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| 1 | Clinical features and management of primary sclerosing cholangitis显示文摘Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts,resulting in cirrhosis and need for liver transplantation and reduced life expectancy.The majority of cases occur in young and middle-aged men,often in association with inflammatory bowel disease.The etiology of primary sclerosing cholangitis includes immune-mediated components and elements of undefined nature.No effective medical therapy has been identified.The multiple complications of primary sclerosing cholangitis include metabolic bone disease,dominant strictures,bacterial cholangitis,and malignancy,particularly cholangiocarcinoma,which is the most lethal complication of primary sclerosing cholangitis.Liver transplantation is currently the only life-extending therapeutic alternative for patients with end-stage disease,although recurrence in the allografted liver has been described.A PSC-like variant attracting attention is cholangitis marked by raised levels of the immunoglobulin G4 subclass,prominence of plasma cells within the lesions,and steroid responsiveness. | Marina G Silveira Keith D Lindor | 2008 | World Journal of Gastroenterology2008，14，21： | 9 |
| 2 | The presence of ANP in rat peritoneal mast cells显示文摘Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fraction of mast cells was obtained by separation of rat peritoneal cells on a Percoll density gradient. By Western blotting, two ANP-immunoreactive proteins of molecular masses of 2.5 kDa and 16.9 kDa were detected in lysates from these mast cells. Electron microscope immunogold labeling has revealed the presence of ANP-immunoreactive material in storage, secreting and released granules of mast cells. Our findings indicate the rat peritoneal mast cells to contain both ANP prohormone and ANP. These both peptides are located in mast cell secretory granules and released by mechanism of degranulation. It is discussed that many mast cell functions might be due to production of natriuretic peptides by these cells. | Marina G MARTYNOVA Olga A BYSTROVA Olga M MOISEEVA Anton L EVDONIN Kirill A KONDRATOV Natalja D MEDVEDEVA | 2005 | Cell Research2005，15，10： | 3 |
| 3 | Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation显示文摘Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stom-ach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distension with CO2 highlighting thickened areas of the esophageal wall, thus allowing an accurate quantifica-tion of their extents. Although there are other alterna-tives for distension (oral contrast agents, water and ef-fervescent granules), they may be suboptimal. Patients with locally advanced esophageal cancer have a dismal prognosis despite surgical resection. Therefore, neo-adjuvant treatment strategies using radiation therapy and chemotherapy were developed to improve sur-vival. Neoadjuvant therapy improves esophageal tumor prognosis in a substantial proportion of patients, and the use of imaging techniques is mandatory to detect their response. PnCT combined with virtual endoscopy and multiplanar reconstruction enhances morphologic details in esophageal cancer, and thus would allow animproved assessment of response to neoadjuvant treat-ment. Therefore, more information could be provided to assess the efficacy of pre-surgical treatment. We de-scribe the potential use of PnCT to assess the response to neoadjuvant therapy in esophageal cancer with an imaging pathologic correlation. | Marina Ulla Ernestina Gentile Ezequiel Levy Yeyati Maria L Diez Demetrio Cavadas Ricardo D Garcia-Monaco Pablo R Ros | 2013 | World Journal of Gastrointestinal Oncology2013，5，12： | 3 |
| 4 | Helicobacter pylori secreted peptidyl prolyl cis , trans -isomerase drives Th17 inflammation in gastric adenocarcinoma显示文摘 | Amedeo Amedei Fabio Munari Chiara Della Bella Elena Niccolai Marisa Benagiano Lapo Bencini Fabio Cianchi Marco Farsi Giacomo Emmi Giuseppe Zanotti Marina Bernard Manikuntala Kundu Mario Milco D’Elios | 2014 | Internal and Emergency Medicine2014，，3： | 2 |
| 5 | Transcriptome reprogramming,epigenetic modifications and alternative splicing orchestrate the tomato root response to the beneficial fungus Trichoderma harzianum显示文摘Beneficial interactions of rhizosphere microorganisms are widely exploited for plant biofertilization and mitigation of biotic and abiotic constraints.To provide new insights into the onset of the roots–beneficial microorganisms interplay,we characterised the transcriptomes expressed in tomato roots at 24,48 and 72 h post inoculation with the beneficial fungus Trichoderma harzianum T22 and analysed the epigenetic and post-trascriptional regulation mechanisms.We detected 1243 tomato transcripts that were differentially expressed between Trichoderma-interacting and control roots and 83 T.harzianum transcripts that were differentially expressed between the three experimental time points.Interaction with Trichoderma triggered a transcriptional response mainly ascribable to signal recognition and