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| 1 | Stem cells for end stage liver disease: How far have we got?显示文摘End stage liver disease (ESLD) is a health problem worldwide. Liver transplantation is currently the only effective therapy, but its many drawbacks include a shortage of donors, operative damage, risk of rejection and in some cases recidivism of the pre-transplant disease. These factors account for the recent growing interest in regenerative medicine. Experiments have sought to identify an optimal source of stem cells, sufficient to generate large amounts of hepatocytes to be used in bioartificial livers or injected in vivo to repair the diseased organ. This update aims to give non-stem cell specialists an overview of the results obtained to date in this fascinating field of biomedical research. | Stefania Lorenzini Stefano Gitto Elena Grandini Pietro Andreone Mauro Bernardi | 2008 | World Journal of Gastroenterology2008，14，29： | 8 |
| 2 | Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis显示文摘 | Erica Villa Calogero Cammà Marco Marietta Monica Luongo Rosina Critelli Stefano Colopi Cristina Tata Ramona Zecchini Stefano Gitto Salvatore Petta Barbara Lei Veronica Bernabucci Ranka Vukotic Nicola De Maria Filippo Schepis Aimilia Karampatou Cristian Ca | 2012 | Gastroenterology2012，，5： | 5 |
| 3 | Gastroesophageal reflux and congenital gastrointestinal malformations显示文摘Although the outcome of newborns with surgical congenital diseases(e.g.,diaphragmatic hernia;esophageal atresia;omphalocele;gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery,infant survivors often require intensive treatment after birth,have prolonged hospitalizations,and,after discharge,may have longterm sequelae including gastro-intestinal comorbidities,above all,gastroesophageal reflux(GER).This condition involves the involuntary retrograde passage of gastric contents into the esophagus,with or without regurgitation or vomiting.It is a well-recognized condition,typical of infants,with an incidence of 85%,which usually resolves after physiological maturation of the lower esophageal sphincter and lengthening of the intra-abdominal esophagus,in the first few months after birth.Although the exact cause of abnormal esophageal function in congenital defects is not clearly understood,it has been hypothesized that common(increased intra-abdominal pressure after closure of the abdominal defect) and/or specific(e.g.,motility disturbance of the upper gastrointestinal tract,damage of esophageal peristaltic pump) pathological mechanisms may play a role in the etiology of GER in patients with birth defects.Improvement of knowledge could positively impact the long-term prognosis of patients with surgical congenital diseases.The present manuscript provides a literature review focused on pathological and clinical characteristics of GER in patients who have undergone surgical treatment for congenital abdominal malformations. | Lucia Marseglia Sara Manti Gabriella D'Angelo Eloisa Gitto Carmelo Salpietro Antonio Centorrino Gianfranco Scalfari Giuseppe Santoro Pietro Impellizzeri Carmelo Romeo | 2015 | World Journal of Gastroenterology2015，21，28： | 3 |
| 4 | Liver transplantation from hepatitis B surface antigen positive donors: A safe way to expand the donor pool显示文摘 | Elisabetta Loggi Lorenzo Micco Giorgio Ercolani Alessandro Cucchetti Florian K. Bihl Gian Luca Grazi Stefano Gitto Andrea Bontadini Mauro Bernardi Paolo Grossi Alessandro Nanni Costa Antonio Daniele Pinna Christian Brander Pietro Andreone | 2011 | Journal of Hepatology2011，，3： | 2 |
