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| 1 | Non-invasive determination of hepatic steatosis by acoustic structure quantification from ultrasound echo amplitude显示文摘AIM:To use leptin-deficient(ob/ob) mice with demonstrated differences in steatosis levels to test a new diagnostic method using the acoustical structure quantification(ASQ) mode and the associated analytical parameter,'focal disturbance ratio'(FD-ratio).METHODS:Nine ob/ob mice,at 5,8,and 12 wk of age(n = 3 in each age group),were used as models for hepatic steatosis.Echo signals obtained from ultrasonography in the mice were analyzed by ASQ,which uses a statistical analysis of echo amplitude to estimate inhomogeneity in the diagnostic region.FD-ratio,as calculated from this analysis,was the focus of the present study.FD-ratio and fat droplet areas and sizes were compared between age groups.RESULTS:No fibrosis or inflammation was observed in any of the groups.The fat droplet area significantly(P < 0.01) increased with age from 1.25% ± 0.28% at 5 wk to 31.07% ± 0.48% at 8 wk to 51.69% ± 3.19% at 12 wk.The median fat droplet size also significantly(P < 0.01) increased with age,from 1.33(0.55-10.52) m at 5 wk,2.82(0.61-44.13) m at 8 wk and 6.34(0.66-81.83) m at 12 wk.The mean FD-ratio was 0.42 ± 0.11 at 5 wk,0.11 ± 0.05 at 8 wk,and 0.03 ± 0.02 at 12 wk.The FD-ratio was significantly lower at 12 wk than at 5 wk and 8 wk(P < 0.01).A significant negative correlation was observed between the FD-ratio and either the fat droplet area(r =-0.7211,P = 0.0017) or fat droplet size(r =-0.9811,P = 0.0052).CONCLUSION:This tool for statistical analysis of signals from ultrasonography using the FD-ratio can be used to accurately quantify fat in vivo in an animal model of hepatic steatosis,and may serve as a quantitative biomarker of hepatic steatosis. | Hidekatsu Kuroda Keisuke Kakisaka Naohisa Kamiyama Takayoshi Oikawa Mio Onodera Kei Sawara Kanta Oikawa Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki | 2012 | World Journal of Gastroenterology2012，18，29： | 15 |
| 2 | Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique显示文摘AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus(HCV) using superb microvascular imaging(SMI) and investigate the use of SMI in the evaluation of liver fibrosis.METHODS: SMI was performed in 100 HCV patients. SMI images were classified into five types according to the vascular pattern, and these patterns were compared with the fibrosis stage. Moreover, the images were analyzed to examine vascularity by integrating the number of SMI signals in the region of interest ROI [number of vascular trees(VT)]. The number of VT, fibrosis stage, serum parameters of liver function, and CD34 expression were investigated.RESULTS: There was a significant difference between SMI distribution pattern and fibrosis stage(P < 0.001). The mean VT values in each of the fibrosis stages were as follows: 26.69 ± 7.08 in F0, 27.72 ± 9.32 in F1, 36.74 ± 9.23 in F2, 37.36 ± 5.32 in F3, and 58.14 ± 14.08 in F4. The VT showed excellent diagnostic ability for F4 [area under the receiver operator characteristic(AUROC): 0.911]. The VT was significantly correlated with the CD34 labeling index(r = 0.617, P < 0.0001).CONCLUSION: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients. | Hidekatsu Kuroda Tamami Abe Keisuke Kakisaka Yudai Fujiwara Yuichi Yoshida Akio Miyasaka Kazuyuki Ishida Hideaki Ishida Tamotsu Sugai Yasuhiro Takikawa | 2016 | World Journal of Gastroenterology2016，22，26： | 12 |
