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| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 2 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 3 | Crystal doping aided by rapid expansion of supercritical solutions 显示文摘 | Chandra V Matthew J M Thomas E N | 2002 | AAPS Pharm-SciTech2002，3，4： | 1 |
| 4 | The hot workability of Cromanite,a high nitrogen austenitic stainless steel显示文摘 | TARBOTON J N MATTHEWS L M SUTCLIFFE A | | 0，，： | 1 |
| 5 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 6 | Schiff Base Catalysts for the Asymmetric Strecker Reaction Identified and Optimized from Parallel Synthetic Libraries显示文摘 | Matthew S Sigman Eric N J | 1998 | J Am Chem1998，120，： | 1 |
| 7 | Functional subdivisions within anterior cingulated cortex and their relationship to autonomic nervous system function显示文摘 | Matthews S C Paulus M P Simmons A N Nelesen R A Dimsdale J E | 2004 | NeuroImage2004，22，： | 1 |
| 8 | Analysis of serial measurements in medical research显示文摘 | Matthews J N S Altman D G CamPell M J | 1990 | BMJ1990，300，6719： | 1 |
| 9 | ^13C record of benthic foraminifera in the last interglacial ocean: Implications for the carbon cycle and the global deep water circulation显示文摘 | Duplessy J C Shackleton N J Matthews R K | 1984 | Quaternary Research1984，21，： | 1 |
| 10 | Ultrasonically assisted synthesis and degradation of poly ( dimethyl siloxane) 显示文摘 | Gareth J P Matthew P H Emma N K W | 1996 | Polymer1996，37，12： | 1 |
| 11 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 12 | Production and characterisation of polyclonal antibodies to the common moiety of some organophosphorous pesticides and development of a generic type ELISA显示文摘 | Banks J N Chaudhry M Q Matthews W A | 1998 | Food Agric Immunol1998，10，： | 1 |
| 13 | Production and characterization of poly clonal antibodies to the common moiety of wome organophosphorus pesticides and development of a generic type ELISA 显示文摘 | Banks J N Chaudhry M Q Matthews W A | 1998 | Food and Agricultural Immunology1998，10，： | 1 |
| 14 | Transcriptional changes underlying the secretory activation phase of mammary gland development显示文摘 | MATTHEW J N SAMANTHA R O GARDEN M G | 2005 | Mol Endocrinol2005，19，7： | 1 |
| 15 | Excitation-emission-matrix fluorescence spectroscopy applied to humic acid bands in coral reefs显示文摘 | Matthews B J H Jones A C Theodorou N K | 1996 | Mar Chem1996，55，34： | 1 |
| 16 | Wound healing dressings and drug delivery systems:a review显示文摘 | Boateng J S Matthews K H Stevens H N | 2008 | Journal of Pharmaceutical Sciences2008，97，8： | 1 |
| 17 | Single-event transient measurements in nMOS and pMOS transistors in a 65 nm bulk CMOS technology at elevated temperatures显示文摘 | MATTHEW J G JONATHAN R A BALAJI N | 2011 | IEEE Transactions on Device and Materials Reli- ability2011，11，： | 1 |
| 18 | Rebar-epoxied optical fiber Bragg gratings for civil structures 显示文摘 | Stephanus J S Peter L F Matthew N | 1998 | Microwave and Optical Technology Letters1998，18，3： | 1 |
| 19 | The biodegradation of surfactants in the environment显示文摘 | Matthew J Scott Malcolm N Jones | 2000 | Biochimica et Biophysica Acta2000，1508，： | 1 |
| 20 | Prurigo nodularis in HIV- infected individuals 显示文摘 | MATTHEWS S N COCKERELL C J | 1998 | Int J Dermatol1998，37，6： | 1 |
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