transduction,stress response,transcriptional regulation and transport.In tomato roots,salicylic acid,and not jasmonate,appears to have a prominent role in orchestrating the interplay with this beneficial strain.Differential regulation of many nutrient transporter genes indicated a strong effect on plant nutrition processes,which,together with the possible modifications in root architecture triggered by ethylene/indole-3-acetic acid signalling at 72 h post inoculation may concur to the well-described growth-promotion ability of this strain.Alongside,T.harzianum-induced defence priming and stress tolerance may be mediated by the induction of reactive oxygen species,detoxification and defence genes.A deeper insight into gene expression and regulation control provided first evidences for the involvement of cytosine methylation and alternative splicing mechanisms in the plant–Trichoderma interaction.A model is proposed that integrates the plant transcriptomic responses in the roots,where interaction between the plant and beneficial rhizosphere microorganisms occurs. | Monica De Palma Maria Salzano Clizia Villano Riccardo Aversano Matteo Lorito Michelina Ruocco Teresa Docimo Anna Lisa Piccinelli Nunzio D’Agostino Marina Tucci | 2019 | Horticulture Research2019，6，1： | 2 |
| 6 | HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response显示文摘 | Gaia Codolo Matteo Fassan Fabio Munari Andrea Volpe Piefrancesco Bassi Massimo Rugge Francesco Pagano Mario Milco D’Elios Marina Bernard | 2012 | Cancer Immunology Immunotherapy2012，，1： | 2 |
| 7 | The immune modulating activity of the Helicobacter pylori HP-NAP: Friend or foe?显示文摘 | Marina de Bernard Mario M. D’Elios | 2009 | Toxicon2009，，7： | 2 |
| 8 | Membrane redistributions through multi-intercellular exchanges and serial trogocytosis显示文摘Trogocytosis 是在膜的房间之间的快速的转移并且联系蛋白质。Trogocytic 交换在不同房间类型之间被调查了,主要在二房间的系统,包含一个施主和一种领受人房间类型。这里,我们在一个更复杂的系统学习了 trogocytosis,包含不仅几个有免疫力的房间子集而且多重肿瘤房间。我们证明 CD4+ T 房间, CD8+ T 房间和单核白血球能获得膜补丁和他们由多重同时的 trogocytoses 从不同肿瘤房间包含的未经触动的蛋白质。CD4+ 和 CD8+ T 房间的 trogocytic 能力被发现类似于自体同源的单核白血球的,却劣等。激活的外部血的 mononuclear 房间(PBMC ) 可以也在一个所有自体同源的系统交换在自己之间的膜。为这个原因,单核白血球能够从多重肿瘤房间来源获得膜,并且再把他们转移到自体同源的 T 房间,与一些他们的自己的膜(连续 trogocytosis ) 一起。我们的数据说明在自体同源的激活的有免疫力的受动器房间和他们的环境之间的膜交换的程度,并且包括鈥渂y stander 鈥 ? 房间,本地环境的细胞的内容怎么可以影响有免疫力的受动器房间的功能。 | Estlbahz Alegre Klave-Yune HoWangYin Benolt Favier Jeremy Baudhuin Emilie Lesport Marina Daouya Alvaro Gonzalez Edgardo D Carosella Joel LeMaoult | 2010 | Cell Research2010，20，11： | 2 |
| 9 | Polyoxygenated oleanane triterpenes from hydrocotyle ranunculoides显示文摘 | Marina D G Antonio F Pietro M | 1994 | Phytochemistry1994，35，2： | 1 |
| 10 | Comparison of two analytical methods for the determination of organotin compounds in marine organisms显示文摘 | CAMILLA L MARINA D C EMANUELE M | 2009 | Comptes Rendus Chirnie2009，12，8： | 1 |
| 11 | Identification of an alternative CD20 transcript variant in B cell malignancies coding for a novel pro- tein associated to rituximab resistance 显示文摘 | Carole H Marina D Pierre - Simon R | 2010 | Blood2010，115，12： | 1 |
| 12 | Examination of cognitive functions in patients with Parkinson's disease 显示文摘 | Jelena S Stojanka D Marina J | 2004 | Medicine and Biology2004，111，2： | 1 |
| 13 | Antimicro bial activity of essential oils and their components against the three major pathogens of the cultivated button mushroom,Agaricus bisporus 显示文摘 | Marina Sokovic Leo J L D van Griensven | 2006 | European Journal of Plant Pathology2006，116，3： | 1 |
| 14 | Characterization of en- tomopathogenie nematodes and symbiotic baeteria active against Spodoptera frugiperda ( Lepidoptera : Noctuidae ) and contribution of bacterial urease to the insecticidal effect 显示文摘 | Juliana M S Marina S D Rodrigo L B | 2012 | Biological Control2012，63，： | 1 |
| 15 | The RDH bandage:Hemostasis and survival in a lethal aortotomy hemorrhage model显示文摘 | John V Marina D | 2003 | Journal of Surgical Research2003，，113： | 1 |
| 16 | An overview of systematic reviews of the effectiveness of opiate maintenance therapies: available evidence to inform clinical practice and research 显示文摘 | Laura A Marina D Carlo AP | 2005 | Journal of Substance Abuse Treatment2005，28，4： | 1 |
| 17 | Human resource management in entrepreneurial firms: a literaturereview显示文摘 | Marina D Marta ODUC andhna MR | 2011 | International Journal of Manpower2011，32，1： | 1 |
| 18 | Effect of lithium ionson oxygen reduction in ionic liquid-based electrolytes 显示文摘 | FRANCESCA D FRANCESCA S MARINA M | 2011 | ElectrochemCommun2011，13，10： | 1 |
| 19 | Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells 显示文摘 | CHEN D DANIEL K G MARINA S | 2005 | Bioehem Pharmacol2005，69，10： | 1 |
| 20 | Polymorphisms in exons 6 and 7 of the ABO locus and their association with venous thrombosis in young Brazilian patients显示文摘 | Sabrina G Paiva Adriano P Sabino Maria G Carvalho Daniel D Ribeiro Karina B Gomes Mariana S Santos Marina S Oliveira Geralda G Lages Luci MS Dusse Ana Paula Fernandes | 2009 | Blood Coagulation & Fibrinolysis2009，，2： | 1 |
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