|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Weight gain following breast cancer diagnosis: Implication and proposed mechanisms显示文摘Weight gain occurs in the majority of women following breast cancer treatment. An overview of studies describing weight gain amongst women treated with early to modern chemotherapy regimens is included. Populations at higher risk include women who are younger, closer to ideal body weight and who have been treated with chemotherapy. Weight gain ranges between 1 to 5 kg, and may be associated with change in body composition with gain in fat mass and loss in lean body mass. Women are unlikely to return to pre-diagnosis weight. Possible mechanisms including inactivity and metabolic changes are explored. Potential interventions are reviewed including exercise, dietary changes andpharmacologic agents. Although breast cancer prognosis does not appear to be significantly impacted, weight gain has negative consequences on quality of life and overall health. Future studies should explore change in body composition, metabolism and insulin resistance. Avoiding weight gain in breast cancer survivors following initial diagnosis and treatment should be encouraged. | Grace Makari-Judson Barry Braun D Joseph Jerry Wilson C Mertens | 2014 | World Journal of Clinical Oncology2014，5，3： | 8 |
| 2 | Long-term antifibrotic action of interferon-γ treatment in patients with chronic hepatitis B virus infection显示文摘BACKGROUND:The first priority in treating fibrosis is to eliminate the causes that result in liver injury,e.g.,hepatitis B and C virus.However,in many liver diseases the cause is either unknown or untreatable.The present study was designed to investigate the long-term antifibrotic effect of interferon-gamma(IFN-γ)treatment in patients chronically infected with hepatitis B virus. METHODS:A total of 42 patients,30 treated with IFN-γand 12 controls,were enrolled from an original clinical trial(Clin Gastroenterol Hepatol 2005;3:819.).Three serial liver biopsies that were obtained at the initiation and end of IFN-γtreatment as well as 4 to 6 years after treatment discontinuation were assessed according to the modified Chevallier scoring system. RESULTS:Twenty-five out of 30 IFN-γ-treated patients were followed up until 4 to 6 years after the treatment was stopped. However,all controls were excluded from follow-up due to death,loss and elevated virus level within 2 years.Twenty-five IFN-γ-treated patients had stable serum liver function and liver fibrosis indices without any further antiviral or anti-fibrotic treatment.Improved inflammatory and fibrotic scores were found after nine months of IFN-γtreatment according to the modified Chevallier scoring system(inflammation:11.8±6.5 at the beginning of IFN-γtreatment vs.9.2±4.1 after 9 months, P<0.05;fibrosis:15.0±7.3 at baseline vs.12.6±6.8 after 9 months, P<0.05).Among them,14 patients accepted a third serial liver biopsy 4 to 6 years after treatment discontinuation,and the fibrotic score was increased(14.2±8.3 vs.11.9±7.6 after 9 months, P<0.05). CONCLUSIONS:Nine-month IFN-γtreatment significantly improves the fibrosis score in patients with chronic HBV infection.The majority of patients demonstrate stable serum biochemical indices and quality of life.However,they do not show a long-term benefit according to histological criteria. Given the limited sample size,long-term IFN-γtreatment regimens should be assessed in further clinical trials. | Peter R Mertens Steven Dooley | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 6 |
| 3 | Scalable and controlled self-assembly of aluminum-based random plasmonic metasurfaces显示文摘Subwavelength metal-dielectric plasmonic metasurfaces enable light management beyond the diffraction limit.However,a costeffective and reliable fabrication method for such structures remains a major challenge hindering their full exploitation.Here,we propose a simple yet powerful manufacturing route for plasmonic metasurfaces based on a bottom-up approach.The fabricated metasurfaces consist of a dense distribution of randomly oriented nanoscale scatterers composed of aluminum(Al)nanohole-disk pairs,which exhibit angle-independent scattering that is tunable across the entire visible spectrum.The macroscopic response of the metasurfaces is controlled via the properties of an isolated Al nanohole-disk pair at the nanoscale.In addition,the optical field confinement at the scatterers and their random distribution of sizes result in a strongly enhanced Raman signal that enables broadly tunable excitation using a single substrate.This unique combination of a reliable and lithography-free methodology with the use of aluminum permits the exploitation of the full potential of random plasmonic metasurfaces for diagnostics and coloration. | Radwanul Hasan Siddique Jan Mertens Hendrik Hölscher Silvia Vignolini | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 4 | Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells显示文摘AIM To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeuticallyapproach for cholangiocellular cancer treatment. METHODS As most cholangiocarcinomas are chemotherapyresistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma(CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases(PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727(Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and q RT-PCR were used to measure expression levels of apoptosis-related molecules Bax and Bcl-2. RESULTS The cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by co-treatment with BI6727.CONCLUSION In conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect. | Svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 5 | Neoadjuvant peptide receptor radionuclide therapy for an inoperable neuroendocrine pancreatic tumor显示文摘Pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the abdomen.At diagnosis many of them are already advanced and diff icult to treat.We report on an initially inoperable malignant pancreatic endocrine tumor in a 33-year-old woman,who received neoadjuvant peptide receptor radionuclide therapy(PRRT)as firstline treatment.This resulted in a signif icant downstaging of the tumor and allowed its subsequent complete surgical removal.Follow-up for eighteen months revealed a complete remission.This is the first report on neoadjuvant PRRT in a neuroendocrine neoplasm with subsequent successful complete resection. | Daniel Kaemmerer Vikas Prasad Wolfgang Daffner Dieter Hrsch Günter Klppel Merten Hommann Richard P Baum | 2009 | World Journal of Gastroenterology2009，15，46： | 2 |
| 6 | 儿童癌症幸存者成年后的慢性疾病显示文摘由于治疗方法的进步,近80%的儿童和青少年癌症患者能够长期生存。在美国,约有270000例儿童癌症的幸存者,即每640名20至39岁成年人中就有一名幸存者。大量的幸存者有利于儿童癌症治疗后长期健康结果的研究。现在可以明确的是,化疗和放疗所致的儿童各器官系统损害在临床上可能潜伏多年。 | Oeffinger KC Mertens AC Sklar CA 贾荟(译) 郑胡镛(校) | 2007 | 国际输血及血液学杂志2007，30，5： | 2 |
| 7 | Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage显示文摘 | Steven Dooley Jafar Hamzavi Loredana Ciuclan Patricio Godoy Iryna Ilkavets Sabrina Ehnert Elke Ueberham Rolf Gebhardt Stephan Kanzler Andreas Geier Katja Breitkopf Honglei Weng Peter R. Mertens | 2008 | Gastroenterology2008，，2： | 2 |
| 8 | A hedgehog survival pathway in ‘undead’ lipotoxic hepatocytes显示文摘 | Keisuke Kakisaka Sophie C. Cazanave Nathan W. Werneburg Nataliya Razumilava Joachim C. Mertens Steve F. Bronk Gregory J. Gores | 2012 | Journal of Hepatology2012，，4： | 2 |
| 9 | Effect of annealing atmosphere on the galvanizing behavior of a dual-phase steel显示文摘 | R. Khondker A. Mertens J.R. McDermid | 2006 | Materials Science & Engineering A2006，，1： | 2 |
| 10 | Mannose metabolism normalizes gut homeostasis by blocking the TNF-α-mediated proinflammatory circuit显示文摘Mannose is a naturally occurring sugar widely consumed in the daily diet;however,mechanistic insights into how mannose metabolism affects intestinal inflammation remain lacking.Herein,we reported that mannose supplementation ameliorated colitis development and promoted colitis recovery.Macrophage-secreted inflammatory cytokines,particularly TNF-α,induced pathological endoplasmic reticulum stress(ERS)in intestinal epithelial cells(IECs),which was prevented by mannose via normalization of protein N-glycosylation.By preserving epithelial integrity,mannose reduced the inflammatory activation of colonic macrophages.On the other hand,mannose directly suppressed macrophage TNF-αproduction translationally by reducing the glyceraldehyde 3-phosphate level,thus promoting GAPDH binding to TNF-αmRNA.Additionally,we found dysregulated mannose metabolism in the colonic mucosa of patients with inflammatory bowel disease.Finally,we revealed that activating PMM2 activity with epalrestat,a clinically approved drug for the treatment of diabetic neuropathy,elicited further sensitization to the therapeutic effect of mannose.Therefore,mannose metabolism prevents TNF-α-mediated pathogenic crosstalk between IECs and intestinal macrophages,thereby normalizing aberrant immunometabolism in the gut. | Peng Xiao Ziwei Hu Jiaheng Lang Tianyuan Pan Randall Tyler Mertens Huilun Zhang Ke Guo Manlu Shen Hongqiang Cheng Xue Zhang Qian Cao Yuehai Ke | 2023 | Cellular & Molecular Immunology2023，20，2： | 2 |
| 11 | Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer显示文摘 | Rosa F. Hwang Todd T. Moore Maureen Mertens Hattersley Meghan Scarpitti Bin Yang Erik Devereaux Vijaya Ramachandran Thiruvengadam Arumugam Baoan Ji Craig D. Logsdon Jeffrey L. Brown Robert Godin | 2012 | Molecular Cancer Research2012，，9： | 2 |
| 12 | Influence of TNF on the sialylation of mueins produced by a transformed cell line MM-39 dedrived from human tracheal gland cells显示文摘 | Delmotte P Degroote S Merten MD | 2001 | Glycoconj J2001，18，： | 1 |
| 13 | The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells 显示文摘 | Crnkovic - Mertens I Muley T Meister M | 2006 | Lung Cancer2006，54，2： | 1 |
| 14 | Use of point spread and beam spread functions for analysis of imagining systems in water 显示文摘 | Mertens L E Replogle F S | 1977 | Opt Soc Am1977，67，8： | 1 |
| 15 | Radiologic staging of thoracoabdominal tumors in childhood显示文摘 | Merten DF Gold SH | 1994 | Radiol Clin North Am1994，32，1： | 1 |
| 16 | Endoscopic and ultrasonographic evaluation of the maxillary sinus after combined sinus floor auginentation and implant insertion显示文摘 | Wiltfang J Schultze-Mosgan S Merten HA | 2000 | Oral Surg Oral Med Oral Pathol Oral Radial Endod2000，89，3： | 1 |
| 17 | Propofol reduces perioperative remifentanil requirements in asynergistic manner : response surface modeling of perioperative remifentanil propofol interactions显示文摘 | Mertens MJ Olofsen E Engbers FH | 2003 | Anest Hesiol2003，99，： | 1 |
| 18 | Evaluation of a rapid real-time RT-PCR assay for detection of enterovirus RNA in cerebrospinal fluid specimens 显示文摘 | Verstrepen WA Bruynseels P Mertens AH | 2002 | J Clin Virol2002，25，1： | 1 |
| 19 | Metal uptake by young trees from dredged brackish sediment:Limitations and possibilities for phytoextraction and phytostabilisation显示文摘 | MERTENS J VERVAEKE P SCHRIJVER A D | | Science of the total environ- ment0，326，： | 1 |
| 20 | Developments of Nonthermal Processes for Food Preservation显示文摘 | Mertens B Knorr D | 1992 | Food Technol1992，46，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员