj J. Gusani Sung W. Cho Christos Colovos Songwon Seo Jan Franko Scott D. Richard Robert P. Edwards Charles K. Brown Matthew P. Holtzman Herbert J. Zeh David L. Bartlett 2008Annals of Surgical Oncology2008,,3:1
16The Beclin 1 network regulates autophagy and apoptosis显示文摘Kang R Zeh HJ Lotze MT 2011Cell Death Differ2011,18,4:1
17High-mobility group box 1 and cancer显示文摘Daolin Tang Rui Kang Herbert J. Zeh Michael T. Lotze 2009BBA - Gene Regulatory Mechanisms2009,,1:1
18Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons显示文摘Wald A Zeh J Selke S 2000N Engl J Med2000,342,12:1
19Dendritic cells incancer immunotherapy: vaccines or autologous transplants 显示文摘Kalinski P Edington H Zeh H J 2011Immunol Res2011,50,23:1
20Metabolic regulation by HMGB1- mediated autophagy and mitophagy 显示文摘Kang R Livesey KM Zeh HJ 2011Autophagy2011,7,10:1
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