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| 1 | Long-term alpha interferon and lamivudine combination therapy in non-responder patients with anti-HBe-positive chronic hepatitis B:Results of an open,controlled trial显示文摘AIM: To investigate the safety and efficacy of long-term combination therapy with alpha interferon and lamivudine in non-responsive patients with anti-HBe-positive chronic hepatitis B.METHODS: 34 patients received combination treatment (1 month lamivudine, 12 month lamivudine+interferon, 6month lamivudine), 24 received lamivudine (12 months),24 received interferon (12 months). Interferon was administered at 6 MU tiw and lamivudine at 100 mg orally once daily. Patients were followed up for 6 months after treatment.RESULTS: At the end of treatment, HBV DNA negativity rates were 88 % with lamivudine+interferon, 99 % with lamivudine and 55 % with interferon, (P=0.004, combination therapy vs. interferon, and P=0.001 lamivudine vs.interferon), and serum transaminase normalization rates were 84 %, 91% and 53 % (P=0.01 combination therapy vs. interferon, and P=0.012 lamivudine vs. interferon). Six months later, HBV DNA negativity rates were 44 % with lamivudine+interferon, 33 % with lamivudine and 25 % with interferon, and serum transaminase normalization rates were 61%, 42 % and 45 %, respectively, without statistical significance. No YMDD variants were observed with lamivudine+interferon (vs. 12 % with lamivudine). The combination therapy appeared to be safe. CONCLUSION: Although viral clearance and transaminase normalization are slower with long-term lamivudine+interferon than that with lamivudine alone, the combination regimen seems to provide more lasting benefits and to protect against the appearance of YMDD variants. Studies with other regimens regarding sequence and duration are needed. | M. Francesca Jaboli Carlo Fabbri Stefania Liva Francesco Azzaroli Giovanni Nigro Silvia Giovanelli Francesco Ferrara Anna Miracolo Sabrina Marchetto Marco Montagnani Antonio Colecchia Davide Festi Letizia Bacchi Reggiani Enrico Roda Giuseppe Mazzella | 2003 | World Journal of Gastroenterology2003，9，7： | 10 |
| 2 | Bone anabolics in osteoporosis: Actuality and perspectives显示文摘Vertebral and nonvertebral fractures prevention is the main goal for osteoporosis therapy by inhibiting bone resorption and/or stimulating bone formation.Antiresorptive drugs decrease the activation frequency,thereby determining a secondary decrease in bone formation rate and a low bone turnover.Bisphosphonates are today’s mainstay among antiresorptive treatment of osteoporosis.Also,oral selective estrogen receptor modulators and recently denosumab have a negative effect on bone turnover.Agents active on bone formation are considered a better perspective in the treatment of severe osteoporosis.Recombinant-human parathyroid hormone(PTH)has showed to increase bone formation and significantly decrease vertebral fractures in severe patients,but with a modest effect on nonvertebral fractures.The study of Wnt signaling pathway,that induces prevalently an osteoblastic activity,opens large possibilities to antagonists of Wnt-inhibitors,such as sclerostin antibodies and dickkopf-1 antagonists,with potential effects not only on trabecular bone but also on cortical bone. | Andrea Montagnani | 2014 | World Journal of Orthopedics2014，5，3： | 7 |
| 3 | Gastric autoimmune disorders in patients with chronic hepatitis C before,during and after interferon-alpha therapy显示文摘AIM: To explore the prevalence of autoimmune gastritis in chronic hepatitis C virus (HCV) patients and the influence of α-intefferon (IFN) treatment on autoimmune gastritis.METHODS: We performed a prospective study on 189patients with positive anti-HCV and viral RNA enrolled in a 12-month IFN protocol. We evaluated: a) the baseline prevalence of autoimmune gastritis, b) the impact of IFN treatment on development of biochemical signs of autoimmune gastritis (at 3, 6 and 12 months), c) the evolution after IFN withdrawal (12 months) in terms of anti-gastric-parietal-cell antibodies (APCA), gastrin, anti-thyroid, and anti-non-organ-specific antibodies.RESULTS: APCA positivity and 3-fold gastrin levels were detected in 3 (1.6 %) and 9 (5 %) patients, respectively, at baseline, in 25 (13 %) and 