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| 1 | NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients显示文摘AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations. | Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，41： | 2 |
| 2 | Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine mode显示文摘 | Martin Pal Chu HW Honour JM | 2001 | Am J Respir Cell Mol Bio2001，24，5： | 1 |
| 3 | Antigen retrieval in prion protern immunohistochemistry显示文摘 | Pals P Martin JJ | 1999 | J Histochem Cytochem1999，47，11： | 1 |
| 4 | Algorithms for reverse engineering boundary representation models 显示文摘 | Benko Pal Martin R R Varady Tamas | 2001 | ComputerAided Design2001，33，11： | 1 |
| 5 | Identification of the Fanconi anemia complementation group I gene, FANCI显示文摘 | Josephine C. Dorsman Marieke Levitus Davy Rockx Martin A. Rooimans Anneke B. Oostra Anneke Haitjema Sietske T. Bakker J?rgen Steltenpool Dezs? Schuler Sheila Mohan Detlev Schindler Fré Arwert Gerard Pals Christopher G. Mathew Quinten Waisfisz Johan P. de | 2007 | Cellular Oncology2007，，3： | 1 |
| 6 | Toll-like receptor 2 mediates cellular activation by the B subunits of type Ⅱ heatlabile enterotoxins显示文摘 | Hajishengallis G Tapping Pal Martin MH | 2005 | Infect Immun2005，73，3： | 1 |
| 7 | Diminished ovarian reserve in a woman with a balanced 13;21 translocation显示文摘 | Nicole Kummer J. Ryan Martin Lubna Pal | 2009 | Fertility and Sterility2009，，3： | 1 |
| 8 | Transmissible spongiform encephalopathies: the story of a pathogenic protein显示文摘 | Van Everbroeck B Pals P Martin J J | 2002 | Peptides2002，23，： | 1 |
| 9 | Solving timedependent engineering problems with multiquadrics 显示文摘 | FERREIRA A J M MARTINS PALS | 2005 | J of Sound and Vibration2005，280，： | 1 |
| 10 | Long-term results of combined-modality therapy in respectable non-small-cell lung cancer显示文摘 | Ginsberg Pal Venkatraman ES | 2002 | J Clin Oncol2002，20，8： | 1 |
| 11 | High heat flux spray cooling 显示文摘 | Louis C Chow Maninder S Sehmbey Martin R Pals | 1997 | Heat Transfer1997，8，： | 1 |
| 12 | Transmissible spongiform encephalopathies:the story of a pathogenic protein显示文摘 | B Van Everbroeck P Pals J J Martin | 2002 | Peptides2002，23，： | 1 |
| 13 | The roles of c‐Jun NH2‐terminal kinases (JNKs) in obesity and insulin resistance显示文摘 | Martin Pal Mark A. Febbraio Graeme I. Lancaster | 2016 | J Physiol2016，，2： | 1 |
| 14 | Evidence of endoplasmic reticulum stress and liver inflammation in the American mink Neovison vison with benign hepatic steatosis显示文摘 | Rouvinen-Watt K Pal C Martin T | 2014 | J Comp Physiol B2014，184，7： | 1 |
| 15 | Evidence of endoplas- mic reticulum stress and liver inflammation in the American mink Neovison vison with benign hepatic steatosis显示文摘 | Rouvinen-Watt K Pal C Martin T | 2014 | J Comp Physio! B2014，184，7： | 1 |
| 16 | Solving time-dependent engineering problems with multiquadrics显示文摘 | FERREIRA AIM MARTINS PALS ROQUE CMC | 2005 | J of Sound and Vibration2005，280，35： | 1 |
| 17 | Diminished ovarian reserve in a woman with a balanced 13;21 translocation 显示文摘 | Kummer N Martin JR Pal L | 2009 | Fertil Steril2009，91，3： | 1 |
| 18 | Aldose reductase inhibition counteracts nitrosative stress and poly (ADP-ribose) polymerase activation in diabetic rat kidney and high-glucoseexposed human mesangial cells 显示文摘 | Viktor R Drel Pal Pacher Martin J Stevens | 2006 | Free Radical Biology & Medicine2006，40，： | 1 |
| 19 | Diminished ovarian reserve in a woman with a balanced 13;21 translocation显示文摘 | Kummer N Martin JR Pal L | 2009 | Fertil Steril2009，91，3： | 1 |
| 20 | Transmissible spongiform encephalopathies: the story of a pathogenic protein显示文摘 | Everbroeck BV Pals P Martin J-J | 2002 | Peptides2002，23，： | 1 |
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