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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Biomass - coal co - combustion: Opportunity for affordable renewable energy 显示文摘 | Baxter L | 2005 | Fuel2005，84，10： | 1 |
| 4 | Winter crop and residue bio-mass potential in China显示文摘 | BAXTER R FEYEREISEN G YU Y L | 2011 | Biofuels2011，2，5： | 1 |
| 5 | Combustion-properties of biomass 显示文摘 | Jenkins B M Baxter L L Miles T R | 1998 | Fuel Processing Technology1998，54，： | 1 |
| 6 | Production of IGF-I and its bindingprotein by breeding cow hepatocytes in primary culture显示文摘 | STICK C D MARTIN J L BAXTER R C | 1998 | Endocrinology1998，163，： | 1 |
| 7 | Depletion of langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘 | MATTHEWS K LEONG C M BAXTER L | 2003 | J Virol2003，77，： | 1 |
| 8 | Laser spark emission spectroscopy for in-situ,realtime monitoring of pulverized coal particle composition显示文摘 | Ottesen D K Baxter L L Radziemski L J | | 0，，02： | 1 |
| 9 | Biomass-coal co-combustion: opportunity for affordable renewable energy 显示文摘 | Baxter L | 2005 | Fuel2005，84，10： | 1 |
| 10 | 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (β-site APP cleaving enzyme):use of structure based design to convert a micromolar hit into a nanomolar lead 显示文摘 | BAXTER E W CONWAY K A KENNIS L | 2007 | J Med Chem2007，50，18： | 1 |
| 11 | Use of cardiac markers to assess the toxic effects of anthraeyclines given to children with cancer: a systematic review 显示文摘 | Bryant J Picot J Baxter L Levitt G Sullivan I Clegg A | 2007 | Eur J Cancer2007，43，13： | 1 |
| 12 | Pilot-scale investigation of the influence of coal-biomass cofiring on ash deposition 显示文摘 | Robinson A L Junker H Baxter L L | 2002 | Energy Fuels2002，16，： | 1 |
| 13 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders 显示文摘 | BAXTER E J SCOTT L M CAMPBELL P J | 2005 | Lancet2005，365，： | 1 |
| 14 | HELLP syndrome : the state of the art 显示文摘 | Baxter JK Weinstein L | 2004 | ObstetGyncolSurv2004，59，： | 1 |
| 15 | New alkaloids and related artifacts from Cyclea peltata显示文摘 | Kupenban S M Liepa A J Baxter R L | 1973 | Jorg Chem1973，38，： | 1 |
| 16 | Micromechanics based random material property fields for particular reinforced composites 显示文摘 | Baxter S C Hossain M I Graham L L | 2001 | International Journal of Solids and Structures2001，38，： | 1 |
| 17 | Ash depositon during biomass and coal combustion; a mechanistic approach 显示文摘 | Baxter L L | 1993 | Biomass and Bioenergy1993，，4： | 1 |
| 18 | Depletion of Langerhans cells in human papillomavirus type 16-Infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘 | Matthews K Leong CM Baxter L | 2003 | J Virol2003，77，15： | 1 |
| 19 | Purification and properties of a novel insulin-like growth factor-If binding protein from transformed human fibroblasts 显示文摘 | Martin J L Willetts K E Baxter R C | 1990 | The Journal of biological chemistry1990，265，7： | 1 |
| 20 | Depletion of langerhans cells in human papillomavirus type 16-Infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘 | Matthews K Leong CM Baxter L | 2003 | J Virol2003，77，15： | 1 |
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