31 (16 %) patients at the end of treatment (both P<0.001, vs baseline), and in 7 (4 %) and 14 (7 %) patients 12 months after withdrawal (P=0.002and ,P=0.01 respectively, vs baseline; P=not significant vs end of treatment). The development of autoimmune gastritis was strictly associated with the presence of autoimmune thyroiditis (P =0.0001), no relationship was found with other markers of autoimmunity.CONCLUSION: In HCV patients, IFN frequently precipitates latent autoimmune gastritis, particularly in females. Following our 12-month protocol, the phenomenon generally regressed. Since APCA positivity and high gastrin levels are associated with the presence of antithyroid antibodies,development of autoimmune thyroiditis during IFN treatment may provide a surrogate preliminary indicator of possible autoimmune gastritis to limit the need for invasive examinations. | Carlo Fabbri M.Francesca Jaboli Silvia Giovanelli Francesco Azzaroli Alessandro Pezzoli Esterita Accogli Stefania Liva Giovanni Nigro Anna Miracolo Davide Festi Antonio Colecchia Marco Montagnani Enrico Roda Giuseppe Mazzella | 2003 | World Journal of Gastroenterology2003，9，7： | 3 |
| 4 | Effectiveness and safety of oxaliplatin compared to cisplatin for advanced, unresectable gastric cancer: a systematic review and meta-analysis显示文摘 | Francesco Montagnani Gina Turrisi Claudio Marinozzi Camillo Aliberti Giammaria Fiorentini | 2011 | Gastric Cancer2011，，1： | 2 |
| 5 | Acute hepatitis B caused by a vaccine-escape HBV strain in vaccinated subject: Sequence analysis and therapeutic strategy显示文摘 | Monica Luongo Rosina Critelli Antonella Grottola Stefano Gitto Veronica Bernabucci Mirco Bevini Chiara Vecchi Giuliano Montagnani Erica Villa | 2014 | Journal of Clinical Virology2014，，： | 2 |
| 6 | Indocyanine green retention test as a noninvasive marker of portal hypertension and esophageal varices in compensated liver cirrhosis显示文摘 | Andrea Lisotti Francesco Azzaroli Federica Buonfiglioli Marco Montagnani Paolo Cecinato Laura Turco Claudio Calvanese Patrizia Simoni Massimo Guardigli Rosario Arena Alessandro Cucchetti Antonio Colecchia Davide Festi Rita Golfieri Giuseppe Mazzella | 2014 | Hepatology2014，，2： | 2 |
| 7 | Severe immune thrombocytopenia after peg-interferonalpha2a, ribavirin and telaprevir treatment completion: a case report and systematic review of literature显示文摘Mild to moderate autoimmune thrombocytopenia(AITP) is a common finding in patients receiving interferonbased antiviral treatment, due to bone marrow suppression. Here we report the case of a patient with chronic genotype 1b hepatitis C virus(HCV) infection treated with pegylated-interferon alpha-2a, ribavirin and telaprevir for 24 wk; the patient developed severe AITP three weeks after treatment withdrawal. We performed a systematic literature search in order to review all published cases of AITP related to HCV antiviral treatment. To our knowledge, this is the second case of AITP observed after antiviral treatment withdrawal. In most published cases AITP occurred during treatment; in fact, among 24 cases of AITP related to interferonbased antiviral treatment, only one occurred after discontinuation. Early diagnosis of AITP is a key factor in order to achieve an early interferon discontinuation; in the era of new direct antiviral agents those patients have to be considered for interferon-free treatment regimens. Prompt prescription of immuno-suppressant treatment(i.e., corticosteroids, immunoglobulin infusion and even rituximab for unresponsive cases) leads to favourable prognosis in most of cases. Physicians using interferonbased treatments should be aware that AITP can occur both during and after treatment, specially in the new era of interferon-free antiviral treatment. Finally, in the case of suspected AITP, presence of anti-platelet antibodies should be checked not only during treatment but alsoafter discontinuation. | Rosario Arena Paolo Cecinato Andrea Lisotti Federica Buonfiglioli Claudio Calvanese Giuseppe Grande Marco Montagnani Francesco Azzaroli Giuseppe Mazzella | 2015 | World Journal of Hepatology2015，7，12： | 2 |