| 3 | Hepatectomy for hepatocellular carcinoma with portal vein tumor thrombus显示文摘Despite surgical removal of tumors with portal vein tumor thrombus(PVTT) in hepatocellular carcinoma(HCC) patients, early recurrence tends to occur, and overall survival(OS) periods remain extremely short. The role that hepatectomy may play in long-term survival for HCC with PVTT has not been established. The operative mortality of hepatectomy for HCC with PVTT has also not been reviewed. Hence, we reviewed recent literature to assess these parameters. The OS of patients who received hepatectomy in conjunction with multidisciplinary treatment tended to be superior to that of patients who did not. Multidisciplinary treatments included the following: preoperative radiotherapy on PVTT; preoperative transarterial chemoembolization(TACE); subcutaneous administration of interferon-alpha(IFN-α) and intra-arterial infusion of 5-fluorouracil(5-FU) with infusion chemotherapy in the affected hepatic artery; cisplatin, doxorubicin and 5-FU locally administered in the portal vein; and subcutaneous injection of IFN-α, adjuvant chemotherapy(5-FU + Adriamycin) administration via the portal vein with postoperative TACE, percutaneous isolated hepatic perfusion and hepatic artery infusion and/or portal vein chemotherapy. The highest reported rate of operative mortality was 9.3%. In conclusion, hepatectomy for patients affected by HCC with PVTT is safe, has low mortality and might prolong survival in conjunction with multidisciplinary treatment. | Toshiya Kamiyama Tatsuhiko Kakisaka Tatsuya Orimo Kenji Wakayama | 2017 | World Journal of Hepatology2017，9，36： | 8 |
| 4 | Significance of functional hepatic resection rate calculated using 3D CT/^(99m)Tc-galactosyl human serum albumin singlephoton emission computed tomography fusion imaging显示文摘AIM: To evaluate the usefulness of the functional hepatic resection rate(FHRR) calculated using 3D computed tomography(CT)/^(99m)Tc-galactosyl-human serum albumin(GSA) single-photon emission computed tomography(SPECT) fusion imaging for surgical decision making. METHODS: We enrolled 57 patients who underwent bi- or trisectionectomy at our institution between October 2013 and March 2015. Of these, 26 patients presented with hepatocellular carcinoma, 12 with hilar cholangiocarcinoma, six with intrahepatic cholangiocarcinoma, four with liver metastasis, and nine with other diseases. All patients preoperatively underwent three-phase dynamic multidetector CT and ^(99m)Tc-GSA scintigraphy. We compared the parenchymal hepatic resection rate(PHRR) with the FHRR, which was defined as the resection volume counts per total liver volume counts on 3D CT/^(99m)Tc-GSA SPECT fusion images.RESULTS: In total, 50 patients underwent bisectionectomy and seven underwent trisectionectomy.Biliary reconstruction was performed in 15 patients, including hepatopancreatoduodenectomy in two. FHRR and PHRR were 38.6 ± 19.9 and 44.5 ± 16.0, respectively; FHRR was strongly correlated with PHRR. The regression coefficient for FHRR on PHRR was 1.16(P < 0.0001). The ratio of FHRR to PHRR for patients with preoperative therapies(transcatheter arterial chemoembolization, radiation, radiofrequency ablation, etc.), large tumors with a volume of > 1000 m L, and/or macroscopic vascular invasion was significantly smaller than that for patients without these factors(0.73 ± 0.19 vs 0.82 ± 0.18, P < 0.05). Postoperative hyperbilirubinemia was observed in six patients. Major morbidities(Clavien-Dindo grade ≥ 3) occurred in 17 patients(29.8%). There was no case of surgeryrelated death.CONCLUSION: Our results suggest that FHRR is an important deciding factor for major hepatectomy, because FHRR and PHRR may be discrepant owing to insufficient hepatic inflow and congestion in patients with preoperative therapies, macroscopic vascular invasion, and/or a tumor volume of > 1000 m L. | Yosuke Tsuruga Toshiya Kamiyama Hirofumi Kamachi Shingo Shimada Kenji Wakayama Tatsuya Orimo Tatsuhiko Kakisaka Hideki Yokoo Akinobu Taketomi | 2016 | World Journal of Gastroenterology2016，22，17： | 6 |
