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| 1 | Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats显示文摘AIM: To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second,to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury.METHODS: Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin,and BDL+vehicle. Cholestasis was achieved by double ligature of the common bile duct. Melatonin was injected intraperitoneally 500 μg/(kg.d) for 8 d. Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA),and reduced GSH. Total nitrite (NOx) concentrations were determined in hepatic homogenates. Histopathological examination was performed using a histological scoring system.RESULTS: The histopathological changes including portal inflammation, necrosis, apoptosis, focal inflammation and fibrosis were severe in the BDL and BDL+vehicle groups. There were numerous large areas of coagulation necrosis. Histological Activity Index scores of these groups were significantly higher than that of the SO group. Treatment with melatonin reduced these alterations significantly. The degree of necro-infiammation and fibrosis showed significant difference between the BDL and BDL+melatonin groups. BDL was accompanied by a significant increase in MDA and NOx, and a significant decrease in GSH levels. Mean±SE values of MDA, GSH and NOx levels of SO group were 147.47±6.69, 0.88±0.33 μmol/g and 180.70±6.58 nm/g, respectively. The values of BDL group were 200.14±21.30, 0.65±0.02 μmol/g, and 400.46±48.89 nm/g, respectively, whereas the values of BDL+melatonin group were 115.93±6.8, 0.74±0.02 μmol/g,and 290.38±32.32 nm/g, respectively. Melatonin treatment was associated with a significant recovery of MDA, GSH and NOx levels.CONCLUSION: We have concluded that oxidative stress is associated with the pathogenesis of cholestatic liver damage and NO contributes to oxidative damage. Melatonin,even at low dose, is an efficient agent in reducing negative parameters of cholestasis. | Mukaddes Esrefoglu Mehmet Gül Memet Hanifi Emre Alaattin Polat Mukadder Ayse Selimoglu | 2005 | World Journal of Gastroenterology2005，11，13： | 6 |
| 2 | Assessment of heavy metal contamination in sediments of the Tigris River (Turkey) using pollution indices and multivariate statistical techniques显示文摘 | Memet Varol | 2011 | Journal of Hazardous Materials2011，，： | 3 |
| 3 | Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats显示文摘 | Alaadin Polat Hakan Parlakpinar Seda Tasdemir Cemil Colak Nigar Vardi Muharrem Ucar Memet Hanifi Emre Ahmet Acet | 2006 | Acta Histochemica2006，，5： | 1 |
| 4 | Visualization of lymphatic vessels through NF-kappaB activity显示文摘 | Saban MR Memet S Jackson DG | 2004 | Blood2004，104，10： | 1 |
| 5 | A - duble - step Savonius Rotor for Local Produc- tion of Electricity: a Design Study 显示文摘 | Memet J L | 2004 | Renewable Energy2004，29，11： | 1 |
| 6 | Assessment of heavy metal contamination in sediments of the Tigris River (Turkey) using pollution indices and multivariate statistical techniques显示文摘 | Memet Varol | 2011 | Journal of Hazardous Materials2011，，： | 1 |
| 7 | NF-kappa B functions in the nervous system:from development to disease显示文摘 | | 2006 | Biochem Pharmacol2006，72，： | 1 |
| 8 | Pulmonarymanifestations of systemic lupus erythematosus显示文摘 | Memet B Ginzler EM | 2007 | Sem in Respir Crit Care Med2007，28，4： | 1 |
| 9 | Corrosion behaviour, microhardness and surface characterisation of low energy, high current ion implanted austenitic stainless steel显示文摘 | S Picard J.B Memet R Sabot J.L Grosseau-Poussard J.P Rivière R Meilland | 2001 | Materials Science & Engineering A2001，，1： | 1 |
| 10 | Visualization of lymphatic vessels through NF-kappaB activity显示文摘 | Saban MR Memet S Jackson DG | 2004 | Blood2004，104，10： | 1 |
| 11 | Complete lack of NT-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defects in neurulation 显示文摘 | Li Q Estepa G Memet S | 2000 | Genes Dev2000，14，14： | 1 |
| 12 | Immobilization of a -amylase onto cyclic carbonatebearing hybrid material 显示文摘 | Oguz Turunc Memet Vezir Kahraman Zumrut Seden Akdemir | 2009 | Food Chemistry2009，112，4： | 1 |
| 13 | A new record of the freshwater jellyfish Craspedacusta sowerbii Lankester,1880(Hydrozoa)in Southeastern Anatolia(Turkey)显示文摘We report the first record of the invasive freshwater jellyfish Craspedacusta sowerbii Lankester in Kralk1z1 Dam Lake,Southeastern Anatolia,Turkey.The medusa was found only in August,2008 when average surface water temperatures were 26.9℃. | Aysel BEKLEYEN Memet VAROL Bulent GOKOT | 2011 | Chinese Journal of Oceanology and Limnology2011，29，2： | 1 |
| 14 | Pulmonary Manifestations of Systemic Lupus Erythematosus显示文摘 | Memet B Ginzler EM | | 0，，： | 1 |
| 15 | Effective biocide to prevent microbiological contamination during PEG impregnation of wet archaeological iron-wood artefacts显示文摘 | Malalanirina Sylvia Rakotonirainy Loic Caillat Cécile Héraud Jean-Bernard Memet Quoc Khoi Tran | 2007 | Journal of Cultural Heritage2007，，2： | 1 |
| 16 | NF-kappaB functions in the nervous system:from development to disease显示文摘 | MEMET S | | 0，，09： | 1 |
| 17 | NF - kappaB activity in transgenic mice : developmental regulation and tissue specificity 显示文摘 | Schmidt- Ullrich R Memet S Lilienbaum A | 1996 | Development1996，122，7： | 1 |
| 18 | Assessment of heavy metal contamination in sedi- ments of the Tigris River (Turkey) using pollution indices and multivariate statistical techniques 显示文摘 | Varol Memet | 2011 | Journal of Hazardous Ma- terial2011，195，： | 1 |
| 19 | Timed NF-kappaB inhibition in skin reveals dual independent effects on development of HED/EDA and chronic inflammation显示文摘 | Ulvmar M H Sur I Memet S | 2009 | J Invest Dermatol2009，129，11： | 1 |
| 20 | Assessment of heavy metal contamination in sediments of the Tigris River (Turkey) using pollution indices and multivariate statistical techniques显示文摘 | Memet V | 2011 | Journal of Hazardous Materials2011，195，： | 1 |
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