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| 1 | Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats显示文摘AIM: To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second,to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury.METHODS: Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin,and BDL+vehicle. Cholestasis was achieved by double ligature of the common bile duct. Melatonin was injected intraperitoneally 500 μg/(kg.d) for 8 d. Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA),and reduced GSH. Total nitrite (NOx) concentrations were determined in hepatic homogenates. Histopathological examination was performed using a histological scoring system.RESULTS: The histopathological changes including portal inflammation, necrosis, apoptosis, focal inflammation and fibrosis were severe in the BDL and BDL+vehicle groups. There were numerous large areas of coagulation necrosis. Histological Activity Index scores of these groups were significantly higher than that of the SO group. Treatment with melatonin reduced these alterations significantly. The degree of necro-infiammation and fibrosis showed significant difference between the BDL and BDL+melatonin groups. BDL was accompanied by a significant increase in MDA and NOx, and a significant decrease in GSH levels. Mean±SE values of MDA, GSH and NOx levels of SO group were 147.47±6.69, 0.88±0.33 μmol/g and 180.70±6.58 nm/g, respectively. The values of BDL group were 200.14±21.30, 0.65±0.02 μmol/g, and 400.46±48.89 nm/g, respectively, whereas the values of BDL+melatonin group were 115.93±6.8, 0.74±0.02 μmol/g,and 290.38±32.32 nm/g, respectively. Melatonin treatment was associated with a significant recovery of MDA, GSH and NOx levels.CONCLUSION: We have concluded that oxidative stress is associated with the pathogenesis of cholestatic liver damage and NO contributes to oxidative damage. Melatonin,even at low dose, is an efficient agent in reducing negative parameters of cholestasis. | Mukaddes Esrefoglu Mehmet Gül Memet Hanifi Emre Alaattin Polat Mukadder Ayse Selimoglu | 2005 | World Journal of Gastroenterology2005，11，13： | 6 |
| 2 | The Treatment with Antibody of TNF-α Reduces the Inflammation, Necrosis and Fibrosis in the Non-alcoholic Steatohepatitis Induced by Methionine- and Choline-deficient Diet显示文摘 | Suleyman Serdar Koca Ibrahim Halil Bahcecioglu Orhan Kursat Poyrazoglu Ibrahim Hanifi Ozercan Kazim Sahin Bilal Ustundag | 2008 | Inflammation2008，，2： | 2 |
| 3 | Preparation and bioactivityevaluation of bone-like hydroxyapatite nan- opowder显示文摘 | FATHI M H HANIFI A MORTAZAVI V | 2008 | Materials Process Technology2008，202，13： | 1 |
| 4 | Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats显示文摘 | Alaadin Polat Hakan Parlakpinar Seda Tasdemir Cemil Colak Nigar Vardi Muharrem Ucar Memet Hanifi Emre Ahmet Acet | 2006 | Acta Histochemica2006，，5： | 1 |
| 5 | Olive mill wastewaters: diversity of the fatal product in olive oil industry and its valorisation as agronomical a- mendment of poor soils: a review显示文摘 | Hanifi S E1 Hadrami I | 2009 | Journal of Agronomy2009，8，： | 1 |
| 6 | The effect of fineness on the properties of the blended cements incorporating ground granulated blast furnace slag and ground basaltic pumice显示文摘 | Hanifi Binici Hu seyin Temiz Mehmet M Ko se | 2007 | Construction and Building Materials2007，21，5： | 1 |
| 7 | Effect of crushed ceramic and basaltic pumice as fine aggregates on concrete mortars properties显示文摘 | Binici Hanifi | 2007 | Construction and Building Materials2007，，21： | 1 |
| 8 | Effect of bacterial calcium carbonate precipitation on compressibility and shear strength of organic soil显示文摘 | HANIFI CANAKCIA WALEED SIDIKA IBRABIM HALIL KILICC | 2015 | Soils and Foundations2015，55，5： | 1 |
| 9 | Preparation and bioactivity evaluation of bone - like hydroxyapatite nanopowder 显示文摘 | Fathi M H Hanifi A Mortazavi V | 2008 | Journal of Materials Processing Technology2008，202，123： | 1 |
| 10 | A kinetic study of the cementation of copper from sulphate solutions onto a rotating aluminum disc显示文摘 | Donmez Bonyamin Sevim Fatih Sarac Hanifi | 1999 | Hydrometallurgy1999，53，： | 1 |
| 11 | Phytotoxicity and fertilising potential of olive mill wastewaters for maize cultivation显示文摘 | Hanifi S Hadrami I | 2008 | Agron Sustain Dev2008，28，： | 1 |
| 12 | Thermal isolation and mechanical properties of fibre reinforced mud bricks as wall materials显示文摘 | Hanifi Binici a Orhan Aksogan b Mehmet Nuri Bodur c Erhan Akca d Selim Kaput | 2007 | Construction and Building Materials2007，21，1： | 1 |
| 13 | The effect of fineness on the properties of the blended cements incorporating ground granulated blast furnace slag and ground basaltic pumice 显示文摘 | Hanifi Binici Hu seyin Temiz Kose M M | 2007 | Construction and Building Materials2007，21，5： | 1 |
| 14 | Preparation and bioactivity evaluation of bone-like hydroxyapatite nanopowder显示文摘 | Fathi M H Hanifi A Mortazavi V | 2008 | Journal of materials processing technology2008，202，53： | 1 |
| 15 | Thermal i~lation and mechanical properties of fibre reinforced mud bricks as wall materials 显示文摘 | Hanifi B Orhan A Mehmct N t3 et and | 2007 | Construction and Building Materials2007，21，： | 1 |
| 16 | Influence of Cd and In on the formation kinetics ofthe δ' metastable phase in Al-Li-In(Cd) alloys显示文摘 | Raho M A Hanifi K | 2006 | Material Science Forum2006，，： | 1 |
| 17 | Effect of crushed ceramic and basaltic pumice as fine aggregates o,1 concrete mortars properties 显示文摘 | Hanifi B | 2007 | Construction and Building Materials2007，21，： | 1 |
| 18 | Craniofacial fibrous dysplasia显示文摘 | Hanifi B Samil KS Yasar C | 2013 | Clin Imaging2013，37，6： | 1 |
| 19 | Thermal Isolation and Mechanical Properties of Fibre Reinforced Mud Bricks as Wall Materials显示文摘 | Hanifi Binici Orhan Aksogan Mehmet Nuri Bodur | 2007 | Construction and Building Materials2007，21，90： | 1 |
| 20 | Malaria mortality in Africa and Asia= evidence from INDEPTH health and demographic surveillance system sites显示文摘 | Streatfield P K Khan W A Bhuiya A Hanifi S M Alam N Diboulo E | 2014 | Glob Health Action2014，7，25： | 1 |
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