| 5 | A hedgehog survival pathway in ‘undead’ lipotoxic hepatocytes显示文摘 | Keisuke Kakisaka Sophie C. Cazanave Nathan W. Werneburg Nataliya Razumilava Joachim C. Mertens Steve F. Bronk Gregory J. Gores | 2012 | Journal of Hepatology2012，，4： | 2 |
| 6 | Elevation of serum thioredoxin levels in patients with type 2 diabetes显示文摘 | Kakisaka Y Nakashima T Sumida Y | 2002 | Horm Metab Res2002，34，： | 1 |
| 7 | Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis(2D-DIGE):up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer显示文摘 | KAKISAKA T KONDO T OKANO T | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，852，： | 1 |
| 8 | Plasma proteomics of pancreatic cancer patients by multidimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE) : Upregulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer 显示文摘 | Kakisaka T Kondo T Okano T | 2007 | J Chromatogr B2007，852，12： | 1 |
| 9 | Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis(2D-DIGE):up-regulation Of leucine-rich alpaha-2-glycoprotein in pancreatic cancer显示文摘 | Kakisaka T Kondo T Okano T | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，852，12： | 1 |
| 10 | Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis显示文摘 | Kakisaka K Cazanave SC Fingas CD | | 0，，： | 1 |
| 11 | Effects of glyeyrrhizin on glueocorticoid signaling pathway in hepatoeytes显示文摘 | Yoh T Nakashima T Sumida Y Kakisaka Y Nakajima Y Ishikawa H | 2002 | Dig Dis Sei2002，47，： | 1 |
| 12 | Non-invasive evaluation of liver fibroisis using acoustic radiation force impulse imaging in chroni chepatitis patients with hepatitis C virus infection显示文摘 | Kuroda H Kakisaka K Tatemichi Y | 2010 | Hepatogastruenterology2010，，57： | 1 |
| 13 | Elevation of serum thioredoxin levels in patients with type 2 diabetes显示文摘 | Kakisaka Y Nakashima T Sumida Y | 2002 | Horm Metab Res2002，34，3： | 1 |
| 14 | Plasma proteomics of lung cancer by a linkage of multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis 显示文摘 | Okano T Kondo T Kakisaka T | 2006 | Proteomics2006，6，13： | 1 |
| 15 | Effects of photody- namic therapy using 5 - aminolevulinic acid on cultured human adenomyosis - derived ceils 显示文摘 | Suzuki - Kakisaka H Murakami T Hirano T | 2007 | Fertil SteriI2007，87，1： | 1 |
| 16 | Hand-assisted laparo- scopic splenectomy for sclerosing angiomatoid nodular transforma- tion of the spleen complicated by chronic disseminated intravascu- lar coagulation: A ease report显示文摘 | Kakisaka T Kamiyama T Yokon H | 2014 | Asian J Endosc Surg2014，7，3： | 1 |
| 17 | Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel elec- trophoresis (2D-DIGE) :up-regulation of leucine-rich al- pha-2-glycoprotein in pancreatic cancer显示文摘 | Kakisaka T Kondo T Okano T | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，852，12： | 1 |
| 18 | Non-invasive evalua- tion of liver fibrosis using acoustic radiation force impulse ima- ging in chronic hepatients with hepatitis C virus infection 显示文摘 | Kuroda H Kakisaka K Tatemichi Y | 2010 | Hepatogastroenterology2010，7，102103： | 1 |
| 19 | Elevation of serum thioredoxin levels in patients with type 2 diabetes显示文摘 | Kakisaka Y Nakashima T Sumida Y | 2002 | Horm Metab Res2002，34，3： | 1 |
| 20 | Plasma proteomics of lung cancer by a linkage of multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis显示文摘 | Okano T Kondo T Kakisaka T | 2006 | Proteomics2006，6，13： | 1 |
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