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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Coronary risk estimation in Spain using a calibrated Framingham function显示文摘 | Marrugat J Solanas P D Agostino R | 2003 | Rev Esp Cardiol2003，56，3： | 1 |
| 3 | Amount and intensity of physical activ- ity, physical fitness, and serum lipids in men显示文摘 | Marrugat J Elosua R Covas MI | 1996 | Am J Epidemlol1996，143，： | 1 |
| 4 | An adaptation of the Framingham coronary heart disease risk function to European Mediterranean areas显示文摘 | D'Agostino R Sullivan L | 2003 | J Epidemiol Community Health2003，57，： | 1 |
| 5 | Coronary risk estimation in Spain using a calibrated Framingham function 显示文摘 | Marrugat J Solanas P D'Agostino R | 2003 | Rev Esp Cardiol2003，56，3： | 1 |
| 6 | Coronary risk estimation in spain using a calibrated framingham function显示文摘 | Marrugat J Solanas P D' Agostino R | 2003 | Rev Esp Cardol2003，56，： | 1 |
| 7 | Enhanced expression of α(1,3)-fucosyltransferase genes correlates with E-Selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells 显示文摘 | Marrugat R Cancelas JA | 1998 | Cancer Res1998，58，： | 1 |
| 8 | Amount and intensity of physical activity,physical fitness and sermn lipids in men显示文摘 | MARRUGAT J ELOSUA R COVAS M I | 1996 | Am J Epide1996，143，： | 1 |
| 9 | Mortality difference between men and women following first myocardial infarction 显示文摘 | Marrugat J Sala J Masia R | 1998 | JAMA1998，280，16： | 1 |
| 10 | coronary risk estimation in Spain using a calibrated Framingham function显示文摘 | Marrugat J Solanas P Agostino R | 2003 | Rev Esp Cardiol2003，56，： | 1 |
| 11 | Validation of the Minnesota leisure-time physical activity questionnaire in Spanish men 显示文摘 | Elosua R Marrugat J Molina L | 1994 | American Journal of Epidemiology1994，139，12： | 1 |
| 12 | Enhanced Expression of α(1,3)-fucosyltransferase Genes Correlates with E-selectin Mediated Adhesion and Metastasis Potential of Human Lung Adenocarcinoma Cells显示文摘 | SATUE M M MARRUGAT R CANCELAS J A | 1998 | Cancer Res1998，58，7： | 1 |
| 13 | Coronary risk estimation in Spain using a calibrated Framingham function显示文摘 | Marrugat J Solanas P D'Agostino R | 2003 | Rev Esp Cardiol2003，56，3： | 1 |
| 14 | Coronary risk estimation in Spain using a calibrated Framingham function显示文摘 | Marrugat J Solanas P Agostino R | 2003 | Rev Esp Cardiol2003，56，： | 1 |
| 15 | Coronary risk estimation in Spain using a calibrated framingham funciton显示文摘 | Solanas P D' Agostino R | 2003 | Rev Esp Cardiol2003，56，3： | 1 |
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