| 8 | Divergent apparent temperature sensitivity of terrestrial ecosystem respiration显示文摘Aims Recent studies revealed convergent temperature sensitivity of ecosys-tem respiration(Re)within aquatic ecosystems and between terrestrial and aquatic ecosystems.We do not know yet whether various terres-trial ecosystems have consistent or divergent temperature sensitivity.Here,we synthesized 163 eddy covariance flux sites across the world and examined the global variation of the apparent activation energy(Ea),which characterizes the apparent temperature sensitivity of and its interannual variability(IAV)as well as their controlling factors.Methods We used carbon fluxes and meteorological data across FLUXNET sites to calculate mean annual temperature,tempera-ture range,precipitation,global radiation,potential radiation,gross primary productivity and Re by averaging the daily values over the years in each site.Furthermore,we analyzed the sites with>8 years data to examine the IAV of Ea and calculated the standard deviation of Ea across years at each site to character-ize IAV.Important Findings The results showed a widely global variation of Ea,with significantly lower values in the tropical and subtropical areas than in temperate and boreal areas,and significantly higher values in grasslands and wetlands than that in deciduous broadleaf forests and evergreen for-ests.Globally,spatial variations of Ea were explained by changes in temperature and an index of water availability with differing contribution of each explaining variable among climate zones and biomes.IAV and the corresponding coefficient of variation of Ea decreased with increasing latitude,but increased with radiation and corresponding mean annual temperature.The revealed patterns in the spatial and temporal variations of Ea and its controlling factors indicate divergent temperature sensitivity of Re,which could help to improve our predictive understanding of Re in response to climate change. | Bing Song Shuli Niu Ruisen Luo Yiqi Luo Jiquan Chen Guirui Yu Janusz Olejnik Georg Wohlfahrt Gerard Kiely Asko Noormets Leonardo Montagnani Alessandro Cescatti Vincenzo Magliulo Beverly Elizabeth Law Magnus Lund Andrej Varlagin Antonio Raschi Matthias Peichl Mats BNilsson Lutz Merbold | 2014 | Journal of Plant Ecology2014，7，5： | 2 |
| 9 | Osteo- porosis and risk of fracture in patients with diabetes: an update显示文摘 | Montagnani A Gonnelli S Alessandri M | 2011 | Aging Clin Exp Res2011，23，2： | 1 |
| 10 | Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms显示文摘 | Kim JA Montagnani M Koh KK | 2006 | Circulation2006，113，： | 1 |
| 11 | Adiponectin stimulates production of nitric oxide in vascular endothelial ceils 显示文摘 | Chen H Montagnani M Funahashi T | 2003 | J Biol Chem2003，278，45： | 1 |
| 12 | Adiponectin stimulates production of nitric oxide in vascular endothelial cells 显示文摘 | Chen H Montagnani M Funahashi T | 2003 | J Biol Chem2003，278，45： | 1 |
| 13 | Discovery of new My- coplasma pneumoniae antigens by use of a whole - genome lambda dis- play library 显示文摘 | Beghetto E De Paolis F Montagnani F | 2009 | Microbes Infect2009，11，1： | 1 |
| 14 | Type 1 gonadotropin- releasing hormone receptor mediates the antiproliferative effects of GnRH-II on prostate cancer cells 显示文摘 | Montagnani Marelli M Moretti RM Mai S | 2009 | J Clin Endocrinol Metab2009，94，5： | 1 |
| 15 | Cardiovascular actions of insulin 显示文摘 | Muniyappa R Montagnani M Koh KK | 2007 | Endocrine reviews2007，28，5： | 1 |
| 16 | Reciprocal relationships between IR and endothelial dysfunction:molecular and pathophysiological mechanisms显示文摘 | KIM JA MONTAGNANI M KOH KK | 2006 | Circulation2006，113，15： | 1 |
| 17 | Granulocyte macrophage colony stimulating factor ( GM-CSF) biological actions on human dermal fibroblasts显示文摘 | Montagnani S Postiglione L Giordano-Lanza G | 2001 | Eur J Histochem2001，45，3： | 1 |
| 18 | Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial ceils 显示文摘 | Montagnani M Golovchenko I Kim I | 2002 | The Journal of biological chemistry2002，277，3： | 1 |
| 19 | Inhibition of phosphatidylinositol 3-kinase enhances mitogenic显示文摘 | Montagnani M Golovchenko I | 2002 | The Jourual of Biological Chemistry2002，1，18： | 1 |
| 20 | Reciprocal relationships between insulin resistance and endothelial dysfunction:molecular and pathophysiological mechanisms显示文摘 | Kim JA Montagnani M Koh KK | 2006 | Circulation2006，113，15： | 1 |
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