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| 1 | Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage显示文摘AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine the accuracy of MR imaging features in predicting their biological behavior.METHODS This study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 Pan NEN patients(29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTS Ill defined margins were more common in G2-3 and stage Ⅲ-Ⅳ PanN ENs than in G1 and low-stage tumors(P < 0.001); this feature had high specificity in the identification of G2-3 and stage Ⅲ-Ⅳ tumors(90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage Ⅲ-Ⅳ lesions compared to well differentiated and low-stage tumors(1.09 × 10-3 mm2/s vs 1.45 × 10-3 mm2/s and 1.10 × 10-3 mm2/s vs 1.53 × 10-3 mm2/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cutoffs of 1.21 and 1.28 × 10-3 mm2/s for the identification of G2-3 and stage Ⅲ-Ⅳ tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64%(95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSION MR features of PanN ENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors. | Riccardo De Robertis Sara Cingarlini Paolo Tinazzi Martini Silvia Ortolani Giovanni Butturini Luca Landoni Paolo Regi Roberto Girelli Paola Capelli Stefano Gobbo Giampaolo Tortora Aldo Scarpa Paolo Pederzoli Mirko D'Onofrio | 2017 | World Journal of Gastroenterology2017，23，2： | 16 |
| 2 | Diffusion-weighted imaging of pancreatic cancer显示文摘Magnetic resonance imaging(MRI) is a reliable and accurate imaging method for the evaluation of patients with pancreatic ductal adenocarcinoma(PDAC). Diffusion-weighted imaging(DWI) is a relatively recent technological improvement that expanded MRI capabilities, having brought functional aspects into conventional morphologic MRI evaluation. DWI can depict the random diffusion of water molecules within tissues(the so-called Brownian motions). Modifications of water diffusion induced by different factors acting on the extracellular and intracellular spaces, as increased cell density, edema, fibrosis, or altered functionality of cell membranes, can be detected using this MR sequence. The intravoxel incoherent motion(IVIM) model is an advanced DWI technique that consent a separate quantitative evaluation of all the microscopic random motions that contribute to DWI, which are essentially represented by molecular diffusion and blood microcirculation(perfusion). Technological improvements have made possible the routine use of DWI during abdominal MRI study. Several authors have reported that the addition of DWI sequence can be of value for the evaluation of patients with PDAC, especially improving the staging; nevertheless, it is still unclear whether and how DWI could be helpful for identification, characterization, prognostic stratification and follow-up during treatment. The aim of this paper is to review up-to-date literature data regarding the applications of DWI and IVIM to PDACs. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Flavia Dal Corso Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Radiology2015，7，10： | 14 |
| 3 | Prognostication and response assessment in liver and pancreatic tumors:The new imaging显示文摘Diffusion-weighted imaging(DWI), dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) and perfusion computed tomography(CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations.Nevertheless, the term 'functional imaging' is commonly used to describe molecular imaging techniques, as positron emission tomography(PET)CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed tomography, functional imaging techniques applied to conventional MRI/CT examinations do not require the administration of radiolabeled drugs or specific equipments. Moreover, DWI and DCE-MRI can be performed during the same session, thus providing a comprehensive 'one-step' morphological and functional evaluation of hepato-bilio-pancreatic tumors. Literature data reveal that functional imaging techniques could be proposed for the evaluation of these tumors before treatment, given that they may improve staging and predict prognosis or clinical outcome. Microscopic changes within neoplastic tissues induced by treatments can be detected and quantified with functional imaging,therefore these techniques could be used also for posttreatment assessment, even at an early stage. The aim of this editorial is to describe possible applications of new functional imaging techniques apart frommolecular imaging to hepatic and pancreatic tumors through a review of up-to-date literature data, with a particular emphasis on pathological correlations,prognostic stratification and post-treatment monitoring. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Gino Puntel Silvia Ortolani Sara Cingarlini Andrea Ruzzenente Alfredo Guglielmi Giampaolo Tortora Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Gastroenterology2015，21，22： | 10 |
