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| 1 | 突发性聋治疗的国际共识显示文摘突发性聋是耳鼻咽喉科常见急症,目前该病的治疗仍存在许多问题。虽然已有很多关于突发性聋的meta分析和治疗指南问世,其治疗方案(包括治疗药物、治疗时程和给药途径)仍未形成标准。本文对突发性聋治疗的临床研究提出方法学建议,这些建议基于2017年法国巴黎国际耳鼻喉科学联合会(International Federation of Oto-rhino-laryng ological Societies,IFOS)大会中与会专家目前使用的主要治疗方案的临床证据等级。突发性聋研究中存在的主要问题是疾病的异质性,即患者初始听力损失程度及治疗后的听力恢复程度均有很大差异。全身应用糖皮质激素治疗突发性聋的有效性,其证据水平并未达到推荐使用的程度,但仍是突发性聋的主要治疗方法,可作为目前的标准方案,为减少受试者数量,建议将纳入标准限制为中度到极重度的听力损失。鼓室内糖皮质激素治疗作为挽救性治疗在几个小样本研究中被提及,需要大规模的随机对照试验加以证实。 | 李姝娜 李越 杨军 Marx M Younes E Chandrasekhar SS | 2018 | 听力学及言语疾病杂志2018，26，4： | 25 |
| 2 | LED照明势在必行显示文摘FrankMarx先生2004年加盟Zetex公司,是Zetex公司董事局成员,负责销售和市场营销工作。Frank先生最早在SGS-ThomsonMicroelectronics公司的技术市场和销售部任职。而后加入国家半导体公司担任市场部经理。1997年,转到飞兆半导体公司,担任美国加利福尼亚地区业务运营市场总监。 | Frank Marx | 2006 | 电子技术(上海)2006，33，4： | 9 |
| 3 | Integral Recrystallization Modelling显示文摘We present models designed to represent the evolution of microstructure and crystallographic texture during recrystallization. For engineering applications the models are tied to a finite element approach. A connection to the deformed microstructure is established by dislocation theory of work hardening and Taylor type texture simulations. For temporal and spatial resolution a modified cellular automaton model was developed. A fast statistical approach for prediction of recrystallization kinetics and texture development discrete in time is presented. Predictions of the models are compared with experimental data. | G. Gottstein, V. Marx, R. Sebald Institut furr Metallkunde und Metallphysik, RWTH Aachen, 52056 Aachen, Germany | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 7 |
| 4 | Insight into the antifungal mechanism of Neosartorya fischeri antifungal protein显示文摘细丝状的子囊菌纲分泌的小、充满半胱氨酸的、高度稳定的抗真菌的蛋白质为新奇抗真菌的策略的发展有大潜力。然而,他们的实际申请仍然由于他们行动的不充分澄清的模式被限制。这个工作的目的是提供深卓见进 Neosartorya fischeri 的抗真菌的机制抗真菌的蛋白质(NFAP ) ,这个蛋白质组的一个新奇代表。在 NFAP 敏感的曲霉属菌 nidulans 在 NFAP,减少的细胞的新陈代谢, apoptosis 正式就职,在肌动朊分发的变化和在菌丝的尖端的几丁质免职的一短暴露时间以内被观察。NFAP 确实由 endocytosis 显示出既不直接的膜破坏效果也不举起。A 的调查。nidulans 发信号异种表明 NFAP 经由表明导致极的生长的 apoptosis 和抑制的 G 蛋白质激活营地 / 蛋白质 kinase A 小径。相反, NFAP 没在房间墙正直小径,而是小径无关的 mitogen 激活的未知房间墙正直上有任何影响蛋白质 kinase 激活 A 的目标被假定涉及房间死亡正式就职。一起拿, NFAP 从曲霉属菌 giganteus 和毛丛 chrysogenum 与二大多数调查 NFAP 相关的蛋白质相比在它抗真菌的行动的模式显示出类似,而且差别,这被结束。 | Mate Viragh Annamaria Marton Csaba Vizier Liliana Toth Csaba Vagvolgyi Florentine Marx Laszlo Galgoczy | 2015 | Protein & Cell2015，6，7： | 4 |
| 5 | 2013 ESC guidelines on the management of stable coronary artery disease显示文摘 | Gilles Montalescot Udo Sechtem Stephan Achenbach Felicita Andreotti Chris Arden Andrzej Budaj Raffaele Bugiardini Filippo Crea Thomas Cuisset Carlo Di Mario J. Rafael Ferreira Bernard J. Gersh Anselm K. Gitt Jean-Sebastien Hulot Nikolaus Marx Lionel H. Op | 2013 | European Heart Journal2013，，38： | 4 |