| 5 | Role of the diet as a link between oxidative stress and liver diseases显示文摘Oxidative stress is caused by an imbalance between the production of reactive oxygen(free radicals) and the body's ability(antioxidant capacity) to readily detoxify the reactive intermediates or easily repair the resulting damage. An adequate diet, characterized by daily intake of foods associated with improvementsin the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation, can modulate the degree of oxidative stress. In fact, dietderived micronutrients may be direct antioxidants, or are components of antioxidant enzymes, leading to improvement of some indicators of hepatic function. However, although their increased dietary intake might be beneficial, literature data are still controversial. This review summarizes what is known about the effects of diet nutrients on oxidative stress, inflammation and liver function. Moreover, we have analyzed:(1) the main nutritional components involved in the production and/or removal of free radicals; and(2) the role of free radicals in the pathogenesis of several hepatic diseases and related comorbidities. | Teresa Arrigo Salvatore Leonardi Caterina Cuppari Sara Manti Angela Lanzafame Gabriella D'Angelo Eloisa Gitto Lucia Marseglia Carmelo Salpietro | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 6 | Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation显示文摘AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic regression.RESULTS: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, 'too sick to be treated' and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the 'non-responders'(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence. | Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone | 2015 | World Journal of Gastroenterology2015，21，13： | 2 |
| 7 | Acute hepatitis B caused by a vaccine-escape HBV strain in vaccinated subject: Sequence analysis and therapeutic strategy显示文摘 | Monica Luongo Rosina Critelli Antonella Grottola Stefano Gitto Veronica Bernabucci Mirco Bevini Chiara Vecchi Giuliano Montagnani Erica Villa | 2014 | Journal of Clinical Virology2014，，： | 2 |
| 8 | Effect of weight reduction on leptin, total ghrelin and obestatin concentrations in prepubertal chiidren显示文摘 | Arrigo T Gitto E Ferrall V | 2012 | J Bioi Regul Homeost Agents2012，26，： | 1 |
| 9 | Intralimb joint coordination patterns of the lower extremity in maximal velocity phase sprint running 显示文摘 | GITTOES M WILSON C | 2010 | J Appl Biom2010，26，2： | 1 |
| 10 | 11beta-hydroxysteroid dehydrogenases,cell proliferation and malignancy显示文摘 | Rabbitt EH Gittoes NJ Stewart PM | 2003 | J Steroid Biochem Mol Biol2003，85，： | 1 |
| 11 | PTTG-a new pituitary tumour transforming gene显示文摘 | McCabe CJ Gittoes NJ | 1999 | J Endocrinol1999，162，2： | 1 |
| 12 | Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage显示文摘 | REITER RJ TAN DX GITTO E | 2004 | Pol J Pharmacol2004，56，2： | 1 |
| 13 | Oxidative stress of the newbornin the pre- and postnatal period arid the clinical utility of melatonin显示文摘 | Gitto E Pellegrino S Gitto P | 2009 | J Pineal Res2009，46，2： | 1 |
| 14 | Pituitary radiotherapy: current controversies 显示文摘 | Gittoes NJ | 2005 | Trends Endocrinol Metab2005，16，： | 1 |
| 15 | Relative efficacies of indole antioxidants in reducing autoxidation and iron induced lipid peroxidation in hamster testes 显示文摘 | KARBOWNIK M GITTO E LEWINSKI A | 2001 | J Cell Biochem2001，81，4： | 1 |
| 16 | Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns:Reduction by melatonin显示文摘 | Fulia F Gitto E Cuzzocrea S | | 0，，： | 1 |
| 17 | Individual and synergistic antioxidative actions of melatonin: studies with vitamin E,vitamin C, glutathione and desferoxamine in liver homogenates显示文摘 | Gitto E Tan DX Reiter RJ | 2001 | J Pharm Pharmacol2001，53，7： | 1 |
| 18 | Radiotherapy for non-functio-ning pituitary adenomas显示文摘 | Boelaert K Gittoes NJL | 2001 | Eur J Endocrinal2001，144，： | 1 |
| 19 | Improving care through health economies analyses: cost of illness and headaehe 显示文摘 | Mennini FS Gitto L Martelletti P | 2008 | Headache Pain2008，9，4： | 1 |
| 20 | Diagnosis and management of hypocalcae?mia显示文摘 | CooperMS Gittoes NJ | 2008 | BMJ2008，336，7656： | 1 |
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