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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017,17,27: | 3 |
| 2 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018,3,3: | 2 |
| 3 | Effect of weekend admission on geriatric hip fractures显示文摘BACKGROUND The care discrepancy for patients presenting to a hospital on the weekend relative to the work week is well documented.With respect to hip fractures,however,there is no consensus about the presence of a so-called“weekend effect”.This study sought to determine the effects,if any,of weekend admission on care of geriatric hip fractures admitted to a large tertiary care hospital.It was hypothesized that geriatric hip fracture patients admitted on a weekend would have longer times to medical optimization and surgery and increased complication and mortality rates relative to those admitted on a weekday.AIM To determine if weekend admission of geriatric hip fractures is associated with poor outcome measures and surgical delay.METHODS A retrospective chart review of operative geriatric hip fractures treated from 2015-2017 at a large tertiary care hospital was conducted.Two cohorts were compared:patients who arrived at the emergency department on a weekend,and those that arrived at the emergency department on a weekday.Primary outcome measures included mortality rate,complication rate,transfusion rate,and length of stay.Secondary outcome measures included time from emergency department arrival to surgery,time from emergency department arrival to medical optimization,and time from medical optimization to surgery.RESULTS There were no statistically significant differences in length of stay(P=0.2734),transfusion rate(P=0.9325),or mortality rate(P=0.3460)between the weekend and weekday cohorts.Complication rate was higher in patients who presented on a weekend compared to patients who presented on a weekday(13.3%vs 8.3%;P=0.044).Time from emergency department arrival to medical optimization(22.7 h vs 20.0 h;P=0.0015),time from medical optimization to surgery(13.9 h vs 10.8 h;P=0.0172),and time from emergency department arrival to surgery(42.7 h vs 32.5 h;P<0.0001)were all significantly longer in patients who presented to the hospital on a weekend compared to patients who presented to the hospital on a weekday.CONCLUSION This study provided insight into the“weekend effect”for geriatric hip fractures and found that day of presentation has a clinically significant impact on delivered care. | Jordan B Pasternack Matthew L Ciminero Michael Silver Joseph Chang Ronald J Simon Kevin K Kang | 2020 | World Journal of Orthopedics2020,11,9: | 2 |
| 4 | The greenness of city 显示文摘 | EDWARD L G MATTHEW K | 2008 | Rappa- port Institute Taubman Center Policy Briefs2008,,3: | 1 |
| 5 | Explaining IT-Based Knowledge Sharing Behavior with IS Continuance Model and Social Factors显示文摘 | Sabrina F S S Matthew L K O | 2006 | PACIS 2006 Proceedings2006,,: | 1 |
| 6 | Depletion of langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘 | MATTHEWS K LEONG C M BAXTER L | 2003 | J Virol2003,77,: | 1 |
| 7 | Psychological Perspectives on Pathways Linking Socioeconomic Status and Physical Heahh显示文摘 | Matthews K A Gallo L C | 2011 | Annual Review of Psychology2011,,4: | 1 |
| 8 | Depletion of Langerhans cells in human papillomavirus type 16-Infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘 | Matthews K Leong CM Baxter L | 2003 | J Virol2003,77,15: | 1 |
| 9 | Depletion of langerhans cells in human papillomavirus type 16-Infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘 | Matthews K Leong CM Baxter L | 2003 | J Virol2003,77,15: | 1 |
| 10 | The relationship between psychological risk attributes and the metabolic syndrome in healthy women:antecedent or consequence显示文摘 | RAIKKONENK K MATTHEWS K A KULLER L H | 2002 | Metabolism2002,51,: | 1 |
| 11 | Strepto- myces competition and co-evolution in relation to plant disease suppression 显示文摘 | Linda L K Daniel C S Matthew G B | 2012 | Research in Microbiology2012,163,8: | 1 |
| 12 | Wild type and innate immune-deficient mice are not susceptible to the middle east respiratory syndrome eoronavirus显示文摘 | Coleman C M Matthews K L Goicochea L Frieman M B | 2014 | J Gen Virol2014,95,2: | 1 |
| 13 | Pretreatment effects on coral skeletal δ^13C and δ^18O显示文摘 | Grottoli A G Rodrigues L J Matthews K A | 2005 | Chemical Geology2005,221,: | 1 |
| 14 | 查看详情显示文摘 | Matthews D L Campbell E M Ceglio N M Hermes G Kauffman R Koppel L Lee R Manes K Rupert V Slivinsky W Turner R Ze F | | 0,,: | 1 |
| 15 | Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of Ecadherin显示文摘 | Matthews K Leong CM Baxter L | 2003 | J Virol2003,77,: | 1 |
| 16 | Depressive symptoms during the menopausal transition : the Study of Women's Health Across the Nation (SWAN)显示文摘 | BROMBERGER J T MATTHEWS K A SCHOTT L L | 2007 | J Affect Disord2007,103,13: | 1 |
| 17 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014,12,: | 1 |
| 18 | Psychological perspectives on pathways linking socioeconomic status and physical health 显示文摘 | MATTHEWS K A GALLO L C | 2011 | Annu Rev Psychol2011,62,: | 1 |
| 19 | EnaR: An R package for ecosystem network analysis 显示文摘 | STUART R B MATTHEW K L | 2014 | Methods in Ecology and Evolution2014,5,: | 1 |
| 20 | Influences of natural menopause on psychological characteristics and symp-toms of middle aged healthy women显示文摘 | MATTHEWS K A WING R R KULLER L H | 1990 | Journal of consulting and clinical psychology1990,58,3: | 1 |