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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | The Nature and Biosynthesis of the Carotenoids of Different Color Varieties of Capsicum annuum显示文摘 | B H Davies S Matthew J T O Kirk | 1970 | Phytochemistry1970，，9： | 1 |
| 3 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 4 | Electrochemistry Communications显示文摘 | Michael J B Matthew H Karen E | 2007 | 9 (1) :42-482007，9，1： | 1 |
| 5 | The influence of carbon dioxide on brain activity and metabolism in conscious humans 显示文摘 | Feng X U Jinsoo U H Matthew R B | 2011 | J Cereb Blood Flow Metab2011，31，1： | 1 |
| 6 | Alpha-actinin-4 is required for normal podocyte adhesion显示文摘 | DANDAPANI S V SUGIMOTO H MATTHEWS B D | 2007 | J Biol Chem2007，282，1： | 1 |
| 7 | Laser capture microdissection (LCM) and comparative microarray expression analysis of syncytial cells isolated from incompatible and compatible soybean (Glycine max) roots infected by soybean cyst nematode (Heterodera glycines)显示文摘 | Klink V P Overall C C Alkharouf N MacDonald M H Matthews B F | | 0，，06： | 1 |
| 8 | A simple inertial formulation of theshallow water equations for efficient two-dimensional flood inundationmodelling显示文摘 | Paul D B Matthew S H Timothy J F | 2010 | Journal of Hydrology2010，387，12： | 1 |
| 9 | Excitation-emission-matrix fluorescence spectroscopy applied to humic acid bands in coral reefs显示文摘 | Matthews B J H Jones A C Theodorou N K | 1996 | Mar Chem1996，55，34： | 1 |
| 10 | Essentials of problem - based learning显示文摘 | Walton H J Matthews M B | 1989 | Medical Education1989，23，： | 1 |
| 11 | Vitamin a deficiency impairs fetal islet development and causes subsequent glucose intolerance in adult rats 显示文摘 | MATTHEWS K A RHOTEN W B DRISCOLL H K | 2004 | The Journal of Nutrition2004，134，8： | 1 |
| 12 | Multivariatestatistical analysis of X-ray data from cellulose : a new method to deter-mine degree of crystallinity and predict hydrolysis rates显示文摘 | PRABUDDHA B MELANIE H MATTHEW J | 2010 | BioresourceTechnology2010，101，： | 1 |
| 13 | Mo-del identification for crystallization:theory and experimental verification显示文摘 | Matthews H B Miller S M Rawlings J B | 1996 | Powder Technology1996，88，： | 1 |
| 14 | Prediction of mammalian microRNA targets显示文摘 | Lewis B P Shih I H Matthew W J | 2003 | Cell2003，115，： | 1 |
| 15 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 16 | Long-distance pollen flow assessment through evaluation of pollinator forag- ing range suggests transgene escape distances 显示文摘 | RE'MY S P Alexis P Matthew B H | 2008 | Proceedings of the National Academy of Sciences of the United States of America2008，105，13： | 1 |
| 17 | Alpha?actinin-4 is required for normal podocyte adhesion显示文摘 | Dandapani S V Sugimoto H Matthews B D | 2007 | J Bioi Chern2007，282，1： | 1 |
| 18 | Differences in entrepreneurial opportunities:the role of tacitness and codification in opportunity identification显示文摘 | Smith B R Matthews C H Schenkel M T | 2009 | Journal of Small Business Management2009，，1： | 1 |
| 19 | Excitation-emission-matrix fluorescence spectroscopy applied to humic acid bands in coral reefs显示文摘 | MATTHEWS B J H JONES A C THEODOROU N K | 1996 | Mar Chem1996，55，： | 1 |
| 20 | Reciprocal mutagenesis between human(L349,M528) and rainbow trout(M317,I496) estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures显示文摘 | Matthews J B Clemons J H Zacharewski T R | 2001 | Mol Cell Endocrinol2001，183，： | 1 |
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