| 6 | 碘(I^—)在水泥,氢氧化铁和岩盐中吸附行为的研究显示文摘采用放射化学法测定了AgI在浓盐溶液中的溶解度。用间歇平衡实验研究了浓盐溶液中碘(I￣-)在水泥、氢氧化铁和天然岩盐中的吸附行为。研究结果表明,在以上三种吸附体系中,I￣-浓度为10￣(-7)-10￣(-4)mol/l时,I￣-的吸附比(R_d)与吸附剂种类有关,与溶液中I￣-的平衡浓度(c_(eq))无关。I￣-在吸附剂上的浓度(c_s)与其在溶液中的平衡浓度(c_(eq))的关系符合Freundlich方程。 | 叶玉星 Marx,G | 1995 | 核化学与放射化学1995，17，1： | 3 |
| 7 | Fluid therapy in sepsis with capillary leakage显示文摘 | G. Marx | 2003 | European Journal of Anaesthesiology2003，，6： | 3 |
| 8 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 9 | HER-2 amplification is highly homogenous in gastric cancer显示文摘 | Andreas H. Marx Lars Tharun Johanna Muth Ana-Maria Dancau Ronald Simon Emre Yekebas Jussuf T. Kaifi Martina Mirlacher Tim H. Brümmendorf Carsten Bokemeyer Jakob R. Izbicki Guido Sauter | 2009 | Human Pathology2009，，6： | 3 |
| 10 | Fibrin microbeads for isolating and growing bone marrow-derived proge-nitor cells capable of forming bone tissue显示文摘 | Gurevich O Vexler A Marx G | 2002 | Tissue Eng2002，8，4： | 2 |
| 11 | System dynamic modelling to assess economic viability and risk trade-offs for ecological restoration in South Africa显示文摘 | D.J. Crookes J.N. Blignaut M.P. de Wit K.J. Esler D.C. Le Maitre S.J. Milton S.A. Mitchell J. Cloete P. de Abreu H. Fourie (nee Vlok) K. Gull D. Marx W. Mugido T. Ndhlovu M. Nowell M. Pauw A. Rebelo | 2013 | Journal of Environmental Management2013，，： | 2 |
| 12 | A microplate fluorimetric assay for the study of enzyme diversity in soils显示文摘 | M.-C Marx M Wood S.C Jarvis | 2001 | Soil Biology and Biochemistry2001，，12： | 2 |
| 13 | PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties显示文摘 | M. Amine Bouhlel Bruno Derudas Elena Rigamonti Rébecca Dièvart John Brozek Stéphan Haulon Christophe Zawadzki Brigitte Jude Gérard Torpier Nikolaus Marx Bart Staels Giulia Chinetti-Gbaguidi | 2007 | Cell Metabolism2007，，2： | 2 |
| 14 | A microplate fluorimetric assay for the study of enzyme diversity in soils显示文摘 | M.-C Marx M Wood S.C Jarvis | 2001 | Soil Biology and Biochemistry2001，，12： | 2 |
| 15 | Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease显示文摘 | Marx N Froehlich J Siam L | 2003 | Arterioscler Thromb Vasc Biol2003，23，2： | 2 |
| 16 | PPARa activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells显示文摘 | Marx N Sukhova GK Collins T | 1999 | Circulation1999，99，24： | 1 |
| 17 | Macroinvertebrate drift density in relation to abiotic factors in the Missouri river 显示文摘 | Hay C H Franti T G Marx D B | 2008 | Hydrobiologia2008，598，： | 1 |
| 18 | American collegiate men's ice hockey:an analysis of injuries显示文摘 | Flik K Lyman S Marx RG | 2005 | Ame J Sports Med2005，33，： | 1 |
| 19 | A new tool for palaeocli mate reconstruction: Noble gas temperatures from fluid inclu sions in speleothems显示文摘 | Kluge T Marx T Scholz D | 2008 | Earth and Planetary Science Let ters2008，269，34： | 1 |
| 20 | Effects of estrogens during embryonal development on crowing in the domestic fowl显示文摘 | Marx G Jurkevich A Grossmann R | 2004 | Physiol Behav2004，82，4： | 1 |
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