| 4 | Radiofrequency ablation of locally advanced pancreatic adenocarcinoma:An overview显示文摘Radiofrequency ablation(RFA)of pancreatic neoplasms is restricted to locally advanced,non-resectable but nonmetastatic tumors.RFA of pancreatic tumors is nowadays an ultrasound-guided procedure performed during laparotomy in open surgery.Intraoperative ultrasound covers the mandatory role of staging,evaluation of feasibility,guidance and monitoring of the procedure.Different types of needle can be used.The first aim in the evaluation of RFA as a treatment for locally advanced pancreatic ductal adenocarcinoma,in order of evaluation but not of importance,is to determine the feasibility of the procedure.The second aim is to establish the effect of RFA on tumoral mass in terms of necrosis andcytoreduction.The most important aim,third in order of evaluation,is the potential improvement of quality of life and survival rate.Nowadays,only a few studies assess the feasibility of the procedure.The present paper is an overview of RFA for pancreatic adenocarcinoma. | Mirko D’Onofrio Emilio Barbi Roberto Girelli Enrico Martone Anna Gallotti Roberto Salvia Paolo Tinazzi Martini Claudio Bassi Paolo Pederzoli Roberto Pozzi Mucelli | 2010 | World Journal of Gastroenterology2010，16，28： | 6 |
| 5 | Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi‐targeted kinase inhibitors in pimasertib‐resistant human lung and colorectal cancer cells显示文摘 | Erika Martinelli Teresa Troiani Elena D’Aiuto Floriana Morgillo Donata Vitagliano Anna Capasso Sarah Costantino Loreta Pia Ciuffreda Francesco Merolla Loredana Vecchione Veerle Vriendt Sabine Tejpar Anna Nappi Vincenzo Sforza Giulia Martini Liberato Berri | 2013 | Int J Cancer2013，，9： | 2 |
| 6 | Effects of hemorrhage and lactated Ringer's resuscitation on coagulation and fibrinogen metabolism in swine显示文摘 | Martini W Z Chinkes D L Sondeen J | 2006 | Shock2006，26，4： | 1 |
| 7 | Reliability of mycophenolicacid monitoring by an enzyme multiplied immunoassay technique显示文摘 | Martiny D Macours P Cotton F | 2010 | Clin Lab2010，56，： | 1 |
| 8 | Effects of alcohol and cigarette consumption on human seminal quality显示文摘 | Martini AC Molina RI Estofan D | 2004 | Fertil Steril2004，82，2： | 1 |
| 9 | The use of a modified TDSP for biodiesel production from soybean,linseed and waste cook-ing oil显示文摘 | Guzatto R Martini T L Samios D | | 0，，： | 1 |
| 10 | IL-1 beta induction of RANTES (regulated upon activation, normal T cell expressed and secreted) chemokine gene expression in endometriotic stromal cells depends on a nuclear factor- kappaB site in the proximal promoter 显示文摘 | Lebovic D I Chao V A Martini J F | 2001 | Clin Endocrinol Metab2001，86，10： | 1 |
| 11 | Antiangiogenic effects of 132 - adrenergic receptor blockade in a mouse model of oxygen - induced retinopathy 显示文摘 | Martini D Monte MD Ristori C | 2011 | J Neurochem2011，119，6： | 1 |
| 12 | Acute T- cell activation is detecable in unstable angina显示文摘 | Neri Semefi GG Priseo D Martini F | 1997 | Circulation1997，95，7： | 1 |
| 13 | Friction reduction in mixed lubri- cation 显示文摘 | Martini A Zhu D Wang Q | 2007 | Tribology Letters2007，28，2： | 1 |
| 14 | Characterization of variants in the promoter of EBV gene BZLF1 in normal donors,HIV-positive patients and in AIDS-relaated lymphomas显示文摘 | Martini M Capello D Senaino D | | 0，，03： | 1 |
| 15 | Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: results from transgenic mice显示文摘 | Dal Monte M Cammalleri M Martini D | 2007 | Invest Ophthalmol Vis Sci2007，48，8： | 1 |
| 16 | Triamcinolone acetonide and hexacetonide intra-articular treatment of symmetrical joints in juvenile idiopathic arthritis:a double-blind triM显示文摘 | Zulian F Martini G Gobber D | 2004 | Rheumatology (Oxford)2004，43，10： | 1 |
| 17 | Characterization of regulatory T cells identified as CD4 (+)CD25 (high)CD39(+) in patients with aclive tuberculosis显示文摘 | Chiacchio T Casetti R Butera O Vanini V Carrara S Girardi E Di Mitri D Battistini L Martini F Borsellino G Goletti D | 2009 | Clin Exp Immunol2009，156，3： | 1 |
| 18 | IL-Ibeta induction of RANTES(regulated upon activation, normal T cell expressed and secreted) chemokine gene expression in endometriotic stromal cells depends on a nuclear factor-kappa B site in the proximal promoter显示文摘 | Lebovic D I Chao V A Martini J F | 2001 | J Clin Endoerinol Memb2001，86，10： | 1 |
| 19 | Comparison of the Microflex LT and Vitek MS systems for routine identification of bacteria by matrix-assisted laser desorption ionization-time of flight mass spectrometry显示文摘 | Martiny D Busson L Wgbo I | 2012 | J Clin Microbiol2012，50，4： | 1 |
| 20 | 查看详情显示文摘 | M D Reid W J Munro F De Martini | | 0，，03： | 1 |
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