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| 1 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 2 | The Epidemiology of Gastroenteropancreatic Neuroendocrine Tumors显示文摘 | Ben Lawrence Bjorn I. Gustafsson Anthony Chan Bernhard Svejda Mark Kidd Irvin M. Modlin | 2011 | Endocrinology and Metabolism Clinics of North America2011，，1： | 6 |
| 3 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 4 | The diagnosis and management of adult intussusception显示文摘 | Dennis G. Begos Andras Sandor Irvin M. Modlin | 1997 | The American Journal of Surgery1997，，2： | 4 |
| 5 | Diagnosis, objective assessment of severity, and management of acute pancreatitis显示文摘 | C. Dervenis C. D. Johnson C. Bassi E. Bradley C. W. Imrie M. J. McMahon I. Modlin | 1999 | International Journal of Pancreatology1999，，3： | 4 |
| 6 | Current Status of Gastrointestinal Carcinoids显示文摘 | Irvin M. Modlin Mark Kidd Igor Latich Michelle N. Zikusoka Michael D. Shapiro | 2005 | Gastroenterology2005，，6： | 2 |
| 7 | The diagnosis and management of adult intussusception显示文摘 | Begos DC Sandor A Modlin IM | 1997 | Am J Surg1997，173，1： | 1 |
| 8 | The toll of innate immunity on microbial pathogens 显示文摘 | Modlin R L Brightbill H D Godowski P J | 1999 | N Engl J Med1999，340，23： | 1 |
| 9 | Control of Mycobacterium tubercu- losis through mammalian Toll-like receptors 显示文摘 | Stenger S Modlin RL | 2002 | Curr Opin Immuno12002，14，4： | 1 |
| 10 | CTL-me- diated killing of intracellular Mycobacterium tubercu- losis is independent of target cell nuclear apoptosis 显示文摘 | Thoma-Uszynski S Stenger S Modlin RL | 2000 | J Immunol2000，165，10： | 1 |
| 11 | Effect of temperature and body size on oxygen consumption of two species of eubranchipus (Crustacea:Anostraca)显示文摘 | | 1983 | Am Midl Nat1983，109，： | 1 |
| 12 | A 5-decade analysis of 13715 carcinoid tumors显示文摘 | Modlin IM Lye KD Kidd M | 2003 | Cancer2003，97，4： | 1 |
| 13 | An analysis of 8305 cases of carcinoid tumors显示文摘 | Modlin IM Sandor A | 1997 | Cancer1997，79，4： | 1 |
| 14 | Neuroendocrine tumors of the diffuse neuroendocrine system显示文摘 | Gustafsson BI Kidd M Modlin IM | 2008 | Curr Opin Oncol2008，20，1： | 1 |
| 15 | Chromogranin A—Biological Function and Clinical Utility in Neuro Endocrine Tumor Disease显示文摘 | Irvin M. Modlin Bjorn I. Gustafsson Steven F. Moss Marianne Pavel Apostolos V. Tsolakis Mark Kidd | 2010 | Annals of Surgical Oncology2010，，9： | 1 |
| 16 | A 5-decade analysis of 13,715 carcinoid tumors 显示文摘 | Modlin IM Lye KD Kidd M | 2003 | Cancer2003，97，4： | 1 |
| 17 | Carcinoid tumors of the stomach显示文摘 | Modlin IM Lye KD Kidd M | 2003 | Surg Oncol2003，12，2： | 1 |
| 18 | Denervated muscles in humans: limitations and problems of currently used functional electrical stimulation training protocols 显示文摘 | Kern H Hofer C Modlin M | 2002 | Artif Organs2002，26，3： | 1 |
| 19 | Neuroendocrine Tumors of the Gallbladder: An Evaluation and Reassessment of Management Strategy显示文摘 | Karim M. Eltawil Bjorn I. Gustafsson Mark Kidd Irvin M. Modlin | 2010 | Journal of Clinical Gastroenterology2010，，10： | 1 |
| 20 | Diagnosis and management of non-erosive reflux disease-the Vevey NERD Consensus Group显示文摘 | MODLIN I M HUNT R H MALFERTHEINER P | 2009 | Diges- tion2009，80，： | 1 |
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